Effects of different exercise modalities on oxygenation stress, inflammatory factors, and drug craving in drug users during the audit period
DOI:
https://doi.org/10.12775/QS.2025.41.60144Keywords
exercise, drug users, inflammatory factors, drug cravingAbstract
Objective:
To explore the effects of different exercise modalities on drug craving and the oxidative stress-inflammatory mechanisms in female addicts during rehabilitation. Methods: Forty female drug users were randomly assigned to yoga, meditation, physical fitness, or control groups (n=10 each). A 12-week intervention (3 sessions/week, 1 h/session) was conducted. Serum levels of malondialdehyde (MDA), homocysteine (HCY), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1, and intercellular adhesion molecule-1 (ICAM-1) were measured pre- and post-intervention. Drug craving was assessed via a visual analog scale (VAS). Results: (1) Female addicts exhibited elevated oxidative stress (MDA, HCY) and inflammatory markers (TNF-α, IL-6, IL-1, ICAM-1) compared to healthy individuals; (2) Post-intervention, these biomarkers significantly decreased in the yoga, meditation, and physical fitness groups (p<0.05); (3) VAS scores in all exercise groups showed marked reduction (p<0.01). Conclusion: Oxidative stress and inflammatory responses are present in female addicts during rehabilitation. Twelve weeks of exercise (yoga, meditation, or fitness training) effectively reduces these biomarkers, promotes inflammatory homeostasis, and alleviates drug craving, with comparable efficacy across modalities.
References
[1] Bachtell R, Hutchinson M R, Wang X, et al. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4[J]. CNS Neurol Disord Drug Targets, 2015,14(6):692-699.
[2] Escubedo E, Guitart L, Sureda F X, et al. Microgliosis and down-regulation of adenosine transporter induced by methamphetamine in rats[J]. Brain Res, 1998,814(1-2):120-126.
[3] Jacobsen J H, Hutchinson M R, Mustafa S. Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy[J]. Curr Opin Pharmacol, 2016,2（6）6:131-137.
[4] Lacagnina M J, Rivera P D, Bilbo S D. Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse[J]. Neuropsychopharmacology, 2017,42(1):156-177.
[5] Mahajan S D, Schwartz S A, Aalinkeel R, et al. Morphine modulates chemokine gene regulation in normal human astrocytes[J]. Clin Immunol, 2005,115(3):323-332.
[6] Trocello J M, Rostene W, Melik-Parsadaniantz S, et al. Implication of CCR2 chemokine receptor in cocaine-induced sensitisation[J]. J Mol Neurosci, 2011,44(3):147-151.
[7] Hutchinson M R, Coats B D, Lewis S S, et al. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia[J]. Brain Behav Immun, 2008,22(8):1178-1189.
[8] Lewitus G M, Konefal S C, Greenhalgh A D, et al. Microglial TNF-alpha Suppresses Cocaine-Induced Plasticity and Behavioural Sensitization[J]. Neuron, 2016,90(3):483-491.
[9] Raghavendra V, Rutkowski M D, DeLeo J A. The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats[J]. J Neurosci, 2002,22(22):9980-9989.
[10] Eidson L N, Inoue K, Young L J, et al. Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling[J]. Neuropsychopharmacology, 2017,42(3):661-670.
[11] Guo M L, Liao K, Periyasamy P, et al. Cocaine-mediated microglial activation involves the ER stress-autophagy axis[J]. Autophagy, 2015,11(7):995-1009.
[12] WANG Yingying, ZHOU Chenglin. Dosage relationship between intensity and inhibitory capacity of acute aerobic exercise - evidence from ERP[J]. Sports Science, 2014,34(11):42-49.
[13] Araos P, Pedraz M, Serrano A, et al. Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity[J]. Addict Biol, 2015,20(4):756-772.
[14] Huang Y N, Yang L Y, Wang J Y, et al. L-Ascorbate Protects Against Methamphetamine-Induced Neurotoxicity of Cortical Cells via Inhibiting Oxidative Stress, Autophagy, and Apoptosis[J]. Mol Neurobiol, 2017,54(1):125-136.
[15] Walker J, Winhusen T, Storkson J M, et al. Total antioxidant capacity is significantly lower in cocaine-dependent and methamphetamine-dependent patients relative to normal controls: results from a preliminary study[J]. Hum Psychopharmacol, 2014,29(6):537-543.
[16] Gupta K, Sharma R, Singh V, et al. Intravenous Cocaine Results in an Acute Decrease in Levels of Biomarkers of Vascular Inflammation in Humans[J]. Cardiovasc Toxicol, 2018,18(4):295-303.
[17] Halpern J H, Sholar M B, Glowacki J, et al. Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration[J]. J Clin Endocrinol Metab, 2003,88(3):1188-1193.
[18] Aguiar A J, Tuon T, Soares F S, et al. The effect of n-acetylcysteine and deferoxamine on exercise-induced oxidative damage in striatum and hippocampus of mice[J]. Neurochem Res, 2008,33(5):729-736.
[19] Engelmann A J, Aparicio M B, Kim A, et al. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase[J]. Brain Struct Funct, 2014,219(2):657-672.
[20] Lafuente J V, Sharma A, Muresanu D F, et al. Repeated Forced Swim Exacerbates Methamphetamine-Induced Neurotoxicity: Neuroprotective Effects of Nanowired Delivery of 5-HT3-Receptor Antagonist Ondansetron[J]. Mol Neurobiol, 2018,55(1):322-334.
[21] Lee S S, Yoo J H, Kang S, et al. The Effects of 12 Weeks Regular Aerobic Exercise on Brain-derived Neurotrophic Factor and Inflammatory Factors in Juvenile Obesity and Type 2 Diabetes Mellitus[J]. J Phys Ther Sci, 2014,26(8):1199-1204.
[22] Radak Z, Chung H Y, Goto S. Exercise and hormesis: oxidative stress-related adaptation for successful aging[J]. Biogerontology, 2005,6(1):71-75.
[23] Radak Z, Chung H Y, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise[J]. Free Radic Biol Med, 2008,44(2):153-159.
[24] Roh H T, So W Y. The effects of aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor levels, and blood-brain barrier function in obese and non-obese men[J]. J Sport Health Sci, 2017,6(4):447-453.
[25] Toborek M, Seelbach M J, Rashid C S, et al. Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood-brain barrier[J]. Mol Neurodegener, 2013,8(4):22- .26
[26] Gleeson M, Bishop N C, Stensel D J, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease[J]. Nat Rev Immunol, 2011,11(9):607-615.
[27] Radin A, Ganz P A, Van Dyk K, et al. Executive Functioning and Depressive Symptoms After Cancer: The Mediating Role of Coping[J]. Psychosom Med, 2021,83(3):291-299.
[28] Starkie R, Ostrowski S R, Jauffred S, et al. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans[J]. FASEB J, 2003,17(8):884-886.
[29] Vecchio L M, Meng Y, Xhima K, et al. The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging[J]. Brain Plast, 2018,4(1):17-52.
[30] LU Chunxia, DONG Weixin, ZHENG Lan, et al. Effects of exercise intervention to activate immune stress and dopamine levels on the mental health of compulsorily isolated drug addicts with amphetamine-type drug addiction[J]. Chinese Journal of Sports Medicine, 2019,38(09):762-770.
[31] YAO Hui, CHEN Yanmei. Effects of different exercise modes on kynurenine metabolic pathway in female drug addicts[J]. Sports Science, 2020,40(10):70-81.
[32] ZHOU Chenglin, SHI Daqing, LI Bin, et al. Application of aerobic exercise in drug abuse rehabilitation[J]. Chinese Journal of Drug Dependence, 2014,23(06):407-411.
[33] Wang Jingsong. Improvement effects of aerobic combined resistance training to reduce IL-1β, TNF-α, and IL-6 plasma levels on craving in methamphetamine quitters[D]. Hunan Normal University, 2020.
[34] Agarwal R P, Kumar A, Lewis J E. A pilot feasibility and acceptability study of yoga/meditation on the quality of life and markers of stress in persons living with HIV who also use crack cocaine[J]. J Altern Complement Med, 2015,21(3):152-158.
[35] Creswell J D, Taren A A, Lindsay E K, et al. Alterations in Resting-State Functional Connectivity Link Mindfulness Meditation With Reduced Interleukin- 6: A Randomised Controlled Trial[J]. Biol Psychiatry, 2016,80(1):53-61.
[36] Dhawan A, Chopra A, Jain R, et al. Effectiveness of yogic breathing intervention on quality of life of opioid dependent users[J]. Int J Yoga, 2015,8(2):144-147.
[37] Shaffer H J, LaSalvia T A, Stein J P. Comparing Hatha yoga with dynamic group psychotherapy for enhancing methadone maintenance treatment: a randomized clinical trial[J]. Altern Ther Health Med, 1997,3(4):57-66.
[38] Zhuang S M, An S H, Zhao Y. Yoga effects on mood and quality of life in Chinese women undergoing heroin detoxification: a randomized controlled trial[J]. Nurs Res, 2013,62(4):260-268.
[39] Amare A T, Schubert K O, Hou L, et al. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: a Genome-Wide Association Study[J]. JAMA Psychiatry, 2018,75(1):65-74.
[40] Pardo C A, Vargas D L, Zimmerman A W. Immunity, neuroglia and neuroinflammation in autism[J]. Int Rev Psychiatry, 2005,17(6):485-495.
[41] Peyrot W J, Van der Auwera S, Milaneschi Y, et al. Does Childhood Trauma Moderate Polygenic Risk for Depression? a Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium[J]. Biol Psychiatry, 2018,84(2):138-147.
[42] Sayana P, Colpo G D, Simoes L R, et al. A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients[J]. J Psychiatr Res, 2017,9( )2:160-182.
[43] Felger J C, Miller A H. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise[J]. Front Neuroendocrinol, 2012,33(3):315-327.
[44] Felger J C, Treadway M T. Inflammation Effects on Motivation and Motor Activity: Role of Dopamine[J]. Neuropsychopharmacology, 2017,42(1):216-241.
[45] Zhang K, Zhang Q, Jiang H, et al. Impact of aerobic exercise on cognitive impairment and oxidative stress markers in methamphetamine-dependent patients [J]. Psychiatry Res, 2018,26( )6:328-333.
[46] WAN Fen, JIANG Lei, WANG Jun, et al. Effects and mechanisms of ginkgolide B on microglia activation and inflammatory response induced by methamphetamine[J]. Journal of Clinical Neurology, 2020,33(06):451-457.
[47] Lu Chunxia. Role and mechanism of exercise-activated immune response in slowing down negative emotions in methamphetamine addicts with auditory delay[D]. Hunan Normal University, 2021.
[48] YANG Linmei. A study on the effects of different exercise modalities on the withdrawal effects of female methamphetamine dependents [D]. Southwest University, 2021.
[49] Butzer B, LoRusso A, Shin S H, et al. Evaluation of Yoga for Preventing Adolescent Substance Use Risk Factors in a Middle School Setting: a Preliminary Group-Randomised Controlled Trial[J]. J Youth Adolesc, 2017,46(3):603-632.
[50] Gupta S, Jhanjee S, Dhawan A. Effectiveness of Interventions Based on Yogic Breathing Practices (IB-YBP) on Substance Use Disorders-A Systematic Review of the Randomised Control Trials and Quasi-Experimental Trials[J]. Subst Use Misuse, 2021,56(11):1624-1641.
[51] Lotfalian S, Spears C A, Juliano L M. The effects of mindfulness-based yogic breathing on craving, affect, and smoking behaviour[J]. Psychol Addict Behav, 2020,34(2):351-359.
[52] Walia N, Matas J, Turner A, et al. Yoga for Substance Use: A Systematic Review[J]. J Am Board Fam Med, 2021,34(5):964-973.
[53] Walia N, Matas J, Turner A, et al. Yoga for Substance Use: A Systematic Review[J]. J Am Board Fam Med, 2021,34(5):964-973.
[54] Wimberly A S, Engstrom M. Stress, Substance Use, and Yoga in the Context of Community Reentry Following Incarceration[J]. J Correct Health Care, 2018,24(1):96-103.
[55] Zaccari B, Callahan M L, Storzbach D, et al. Yoga for veterans with PTSD: Cognitive functioning, mental health, and salivary cortisol[J]. Psychol Trauma, 2020,12(8):913-917.
[56] Bock B C, Rosen R K, Fava J L, et al. Testing the efficacy of yoga as a complementary therapy for smoking cessation: design and methods of the BreathEasy trial [J]. Contemp Clin Trials, 2014,38(2):321-332.
[57] Kumar J, Dave A R, Vyas M G. A comparative clinical study of Shatapatrayadi churna tablet and Patoladi yoga in the management of Amlapitta[J]. Ayu, 2011,32(3):361-364.
[58] Shahab L, Sarkar B K, West R. The acute effects of yogic breathing exercises on craving and withdrawal symptoms in abstaining smokers[J]. Psychopharmacology (Berl), 2013,225(4):875-882.
[59] Sussman S, Reynaud M, Aubin H J, et al. Drug addiction, love, and the higher power[J]. Eval Health Prof, 2011,34(3):362-370.
[60] Faraj M M, Lipanski N M, Morales A, et al. A Virtual Reality Meditative Intervention Modulates Pain and the Pain Neuromatrix in Patients with Opioid Use Disorder[J]. Pain Med, 2021,22(11):2739-2753.
[61] WANG Dongshi, ZHU Ting. Effects of aerobic exercise on physical fitness, craving and emotional state of methamphetamine-dependent individuals[J]. Sports Science, 2017,37(07):50-59.
[62] Jeffries E R, Zvolensky M J, Buckner J D. The Acute Impact of Hatha Yoga on Craving Among Smokers Attempting to Reduce or Quit[J]. Nicotine Tob Res, 2020,22(3):446-451.
[63] Witkiewitz K, Warner K, Sully B, et al. Randomized trial comparing mindfulness-based relapse prevention with relapse prevention for women offenders at a residential addiction treatment centre[J]. Subst Use Misuse, 2014,49(5):536-546.
[64] Bowen S, Chawla N, Collins S E, et al. Mindfulness-based relapse prevention for substance use disorders: a pilot efficacy trial[J]. Subst Abus, 2009,30(4):295-305.
[65] Witkiewitz K, Bowen S, Douglas H, et al. Mindfulness-based relapse prevention for substance craving[J]. Addict Behav, 2013,38(2):1563-1571.
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