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Quality in Sport

Modern Approaches to Obesity Treatment – literature review
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Modern Approaches to Obesity Treatment – literature review

Authors

  • Mateusz Romaniuk Independent Public Health Care Center of the Polish Ministry of Interior and Administration in Lublin, ul. Grenadierów 3, 20-331 Lublin, Poland https://orcid.org/0009-0007-1486-5522
  • Maria Wachowska Podhale Specialist Hospital named after St John Paul II in Nowy Targ, ul. Szpitalna 14, 34-400 Nowy Targ, Poland https://orcid.org/0009-0004-2069-9469
  • Wojciech Sowiński 1st Military Clinical Hospital with the Outpatient Clinic, Lublin, Poland https://orcid.org/0000-0002-2267-4773
  • Paweł Maciej Rycąbel Independent Public Health Care Center of the Polish Ministry of Interior and Administration in Lublin, ul. Grenadierów 3, 20-331 Lublin, Poland https://orcid.org/0009-0008-4039-8312
  • Marta Szymura Independent Public Healtcare Center No.1 in Rzeszów, ul. Tadeusza Czackiego 2 35-051 Rzeszów https://orcid.org/0009-0000-2776-8974
  • Marek Jarosław Molenda 4th Clinical University Hospital in Lublin, ul. Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland https://orcid.org/0009-0002-7900-4970
  • Oliwia Woszczyńska Independent Public Health Care of the Ministry of the Internal Affairs, ul. Kartuska 4/6, 80-104 Gdańsk, Poland https://orcid.org/0009-0001-7724-544X
  • Agnieszka Ewelina Wojciechowska Cardinal Stefan Wyszyński Province Specialist Hospital in Lublin, ul. al. Kraśnicka 100, 20-718 Lublin https://orcid.org/0009-0009-3344-9115
  • Michał krawczyk 1. Pediatric Cardiac Surgery Department of Mikołaj Kopernik Hospital in Gdańsk, Gdańsk, Poland https://orcid.org/0009-0008-9697-6548
  • Mateusz Paniak Wojewódzki Szpital Specjalistyczny w Lublinie https://orcid.org/0009-0009-0110-9634

DOI:

https://doi.org/10.12775/QS.2025.41.60022

Keywords

Obesity, Obesity treatment, Causes of obesity, Liraglutide, Phentermine

Abstract

Abstract

Introduction and Purpose:

Obesity constitutes a complex health issue of an epidemiological nature, affecting an increasing number of individuals globally. It is associated with numerous health complications, including cardiovascular diseases, type 2 diabetes, hypertension, as well as mental health disorders and a reduced quality of life. The treatment of obesity is a multifaceted process that should encompass lifestyle modifications such as dietary improvement, enhanced physical activity, and psychological support. In certain cases—depending on the severity of obesity and the presence of comorbid conditions—it may become necessary to implement pharmacotherapy or surgical interventions, such as bariatric procedures. This article provides a comprehensive overview of the condition of obesity and its underlying causes. Furthermore, the epidemiology of the phenomenon is presented. The primary focus, however, is placed on the available pharmacological solutions that may assist in combating obesity.

Summary:

At present, alongside the modification of dietary habits and the enhancement of physical activity, the use of pharmacological agents is becoming an increasingly significant component of obesity therapy. These medications primarily contribute to the reduction of appetite and the limitation of fat absorption, thereby supporting the overall effectiveness of the treatment process.

 

References

[1] Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253. PMID: 11234459.

[2] Gilden AH, Catenacci VA, Taormina JM. Obesity. Ann Intern Med. 2024 May;177(5):ITC65-ITC80. doi: 10.7326/AITC202405210. Epub 2024 May 14. PMID: 38739920.

[3] https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight; [dostęp: 22.11.2024r.]

[4] Panasiuk D, Szponarowicz P, Panek E, Jasłowski D, Rzeszutko M, Raczkiewicz P, Skrętowicz M, Snopkowski B, Korzec T, Sosnowski J, Obesity of children and adults - pandemic of the 21st century. Journal of Education, Health and Sport. 2023;22(1):36-45. eISSN 2391-8306; doi:10.12775/JEHS.2023.22.01.003

[5] Kelly AS, Armstrong SC, Michalsky MP, Fox CK. Obesity in Adolescents: A Review. JAMA. 2024 Sep 3;332(9):738-748. doi: 10.1001/jama.2024.11809. PMID: 39102244.

[6] Nuttall FQ. Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2015 May;50(3):117-128. doi: 10.1097/NT.0000000000000092. Epub 2015 Apr 7. PMID: 27340299; PMCID:PMC4890841.

[7] Haufs MG, Zöllner YF. Waist-Hip Ratio More Appropriate Than Body Mass Index. Dtsch Arztebl Int. 2020 Sep 25;117(39):659. doi: 10.3238/arztebl.2020.0659a. PMID: 33357347; PMCID: PMC78294

[8] van Baak MA, Pramono A, Battista F, Beaulieu K, Blundell JE, Busetto L, Carraça EV, Dicker D, Encantado J, Ermolao A, Farpour-Lambert N, Woodward E, Bellicha A, Oppert JM. Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses. Obes Rev. 2021 Jul;22 Suppl 4:e13239. doi: 10.1111/obr.13239. Epub 2021 May 3. PMID: 33939229; PMCID: PMC8365680.

[9] Suchodolska P, Orkusz A. Otyłość – przyczyny, rodzaje, leczenie, skutki. Nauki Inż Technol. 2018; 4(31): 65-79; doi: 10.15611/nit.2018.4.04

[10] Loos RJ. The genetics of adiposity. Curr Opin Genet Dev. 2018 Jun;50:86-95. doi:10.1016/j.gde.2018.02.009. Epub 2018 Mar 9. PMID: 29529423; PMCID: PMC6089650.

[11] Singh RK, Kumar P, Mahalingam K. Molecular genetics of human obesity: A comprehensive review. C R. Biol. 2017 Feb;340(2):87-108. doi: 10.1016/j.crvi.2016.11.007. Epub 2017 Jan 13. PMID: 28089486.

[12] Loos RJ. The genetics of adiposity. Curr Opin Genet Dev. 2018 Jun;50:86-95. doi:10.1016/j.gde.2018.02.009. Epub 2018 Mar 9. PMID: 29529423; PMCID: PMC6089650

[13] Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. 2022 Feb;23(2):120-133. doi: 10.1038/s41576-021-00414-z. Epub 2021 Sep 23. PMID: 34556834; PMCID: PMC8459824.

[14] Hetman M, Barg E, Placzkowska S. Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome - a sibling-controlled study. Pediatr Endocrinol Diabetes Metab. 2023;29(3):134-142. doi: 10.5114/pedm.2023.131513. PMID: 38031829; PMCID: PMC10679903.

[15] Calcaterra V, Verduci E, Cena H, Magenes VC, Todisco CF, Tenuta E, Gregorio C, De Giuseppe R, Bosetti A, Di Profio E, Zuccotti G. Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility. Nutrients. 2021 May 28;13(6):1848. doi: 10.3390/nu13061848. PMID: 34071499; PMCID: PMC8228678.

[16] Cena H, Chiovato L, Nappi RE. Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists. J Clin Endocrinol Metab. 2020 Aug 1;105(8):e2695–709. doi: 10.1210/clinem/dgaa285. PMID: 32442310; PMCID: PMC7457958.

[17] Biondi B. Subclinical Hypothyroidism in Patients with Obesity and Metabolic Syndrome: A Narrative Review. Nutrients. 2023 Dec 27;16(1):87. doi: 10.3390/nu16010087. PMID: 38201918; PMCID: PMC10780356.

[18] Juszczak A, Morris D, Grossman A. Cushing’s Syndrome. 2024 Sep 5. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905314.

[19] Romanelli R, Cecchi N, Carbone MG, Dinardo M, Gaudino G, Miraglia Del Giudice E, Umano GR.Pediatric obesity: prevention is better than care. Ital J Pediatr. 2020 Jul 24;46(1):103. doi: 10.1186/s13052-020-00868-7. PMID: 32709246; PMCID: PMC7379757.

[20] Masood B, Moorthy M. Causes of obesity: a review. Clin Med (Lond). 2023 Jul;23(4):284-291. doi: 10.7861/clinmed.2023-0168. PMID: 37524429; PMCID: PMC10541056.

[21] Global Obesity Health Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27; doi: 10.1056/NEJMc1710026.

[22] Dobrowolski P, Prejbisz A, Kuryłowicz A, Baska A, Burchardt P, Chlebus K, Dzida G, Jankowski P, Jaroszewicz J, Jaworski P, Kamiński K, Kapłon-Cieślicka A, Klocek M, Kukla M, Mamcarz A, Mastalerz-Migas A, Narkiewicz K, Ostrowska L, Śliż D, Tarnowski W, Wolf J, Wyleżoł M, Zdrojewski T, Banach M, Januszewicz A, Bogdański P. Metabolic syndrome - a new definition and management guidelines: A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, "Club 30" Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons. Arch Med Sci. 2022 Aug 30;18(5):1133-1156. doi: 10.5114/aoms/152921. PMID: 36160355; PMCID: PMC9479724.

[23] Fonseca-Pérez D, Arteaga-Pazmiño C, Maza-Moscoso CP, Flores-Madrid S, Álvarez-Córdova L. Food insecurity as a risk factor of sarcopenic obesity in older adults. Front Nutr. 2022 Oct 20;9:1040089. doi: 10.3389/fnut.2022.1040089. PMID: 36337623; PMCID: PMC9630347.

[24] Fink J, Seifert G, Blüher M, Fichtner-Feigl S, Marjanovic G. Obesity Surgery. Dtsch Arztebl Int. 2022 Feb 4;119(5):70-80. doi: 10.3238/arztebl.m2021.0359. PMID: 34819222; PMCID: PMC9059860.

[25] Kelly AS, Armstrong SC, Michalsky MP, Fox CK. Obesity in Adolescents: A Review. JAMA. 2024 Sep 3;332(9):738-748. doi: 10.1001/jama.2024.11809. PMID: 39102244.

[26] Sachs, J., Schmidt-Traub, G., Kroll, C., Lafortune, G. i Fuller, G. Sustainable development report. New York. Pobrano 2019, [w:] https://www.sdgindex.org/reports/sustainable-development-report-2019; [dostęp: 20.11.2024r.]

[27] Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity Management in Adults: A Review. JAMA. 2023 Nov 28;330(20):2000-2015. doi: 10.1001/jama.2023.19897. PMID: 38015216; PMCID: PMC11325826.

[28] Elmadfa I, Meyer A, Nowak V, Hasenegger V, Putz P, Verstraeten R, Remaut-DeWinter AM, Kolsteren P, Dostálová J, Dlouhý P, Trolle E, Fagt S, Biltoft-Jensen A, Mathiessen J, Velsing Groth M, Kambek L, Gluskova N, Voutilainen S, Erkkilä A, Vernay M, Krems C, Strassburg A, Vasquez-Caicedo AL, Urban C, Naska A, Efstathopoulou E, Oikonomou E, Tsiotas K, Bountziouka V, Benetou V, Trichopoulou A, Zajkás G, Kovács V, Martos E, Heavey P, Kelleher C, Kennedy J, Turrini A, Selga G, Sauka M, Petkeviciene J, Klumbiene J, Holm Totland T, Andersen LF, Halicka E, Rejman K, Kowrygo B, Rodrigues S, Pinhão S, Ferreira LS, Lopes C, Ramos E, Vaz Almeida MD, Vlad M, Simcic M, Podgrajsek K, Serra Majem L, Román Viñas B, Ngo J, Ribas Barba L, Becker W, Fransen H, Van Rossum B, Ocké M, Margetts B, Rütten A, Abu-Omar K, Gelius P, Cattaneo A. European Nutrition and Health Report 2009. Ann Nutr Metab. 2009 Oct;55 Suppl 2:1-40. doi: 10.1159/000244607. Epub 2009 Oct 26. PMID: 20104000.

[29] Csige I, Ujvárosy D, Szabó Z, Lőrincz I, Paragh G, Harangi M, Somodi S. The Impact of Obesity on the Cardiovascular System. J Diabetes Res. 2018 Nov 4;2018:3407306. doi: 10.1155/2018/3407306. PMID:30525052; PMCID: PMC6247580

[30] Kumral E, Erdoğan CE, Arı A, Bayam FE, Saruhan G. Association of obesity with recurrent stroke and cardiovascular events. Rev Neurol (Paris). 2021 Apr;177(4):414-421. doi: 10.1016/j.neurol.2020.06.019. Epub2020 Oct 9. PMID: 33041060.

[31] Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, Lear SA, Ndumele CE, Neeland IJ, Sanders P, St-Onge MP; American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; and Stroke Council. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021 May 25;143(21):e984-e1010. doi:10.1161/CIR.0000000000000973. Epub 2021 Apr 22. PMID: 33882682; PMCID: PMC8493650.

[32] Marinelli S, Napoletano G, Straccamore M, Basile G. Female obesity and infertility: outcomes and regulatory guidance. Acta Biomed. 2022 Aug 31;93(4):e2022278. doi: 10.23750/abm.v93i4.13466. PMID: 36043953; PMCID: PMC9534231.

[33] Lega IC, Lipscombe LL. Review: Diabetes, Obesity, and Cancer-Pathophysiology and Clinical Implications. Endocr Rev. 2020 Feb 1;41(1):bnz014. doi: 10.1210/endrev/bnz014. PMID: 31722374.

[34] Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism. 2019 Mar;92:121-135. doi: 10.1016/j.metabol.2018.11.001. Epub

2018 Nov 13. PMID: 30445141.

[35] Bardou M, Rouland A, Martel M, Loffroy R, Barkun AN, Chapelle N. Review article: obesity and colorectal cancer. Aliment Pharmacol Ther. 2022 Aug;56(3):407-418. doi: 10.1111/apt.17045. Epub 2022 Jun16. PMID: 35707910.

[36] Wong G, Srivastava G. Obesity Management in Children and Adolescents. Gastroenterol Clin North Am. 2023 Jun;52(2):443-455. doi: 10.1016/j.gtc.2023.03.011. Epub 2023 Apr 7. PMID: 37197885.

[37] Lin CH, Shao L, Zhang YM, Tu YJ, Zhang Y, Tomlinson B, Chan P, Liu Z. An evaluation of liraglutide including its efficacy and safety for the treatment of obesity. Expert Opin Pharmacother. 2020 Feb;21(3):275-285. doi: 10.1080/14656566.2019.1695779. Epub 2019 Dec 2. PMID: 31790314.

[38] Alruwaili H, Dehestani B, le Roux CW. Clinical Impact of Liraglutide as a Treatment of Obesity. Clin Pharmacol. 2021 Mar 11;13:53-60. doi: 10.2147/CPAA.S276085. PMID: 33732030; PMCID: PMC7958997.

[39] Saunders KH, Umashanker D, Igel LI, Kumar RB, Aronne LJ. Obesity Pharmacotherapy. Med Clin North Am. 2018 Jan;102(1):135-148. doi: 10.1016/j.mcna.2017.08.010. PMID: 29156182.

[40] Deng Y, Park A, Zhu L, Xie W, Pan CQ. Effect of semaglutide and liraglutide in individuals with obesity or overweight without diabetes: a systematic review. Ther Adv Chronic Dis. 2022 Jul 4;13:20406223221108064. doi: 10.1177/20406223221108064. PMID: 35813188; PMCID: PMC9260566.

[41] Hughes S, Neumiller JJ. Oral Semaglutide. Clin Diabetes. 2020 Jan;38(1):109-111. doi: 10.2337/cd19-0079. PMID: 31975761; PMCID: PMC6969659.

[42] Yu CC, Li AM, Chan KO, Chook P, Kam JT, Au CT, So RC, Sung RY, McManus AM. Orlistat improves endothelial function in obese adolescents: a randomised trial. J Paediatr Child Health. 2013 Nov;49(11):969-975. doi: 10.1111/jpc.12252. Epub 2013 Jun 5. PMID: 23735004.

[43] Filippatos TD, Derdemezis CS, Gazi IF, Nakou ES, Mikhailidis DP, Elisaf MS. Orlistat-associated adverse effects and drug interactions: a critical review. Drug Saf. 2008;31(1):53-65. doi: 10.2165/00002018-200831010-00005. PMID: 18095746.

[44] Markham A. Setmelanotide: First Approval. Drugs. 2021 Feb;81(3):397-403. doi: 10.1007/s40265-021-01470-9. PMID: 33638809.

[45] Frączkowski D. Setmelanotyd – od genów do terapii celowanej w niektórych, rzadkich formach otyłości. Farm Pol. 2021; 77(6): 349–359.

[46] Saunders KH, Umashanker D, Igel LI, Kumar RB, Aronne LJ. Obesity Pharmacotherapy. Med Clin North Am. 2018 Jan;102(1):135-148. doi: 10.1016/j.mcna.2017.08.010. PMID: 29156182.

[47] Pilitsi E, Farr OM, Polyzos SA, Perakakis N, Nolen-Doerr E, Papathanasiou AE, Mantzoros CS. Pharmacotherapy of obesity: Available medications and drugs under investigation. Metabolism. 2019 Mar;92:170-192. doi: 10.1016/j.metabol.2018.10.010. Epub 2018 Nov 1. PMID: 30391259.

[48] Acosta A, Camilleri M, Abu Dayyeh B, Calderon G, Gonzalez D, McRae A, Rossini W, Singh S, Burton D, Clark MM. Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic. Obesity (Silver Spring). 2021 Apr;29(4):662-671. doi: 10.1002/oby.23120. Erratum in: Obesity (Silver Spring). 2021 Sep;29(9):1565-1566. doi: 10.1002/oby.23236. Erratum in: Obesity (Silver Spring). 2022 Jul;30(7):1521. doi: 10.1002/oby.23498. PMID: 33759389; PMCID: PMC8168710.

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2025-05-05

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ROMANIUK, Mateusz, WACHOWSKA, Maria, SOWIŃSKI, Wojciech, RYCĄBEL, Paweł Maciej, SZYMURA, Marta, MOLENDA, Marek Jarosław, WOSZCZYŃSKA, Oliwia, WOJCIECHOWSKA, Agnieszka Ewelina, KRAWCZYK, Michał and PANIAK, Mateusz. Modern Approaches to Obesity Treatment – literature review. Quality in Sport. Online. 5 May 2025. Vol. 41, p. 60022. [Accessed 28 June 2025]. DOI 10.12775/QS.2025.41.60022.
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Copyright (c) 2025 Mateusz Romaniuk, Maria Wachowska, Wojciech Sowiński, Paweł Maciej Rycąbel, Marta Szymura, Marek Jarosław Molenda, Oliwia Woszczyńska, Agnieszka Ewelina Wojciechowska, Michał krawczyk, Mateusz Paniak

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