β-alanine: A Comprehensive Review of Athletic and Systemic Benefits
DOI:
https://doi.org/10.12775/QS.2025.40.59882Keywords
beta-alanine, β-alanine supplementation, supplementation, β-alanine, athletic performance, beta-alanine supplementation, amino acid supplementation, supplements in sportAbstract
Purpose: This paper aims to critically review the latest research on β‐alanine supplementation, examining its impact on muscle performance, endurance, and overall athletic output. In addition, the study explores the supplement’s systemic effects - including metabolic regulation and cognitive function - while addressing optimal dosing strategies and potential health risks.
Methodology: A comprehensive literature review was conducted using multiple scientific databases, including PubMed, Scopus, and Google Scholar. The selection criteria prioritized clinical trials, systematic reviews, and meta-analyses that investigated the effects of β‐alanine on muscular function, metabolic parameters, and cognitive outcomes. Studies were evaluated for their methodological rigor, relevance, and practical applications, with special attention given to the mechanisms underlying β‐alanine’s role in increasing muscle carnosine levels and mitigating exercise-induced fatigue.
Findings: The review found that β‐alanine supplementation effectively elevates muscle carnosine levels, enhancing the muscle’s buffering capacity against acid accumulation during high-intensity exercise. This biochemical improvement is associated with delayed onset of fatigue and enhanced performance in short-duration, high-intensity activities. Additionally, emerging evidence suggests that β‐alanine may offer ancillary benefits, such as improved glucose regulation, reduced oxidative stress, and potential cognitive enhancements under stressful conditions.
Conclusions: β‐alanine supplementation represents a promising ergogenic aid for athletes, with multifaceted benefits that extend beyond muscle performance to include metabolic and cognitive health. Current research supports its efficacy in improving anaerobic performance and delaying fatigue. These insights can guide athletes, trainers, and healthcare professionals in the strategic integration of β‐alanine into performance and recovery regimens.
References
Gardner ML, Illingworth KM, Kelleher J, Wood D. Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. J Physiol. 1991;439(1):411–22.doi:10.1113/jphysiol.1991.sp018673
Tanokura M, Tasumi M, Miyazawa T. 1H nuclear magnetic resonance studies of histidine-containing di- and tripeptides. Estimation of the effects of charged groups on the pKa value of the imidazole ring. Biopolymers.1976;15(2):393–401. doi:10.1002/bip.1976.360150215.
DAVEY CL. The significance of carnosine and anserine in striated skeletal muscle. Arch Biochem Biophys. 1960 Aug;89:303-8. doi: 10.1016/0003-9861(60)90059-x. PMID: 13814256.
Schnuck JK, Sunderland KL, Kuennen MR, Vaughan RA. Characterization of the metabolic effect of β-alanine on markers of oxidative metabolism and mitochondrial biogenesis in skeletal muscle. J Exerc Nutrition Biochem. 2016 Jun;20(2):34-41. doi: 10.20463/jenb.2016.06.20.2.5. Epub 2016 Jun 30. PMID: 27508152; PMCID: PMC4977905.
Klebanov GI, Teselkin YuO, Babenkova IV, Lyubitsky OB, Rebrova OYu, Boldyrev AA, Vladimirov YuA. Effect of carnosine and its components on free-radical reactions. Membr Cell Biol. 1998;12(1):89-99. PMID: 9829262.
Kohen R, Yamamoto Y, Cundy KC, Ames BN. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci U S A. 1988 May;85(9):3175-9. doi: 10.1073/pnas.85.9.3175. PMID: 3362866; PMCID: PMC280166.
Baltazar-Martins G, Brito de Souza D, Aguilar-Navarro M, Muñoz-Guerra J, Plata MDM, Del Coso J. Prevalence and patterns of dietary supplement use in elite Spanish athletes. J Int Soc Sports Nutr. 2019 Jul 18;16(1):30. doi: 10.1186/s12970-019-0296-5. PMID: 31319850; PMCID: PMC6639916.
Furst T, Massaro A, Miller C, Williams BT, LaMacchia ZM, Horvath PJ. β-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals. J Int Soc Sports Nutr. 2018 Jul 11;15(1):32. doi: 10.1186/s12970-018-0238-7. PMID: 29996843; PMCID: PMC6042354.
Woitas, L. R., & Ribas, J. W. (2022). Major clinical findings of β-alanine in sports performance: a systematic review. International Journal of Nutrology, 15(2). https://doi.org/10.54448/ijn22205
Saunders B, Elliott-Sale K, Artioli GG, Swinton PA, Dolan E, Roschel H, Sale C, Gualano B. β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med. 2017 Apr;51(8):658-669. doi: 10.1136/bjsports-2016-096396. Epub 2016 Oct 18. PMID: 27797728.
Sas-Nowosielski K, Wyciślik J, Kaczka P. Beta-Alanine Supplementation and Sport Climbing Performance. Int J Environ Res Public Health. 2021 May 18;18(10):5370. doi: 10.3390/ijerph18105370. PMID: 34069981; PMCID: PMC8157844.
Kendrick IP, Harris RC, Kim HJ, Kim CK, Dang VH, Lam TQ, Bui TT, Smith M, Wise JA. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. 2008 May;34(4):547-54. doi: 10.1007/s00726-007-0008-3. Epub 2008 Jan 4. PMID: 18175046.
Fernández-Lázaro D, Fiandor EM, García JF, Busto N, Santamaría-Peláez M, Gutiérrez-Abejón E, Roche E, Mielgo-Ayuso J. β-Alanine Supplementation in Combat Sports: Evaluation of Sports Performance, Perception, and Anthropometric Parameters and Biochemical Markers-A Systematic Review of Clinical Trials. Nutrients. 2023 Aug 28;15(17):3755. doi: 10.3390/nu15173755. PMID: 37686787; PMCID: PMC10490143.
Donovan T, Ballam T, Morton JP, Close GL. β-alanine improves punch force and frequency in amateur boxers during a simulated contest. Int J Sport Nutr Exerc Metab. 2012 Oct;22(5):331-7. doi: 10.1123/ijsnem.22.5.331. Epub 2012 Jul 4. PMID: 22805175.
Halz M, Kaszuba M, Helbin J, Krzysztofik S, Suchanecka A, Zajac A. Beta-alanine supplementation and anaerobic performance in highly trained judo athletes. Balt J Health Phys Act. 2022;14(2):Article1. https://doi.org/10.29359/BJHPA.14.2.01
Kim KJ, Song HS, Yoon DH, Fukuda DH, Kim SH, Park DH. The effects of 10 weeks of β-alanine supplementation on peak power, power drop, and lactate response in Korean national team boxers. J Exerc Rehabil. 2018 Dec 27;14(6):985-992. doi: 10.12965/jer.1836462.231. PMID: 30656159; PMCID: PMC6323321.
Kern BD, Robinson TL. Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players. J Strength Cond Res. 2011 Jul;25(7):1804-15. doi: 10.1519/JSC.0b013e3181e741cf. PMID: 21659893.
Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. 2010 Jun;42(6):1162-73. doi: 10.1249/MSS.0b013e3181c74e38. PMID: 20479615.
Khorshidi, M., Jamshidi, S., Heshmati, J., Sajadi Hezaveh, Z., Olang, B., Moradi Moghaddam, O., Shahveghar, Z., Ghoreishi, Z., Ostadrahimi, A., & Zarezadeh, M. (2024). The effects of β-alanine supplementation on body composition indices: A systematic review and meta-analysis of controlled clinical trials. Journal of Nutrition and Food Security, 9(4), 788–801. https://doi.org/10.18502/jnfs.v9i4.16907
Matthews JJ, Creighton JV, Donaldson J, Swinton PA, Kyrou I, Bellary S, Idris I, Santos L, Turner MD, Doig CL, Elliott-Sale KJ, Sale C. β-alanine supplementation in adults with overweight and obesity: a randomized controlled feasibility trial. Obesity (Silver Spring). 2025 Feb;33(2):278-288. doi: 10.1002/oby.24204. Epub 2025 Jan 12. PMID: 39800667; PMCID: PMC11774002.
Silveira, D. F. C. da, Gomes, P. S. C., & Meirelles, C. M. (2024). Effects of β-alanine supplementation on cognitive function: a systematic review. Cuadernos De Educación Y Desarrollo, 16(10), e6012. https://doi.org/10.55905/cuadv16n10-122
Hoffman JR, Landau G, Stout JR, Dabora M, Moran DS, Sharvit N, Hoffman MW, Ben Moshe Y, McCormack WP, Hirschhorn G, Ostfeld I. β-alanine supplementation improves tactical performance but not cognitive function in combat soldiers. J Int Soc Sports Nutr. 2014 Apr 10;11(1):15. doi: 10.1186/1550-2783-11-15. PMID: 24716994; PMCID: PMC3983672.
Varanoske AN, Wells AJ, Boffey D, Harat I, Frosti CL, Kozlowski GJ, Gepner Y, Hoffman JR. Effects of High-Dose, Short-Duration β-Alanine Supplementation on Cognitive Function, Mood, and Circulating Brain-Derived Neurotropic Factor (BDNF) in Recreationally-Active Males Before Simulated Military Operational Stress. J Diet Suppl. 2021;18(2):147-168. doi: 10.1080/19390211.2020.1733730. Epub 2020 Mar 6. PMID: 32138563.
Ostfeld I, Ben-Zeev T, Zamir A, Levi C, Gepner Y, Springer S, Hoffman JR. Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study. Nutrients. 2023 Feb 12;15(4):923. doi: 10.3390/nu15040923. PMID: 36839281; PMCID: PMC9960300.
Varanoske AN, Wells AJ, Kozlowski GJ, Gepner Y, Frosti CL, Boffey D, Coker NA, Harat I, Hoffman JR. Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation. Physiol Rep. 2018 Dec;6(24):e13938. doi: 10.14814/phy2.13938. PMID: 30565426; PMCID: PMC6299243.
Yamashita S, Sato M, Matsumoto T, Kadooka K, Hasegawa T, Fujimura T, Katakura Y. Mechanisms of carnosine-induced activation of neuronal cells. Biosci Biotechnol Biochem. 2018 Apr;82(4):683-688. doi: 10.1080/09168451.2017.1413325. Epub 2017 Dec 11. PMID: 29224504.
Verity, H.; Candow, D.; Chilibeck, P.D. Beta-Alanine Supplementation for CrossFit® Performance. Nutraceuticals 2024, 4, 673–682. https://doi.org/10.3390/ nutraceuticals4040037
Li G, Li Z, Liu J. Amino acids regulating skeletal muscle metabolism: mechanisms of action, physical training dosage recommendations and adverse effects. Nutr Metab (Lond). 2024 Jul 2;21(1):41. doi: 10.1186/s12986-024-00820-0. PMID: 38956658; PMCID: PMC11220999.
Trexler ET, Smith-Ryan AE, Stout JR, Hoffman JR, Wilborn CD, Sale C, Kreider RB, Jäger R, Earnest CP, Bannock L, Campbell B, Kalman D, Ziegenfuss TN, Antonio J. International society of sports nutrition position stand: Beta-Alanine. J Int Soc Sports Nutr. 2015 Jul 15;12:30. doi: 10.1186/s12970-015-0090-y. PMID: 26175657; PMCID: PMC4501114.
Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release β-alanine tablets on absorption kinetics and paresthesia. Amino Acids. 2012 Jul;43(1):67-76. doi: 10.1007/s00726-011-1169-7. Epub 2011 Dec 3. Erratum in: Amino Acids. 2013 Oct;45(4):1015. PMID: 22139410.
Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. 2006 May;30(3):279-89. doi: 10.1007/s00726-006-0299-9. Epub 2006 Mar 24. PMID: 16554972.
Dolan E, Swinton PA, Painelli VS, Stephens Hemingway B, Mazzolani B, Infante Smaira F, Saunders B, Artioli GG, Gualano B. A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation. Adv Nutr. 2019 May 1;10(3):452-463. doi: 10.1093/advances/nmy115. PMID: 30980076; PMCID: PMC6520041.
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Copyright (c) 2025 Dominik Stanibuła, Aneta Redner, Jakub Rybowski, Michał Popiel , Kamila Smala, Kamil Dziekoński , Patrycja Zwierzchlewska, Julia Głowacz, Klaudia Kulig, Maksymilian Wiśniowski

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