The Impact of diet on wound healing after dental surgery - the role of micro- and macronutrients in the regeneration of oral tissues
DOI:
https://doi.org/10.12775/QS.2025.39.59476Keywords
diet, wound healing, oral surgery, Micronutrients, macronutrients, tissue regeneration, oral healthAbstract
The process of wound healing after oral surgery is a complex biological phenomenon influenced by multiple factors, including proper nutrition. Nutrients, both micro- and macronutrients, play a crucial role in oral tissue regeneration by supporting collagen synthesis, cell proliferation, and modulation of inflammation. Vitamins, minerals, and an adequate intake of proteins, fats, and carbohydrates can accelerate the healing process and reduce the risk of complications. The aim of this study is to analyze the available literature on the impact of diet on regenerative processes in the oral cavity, with a particular focus on the role of micro- and macronutrients, as well as the microbiota, and to determine optimal dietary recommendations for patients undergoing oral surgical procedures.
References
1. Giridhar Vu. Role of nutrition in oral and maxillofacial surgery patients. Natl. J. Maxillofac. Surg. 2016;7:3.
2. Wziątek-Kuczmik D, Wieczorek M, Rymarczyk M, Świątkowski A, Rogulski M, Niedzielska I. Interdyscyplinarna opieka nad chorymi po zabiegach z zakresu chirurgii szczękowo-twarzowej. Chir. Pol. 2023;24:1–9.
3. Jain S, Jain A, Palekar U, Shigli K, Pillai A, Pathak AD. Nutritional considerations for patients undergoing maxillofacial surgery – A literature review. Indian J. Dent. 2014;5:52–5.
4. Chu Y, Kong J, Xu J, Han G, Yu W, Xu X. Role of nutritional support in nursing practice for improving surgical site wound healing in patients post‐surgery with risk of pressure ulcers. Int. Wound J. 2024;21:e14855.
5. Paine H, Jones F, Kinross J. Preparing the Bowel (Microbiome) for Surgery: Surgical Bioresilience. Clin. Colon Rectal Surg. 2023;36:138–45.
6. Aghaloo T. How Important Is Nutrition in Oral and Maxillofacial Surgery? J. Oral Maxillofac. Surg. 2023;81:1321–2.
7. Strączek A, Szałkowska J, Sutkowska P, Srebrna A, Puzio N, Piasecka A, et al. Impact of nutrition on the condition of the oral mucosa and periodontium: A narrative review. Dent. Med. Probl. 2023;60:697–707.
8. Razzaghi R, Pourbagheri H, Momen-Heravi M, Bahmani F, Shadi J, Soleimani Z, et al. The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. J. Diabetes Complications 2017;31:766–72.
9. Shimabukuro Y, Nakayama Y, Ogata Y, Tamazawa K, Shimauchi H, Nishida T, et al. Effects of an Ascorbic Acid–Derivative Dentifrice in Patients With Gingivitis: A Double‐Masked, Randomized, Controlled Clinical Trial. J. Periodontol. 2015;86:27–35.
10. Barchitta M, Maugeri A, Favara G, Magnano San Lio R, Evola G, Agodi A, et al. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Int. J. Mol. Sci. 2019;20:1119.
11. Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Roy Paladhi U, et al. Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe 2021;29:394-407.e5.
12. Aboulfotoh MM. The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study. BMC Oral Health 2024;24:153.
13. Ghaly P, Iliopoulos J, Ahmad M. The role of nutrition in wound healing: an overview. Br. J. Nurs. 2021;30:S38–42.
14. Herberger K, Müller K, Protz K, Zyriax B, Augustin M, Hagenström K. Nutritional status and quality of nutrition in chronic wound patients. Int. Wound J. 2020;17:1246–54.
15. Polcz ME, Barbul A. The Role of Vitamin A in Wound Healing. Nutr. Clin. Pract. 2019;34:695–700.
16. Sun Y, Sun M, Liu B, Du Y, Rong S, Xu G, et al. Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States. Front. Endocrinol. 2019;10:414.
17. Hajj J, Sizemore B, Singh K. Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing. Int. J. Mol. Sci. 2024;25:10474.
18. Pullar J, Carr A, Vissers M. The Roles of Vitamin C in Skin Health. Nutrients 2017;9:866.
19. Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, Flood V. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br. J. Nutr. 2021;126:1451–8.
20. Bechara N, Flood VM, Gunton JE. A Systematic Review on the Role of Vitamin C in Tissue Healing. Antioxidants 2022;11:1605.
21. Muniz FWMG, Nogueira SB, Mendes FLV, Rösing CK, Moreira MMSM, De Andrade GM, et al. The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review. Arch. Oral Biol. 2015;60:1203–14.
22. Oda Y, Tu CL, Menendez A, Nguyen T, Bikle DD. Vitamin D and calcium regulation of epidermal wound healing. J. Steroid Biochem. Mol. Biol. 2016;164:379–85.
23. Aral K, Alkan BA, Saraymen R, Yay A, Şen A, Önder GÖ. Therapeutic Effects of Systemic Vitamin K2 and Vitamin D3 on Gingival Inflammation and Alveolar Bone in Rats With Experimentally Induced Periodontitis. J. Periodontol. 2015;86:666–73.
24. Tanaydin V, Conings J, Malyar M, Van Der Hulst R, Van Der Lei B. The Role of Topical Vitamin E in Scar Management: A Systematic Review. Aesthet. Surg. J. 2016;36:959–65.
25. Lynch RJM, Duckworth RM. Chapter 4: Microelements: Part I: Zn, Sn, Cu, Fe and I [Internet]. In: Zohoori FV, Duckworth RM, editors. Monographs in Oral Science. S. Karger AG; 2020 [cited 2025 Feb 28]. page 32–47.Available from: https://karger.com/books/book/335/chapter/5520979
26. Lin PH, Sermersheim M, Li H, Lee PHU, Steinberg SM, Ma J. Zinc in Wound Healing Modulation. Nutrients 2017;10:16.
27. Lippert F. Chapter 3: Macroelements: Ca, Na, K, P, Cl. Monogr. Oral Sci. 2020;28:22–31.
28. Najeeb S, Zafar M, Khurshid Z, Zohaib S, Almas K. The Role of Nutrition in Periodontal Health: An Update. Nutrients 2016;8:530.
29. Błaszczyk JW. Metabolites of Life: Phosphate. Metabolites 2023;13:860.
30. Molnar JA, Underdown MJ, Clark WA. Nutrition and Chronic Wounds. Adv. Wound Care 2014;3:663–81.
31. Watford M, Wu G. Protein. Adv. Nutr. 2018;9:651–3.
32. Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Nutrients 2021;13:2498.
33. Jara CP, Mendes NF, Prado TPD, De Araújo EP. Bioactive Fatty Acids in the Resolution of Chronic Inflammation in Skin Wounds. Adv. Wound Care 2020;9:472–90.
34. Coniglio S, Shumskaya M, Vassiliou E. Unsaturated Fatty Acids and Their Immunomodulatory Properties. Biology 2023;12:279.
35. Astrup A, Teicholz N, Magkos F, Bier DM, Brenna JT, King JC, et al. Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based? Nutrients 2021;13:3305.
36. Hew JJ, Parungao RJ, Mooney CP, Smyth JK, Kim S, Tsai KHY, et al. Low-protein diet accelerates wound healing in mice post-acute injury. Burns Trauma 2021;9:tkab010.
37. Woelber JP, Tennert C, Ernst SF, Vach K, Ratka-Krüger P, Bertz H, et al. Effects of a Non-Energy-Restricted Ketogenic Diet on Clinical Oral Parameters. An Exploratory Pilot Trial. Nutrients 2021;13:4229.
38. Arsyad A, Idris I, Rasyid AA, Usman RA, Faradillah KR, Latif WOU, et al. Long-Term Ketogenic Diet Induces Metabolic Acidosis, Anemia, and Oxidative Stress in Healthy Wistar Rats. J. Nutr. Metab. 2020;2020:1–7.
39. Arnke K, Pfister P, Reid G, Vasella M, Ruhl T, Seitz AK, et al. Impact of a High-Fat Diet at a Young Age on Wound Healing in Mice. Int. J. Mol. Sci. 2023;24:17299.
40. Canesso MCC, Cassini-Vieira P, Moreira CF, Luong S, Rachid MA, Martins FS, et al. Dietary Fiber Improves Skin Wound Healing and Scar Formation through the Metabolite-Sensing Receptor GPR43. J. Invest. Dermatol. 2023;143:1850-1854.e6.
41. Puddu PE, Menotti A. Simple versus complex carbohydrates and health: A frequently neglected problem. Nutr. Metab. Cardiovasc. Dis. 2021;31:1949–52.
42. Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat. Rev. Microbiol. 2018;16:745–59.
43. Cugini C, Ramasubbu N, Tsiagbe VK, Fine DH. Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease. Front. Microbiol. 2021;12:617485.
44. Esberg A, Haworth S, Hasslöf P, Lif Holgerson P, Johansson I. Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes. Nutrients 2020;12:681.
45. Liu Z, Guo H, Zhang W, Ni L. Salivary Microbiota Shifts under Sustained Consumption of Oolong Tea in Healthy Adults. Nutrients 2020;12:966.
46. Musarra-Pizzo M, Ginestra G, Smeriglio A, Pennisi R, Sciortino MT, Mandalari G. The Antimicrobial and Antiviral Activity of Polyphenols from Almond (Prunus dulcis L.) Skin. Nutrients 2019;11:2355.
47. Tsou SH, Hu SW, Yang JJ, Yan M, Lin YY. Potential Oral Health Care Agent from Coffee against Virulence Factor of Periodontitis. Nutrients 2019;11:2235.
48. Cueva C, Silva M, Pinillos I, Bartolomé B, Moreno-Arribas MV. Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer. Nutrients 2020;12:625.
49. Yadav MK, Kumari I, Singh B, Sharma KK, Tiwari SK. Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics. Appl. Microbiol. Biotechnol. 2022;106:505–21.
50. Ferrillo M, Giudice A, Migliario M, Renó F, Lippi L, Calafiore D, et al. Oral–Gut Microbiota, Periodontal Diseases, and Arthritis: Literature Overview on the Role of Probiotics. Int. J. Mol. Sci. 2023;24:4626.
51. Mahasneh S, Mahasneh A. Probiotics: A Promising Role in Dental Health. Dent. J. 2017;5:26.
52. Murtaza N, Burke LM, Vlahovich N, Charlesson B, O’Neill HM, Ross ML, et al. Analysis of the Effects of Dietary Pattern on the Oral Microbiome of Elite Endurance Athletes. Nutrients 2019;11:614.
53. Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms 2019;7:14.
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