How Does Acute Blood Flow Restriction Resistance Training Influence Free Fatty Acids in Obese Individuals?
DOI:
https://doi.org/10.12775/QS.2025.38.58841Keywords
free fatty acids, blood flow restriction resistance exercise, the obese, hypoxia, vascular, angiogenesisAbstract
Background FFAs play an important role in the obesity management. Recent studies suggest that BFR training may also influence metabolic responses, including the regulation of FFAs in the bloodstream. Understanding how acute BFR resistance training affects FFAs could provide valuable insights into effective interventions for improving metabolic health in this population. Methods A two-arm randomized controlled design was employed. A total of 22 eligible subjects were randomly divided into BFR-RE (n=11) and RE group (RE, n=11). Each participant underwent an acute moderate-intensity exercise intervention. Venous blood samples were collected at Pre, Post 0h, Post 1h, and Post 24h. FFAs, ANG-Ⅱ, NO, HIF-1α, and VEGF-A were measured. Results Significant group effects were observed in FFAs, ANG-Ⅱ, VEGF-A, and NO; significant time effects were observed in FFAs and NO; significant interactions of group*time were observed in HIF-1α and NO. In BFR-RE group, FFAs significantly decreased at Post 1h and Post 24h; HIF-1α increased significantly at Post 0h, Post 1h, and Post 24h; VEGF-A significantly increased at Post 0h and then decreased until Post 24h. In RE group, FFAs also significantly decreased at Post 1h and Post 24h; HIF-1α significantly decreased at Post 24h; NO significantly decreased at Post 0h, then increased until Post 24h. Conclusions BFR-RE showed advantages in reducing the plasma FFAs of obese individuals compared to RE. The vasodilation and angiogenic responses induced by BFR-RE may be the reason for this difference, which supported BFR-RE as a hypoxic training modality to improve obesity.
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