The Impact of Time-Restricted Eating and Intermittent Fasting on Glycemia, Body Weight, and Overall Well-Being in Patients with Type 2 Diabetes – A Review of Studies
DOI:
https://doi.org/10.12775/QS.2025.38.58230Keywords
time-restricted eating (TRE), intermittent fasting (IF), , type 2 diabetes, hypoglycemia, body weight, glycated hemoglobin (HbA1c), well-beingAbstract
Introduction
Intermittent fasting is becoming increasingly popular, particularly among individuals with obesity. One variation of this approach is time-restricted eating (TRE), which involves consuming meals only during a specific time window, typically lasting between eight to twelve hours each day.
Aim Of The Study
The objective of this article was to analyze studies conducted on both animal and human models. This analysis enabled a presentation of the benefits and potential risks associated with time-restricted eating in the context of type 2 diabetes.
Materials and Methods
In the study, scientific articles retrieved from the PubMed and Google Scholar databases were used, utilizing keywords such as "intermittent fasting and type 2 diabetes," "intermittent fasting and glycemia," "metabolic effects of fasting," and "intermittent fasting in animals,". Articles in languages other than English were excluded.
Summary
Various fasting types led to reduced HbA1c, weight loss, and improved well-being in experimental groups. Researchers emphasize the need for further trials involving larger groups and longer observation periods to objectively assess the long-term effects of TRE on T2D. Establishing these findings is essential to maximizing the benefits of fasting while minimizing the risk of hypoglycemia. If practiced cautiously under medical supervision, intermittent fasting could serve as an effective and safe method for managing type 2 diabetes. Adjusting medication, monitoring glucose, and staying hydrated are crucial to minimizing hypoglycemia risk.
References
1. B. Balkau et al., "Factors associated with weight gain in people with type 2 diabetes starting on insulin," Diabetes Care, vol. 37, no. 8, pp. 2108–2113, Aug. 2014, doi: 10.2337/dc13-3010.
2. T. Teruya et al., "Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood," Sci Rep, vol. 9, no. 1, p. 854, Jan. 2019, doi: 10.1038/s41598-018-36674-9.
3. M. A. Wijngaarden et al., "Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans," American Journal of Physiology-Endocrinology and Metabolism, vol. 307, no. 10, pp. E885–E895, Nov. 2014, doi: 10.1152/ajpendo.00215.2014.
4. M. H. Vendelbo et al., "Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling," PLOS ONE, vol. 9, no. 7, p. e102031, Jul. 2014, doi: 10.1371/journal.pone.0102031.
5. Mihaylova MM, Shaw RJ. "The AMPK signalling pathway coordinates cell growth, autophagy and metabolism." Nat Cell Biol. 2011;13(9):1016-1023. doi:10.1038/ncb2329.
6. J. Guevara-Aguirre et al., "Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer and diabetes in humans," Sci Transl Med, vol. 3, no. 70, p. 70ra13, Feb. 2011, doi: 10.1126/scitranslmed.3001845.
7. C. E. Geisler et al., "Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice," Nutrition & Metabolism, vol. 13, no. 1, p. 62, Sep. 2016, doi: 10.1186/s12986-016-0122-x.
8. P. K. Fazeli et al., "Prolonged fasting drives a program of metabolic inflammation in human adipose tissue," Molecular Metabolism, vol. 42, p. 101082, Dec. 2020, doi: 10.1016/j.molmet.2020.101082.
9. H. Jamshed et al., "Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans," Nutrients, vol. 11, no. 6, p. 1234, May 2019, doi: 10.3390/nu11061234.
10. Y. Wu et al., "Exogenous fibroblast growth factor 1 ameliorates diabetes-induced cognitive decline via coordinately regulating PI3K/AKT signaling and PERK signaling," Cell Commun Signal, vol. 18, no. 1, p. 81, May 2020, doi: 10.1186/s12964-020-00588-9.
11. Z. Liu et al., "Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment," Nat Commun, vol. 11, no. 1, p. 855, Feb. 2020, doi: 10.1038/s41467-020-14676-4.
12. C. M. McCay et al., "The effect of retarded growth upon the length of life span and upon the ultimate body size: One figure," The Journal of Nutrition, vol. 10, no. 1, pp. 63–79, Jul. 1935, doi: 10.1093/jn/10.1.63.
13. S. Wei et al., "Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice," Nutr. Metab., vol. 16, p. 60, 2019, doi: 10.1186/s12986-019-0388-x.
14. Y. Nonaka et al., "Short-term calorie restriction maintains plasma insulin concentrations along with a reduction in hepatic insulin-degrading enzyme levels in db/db mice," Nutrients, vol. 13, no. 4, p. 1190, Apr. 2021, doi: 10.3390/nu13041190.
15. R. J. Colman et al., "Caloric restriction delays disease onset and mortality in rhesus monkeys," Science, vol. 325, no. 5937, pp. 201–204, Jul. 2009, doi: 10.1126/science.1173635.
16. J. A. Mattison et al., "Impact of caloric restriction on health and survival in rhesus monkeys: The NIA study," Nature, vol. 489, no. 7415, p. 10.1038/nature11432, Sep. 2012, doi: 10.1038/nature11432.
17. E. Beli et al., "Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice," Diabetes, vol. 67, no. 9, pp. 1867–1879, Apr. 2018, doi: 10.2337/db18-0158.
18. C. Li et al., "Effects of a one-week fasting therapy in patients with Type-2 diabetes mellitus and metabolic syndrome – A randomized controlled explorative study," Experimental and Clinical Endocrinology & Diabetes, vol. 125, pp. 618–624, Apr. 2017, doi: 10.1055/s-0043-101700.
19. B. T. Corley et al., "Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial," Diabet. Med., vol. 35, no. 5, pp. 588–594, 2018, doi: 10.1111/dme.13595.
20. E. B. Parr et al., "Time-restricted eating as a nutrition strategy for individuals with Type 2 diabetes: A feasibility study," Nutrients, vol. 12, no. 11, Art. nr 11, Nov. 2020, doi: 10.3390/nu12113228.
21. A. Obermayer et al., "Efficacy and safety of intermittent fasting in people with insulin-treated Type 2 diabetes (INTERFAST-2)—A randomized controlled trial," Diabetes Care, vol. 46, no. 2, pp. 463–468, Dec. 2022, doi: 10.2337/dc22-1622.
22. S. Carter et al., "Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with Type 2 diabetes," JAMA Netw Open, vol. 1, no. 3, p. e180756, Jul. 2018, doi: 10.1001/jamanetworkopen.2018.0756.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Szymon Przemysław Stolarczyk, Kuba Borys Romańczuk, Zofia Wójcik , Bartosz Omasta, Daria Rybak, Magdalena Agata Czerska, Paulina Dorota Pietrukaniec , Olga Krupa , Katarzyna Kamińska-Omasta, Kinga Furtak
![Creative Commons License](http://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 35
Number of citations: 0