Assessment of the Impact of Different Types and Intensities of Physical Exercise on the Quality of Life of Patients with Alzheimer’s Disease: A Literature Review
DOI:
https://doi.org/10.12775/QS.2025.37.57776Keywords
Alzheimer's disease, Physical activity, intensive exercise, cognitive functions, biomarkers, BDNF, Quality of life, neuroplasticityAbstract
Objective
Alzheimer’s Disease (AD) is the most common form of dementia, representing a global health challenge. The aim of this review is to assess the impact of different types and intensities of physical exercise on cognitive functions, biomarkers, and the quality of life of AD patients.
Methods
Studies from PubMed, Scopus, Cochrane Library, and Web of Science (2000–2024) were analyzed, focusing on the effects of aerobic, resistance, and combined exercises on memory, executive functions, biomarkers (amyloid beta, tau protein, BDNF), daily living abilities (ADL), and quality of life. The review included 42 studies, including randomized controlled trials and meta-analyses.
Results
Moderate-intensity aerobic and combined exercises improve memory and executive functions, while resistance training increases hippocampal volume, supporting spatial memory. High-intensity exercises boost BDNF levels, and moderate-intensity exercises reduce neurodegenerative biomarkers and improve ADL.
Conclusions
Moderate aerobic and combined exercises are effective in preventing and supporting AD therapy. Further research is needed to standardize exercise protocols and evaluate their long-term effects.
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Copyright (c) 2025 Katarzyna Barabasz, Paulina Więcławek, Piotr Juda, Patrycja Kłaptocz, Katarzyna Łukoś-Karcz, Dominik Bańkowski, Gabriela Pabian, Karol Musiał, Kamil Bielak
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