Magnesium Homeostasis and Implications for Human Health: A Review of the Literature
DOI:
https://doi.org/10.12775/QS.2025.38.57768Keywords
Magnesium, physiologyAbstract
Magnesium ions (Mg²⁺) is a vital ion for human health, involved in numerous bodily functions, including energy production and protein synthesis. Despite its significance, serum magnesium levels are often overlooked in clinical settings, even though they can be disrupted in various health conditions. This review delves into the role of magnesium in human health and disease, highlighting its importance in key organs like the brain, heart, and muscles. Magnesium supplementation has shown promise in treating conditions such as migraine, depression, heart disease, and asthma. Recent discoveries have unveiled genetic factors, including mutations in specific genes, that can lead to magnesium deficiency. Additionally, certain medications, such as diuretics and proton pump inhibitors, can contribute to low magnesium levels. This review explores the mechanisms of magnesium regulation in the intestines, kidneys, and bones.
References
• 1. SuhWC, LeirmoS, RecordMTJr. Roles of Mg2+ in the mechanism of formation and dissociation of open complexes between Escherichia coli RNA polymerase and the lambda PR promoter: kinetic evidence for a second open complex requiring Mg2+. Biochemistry 31: 7815–7825, 1992. https://pubmed.ncbi.nlm.nih.gov/1387321/
• 2. BrautigamCA, SteitzTA. Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr Opin Struct Biol 8: 54–63, 1998. https://pubmed.ncbi.nlm.nih.gov/9519297/
• 3. YangL, AroraK, BeardWA, WilsonSH, SchlickT. Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. J Am Chem Soc 126: 8441–8453, 2004. https://pubmed.ncbi.nlm.nih.gov/15238001/
• 4. CalsouP, SallesB. Properties of damage-dependent DNA incision by nucleotide excision repair in human cell-free extracts. Nucleic Acids Res 22: 4937–4942, 1994. https://pubmed.ncbi.nlm.nih.gov/7800483/
• 5. BarzilayG, MolCD, RobsonCN, WalkerLJ, CunninghamRP, TainerJA, HicksonID. Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nature Struct Biol 2: 561–568, 1995. https://pubmed.ncbi.nlm.nih.gov/7664124/
• 6. BanC, JunopM, YangW. Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell 97: 85–97, 1999. https://pubmed.ncbi.nlm.nih.gov/10199405
• 7. GarfinkelL, GarfinkelD. Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium 4: 60–72, 1985. https://pubmed.ncbi.nlm.nih.gov/2931560/
• 8. BarbagalloM, DominguezLJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys 458: 40–47, 2007. https://pubmed.ncbi.nlm.nih.gov/16808892/
• 9. Curiel-GarciaJA, Rodriguez-MoranM, Guerrero-RomeroF. Hypomagnesemia and mortality in patients with type 2 diabetes. Magnesium Res 21: 163–166, 2008. https://pubmed.ncbi.nlm.nih.gov/19009819/
• 10. HubbardSR. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J 16: 5572–5581, 1997. https://pubmed.ncbi.nlm.nih.gov/9312016/
• 11. GuntherT. The biochemical function of Mg2+ in insulin secretion, insulin signal transduction and insulin resistance. Magnesium Res 23: 5–18, 2010. https://pubmed.ncbi.nlm.nih.gov/20228013/
• 12.NairAV, HocherB, VerkaartS, van ZeelandF, PfabT, SlowinskiT, ChenYP, SchlingmannKP, SchallerA, GallatiS, BindelsRJ, KonradM, HoenderopJG. Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy. Proc Natl Acad Sci USA 109: 11324–11329, 2012. https://pubmed.ncbi.nlm.nih.gov/22733750/
• 13. De Lordes LimaM, CruzT, PousadaJC, RodriguesLE, BarbosaK, CangucuV. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 21: 682–686, 1998. https://pubmed.ncbi.nlm.nih.gov/9589224/
• 14. BrodowskiJ. Levels of ionized magnesium in women with various stages of postmenopausal osteoporosis progression evaluated on the basis of densitometric examinations]. Przeglad lekarski 57: 714–716, 2000. https://pubmed.ncbi.nlm.nih.gov/11398593/
• 15. EisingerJ, ClairetD. Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study. Magnesium Res 6: 247–249, 1993. https://pubmed.ncbi.nlm.nih.gov/8292498/
• 16. Stendig-LindbergG, TepperR, LeichterI. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Res 6: 155–163, 1993. https://pubmed.ncbi.nlm.nih.gov/8274361/
• 17. OyanagiK, KawakamiE, Kikuchi-HorieK, OharaK, OgataK, TakahamaS, WadaM, KihiraT, YasuiM. Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Neuropathology 26: 115–128, 2006. https://pubmed.ncbi.nlm.nih.gov/16708544/
• 18. KolisekM, SponderG, MastrototaroL, SmorodchenkoA, LaunayP, VormannJ, Schweigel-RontgenM. Substitution p A350V in Na+/Mg2+ exchanger SLC41A1, potentially associated with Parkinson's Disease, is a gain-of-function mutation. PloS One 8: e71096, 2013. https://pubmed.ncbi.nlm.nih.gov/23976986/
• 19. AbbottRD, AndoF, MasakiKH, TungKH, RodriguezBL, PetrovitchH, YanoK, CurbJD. Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). Am J Cardiol 92: 665–669, 2003. https://pubmed.ncbi.nlm.nih.gov/12972103/
• 20. HeK, LiuK, DaviglusML, MorrisSJ, LoriaCM, Van HornL, JacobsDRJr, SavagePJ. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation 113: 1675–1682, 2006. https://pubmed.ncbi.nlm.nih.gov/16567569/
• 21. TeragawaH, KatoM, YamagataT, MatsuuraH, KajiyamaG. Magnesium causes nitric oxide independent coronary artery vasodilation in humans. Heart 86: 212–216, 2001. https://pubmed.ncbi.nlm.nih.gov/11454846/
• 22. ShechterM, SharirM, LabradorMJ, ForresterJ, SilverB, Bairey MerzCN. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation 102: 2353–2358, 2000. https://pubmed.ncbi.nlm.nih.gov/11067788/
• 23. PokanR, HofmannP, von DuvillardSP, SmekalG, WonischM, LettnerK, SchmidP, ShechterM, SilverB, BachlN. Oral magnesium therapy, exercise heart rate, exercise tolerance, and myocardial function in coronary artery disease patients. Br J Sports Med 40: 773–778, 2006. https://pubmed.ncbi.nlm.nih.gov/16825271/
• 24. MilnerRD, HalesCN. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 3: 47–49, 1967. https://pubmed.ncbi.nlm.nih.gov/4903553/
• 25. CohenL, KitzesR. Infrared spectroscopy and magnesium content of bone mineral in osteoporotic women. Israel J Med Sci 17: 1123–1125, 1981. https://pubmed.ncbi.nlm.nih.gov/7327911/
• 26. Maier JA, Malpuech-Brugère C, Zimowska W, Rayssiguier Y, Mazur A. Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochim Biophys Acta. 2004;1689(1):13–21. doi: 10.1016/j.bbadis.2004.01.002. https://pubmed.ncbi.nlm.nih.gov/15158909/
• 27 35.Su NY, Peng TC, Tsai PS, Huang CJ. Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate. J Surg Res. 2013;185(2):726–732. doi: 10.1016/j.jss.2013.06.030. https://pubmed.ncbi.nlm.nih.gov/23859135/
• 28. Ashique S, Kumar S, Hussain A, Mishra N, Garg A, Gowda BHJ, Farid A, Gupta G, Dua K, Taghizadeh-Hesary F. A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer. J Health Popul Nutr. 2023 Jul 27;42(1):74. doi: 10.1186/s41043-023-00423-0. Erratum in: J Health Popul Nutr. 2023 Nov 2;42(1):117. doi: 10.1186/s41043-023-00461-8. PMID: 37501216; PMCID: PMC10375690. https://pmc.ncbi.nlm.nih.gov/articles/PMC10375690/#CR34
• 29. https://journals.physiology.org/doi/full/10.1152/physrev.00012.2014
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Copyright (c) 2025 Piotr Dudziak, Maria Golińska, Mateusz Łyko, Jakub Kurasz, Paweł Siudziński, Wojciech Maj, Alicja Skoczylas, Wiktoria Podlasiewicz, Katarzyna Pala, Anna Nowak

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