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Quality in Sport

Ovulation Induction Techniques in Polycystic Ovary Syndrome - Systematic Review
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Ovulation Induction Techniques in Polycystic Ovary Syndrome - Systematic Review

Authors

  • Daria Michałka NZOZ „Centrum Zdrowia i Profilaktyki Dąbie” sp. z o. o., Widok 31 street, 31-567 Kraków https://orcid.org/0009-0009-6812-6543
  • Natalie Papachristoforou SP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 Kraków https://orcid.org/0009-0006-8417-3794
  • Natalia Tekiela SP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 Kraków https://orcid.org/0009-0000-5208-251X
  • Zuzanna Gałuszka SPZOZ Hospital in Myślenice, Szpitalna 2 street, 32-400 Myślenice https://orcid.org/0009-0009-1729-2146
  • Monika Makar Niepołomickie Centrum Profilaktyczno- Lecznicze, Stefana Batorego 41C street, 32-005 Niepołomice https://orcid.org/0009-0009-8023-6964
  • Tomasz Bartuś Andrzej Frycz Modrzewski University in Kraków, Gustawa Herlinga-Grudzińskiego 1 street, 30-705 Kraków https://orcid.org/0009-0000-3980-3191
  • Emilia Bąk SP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 Kraków https://orcid.org/0000-0002-6407-4063
  • Justyna Głowacka Gabriel Narutowicz Municipal Hospital in Kraków, Prądnicka 35 street, 31-202 Kraków https://orcid.org/0009-0009-8289-8822
  • Aleksandra Kocjan Ludwik Rydygier Specialist Hospital, Osiedle Złotej Jesieni 1 street, 31-820 Kraków https://orcid.org/0009-0001-5740-6867
  • Radosław Chmiel SP ZOZ MSWiA Hospital in Kraków, Kronikarza Galla 25 street, 30-053 Kraków https://orcid.org/0009-0002-2726-6207

DOI:

https://doi.org/10.12775/QS.2024.37.57739

Keywords

Polycystic ovary syndrome, ovulation induction, Stein-Leventhal Syndrome, infertility treatment, anovulation

Abstract

Introduction & Purpose of Research: Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder affecting women of reproductive age. Given the high prevalence of PCOS and its impact on infertility, this research explores strategies to stimulate ovulation and improve pregnancy outcomes. To address this issue comprehensively, we specifically selected six main treatment methods: lifestyle changes, clomiphene citrate, antidiabetic drugs, gonadotropin analogues, aromatase inhibitors, and surgical approaches. Our aim was to review various studies, including meta-analyses and comparisons of methods from published texts, to gain valuable insights into the topic.

References

1. Ovulation induction techniques in women with polycystic ovary syndrome

Andreas A Vyrides, Essam El Mahdi, Konstantinos Giannakou

Front Med (Lausanne) 2022 Aug 12:9:982230. doi: 10.3389/fmed.2022.982230. eCollection 2022. PMID: 36035398 PMCID: PMC9411864 DOI: 10.3389/fmed.2022.982230

2. The pathogenesis and treatment of polycystic ovary syndrome: What’s new?

Sylwia Bednarska, Agnieszka Siejka

Advances in Clinical and Experimental Medicine, ISSN 1899-5276 (print), ISSN 2451-2680 (online) DOI 10.17219/acem/59380 Adv Clin Exp Med 2017 Mar-Apr;26(2):359-367. doi: 10.17219/acem/59380.

3. Polycystic ovary syndrome in Latin American populations: What is known and what remains unresolved.

Abruzzese GA, Velazquez ME, Cerrone GE, Motta AB.

J Steroid Biochem Mol Biol. 2023 Jan;225:106195. doi: 10.1016/j.jsbmb.2022.106195. Epub 2022 Sep 29. PMID: 36183993 Review

4.Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

Hosna Mohammad Sadeghi, Ida Adeli, Daniela Calina, Anca Oana Docea,Taraneh Mousavi, Marzieh Daniali, Shekoufeh Nikfar, Aristidis Tsatsakis and Mohammad Abdollahi

Int. J. Mol. Sci. 2022, 23(2), 583; https://doi.org/10.3390/ijms23020583

5.Ovulation induction in polycystic ovarian syndrome -basics for gynecologist

Punita Yadav,

International Journal of Reproduction, Contraception, Obstetrics and GynecologyYadav P. Int J Reprod Contracept Obstet Gynecol. 2021Mar;10(3):1236-1240

6. Doppler for prediction of adverse perinatal outcome in preeclampsia in a low resource setting. Agrawal S, Das V, Agarwal A, Pandey A.Fetal

Int J Reprod Contracept Obstet Gynecol 2021;10:1236-40.

7. PCOS and pregnancy: a review of available therapies to improve the outcome of pregnancy in women with polycystic ovary syndrome

Paolo Giovanni Artini, Maria Elena Rosa Obino, Claudia Sergiampietri, Sara Pinelli, Francesca Papini, Elena Casarosa, Vito Cela

PMID: 30058861 DOI: 10.1080/17446651.2018.1431122 Expert Rev Endocrinol Metab 2018 Mar;13(2):87-98. doi: 10.1080/17446651.2018.1431122. Epub 2018 Jan 29.

8. Dietary Modification for Reproductive Health in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Yujie Shang, Huifang Zhou, Ruohan He, Wentian Lu

PMID: 34790167 PMCID: PMC8591222 DOI: 10.3389/fendo.2021.735954 Front Endocrinol (Lausanne) 2021 Nov 1:12:735954. doi: 10.3389/fendo.2021.735954. eCollection 2021.

9. Lifestyle management in polycystic ovary syndrome - beyond diet and physical activity

Stephanie Cowan, Siew Lim, Chelsea Alycia, Stephanie Pirotta, Rebecca Thomson, Melanie Gibson-Helm, Rebecca Blackmore, Negar Naderpoor, Christie Bennett, Carolyn Ee, Vibhuti Rao, Aya Mousa, Simon Alesi, Lisa Moran

PMID: 36647089 PMCID: PMC9841505 DOI: 10.1186/s12902-022-01208-y Review BMC Endocr Disord 2023 Jan 16;23(1):14. doi: 10.1186/s12902-022-01208-y.

10. Effectiveness of Lifestyle Modification in Polycystic Ovary Syndrome Patients with Obesity: A Systematic Review and Meta-Analysis

Chan-Hee Kim, Seon-Heui Lee

PMID: 35207595 PMCID: PMC8876590 DOI: 10.3390/life12020308 Life (Basel) 2022 Feb 18;12(2):308. doi: 10.3390/life12020308.

11. Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS)

Shannon Herbert, Kathleen Woolf

PMID: 38140328 PMCID: PMC10745999 DOI: 10.3390/nu15245069 Nutrients 2023 Dec 11;15(24):5069. doi: 10.3390/nu15245069.

12.Usefulness of intermittent clomiphene citrate treatment for women with polycystic ovarian syndrome that is resistant to standard clomiphene citrate treatment

Akihisa Takasaki, Isao Tamura, Maki Okada-Hayashi, Takeshi Orita, Manabu Tanabe, Shoko Maruyama, Katsunori Shimamura, Hitoshi Morioka

PMID: 30377399 PMCID: PMC6194245 DOI: 10.1002/rmb2.12219 Reprod Med Biol 2018 Jul 6;17(4):454-458. doi: 10.1002/rmb2.12219. eCollection 2018 Oct.

13.Identification of predictors of the ovarian response to clomiphene citrate in infertile women with polycystic ovary syndrome: a prospective cohort study

Hexia Xia, Xiaoli Sun, Haiyun Guan, Ruixiu Zhang, Wei Zhang

PMID: 33866836 PMCID: PMC8753794 DOI: 10.1177/03000605211000569 J Int Med Res 2021 Apr;49(4):3000605211000569. doi: 10.1177/03000605211000569.

14.Novel clomiphene "stair-step" protocol reduces time to ovulation in women with polycystic ovarian syndrome

Bradley S Hurst, Jennifer M Hickman, Michelle L Matthews, Rebecca S Usadi, Paul B Marshburn

PMID: 19114272 DOI: 10.1016/j.ajog.2008.10.031 Am J Obstet Gynecol 2009 May;200(5):510.e1-4. doi: 10.1016/j.ajog.2008.10.031. Epub 2008 Dec 27.

15.Clomiphene Stair-Step Protocol for Women With Polycystic Ovary Syndrome

Tiffanny Jones, Jacqueline R Ho, Marc Gualtieri, Janet Bruno-Gaston, Karine Chung, Richard J Paulson, Kristin A Bendikson

PMID: 29215516 DOI: 10.1097/AOG.0000000000002418 Comparative Study Obstet Gynecol 2018 Jan;131(1):91-95. doi: 10.1097/AOG.0000000000002418.

16.First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis

Rui Wang, Wentao Li, Esmée M Bordewijk, Richard S Legro, Heping Zhang, Xiaoke Wu, Jingshu Gao, Laure Morin-Papunen, Roy Homburg, Tamar E König, Etelka Moll, Sujata Kar, Wei Huang, Neil P Johnson, Saad A Amer, Walter Vegetti, Stefano Palomba, Angela Falbo, Ülkü Özmen, Hakan Nazik, Christopher D Williams, Grasso Federica, Jonathan Lord, Yilmaz Sahin, Siladitya Bhattacharya, Robert J Norman, Madelon van Wely, Ben Willem Mol

PMID: 31647106 DOI: 10.1093/humupd/dmz029 Meta-Analysis Hum Reprod Update 2019 Nov 5;25(6):717-732. doi: 10.1093/humupd/dmz029.

17.Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome

Abigail Sharpe, Lara C Morley, Thomas Tang, Robert J Norman, Adam H Balen

PMID: 31845767 PMCID: PMC6915832 DOI: 10.1002/14651858.CD013505 Meta-Analysis Cochrane Database Syst Rev 2019 Dec 17;12(12):CD013505. doi: 10.1002/14651858.CD013505.

18.Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials

S Palomba, A Falbo, G B La Sala

PMID: 23194199 DOI: 10.1111/1471-0528.12070 BJOG 2013 Feb;120(3):267-76. doi: 10.1111/1471-0528.12070. Epub 2012 Nov 30.

19.The effect of metformin use on pregnancy rates among polycystic ovary syndrome patients undergoing in vitro fertilization: A retrospective-cohort study

Yazed Sulaiman Al-Ruthia, Hazem Al-Mandeel, Hisham AlSanawi, Bander Balkhi, Wael Mansy, Reem AlGasem, Lama AlMutairi

PMCID: PMC5605958 PMID: 28951677 Saudi Pharm J. 2017 Feb 14;25(6):906–910. doi: 10.1016/j.jsps.2017.02.008

20.Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Lara C Morley, Thomas Tang, Ephia Yasmin, Robert J Norman, Adam H Balen

PMID: 29183107 PMCID: PMC6486196 DOI: 10.1002/14651858.CD003053.pub6 Cochrane Database Syst Rev 2017 Nov 29;11(11):CD003053. doi: 10.1002/14651858.CD003053.pub6.

21.Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome

Leopoldo O Tso, Michael F Costello, Luiz Eduardo T Albuquerque, Regis B Andriolo, Cristiane R Macedo

PMID: 33347618 PMCID: PMC8171384 DOI: 10.1002/14651858.CD006105.pub4 Cochrane Database Syst Rev 2020 Dec 21;12(12):CD006105. doi: 10.1002/14651858.CD006105.pub4.

22.The use of metformin in women with polycystic ovary syndrome: an updated review

Adriana Leal Griz Notaro, Filipe Tenorio Lira Neto

PMID: 35156149 PMCID: PMC8995234 DOI: 10.1007/s10815-022-02429-9 J Assist Reprod Genet 2022 Mar;39(3):573-579. doi: 10.1007/s10815-022-02429-9. Epub 2022 Feb 14.

23.Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome

Sebastian Franik, Quang-Khoi Le, Jan Am Kremer, Ludwig Kiesel, Cindy Farquhar

PMID: 36165742 PMCID: PMC9514207 DOI: 10.1002/14651858.CD010287.pub4 Cochrane Database Syst Rev 2022 Sep 27;9(9):CD010287. doi: 10.1002/14651858.CD010287.pub4.

24.Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis

Alexandra P Tsiami, Dimitrios G Goulis, Alexandros I Sotiriadis, Efstratios M Kolibianakis

PMID: 34033068 DOI: 10.1007/s42000-021-00289-z Hormones (Athens) 2021 Sep;20(3):449-461. doi: 10.1007/s42000-021-00289-z. Epub 2021 May 25.

25.Letrozole versus clomiphene citrate in polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Shifu Hu, Qiong Yu, Yingying Wang, Mei Wang, Wei Xia, Changhong Zhu

PMID: 29392438 DOI: 10.1007/s00404-018-4688-6 Arch Gynecol Obstet 2018 May;297(5):1081-1088. doi: 10.1007/s00404-018-4688-6. Epub 2018 Feb 1.

26.Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Qiong Yu, Shifu Hu, Yingying Wang, Guiping Cheng, Wei Xia, Changhong Zhu

PMID: 30728032 PMCID: PMC6366034 DOI: 10.1186/s12958-019-0461-3 Reprod Biol Endocrinol 2019 Feb 6;17(1):17. doi: 10.1186/s12958-019-0461-3.

27. Gonadotrophins for ovulation induction in women with polycystic ovary syndrome

Nienke S Weiss, Elena Kostova, Marleen Nahuis, Ben Willem J Mol, Fulco van der Veen, Madelon van Wely

PMID: 30648738 PMCID: PMC6353048 DOI: 10.1002/14651858.CD010290.pub3 Cochrane Database Syst Rev 2019 Jan 16;1(1):CD010290. doi: 10.1002/14651858.CD010290.pub3.

28.Low-dose gonadotropin induction of ovulation in anovulatory women: still needed in the age of IVF

Davinia M White, Kate Hardy, Suzannah Lovelock, Stephen Franks

PMID: 29459401 DOI: 10.1530/REP-17-0697 Reproduction 2018 Jul;156(1):F1-F10. doi: 10.1530/REP-17-0697. Epub 2018 Feb 19

29.Follicular-Phase GnRH Agonist Protocol Is Another Choice for Polycystic Ovary Syndrome Patients With Lower LH/FSH and Lower AMH Levels Without Increasing Severe OHSS Risk

Rui Gao, Xin Liao, Wanrong Huang, Rujun Zeng, Lang Qin, Peng Bai

PMID: 35757417 PMCID: PMC9232123 DOI: 10.3389/fendo.2022.905263 Front Endocrinol (Lausanne) 2022 Jun 10:13:905263. doi: 10.3389/fendo.2022.905263. eCollection 2022.

30.Competence of Combined Low Dose of Human Chorionic Gonadotropin (HCG) and Clomiphene Citrate (CC) Versus Continued CC during Ovulation Induction in Women with CC-Resistant Polycystic Ovarian Syndrome: A Randomized Controlled Trial

Mahmoud Thabet, Mohamed Sayed Abdelhafez, Maged Ragheb Elshamy, Ibrahim A Albahlol, Emad Fayala, Alaa Wageeh, Ahmed Abdelhamid El-Zayadi, Nagwan Ahmed Bahgat, Shereen M Mohammed, Alhussein Ahmed Mohamed, Mahmoud Mohamed Awad, Ahmed El-Menayyer, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Rayan G Albarakati, Ahmed Baker A Alshaikh, Fawaz E Edris, Nayla Jamal Bushaqer, Youstina Georges Makarious Salama, Mahmoud Mohamed Abdel-Razik

PMID: 39202581 PMCID: PMC11356540 DOI: 10.3390/medicina60081300 Medicina (Kaunas) 2024 Aug 12;60(8):1300. doi: 10.3390/medicina60081300.

31.Laparoscopic ovarian drilling for ovulation induction in women with anovulatory polycystic ovary syndrome

Esmée M Bordewijk, Ka Ying Bonnie Ng, Lidija Rakic, Ben Willem J Mol, Julie Brown, Tineke J Crawford, Madelon van Wely

PMID: 32048270 PMCID: PMC7013239 DOI: 10.1002/14651858.CD001122.pub5 Cochrane Database Syst Rev 2020 Feb 11;2(2):CD001122. doi: 10.1002/14651858.CD001122.pub5.

32.The effect of laparoscopic ovarian drilling on pregnancy outcomes in polycystic ovary syndrome women with more than 2 in-vitro fertilization cycle failures: A pilot RCT

Ashraf Moini, Tayebeh Esfidani, Arezoo Arabipoor, Reihaneh Hosseini, Shima Mohiti, Sakineh Noor Mohammadi

PMID: 38292507 PMCID: PMC10823117 DOI: 10.18502/ijrm.v21i11.14653 Int J Reprod Biomed 2023 Dec 19;21(11):901-908. doi: 10.18502/ijrm.v21i11.14653. eCollection 2023 Nov.

33. Laparoscopic ovarian drilling before IVF/ICSI in polycystic ovarian syndrome patients with high antimullarian hormone

Mohamed Sayed Abdelhafez, Maher Shams, Mahmoud Mohamed Abdel-Razik, Alaa Wageh

PMID: 35063718 DOI: 10.1016/j.jogoh.2022.102324 J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102324. doi: 10.1016/j.jogoh.2022.102324. Epub 2022 Jan 19.

34. Metformin With or Without Clomiphene Citrate Versus Laparoscopic Ovarian Drilling With or Without Clomiphene Citrate to Treat Patients With Clomiphene Citrate-Resistant Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Ming-Li Sun , Wen-Pei Bai, Qing-Kun Song, Hui-Ying Wang, Guo-Lan Gao, Liang Zheng, Xing-He Wang

PMID: 35814214 PMCID: PMC9256960 DOI: 10.3389/fphar.2022.576458 Front Pharmacol 2022 Jun 22:13:576458. doi: 10.3389/fphar.2022.576458. eCollection 2022.

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Published

2025-01-27

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MICHAŁKA, Daria, PAPACHRISTOFOROU, Natalie, TEKIELA, Natalia, GAŁUSZKA , Zuzanna, MAKAR , Monika, BARTUŚ , Tomasz, BĄK, Emilia, GŁOWACKA , Justyna, KOCJAN , Aleksandra and CHMIEL, Radosław. Ovulation Induction Techniques in Polycystic Ovary Syndrome - Systematic Review. Quality in Sport. Online. 27 January 2025. Vol. 37, p. 57739. [Accessed 18 June 2025]. DOI 10.12775/QS.2024.37.57739.
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Vol. 37 (2025)

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Copyright (c) 2025 Daria Michałka, Natalie Papachristoforou, Natalia Tekiela, Zuzanna Gałuszka , Monika Makar , Tomasz Bartuś , Emilia Bąk, Justyna Głowacka , Aleksandra Kocjan , Radosław Chmiel

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