Mesenchymal stem cells transplantation in the treatment of tendon disorders

Abstract

Introduction and purpose:

Tendon disorders are conditions that lead to pain, reduced mobility, and are often associated with recurrences and complications. A novel therapeutic approach for these conditions is the transplantation of mesenchymal stem cells (MSCs) into the affected area. This paper presents knowledge on the use of MSCs for the treatment of tendon disorders. Additionally, it presents advances in research regarding the application of MSC transplantation in the following conditions: rotator cuff tendon injuries, lateral epicondylitis, Achilles tendon disorders, and patellar tendon injuries.

Material and methods:

A review of the PubMed and Google Scholar databases was conducted.

Results:

It is suggested that MSCs support tendon regeneration through the regulation of inflammatory processes, their capacity to differentiate into various cell types, their influence on collagen synthesis, and their effect on the migration and proliferation of tenocytes. Research indicates that transplantation into damaged tendons enhances tendon function and reduces pain. While many studies have not reported the occurrence of side effects, some have noted such cases.

Conclusions:

Further research is required to develop a deeper understanding of the role that MSCs play in the treatment of tendon disorders. Additionally, there is a need to establish precise treatment protocols and evaluate the safety of this procedure.