Review of Urinary Tract Infections in Pregnancy: Risks, Complications and Management
DOI:
https://doi.org/10.12775/QS.2025.37.57277Keywords
urinary tract infections, pregnancy, maternal outcomes, perinatal infectionsAbstract
Background: Urinary tract infections (UTIs) are common in pregnant women due to significant changes during gestation. UTIs can affect any part of the urinary system and are typically caused by bacteria, though fungi and viruses can also be responsible. Asymptomatic bacteriuria (ASB is frequent in pregnancy and must be treated to prevent serious maternal and fetal complications. Routine screening for ASB is standard in prenatal care, and treatment with safe, effective antibiotics is essential. Preventive strategies also help reduce UTI during pregnancy.
Aim of the study: The study aimed to explore the changes that occur during gestation, which predispose pregnant women to UTIs, assess the diagnostic methods and select the most effective treatment to prevent complications.
State of knowledge: Urinary tract infections (UTIs) are common perinatal complications, with higher prevalence in pregnancy due to changes that occur during gestation. UTIs can perform as asymptomatic bacteriuria (ASB), cystitis and pyelonephritis, which can result in severe complications. Clinical guidelines recommend screening for ASB in early pregnancy and prescribing a short course of antibiotics if detected. Escherichia coli is the most common cause of UTIs. As most antibiotics cross the placenta, treatment must be safe for the fetus and effective against the pathogens. Guidelines recommend short courses of antibiotics.
Conclusions: UTIs in pregnancy are common and lead to serious complications
if untreated. Pregnant women are more susceptible to UTIs due changes that occur during gestation. Healthcare professionals play a critical role in managing UTIs during pregnancy. Early detection through routine screening and prompt treatment is crucial for optimal outcomes. Healthcare professionals, including obstetricians, should educate patients on preventive measures and recognizing early UTI symptoms.
Abbreviations: UTIs- urinary tract infections; ASB- asymptomatic bacteriuria
References
1. Shaheen, Hala M.; El-Hakeem Hammad, Nesreen A.; and Farahat, Taghreed M. (2016) "Prevalence of urinary tract infection among pregnant women and possible risk factors," Menoufia Medical Journal: Vol. 29.
Doi:/10.4103/1110-2098.202505
2. Baraka MA, AlLehaibi LH, AlSuwaidan HN, Alsulaiman D, Islam MA, Alotaibi BS, Alboghdadly A, Homoud AH, Al-Ghamdi FH, Al Ghamdi MS, Babar ZU. Patterns of infections and antimicrobial drugs' prescribing among pregnant women in Saudi Arabia: a cross sectional study. J Pharm Policy Pract. 2021 Jan 14; 14(1):9.. PMID: 33441164; PMCID: PMC7807808
Doi:/ 10.1186/s40545-020-00292-6
3. Herness J, Buttolph A, Hammer NC. Acute Pyelonephritis in Adults: Rapid Evidence Review. Am Fam Physician. 2020 Aug 1; 102(3):173-180. PMID: 32735433.
4. Urinary Tract Infections in Pregnant Individuals. Obstet Gynecol. 2023 Aug 1; 142(2):435-445. PMID: 37473414
Doi:/10.1097/AOG.0000000000005269
5. Glaser AP, Schaeffer AJ. Urinary Tract Infection and Bacteriuria in Pregnancy. Urol Clin North Am. 2015 Nov; 42(4):547-60. PMID: 26475951
Doi:/10.1016/j.ucl.2015.05.004
6. Kashif, Uzma & Riaz, Nadia & Ramasubramanian, Swapna & Iles, David. (2021). Urogynaecological complications in pregnancy. Obstetrics, Gynaecology & Reproductive Medicine. Doi:/31. 10.1016/j.ogrm.2020.12.004.
7. Urogynaecological complications in pregnancy: an overview
Cox, Samantha et al. Obstetrics, Gynaecology and Reproductive Medicine, Volume 25, Doi:/10.1016/j.ogrm.2015.02.002
8. Habak PJ, Carlson K, Griggs, Jr RP. Urinary Tract Infection in Pregnancy. 2024 Apr 20. In: StatPearls Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30725732.
9. Al Lawati H, Blair BM, Larnard J. Urinary Tract Infections: Core Curriculum 2024. Am J Kidney Dis. 2024 Jan; 83(1):90-100. PMID: 37906240
Doi: 10.1053/j.ajkd.2023.08.009
10. Larry C. Gilstrap, Susan M. Ramin, URINARY TRACT INFECTIONS DURING PREGNANCY,Obstetrics and Gynecology Clinics of North America,2001, Doi:/10.1016/S0889-8545(05)70219-9.
11. Wing DA, Fassett MJ, Getahun D. Acute pyelonephritis in pregnancy: an 18-year retrospective analysis. Am J Obstet Gynecol. 2014 Mar; 210(3):219.e1-6.
PMID: 24100227
Doi:/10.1016/j.ajog.2013.10.006
12. Sheffield, Jeanne S. MD; Cunningham, F Gary MD. Urinary Tract Infection in Women. Obstetrics & Gynecology 106(5 Part 1):p 1085-1092, November 2005. Doi:/10.1097/01.AOG.0000185257.52328.a2
13. FitzGerald MP, Graziano S. Anatomic and functional changes of the lower urinary tract during pregnancy. Urol Clin North Am. 2007 Feb; 34(1):7-12. PMID: 17145355.
Doi:/10.1016/j.ucl.2006.10.007.
14. Giraldo, Paulo César, Araújo, Edilson D., Junior, José Eleutério, Amaral, Rose Luce Gomes do, Passos, Mauro R. L., Gonçalves, Ana Katherine, The Prevalence of Urogenital Infections in Pregnant Women Experiencing Preterm and Full-Term Labor, Infectious Diseases in Obstetrics and Gynecology, 2012, 878241, 4 pages, 2012. Doi:/10.1155/2012/878241
15. Hytten FE. The renal excretion of nutrients in pregnancy. Postgrad Med J. 1973 Sep ; 49(575):625-9.. PMID: 4788916; PMCID: PMC2495760.
Doi: 10.1136/pgmj.49.575.625
16. Johnson CY, Rocheleau CM, Howley MM, Chiu SK, Arnold KE, Ailes EC. Characteristics of Women with Urinary Tract Infection in Pregnancy. J Womens Health (Larchmt). 2021 Nov;30(11):1556-1564.. Sep 1. PMID: 34491115; PMCID: PMC8969170
Doi: 10.1089/jwh.2020.8946
17. Ali SB, Perdawood D, Abdulrahman R, Al Farraj DA, Alkubaisi NA. Vitamin D deficiency as a risk factor for urinary tract infection in women at reproductive age. Saudi J Biol Sci. 2020 Nov; 27(11):2942-2947. PMID: 33100850;
Doi: 10.1016/j.sjbs.2020.08.008
18. Sheiner E, Mazor-Drey E, Levy A. Asymptomatic bacteriuria during pregnancy. J Matern Fetal Neonatal Med. 2009 May; 22(5):423-7. PMID: 19530000
Doi: 10.1080/14767050802360783
19. Lindsay E. Nicolle, Suzanne Bradley, Richard Colgan, James C. Rice, Anthony Schaeffer, Thomas M. Hooton, Infectious Diseases Society of America Guidelines for the Diagnosis and Treatment of Asymptomatic Bacteriuria in Adults, Clinical Infectious Diseases, Volume 40, Issue 5, 1 March 2005, Pages 643–654, Doi:/10.1086/427507
20. Easter SR, Cantonwine DE, Zera CA, Lim KH, Parry SI, McElrath TF. Urinary tract infection during pregnancy, angiogenic factor profiles, and risk of preeclampsia. Am J Obstet Gynecol. 2016 Mar; 214(3):387.e1-7. Epub 2015 Oct 9. PMID: 26450405.
Doi: / 10.1016/j.ajog.2015.09.101.
21. Kalinderi K, Delkos D, Kalinderis M, Athanasiadis A, Kalogiannidis I. Urinary tract infection during pregnancy: current concepts on a common multifaceted problem. J Obstet Gynaecol. 2018 May; 38(4):448-453. Epub 2018 Feb 6. PMID: 29402148.
Doi:/10.1080/01443615.2017.1370579.
22. L A Schieve, A Handler, R Hershow, V Persky, and F DavisSchool of Public Health, University of Illinois at Chicago 60680. “Urinary tract infection during pregnancy: its association with maternal morbidity and perinatal outcome.” American Journal of Doi:/10.2105/ajph.84.3.405
23. Kwok M, McGeorge S, Mayer-Coverdale J, Graves B, Paterson DL, Harris PNA, Esler R, Dowling C, Britton S, Roberts MJ. Guideline of guidelines: management of recurrent urinary tract infections in women. BJU Int. 2022 Nov; 130 Suppl 3(Suppl 3):11-22. Doi:/10.1111/bju.15756. Epub 2022 May 17. PMID: 35579121;
24. Jodi S. Dashe, Larry C. Gilstrap, Antibiotic Use in Pregnancy,
Obstetrics and Gynecology Clinics of North America, 1997,
Doi:/10.1016/S0889-8545 (05)70326-0. ISSN 0889-8545
25. Urinary Tract Infections in Pregnant Individuals. Obstet Gynecol. 2023 Aug 1; 142(2):435-445. Doi:/10.1097/AOG.0000000000005269. PMID: 37473414.
26. Hill JB, Sheffield JS, McIntire DD, Wendel GD Jr. Acute pyelonephritis in pregnancy. Obstet Gynecol. 2005 Jan; 105(1):18-23.
Doi: 10.1097/01.AOG.0000149154.96285.a0. PMID: 15625136.
27. Ansaldi Y, Martinez de Tejada Weber B. Urinary tract infections in pregnancy. Clin Microbiol Infect. 2023 Oct; 29(10):1249-1253. Doi: 10.1016/j.cmi.2022.08.015. Epub 2022 Aug 27. PMID: 36031053.
28. Corrales M, Corrales-Acosta E, Corrales-Riveros JG. Which Antibiotic for Urinary Tract Infections in Pregnancy? A Literature Review of International Guidelines. J Clin Med. 2022 Dec 5; 11(23):7226. Doi:/10.3390/jcm11237226. PMID: 36498799;
29. Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, Moran GJ, Nicolle LE, Raz R, Schaeffer AJ, Soper DE; Infectious Diseases Society of America; European Society for Microbiology and Infectious Diseases. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011 Mar 1;52(5):e103-20. Doi: 10.1093/cid/ciq257. PMID: 21292654.
30. Urogynaecological complications in pregnancy: an overview
Cox, Samantha et al. Obstetrics, Gynaecology and Reproductive Medicine, Volume 25, Doi:/10.1016/j.ogrm.2015.02.002
31. Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023 Nov 10; 11(11):CD001321. Doi: 10.1002/14651858.CD001321.pub7. PMID: 37947276;
32. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012 Oct 17; 10(10):CD001321. Doi: 10.1002/14651858.CD001321.pub5. Update in: Cochrane Database Syst Rev. 2023 Apr 17; 4: CD001321. doi: 10.1002/14651858.CD001321 PMID: 23076891;
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