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Quality in Sport

A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus
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  3. Vol. 37 (2025) /
  4. Medical Sciences

A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus

Authors

  • Wojciech Florczak Medical University of Lublin https://orcid.org/0009-0006-8003-0999
  • Joanna Śnieżna Medical University of Lublin https://orcid.org/0009-0006-2713-0835
  • Jakub Dziewic Medical University of Lublin https://orcid.org/0009-0008-4338-4573
  • Karol Dzwonnik Medical University of Lublin https://orcid.org/0009-0007-1366-3945
  • Wiktoria Domino Clinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-501 Rzeszów, Poland https://orcid.org/0009-0005-0034-7463
  • Urszula Zelik University Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, Poland https://orcid.org/0009-0009-3369-7936
  • Gabriela Trestka Clinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-501 Rzeszów, Poland https://orcid.org/0009-0009-9504-8923
  • Maria Przygoda Specialist Hospital named after Stefan Żeromski, Independent Public Healthcare Facility (SP ZOZ), in Kraków https://orcid.org/0000-0002-6409-7265
  • Jagienka Włodyka University Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, Poland https://orcid.org/0009-0000-7243-7023
  • Kamila Stępień Independent Public Health Care Facility of the Ministry of Internal Affairs and Administration in Kielce, Poland Wojska Polskiego 51, 25-375 Kielce, Poland https://orcid.org/0009-0000-3579-9308
  • Sabina Adamczyk Independent Public Healthcare Facility of the Ministry of Internal Affairs and Administration in Opole, Poland https://orcid.org/0009-0003-9671-6619

DOI:

https://doi.org/10.12775/QS.2024.37.57099

Keywords

celiac, CeD, T1DM, diabetes, gluten

Abstract

Introduction: 

Celiac disease (CeD) and Type 1 diabetes mellitus (T1DM) are autoimmune diseases that sometimes co-occur in genetically predisposed people. Both diseases share common genetic factors, such as human leukocyte antigens: HLA-DQ2 and HLA-DQ8. Apart from that, they share environmental factors such as gluten exposure, viral infections, and alterations in gut microbiota composition. CeD is a gluten-induced disease resulting in inflammation and impaired absorption of the nutrients, leading to malnutrition. In T1DM, β-cells in the pancreatic tissue are destroyed during the T-cell mediated reaction, which leads to impaired insulin production and development of insulin deficiency which leads to hyperglycemia and chronic complications.

Materials and methods: 

This study is based on a review of multiple articles and prospective studies we managed to find online in the PubMed database.
Aim of the study: 

The aim of the study is to investigate the clinical implications of T1DM and CeD, focusing on the importance of early screening for CeD in patients with T1DM and evaluate the challenges in the management of both diseases simultaneously. Additionally, the study highlights the potential benefits of a personalized approach to treatment.

Conclusions: 

The co-occurrence of CeD and T1DM is common and it’s determined by shared genetic, immune, and environmental factors. Early screening and diagnosis are very important regarding the management strategies for these conditions. Gluten free diet (GFD) is the main treatment for CeD, but its adherence may be challenging, especially in T1DM patients who already face many restrictions on a daily basis. Personalized treatment approaches seem to be essential for simultaneously managing and optimizing CeD and T1DM. However, the lower compliance to GFD among T1DM patients suggests the need for further research to provide support for long-term management of both T1DM and CeD.

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Published

2025-01-27

How to Cite

1.
FLORCZAK, Wojciech, ŚNIEŻNA, Joanna, DZIEWIC, Jakub, DZWONNIK, Karol, DOMINO, Wiktoria, ZELIK, Urszula, TRESTKA, Gabriela, PRZYGODA, Maria, WŁODYKA, Jagienka, STĘPIEŃ, Kamila and ADAMCZYK, Sabina. A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus. Quality in Sport. Online. 27 January 2025. Vol. 37, p. 57099. [Accessed 19 June 2025]. DOI 10.12775/QS.2024.37.57099.
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Issue

Vol. 37 (2025)

Section

Medical Sciences

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Copyright (c) 2025 Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Karol Dzwonnik, Wiktoria Domino, Urszula Zelik, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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