Effects of hydrolyzed collagen supplementation for Skin Anti-Aging
DOI:
https://doi.org/10.12775/QS.2025.37.57098Keywords
hydration, hydrolyzed collagen, skin elasticity, wrinkles reduction, skin moisture, skin aging, skin rejuvenation, anti aging, supplements, skin health, anti-agingAbstract
In an era of an aging population with the rise of social media, both men and women are paying more and more attention to the healthy appearance of their skin and overall health.
Collagen is an essential component of the structure of the skin.With age, the amount of collagen in the skin decreases, there is a loss of elasticity as a result,wrinkles form and the appearance of the skin deteriorates. On the market there are more and more preparations both in the form of creams and means for oral application.One of the most popular dietary supplements that affect the quality of the skin and with tested bioavailability is hydrolyzed collagen .
One can find many studies showing the positive effects of collagen supplementation on improving the quality and alleviating the visible signs of skin aging. In this review paper, we aim to evaluate the current state of knowledge of the effectiveness of hydrolyzed collagen supplementation on skin quality status. In order to investigate the efficacy and effects of hydrolyzed collagen for the skin, we need both preclinical studies, availability assessments and controlled clinical trials on a wide range of patients.
Overall, it can be concluded that as little as 12 weeks of hydrolyzed fish collagen supplementation improves the quality and appearance of skin in the aging population.Importantly, HC-containing formulations were found to be safe and well-tolerated. However, further large-scale randomized controlled studies taking into account factors such as excipients in the supplements, age range and general lifestyle of the subjects are needed to confirm these results.
References
1. Jafari H, Lista A, Siekapen MM, Ghaffari-Bohlouli P, Nie L, Alimoradi H, Shavandi A: Fish collagen:extraction, characterization, and applications for biomaterials engineering. Polymers (Basel). 2020, 12:2230.
DOI: 10.3390/polym12102230
2.De Luca C, Mikhal’chik EV, Suprun MV, Papacharalambous M,Truhanov AI, Korkina LG. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid
DOI:10.1155/2016/4389410
3.Szu-Yu Pu, Ya-Li Huang, Chi-Ming Pu , Yi-No Kang, Khanh Dinh Hoang, Kee-Hsin Chen, Chiehfeng Chen
Effects of Oral Collagen for Skin Anti-Aging: A Systematic
Review and Meta-Analysis
DOI: 10.1111/jocd.13676
5.Koopman, R.; Crombach, N.; Gijsen, A.P.;Walrand, S.; Fauquant, J.; Kies, A.K.; Lemosquet, S.; Saris,W.H.; Boirie, Y.; van Loon,
L.J. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am. J. Clin. Nutr. 2009, 90, 106–115.
DOI: 10.3945/ajcn.2009.27474
6.Campos LD, Santos Junior VA, Pimentel JD, Carregã GL, Cazarin CB: Collagen supplementation in skin and orthopedic diseases: a review of the literature. Heliyon. 2023, 9:e14961.
DOI: 10.1016/j.heliyon.2023.e14961
7.Nomoto T, Iizaka S: Effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity in hospitalized older adults: a multicenter open-label randomized controlled study. Adv Skin Wound Care. 2020, 33:186-91.
DOI: 10.1097/01.ASW.0000655492.40898.55
8.Watanabe-Kamiyama, M.; Shimizu, M.; Kamiyama, S.; Taguchi, Y.; Sone, H.; Morimatsu, F.; Shirakawa, H.; Furukawa, Y.; Komai,
M. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J. Agric. Food Chem.
2010, 58, 835–841.
DOI: 10.1021/jf9031487
9.Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N:
A randomized, triple-blind, placebo-controlled,parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021
DOI: 10.1111/jocd.13676
10.Žmitek K, Žmitek J, Rogl Butina M, Pogačnik T: Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: results of a randomised, placebo-controlled, double-blind study. Nutrients. 2020,
DOI: 10.3390/nu12030618
11.Campos LD, Santos Junior VA, Pimentel JD, Carregã GL, Cazarin CB: Collagen supplementation in skin and orthopedic diseases: a review of the literature. Heliyon. 2023,
DOI: 10.1016/j.heliyon.2023.e14961
12.Inoue N, Sugihara F, Wang X: Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J SciFood Agric. 2016,
DOI: 10.1002/jsfa.7606
13.Choi SY, Ko EJ, Lee YH, et al. Effects of collagen tripeptide supplement
on skin properties: A prospective, randomized, controlled
study. J Cosmet Laser Ther.
DOI: 10.3109/14764172.2013.854119
14.Yoon HS, Cho HH, Cho S, Lee SR, Shin MH, Chung JH.
Supplementating with dietary astaxanthin combined with collagen
hydrolysate improves facial elasticity and decreases matrix metalloproteinase-
1 and -12 expression: a comparative study with placebo.
DOI: 10.1194/jlr.M500420-JLR200
15.Campos P, Melo M, Calixto L, Fossa M. An oral supplementation
based on hydrolyzed collagen and vitamins improves skin elasticity
and dermis echogenicity: a clinical placebo-controlled study. Clinical Pharmacology & Biopharmaceutics.
DOI:10.4172/2167-065X.1000142
16.Zhou S-L, Wang H-Y, Yue D-X. Clinical Effects and Safety of Oral Treatment with Low-Molecular Fish Collagen Hydrolysate on Female Facial Skin Properties. J Pract Dermatol. 2011;4(3).
17.Bonnet D.Introduction to Naticol® marine collagen peptides for
anti-aging and overview of clinical studies. https://pdfs.seman ticsc
holar.org/fed1/fa27d e3676 b4626 343d3 5ea1d 1567c a3f216.pdf
Accessed October 5 2017.
18.Dian Andriani Ratna Dewi , Abraham Arimuko , Lilik Norawati , Satya W Yenny , Nenden L Setiasih , Angki Perdiyana , Nabila Arkania , Farrasila Nadhira , Ni Wiliantari
DOI: 10.7759/cureus.50231
19.Szu-Yu Pu, Ya-Li Huang, Chi-Ming Pu , Yi-No Kang, Khanh Dinh Hoang, Kee-Hsin Chen, Chiehfeng Chen
Effects of Oral Collagen for Skin Anti-Aging: A Systematic
Review and Meta-Analysis
DOI: 10.1111/jocd.13676
20.Paulson KG, Iyer JG, Nghiem P. Asymmetric lateral distribution of
melanoma and Merkel cell carcinoma in the United States. J Am
Acad Dermatol.
DOI: 10.1016/j.jaad.2010.05.026
21.Poljsak B, Godic A, Lampe T, Dahmane R. The influence of the
sleeping on the formation of facial wrinkles. J Cosmet Laser Ther.
DOI: 10.3109/14764172.2012.685563
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Copyright (c) 2025 Anna Gliwa, Marek Kurowski, Karolina Kuczapska, Monika Ryglewicz, Dariusz Fabian, Elbieta Leszczynska-Knaga, Natalia Jakubczyk, Weronika Rutkowska-Kawalec, Paweł Moczydłowski , Karolina Michhalczuk
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