The Influence of Physical Activity on Inflammatory Markers, Intestinal Microbiota Composition and Disease Activity in Inflammatory Bowel Disease

Paulina Jakubczyk; Piotr Widera; Justyna Helis; Maciej Michalik; Aleksandra Buczek; Hubert Bigajski; Aleksandra Banaś; Olga Bilczewska; Wiktoria Janik; Marta Handschuh

doi:10.12775/QS.2025.37.57083

Authors

Paulina Jakubczyk University Hospital of Karol Marcinkowski in Zielona Góra https://orcid.org/0000-0001-9821-7678
Piotr Widera Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0008-7518-2482
Justyna Helis Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0003-5657-2569
Maciej Michalik Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0007-9778-8736
Aleksandra Buczek Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0008-7534-7830
Hubert Bigajski Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0007-0570-5367
Aleksandra Banaś Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0009-5584-5944
Olga Bilczewska Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0006-7097-1226
Wiktoria Janik Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0006-8406-3309
Marta Handschuh Faculty of Medical Sciences in Katowice, Medical University of Silesia https://orcid.org/0009-0005-1539-8589

DOI:

https://doi.org/10.12775/QS.2025.37.57083

Keywords

inflammatory bowel disease, Crohn's disease, ulcerative colitis, physical activity

Abstract

Aim of the Study
This review investigates the relationship between physical activity and inflammatory bowel disease (IBD), focusing on inflammatory markers, gut microbiota composition, and disease activity. The objective is to examine how exercise intensities influence inflammation, microbial diversity, and patient outcomes for IBD management.

Materials and Methods
A literature review synthesized peer-reviewed studies from 2010-2024 using PubMed, Scopus, and Embase databases, examining physical activity effects on inflammatory markers, gut microbiota, and clinical outcomes in IBD patients. Inclusion criteria emphasized human studies, excluding research unrelated to IBD or focused on animal models.

State of Knowledge
Moderate-intensity aerobic and resistance exercises reduce systemic inflammatory markers, (CRP and cytokines) and enhance gut microbiota diversity, increasing anti-inflammatory species. Low-to-moderate intensity activities improve quality of life in IBD patients. Exercise supports intestinal barrier integrity through mucin production and fatty acid synthesis. High-intensity exercise can worsen inflammation, necessitating tailored protocols.

Conclusions
Physical activity is a promising adjunctive therapy in IBD management. Moderate-intensity programs effectively maintain remission and enhance outcomes. Future research should focus on longitudinal studies, advanced omics technologies, and combined approaches with dietary and pharmacological therapies.

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The Influence of Physical Activity on Inflammatory Markers, Intestinal Microbiota Composition and Disease Activity in Inflammatory Bowel Disease

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The Influence of Physical Activity on Inflammatory Markers, Intestinal Microbiota Composition and Disease Activity in Inflammatory Bowel Disease

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