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Quality in Sport

NSAIDs in Sports Medicine: Balancing Quick Relief with Long-Term Health Impacts
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NSAIDs in Sports Medicine: Balancing Quick Relief with Long-Term Health Impacts

Authors

  • Wojciech Urbański Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0008-6559-7510
  • Natalia Dolata Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0003-9564-9231
  • Bartosz Balcer Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0003-2994-3918
  • Adrianna Kruczkowska Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0000-0003-0549-0849
  • Emil Bulzacki Nicolaus Copernicus Memorial Hospital, Pabianicka 62, 93-513 Łódź, Poland https://orcid.org/0009-0009-4303-7114
  • Agnieszka Cebula Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0002-7966-6333
  • Maja Weimann Internship at Copernicus Hospital, Nowe Ogrody 1/6 , 80-803, Gdańsk, Poland https://orcid.org/0009-0004-1375-1337
  • Aleksandra Stosiek Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0001-9276-3528
  • Mateusz Pakuła Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0001-1792-0378
  • Paweł Liszka Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0003-5465-3656

DOI:

https://doi.org/10.12775/QS.2024.36.56892

Keywords

NSAIDs in sports injuries, NSAID mechanism, short-term and long-term effects of NSAIDs, athletic performance and NSAIDs, pain management in sports, NSAID side effects and NSAID alternatives

Abstract

Introduction and Purpose
Nonsteroidal anti-inflammatory drugs (NSAIDs) are regularly used in sports medicine to manage pain and inflammation caused by acute and chronic injuries. Their mechanism involves inhibition of cyclooxygenase (COX) enzymes, reducing the body’s natural inflammatory response. This review aims to analyze the effects of NSAID use in sports contexts, focusing on short- and long-term benefits and risks, specifically concerning tissue healing, athletic performance, and general health outcomes.
Materials and Methods
We reviewed studies from PubMed, Google Scholar and ResearchGate, focusing on key search terms including NSAIDs in sports injuries, NSAID mechanism, short-term and long-term effects of NSAIDs, athletic performance and NSAID, pain management in sports, NSAID side-effects and NSAID alternatives
Conclusions
Short-term NSAID use can provide effective pain relief and support functional recovery, benefiting professional and recreational athletes in their sports. However, prolonged use may decrease natural tissue healing abilities, increase susceptibility to various side effects, and potentially affect long-term performance. Alternative pain management strategies are recommended to complement NSAID use, providing athletes with safer, long-term options for recovery. This review highlights the need for a balanced approach to NSAID usage, recommending cautious decision making among sportspeople, coaches, and healthcare workers.

References

Brennan R, Wazaify M, Shawabkeh H, Boardley I, McVeigh J , Van Hout M . A scoping review of non-medical and extra-medical use of non-steroidal anti-inflammatory drugs (NSAIDs). Drug Safety. 2021;44:937–953. https://doi.org/10.1007/s40264-021-01085-9.

Machado GC, Underwood M.Abdel-Shaheed C, O Day R. Non-steroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain. BMJ. 2021;104:372. https://doi.org/10.1136/bmj.n104.

Palmer D, Cooper DJ, Emery C, Batt ME, Engebretsen L, Scamell BE, Schamasch P, Shroff M, Soligard T, Steffen K, Whittaker JL, Budgett R. Self-reported sports injuries and later-life health status in 3357 retired Olympians from 131 countries: a cross-sectional survey among those competing in the games. Br J Sports Med. 2021;55(1):46-51. https://doi.org/10.1136/bjsports-2019-101772

Tricker R. Painkilling Drugs in Collegiate Athletics: Knowledge, Attitudes, and Use of Student Athletes. J. Drug Educ. 2000, 30, 313–324. https://doi.org/10.2190/N1K3-V8BK-90GH-TTHU

Lilly KF. Athletes, NSAID, Coxibs, and the Gastrointestinal Tract. Curr. Sports Med. Rep. 2010, 9, 103–105. https://doi.org/10.1249/jsr.0b013e3181d405a9.

Hörl WH.Nonsteroidal anti-inflammatory drugs and the kidney. Pharmaceuticals (2010) 3, 2291–2321 . https://doi.org/10.3390/ph3072291.

Ziltener J-L, Leal S, Fournier P-E. Non-steroidal anti-inflammatory drugs for athletes: An update. Ann Phys Rehabil Med. (2010);53(4):278-82. https://doi.org/10.1016/j.rehab.2010.03.001

Ribeiro H , Rodrigues I , Napoleão L , Lira L , Marques D , Veríssimo M , Andrade JP , Dourado M. Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features. Biomed Pharmacother. (2022);150, 112958. https://doi.org/10.1016/j.biopha.2022.112958

Larsen AC, Pedersen JR, Møller M, Storm LK, Koes B, Thorlund JB. The impact of injuries on sports-related analgesic use in Danish youth elite athletes: A 4-week prospective cohort study. J Sci Med Sport. 2024 Aug 15:S1440-2440(24)00486-9. https://doi.org/10.1016/j.jsams.2024.08.201

Er Y, Faki A. Different chemical structures and physiological/pathological roles of cyclooxygenases. Rambam Maimonides Med J. 2021;12(3) https://doi.org/10.5041/RMMJ.10426

Sinniah A, Yazid S, Flower RJ. From NSAIDs to glucocorticoids and beyond. Cells. 2021;10(12):3524. https://doi.org/10.3390/cells10123524

Singh G, Scolnik M. Combination therapy versus celecoxib, a single selective COX-2 agent, to reduce gastrointestinal toxicity in arthritic patients: patient and cost-effectiveness considerations. Open Access Rheumatol. 2011;3:53-62. https://doi.org/10.2147/oarrr.s14568

Bondesen BA, Mills ST, Pavlath GK. The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms. Am J Physiol Cell Physiol.Jun;290(6):C16511659 https://doi.org/10.1152/ajpcell.00518.2005

Holgado D, Hopker J, Sanabria D, Zabala M. Analgesics and sport performance: Beyond the pain-modulating effects. PM R. 2018;10(1):72–82. https://doi.org/10.1016/j.pmrj.2017.07.068

Meyer-Glitza PS, Langer T, Wieder O. Non-steroidal anti-inflammatory drug use in endurance sports: balancing performance and health implications. OSF Preprints 2023;(9) http://dx.doi.org/10.31219/osf.io/b24nr

Tso J, Hollowed C, Liu C, Alkhoder A, Dommisse M, Gowani Z, Miller A, Nguyen G, Nguyen P, Prabakaran G, Wehbe M, Galante A, Gilson CR, Clark C, Marshall T, Patterson G, Quyyumi AA, Baggish AL, Kim JH. Nonsteroidal Anti-inflammatory Drugs and Cardiovascular Risk in American Football. Med Sci Sports Exerc. 2020 Dec;52(12):2522-2528. https://doi.org/10.1249/mss.0000000000002404

Tscholl PM, Gard S, Schindler M. A sensible approach to the use of NSAIDs in sports medicine. Sports Med. 2019 Nov; https://doi.org/10.34045/SSEM/2017/8

Pham H, Spaniol F. The efficacy of non-steroidal anti-inflammatory drugs in athletes for injury management, training response, and athletic performance: A systematic review. Sports. 2024;12(11):302. https://doi.org/10.3390/sports12110302

Waterman JJ, Kapur R. Upper gastrointestinal issues in athletes. Curr Sports Med Rep. 2012;11(2):99-104. https://doi.org/10.1249/jsr.0b013e318249c311

Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006;332(7553):1302–1308. https://doi.org/10.1136/bmj.332.7553.1302

Pedersen JR, Andreucci A, Thorlund JB, Koes B, Møller M, Storm LK, Bricca A. Prevalence, frequency, adverse events, and reasons for analgesic use in youth athletes: A systematic review and meta-analysis of 44,381 athletes. J Sci Med Sport. 2022 Oct;25(10):810-819 https://doi.org/10.1016/j.jsams.2022.08.018

Leone James E, Maurer-Starks Suanne, Wise Kimberly A,Muse Daniel A. (2019). Opioids, Acute Pain Management, Athletes, and Policy. Bridgewater Review. 38(2), 4-9.

Baker J, Cotter JD, Gerrard DF, Bell ML, Walker RJ. Effects of indomethacin and celecoxib on renal function in athletes. Med Sci Sports Exerc. 2005 May;37(5):712-7. https://doi.org/10.1249/01.mss.0000162700.66214.ce

Lipman GS, Shea K, Christensen M, Phillips C, Burns P, Higbee R, Koskenoja V, Eifling K, Krabak BJ. Ibuprofen versus placebo effect on acute kidney injury in ultramarathons: a randomised controlled trial. Emerg Med J. 2017 Oct;34(10):637-642. https://doi.org/10.1136/emermed-2016-206353

Shoor S. Athletes, nonsteroidal anti-inflammatory drugs, coxibs, and the gastrointestinal tract. Curr Sports Med Rep. 2002;1(2):107–15. https://doi.org/10.1249/00149619-200204000-00008

Van Wijck K, Lenaerts K, Grootjans J, Wijnands KAP, Poeze M, Van Loon LJC, et al. Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention. Am J Physiol Gastrointest Liver Physiol. https://doi.org/10.1152/ajpgi.00066.2012

Papantoniou K, Michailides C, Bali M, Papantoniou P, Thomopoulos K. Gastrointestinal bleeding in athletes. Ann Gastroenterol. 2023;36(3):267–274. https://doi.org/10.20524/aog.2023.0788

García Rodríguez LA, Pérez Gutthann S, Walker AM, Lueck L. The role of non-steroidal anti-inflammatory drugs in acute liver injury. BMJ. 1992;305(6858):865–8. doi: https://doi.org/10.1136/bmj.305.6858.865

Vuolteenaho K, Moilanen T, Moilanen E. Non-steroidal anti-inflammatory drugs, COX-2, and the bone healing process. Basic Clin Pharmacol Toxicol. 2008;102(1):10–4. https://doi.org/10.1111/j.1742-7843.2007.00149.x

Lisowska B, Kosson D, Domaracka K. Positives and negatives of NSAIDs in bone healing: The effects on repair. Drug Des Devel Ther. 2018;12:3267–74. https://doi.org/10.2147/DDDT.S164565

Gorski T, Cadore EL, Pinto SS, da Silva EM, Correa CS, Beltrami FG, Kruel LF. Use of NSAIDs in triathletes: prevalence, level of awareness and reasons for use. Br J Sports Med. 2011;45(2):85–90.

https://doi.org/10.1136/bjsm.2009.062166

Schweiger V, Niederseer D, Schmied C, Attenhofer-Jost C, Caselli S. Athletes and hypertension. Curr Cardiol Rep. 2021;23(12):176. https://doi.org/10.1007/s11886-021-01608-x

Warden SJ. Prophylactic use of NSAIDs by athletes: a risk/benefit assessment. Phys Sportsmed. 2010;38(1):132–8. https://doi.org/10.3810/psm.2010.04.1770

Heapy AM, Hoffman MD, Verhagen HH, Thompson SW, Dhamija P, Sandford FJ, Cooper MC. A randomized controlled trial of manual therapy and pneumatic compression for recovery from prolonged running - an extended study. Res Sports Med. 2018;26(3):354–364 https://doi.org/10.1080/15438627.2018.1447469

Zainuddin Z, Newton M, Sacco P, Nosaka K. Effects of massage on delayed-onset muscle soreness, swelling, and recovery of muscle function. J Athl Train. 2005;40(3):174–80.

Tang CT, Song B. Acupuncture and dry needling for sports performance and recovery. Curr Sports Med Rep. 2022;21(6):213–8. https://doi.org/10.1249/jsr.0000000000000968

Reiman MP, Lorenz DS. Integration of strength and conditioning principles into a rehabilitation program. Int J Sports Phys Ther. 2011;6(3):241–53.

Dupuy O, Douzi W, Theurot D, Bosquet L, Dugué B. An evidence-based approach for choosing post-exercise recovery techniques to reduce markers of muscle damage, soreness, fatigue, and inflammation: A systematic review with meta-analysis. Front Physiol. 2018;9:403. https://doi.org/10.3389/fphys.2018.00403

Bailey DM, Erith SJ, Griffin PJ, Dowson A, Brewer DS, Gant N, Williams C. Influence of cold-water immersion on indices of muscle damage following prolonged intermittent shuttle running. J Sports Sci. 2007;25(11):1163–70. https://doi.org/10.1080/02640410600982659

Manoukian MAC, Migdal CW, Tembhekar AR, Harris JA, DeMesa C. Topical administration of ibuprofen for injured athletes: considerations, formulations, and comparison to oral delivery. Sports Med Open. 2017;3(1):36. https://doi.org/10.1186/s40798-017-0103-2

Wang L, Meng Q, Su CH. From food supplements to functional foods: Emerging perspectives on post-exercise recovery nutrition. Nutrients. 2024;16(23):4081. https://doi.org/10.3390/nu16234081

Zeidan F, Vago DR. Mindfulness meditation-based pain relief: a mechanistic account. Ann N Y Acad Sci. 2016;1373(1):114–27. https://doi.org/10.1111/nyas.13153

Bonilla DA, Pérez-Idárraga A, Odriozola-Martínez A, Kreider RB. The 4R's framework of nutritional strategies for post-exercise recovery: A review with emphasis on new generation of carbohydrates. Int J Environ Res Public Health. 2020;18(1):103. https://doi.org/10.3390/ijerph18010103

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Published

2024-12-24

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URBAŃSKI, Wojciech, DOLATA, Natalia, BALCER, Bartosz, KRUCZKOWSKA, Adrianna, BULZACKI, Emil, CEBULA, Agnieszka, WEIMANN, Maja, STOSIEK, Aleksandra, PAKUŁA, Mateusz and LISZKA, Paweł. NSAIDs in Sports Medicine: Balancing Quick Relief with Long-Term Health Impacts. Quality in Sport. Online. 24 December 2024. Vol. 36, p. 56892. [Accessed 1 July 2025]. DOI 10.12775/QS.2024.36.56892.
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Vol. 36 (2024)

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Physical Culture Sciences

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Copyright (c) 2024 Wojciech Urbański, Natalia Dolata, Bartosz Balcer, Adrianna Kruczkowska, Emil Bulzacki, Agnieszka Cebula, Maja Weimann, Aleksandra Stosiek, Mateusz Pakuła, Paweł Liszka

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