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Quality in Sport

5-aminolevulinic acid in photodynamic therapy used in dermatology as a method of treating acne vulgaris.
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5-aminolevulinic acid in photodynamic therapy used in dermatology as a method of treating acne vulgaris.

Authors

  • Karolina Sacher Śląskie Centrum Chorób Serca Zabrze, Marii Skłodowskiej-Curie 9 / Silesian Center for Heart Diseases Zabrze, Marii Skłodowskiej-Curie 9 https://orcid.org/0009-0001-8875-5912
  • Krystyna Zabojska Hospital of Our Lady of Perpetual Help in Wolomin, Gdynska 1/3, 05-200 Wolomin, Poland / Szpital Matki Bożej Nieustającej Pomocy w Wołominie, Gdyńska 1/3, 05-250 Wołomin https://orcid.org/0009-0002-6962-0497
  • Aleksandra Cygnarowicz Bonifraters Medical Center sp. z. o. o. Branch in Krakow, Trynitarska 11 St., 31-061 Krakow, Poland https://orcid.org/0009-0002-2208-0104
  • Mariola Turemka Voivodeship Hospital in Bialystok/Marii Sklodowskiej-Curie 26, 15-278 Bialystok, Poland/ Wojewódzki Szpital Zespolony w Białymstoku, Marii Skłodowskiej-Curie 26, 15-278 Białystok https://orcid.org/0009-0001-8219-6515
  • Negar Hosseinnejad The 5 Military Clinical Hospital with Polyclinic SPZOZ in Cracow, Wroclawska Street 1/3, 30-901 Cracow, Poland/ 5 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Krakowie, ul. Wrocławska 1/3, 30-901 Kraków, Polska https://orcid.org/0009-0002-3552-9513
  • Aneta Klaudia Wojtas Municipal Hospital in Siemianowice Śląskie sp. z o.o., 1. Maja 9 St., 41-100 Siemianowice Śląskie, Poland https://orcid.org/0009-0002-6072-1232
  • Mikołaj Biskupski Department of Interventional Cardiology and Cardiac Arrhythmias, Teaching Hospital No. 2 of the Medical University of Lodz, Zeromskiego Street 113 90-549 Lodz, Poland/ Klinika Kardiologii Interwencyjnej i Zaburzeń Rytmu Serca, Uniwersytecki Szpital Kliniczny nr. 2 Uniwersytetu Medycznego w Łodzi, ul. Żeromskiego 113, 90-549 Łódź, Polska https://orcid.org/0009-0009-8103-4053
  • Urszula Korotko The Provincial Specialist Hospital in Ciechanów, Powstańców Wielkopolskich 2 St., 06-400 Ciechanów, Poland/ Specjalistyczny Szpital Wojewódzki w Ciechanowie https://orcid.org/0009-0004-9226-6451
  • Kinga Witowska The 5 Military Clinical Hospital with Polyclinic SPZOZ in Cracow, Wroclawska Street 1/3, 30-901 Cracow, Poland/ 5 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Krakowie, ul. Wrocławska 1/3, 30-901 Kraków, Polska https://orcid.org/0009-0003-2389-4887
  • Aneta Mandziuk Municipal Hospital in Siemianowice Śląskie sp. z o.o., 1. Maja 9 St., 41-100 Siemianowice Śląskie, Poland https://orcid.org/0009-0001-2787-9479

DOI:

https://doi.org/10.12775/QS.2025.37.56853

Keywords

Acne vulgaris, photodynamic treatment, acid 5-aminolevulini, light therapy, red light.

Abstract

Acne therapy is a difficult task and the number of patients struggling with the disease is increasing, but new treatment options are emerging. One such indication is precisely the use of 5-aminolevulinic acid in photodynamic therapy for the treatment of acne lesions. The given issue has been widely discussed on the basis of a number of research papers from around the world, whose publications have promising results. The results of the studies show the effectiveness of using ALA-PTD terpy in the treatment of acne lesions occurring in acne vulgaris. Photodynamic therapy with 5-ALA acid may also serve as a good complementary treatment to other substances. However, studies need to be conducted to obtain data to develop procedures to achieve the most effective results, with the development of minimal side effects, which include pruritus, redness, transient hyperpigmentation coming off without leaving a scar and the occurrence of allergic reactions

References

1..Szymańczyk J, Domaniecki J, Tomczak M, Kwaśny M, Steć M, Mierczyk Z. 5- aminolevulinic acid in photodynamic treatment of superficial basocellular epithelial lesions of the skin. Contemporary Oncology/Współczesna Onkologia. 1999;3(2):76-79.

2.Hongcharu W, Taylor CR, Chang Y, Aghassi D, Suthamjariya K, Anderson RR. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol. 2000 Aug;115(2):183-92. doi: 10.1046/j.1523-1747.2000.00046.x. PMID: 10951234.

3.Goldman MP, Boyce SM. A single-center study of aminolevulinic acid and 417 NM photodynamic therapy in the treatment of moderate to severe acne vulgaris. J Drugs Dermatol. 2003 Aug;2(4):393-6. PMID: 12884461.

4.Pollock B, Turner D, Stringer MR, Bojar RA, Goulden V, Stables GI, Cunliffe WJ. Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol. 2004 Sep;151(3):616-22. doi: 10.1111/j.1365-2133.2004.06110.x. PMID: 15377348.

5.An, J. S., Kim, J. E., Lee, D. H., Kim, B. Y., Cho, S., Kwon, I. H., … Moon, K. C. (2011). 0.5% Liposome-encapsulated 5-aminolevulinic acid (ALA) photodynamic therapy for acne treatment. Journal of Cosmetic and Laser Therapy, 13(1), 28–32. https://doi.org/ 10.3109/14764172.2011.552613

6.Ma L, Xiang LH, Yu B, Yin R, Chen L, Wu Y, Tan ZJ, Liu YB, Tian HQ, Li HZ, Lin T, Wang XL, Li YH, Wang WZ, Yang HL, Lai W. Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):583-90. doi: 10.1016/j.pdpdt.2013.06.007. Epub 2013 Aug 8. PMID: 24284115.

7.Chen X, Song H, Chen S, Zhang J, Niu G, Liu X. Clinical efficacy of 5- aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris. Exp Ther Med. 2015 Sep;10(3):1194-1198. doi: 10.3892/etm.2015.2638. Epub 2015 Jul 15. PMID: 26622463; PMCID: PMC4533172.

8.Wang P, Wang B, Zhang L, Liu X, Shi L, Kang X, Lei X, Chen K, Chen Z, Li C, Zhang C, Tu P, Pan M, Ju Q, Man X, Lu Y, Yu N, Li Y, Zhu H, Zhang R, Su J, Tao S, Qiao J, Mu Q, Zeng W, Li Z, Gao Y, Gu H, Wang X. Clinical practice Guidelines for 5- Aminolevulinic acid photodynamic therapy for acne vulgaris in China. Photodiagnosis Photodyn Ther. 2023 Mar;41:103261. doi: 10.1016/j.pdpdt.2022.103261. Epub 2022 Dec 30. PMID: 36587863.

9.Zhang L, Yang Y, Wang B, Zhao Y, Wang P, Liu J, Yang J, Wu Y, Lv T, Wei Z, Liu X, Wang R, Wong H, Ju Q, Shi L, Wang X. Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study. J Am Acad Dermatol. 2023 Dec;89(6):1141-1148. doi: 10.1016/j.jaad.2023.07.1023. Epub 2023 Aug 7. PMID: 37558093

10.Brzezińska N, Bulińska B, Zawadzka N, Roter G, Szczerkowska-Dobosz A. Comparison of 15% 5-aminolevulinic acid and 10% 5-aminolevulinic acid photodynamic therapy for the treatment of acne vulgaris: a split-face randomized pilot study. Postepy Dermatol Alergol. 2024 Oct;41(5):479-486. doi: 10.5114/ada.2024.144417. Epub 2024 Oct 22. PMID: 39606608; PMCID: PMC11589636.

11.Qureshi S, Rehan Z, Ao A, Mukovozov I. Photodynamic Therapy in Acne Vulgaris: A Systematic Review. J Cutan Med Surg. 2024 Nov 18:12034754241291031. doi: 10.1177/12034754241291031. Epub ahead of print. PMID: 39552358.

12.Akaraphanth, R., Kanjanawanitchkul, W. and Gritiyarangsan, P. (2007), Efficacy of ALA-PDT vs blue light in the treatment of acne. Photodermatology, Photoimmunology & Photomedicine, 23: 186-190. https://doi.org/10.1111/j.1600-0781.2007.00303.x

13.Dąbrowska A, Mastalerz J, Wilczyński B, Osiecka B, Choromańska A. Determinants of Photodynamic Therapy Resistance in Cancer Cells. Int J Mol Sci. 2024 Nov 10;25(22):12069. doi: 10.3390/ijms252212069. PMID: 39596137; PMCID: PMC11594179.

14.Fan H, Tuo H, Xie Y, Ju M, Sun Y, Yang Y, Han X, Ren Z, Zheng Y, He D. Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study. Photodiagnosis Photodyn Ther. 2024 Oct;49:104325. doi: 10.1016/j.pdpdt.2024.104325. Epub 2024 Sep 6. PMID: 39245305.

15.Jiang S, Dong B, Peng X, Chen Y, Mao H. 5-Aminolaevulinic acid-based photodynamic therapy suppresses lipid secretion by inducing mitochondrial stress and oxidative damage in sebocytes and ameliorates ear acne in mice. Int Immunopharmacol. 2024 Oct 25;140:112795. doi: 10.1016/j.intimp.2024.112795. Epub 2024 Aug 3. PMID: 39096873

16.Chang Q, Liu X, Wang P, Yang Y, Zhang L, Wang B, Wang X. IPL-PDT as an effective treatment for mild-to-moderate acne vulgaris: A prospective, single-center, selfcontrolled study. Photodiagnosis Photodyn Ther. 2024 Apr;46:103999. doi: 10.1016/ j.pdpdt.2024.103999. Epub 2024 Feb 7. PMID: 38336151.

17.Yu Q, Wu X, Lu Y, Chen Z, Zhu Q, Wu W. Ionic Liquid Pretreatment Enhances Skin Penetration of 5-Aminolevulinic Acid: A Promising Scheme for Photodynamic Therapy for Acne Vulgaris. ACS Appl Bio Mater. 2024 May 20;7(5):2899-2910. doi: 10.1021/ acsabm.3c01295. Epub 2024 Apr 12. PMID: 38607995.

18.Wang D, Yan Y, Wang P, Zhang H, Cao Y, Wang B, Zhang L, Wang X. A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea. Photodiagnosis Photodyn Ther. 2024 Feb;45:103973. doi: 10.1016/ j.pdpdt.2024.103973. Epub 2024 Feb 3. PMID: 38316341.

19.Morton CA, Szeimies RM, Braathen LR. Review of the European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2022. Eur J Dermatol. 2023 Oct 1;33(5):467-473. doi: 10.1684/ejd.2023.4562. PMID: 38297922..

20.Bhatia N. The Interventions to Minimize Pain During Photodynamic Therapy With 5- Aminolevulinic Acid for the Treatment of Cutaneous Diseases. J Drugs Dermatol. 2023 Nov 1;22(11):1082-1087. doi: 10.36849/JDD.7637. PMID: 37943263.

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Published

2025-01-28

How to Cite

1.
SACHER, Karolina, ZABOJSKA, Krystyna, CYGNAROWICZ, Aleksandra, TUREMKA, Mariola, HOSSEINNEJAD, Negar, WOJTAS, Aneta Klaudia, BISKUPSKI, Mikołaj, KOROTKO, Urszula, WITOWSKA, Kinga and MANDZIUK, Aneta. 5-aminolevulinic acid in photodynamic therapy used in dermatology as a method of treating acne vulgaris. Quality in Sport. Online. 28 January 2025. Vol. 37, p. 56853. [Accessed 8 July 2025]. DOI 10.12775/QS.2025.37.56853.
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Vol. 37 (2025)

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Medical Sciences

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Copyright (c) 2025 Karolina Sacher, Krystyna Zabojska, Aleksandra Cygnarowicz, Mariola Turemka, Negar Hosseinnejad, Aneta Klaudia Wojtas, Mikołaj Biskupski, Urszula Korotko, Kinga Witowska, Aneta Mandziuk

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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