Endometriosis - A Medical Challenge: Impact on Fertility and Treatment Method
DOI:
https://doi.org/10.12775/QS.2024.25.56839Keywords
endometriosis, 'fertility', infertility, pelvic pain, IVF, endometriosis-related painAbstract
Aim of study:
The subject of this review is to highlight the complexity of the disease known as endometriosis. This disease affects 10% of women of reproductive age, causing a number of symptoms of various origins, and additionally affects women’s fertility, mental health and role in society. The work aims to systematize knowledge about endometriosis, the mechanism by which it affects fertility and possible therapies, including surgical methods and assisted reproductive technology (ART.). The issue of infertility associated with endometriosis is has not been fully explored yet. A personalized treatment plan including medication, surgical assisted reproductive techniques and psychological support should be developed to improve the quality of life of patients with endometriosis and enable them to become pregnant.
Material and methods:
A systematic review of scientific and medical literature from the PubMed and Google Scholar databases was conducted.
Results:
Currently, the most effective treatment for infertility is in vitro fertilization (IVF). Successful treatment of endometriosis-related infertility should be discussed in detail with each patient and the decision on the therapy plan should be individual and comprehensive.
Keywords: endometriosis, infertility, chronic pelvic pain, gynecology, IVF, IVI
References
Koninckx PR, Fernandes R, Ussia A, et al. Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front Endocrinol (Lausanne). 2021;12:745548. Published 2021 Nov 25. doi:10.3389/fendo.2021.745548
As-Sanie S, Black R, Giudice LC, et al. Assessing research gaps and unmet needs in endometriosis. Am J Obstet Gynecol. 2019;221(2):86-94. doi:10.1016/j.ajog.2019.02.033
Horne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022;379:e070750. Published 2022 Nov 14. doi:10.1136/bmj-2022-070750
Eisenberg VH, Decter DH, Chodick G, Shalev V, Weil C. Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization. J Clin Med. 2022;11(4):1133. Published 2022 Feb 21. doi:10.3390/jcm11041133
Sachedina A, Todd N. Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents. J Clin Res Pediatr Endocrinol. 2020;12(Suppl 1):7-17. doi:10.4274/jcrpe.galenos.2019.2019.S021
Nezhat C, Lindheim SR, Backhus L, et al. Thoracic Endometriosis Syndrome: A Review of Diagnosis and Management. JSLS. 2019;23(3):e2019.00029. doi:10.4293/JSLS.2019.00029
Kołodziej A, Krajewski W, Dołowy Ł, Hirnle L. Urinary Tract Endometriosis. Urol J. 2015;12(4):2213-2217. Published 2015 Sep 4.
Kocas HD, Rubin LR, Lobel M. Stigma and mental health in endometriosis. Eur J Obstet Gynecol Reprod Biol X. 2023;19:100228. Published 2023 Aug 14. doi:10.1016/j.eurox.2023.100228
Agarwal SK, Chapron C, Giudice LC, et al. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019;220(4):354.e1-354.e12. doi:10.1016/j.ajog.2018.12.039
Pascoal E, Wessels JM, Aas-Eng MK, et al. Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research. Ultrasound Obstet Gynecol. 2022;60(3):309-327. doi:10.1002/uog.24892
Crump J, Suker A, White L. Endometriosis: A review of recent evidence and guidelines. Aust J Gen Pract. 2024;53(1-2):11-18. doi:10.31128/AJGP/04-23-6805
Schliep KC, Mumford SL, Peterson CM, et al. Pain typology and incident endometriosis. Hum Reprod. 2015;30(10):2427-2438. doi:10.1093/humrep/dev147
Smolarz B, Szyłło K, Romanowicz H. Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature). Int J Mol Sci. 2021;22(19):10554. Published 2021 Sep 29. doi:10.3390/ijms221910554
Pašalić E, Tambuwala MM, Hromić-Jahjefendić A. Endometriosis: Classification, pathophysiology, and treatment options. Pathol Res Pract. 2023;251:154847. doi:10.1016/j.prp.2023.154847
Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-549. doi:10.1016/j.ogc.2012.10.002
Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E. Association of endometriosis and adenomyosis with pregnancy and infertility. Fertil Steril. 2023;119(5):727-740. doi:10.1016/j.fertnstert.2023.03.018
Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand. 2017;96(6):659-667. doi:10.1111/aogs.13082
Bonavina G, Taylor HS. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Front Endocrinol (Lausanne). 2022;13:1020827. Published 2022 Oct 26. doi:10.3389/fendo.2022.1020827
Muzii L, Di Tucci C, Di Feliciantonio M, et al. Antimüllerian hormone is reduced in the presence of ovarian endometriomas: a systematic review and meta-analysis. Fertil Steril. 2018;110(5):932-940.e1. doi:10.1016/j.fertnstert.2018.06.025
Carson SA, Kallen AN. Diagnosis and Management of Infertility: A Review. JAMA. 2021;326(1):65-76. doi:10.1001/jama.2021.4788
Alkatout I, Mettler L, Beteta C, et al. Combined surgical and hormone therapy for endometriosis is the most effective treatment: prospective, randomized, controlled trial. J Minim Invasive Gynecol. 2013;20(4):473-481. doi:10.1016/j.jmig.2013.01.019
Hughes E, Brown J, Collins JJ, Farquhar C, Fedorkow DM, Vanderkerchove P. Ovulation suppression for endometriosis for women with subfertility. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD000155. DOI: 10.1002/14651858.CD000155.pub2. Accessed 06 December 2024.
Filip L, Duică F, Prădatu A, et al. Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina (Kaunas). 2020;56(9):460. Published 2020 Sep 9. doi:10.3390/medicina56090460
Hodgson RM, Lee HL, Wang R, Mol BW, Johnson N. Interventions for endometriosis-related infertility: a systematic review and network meta-analysis. Fertil Steril. 2020;113(2):374-382.e2. doi:10.1016/j.fertnstert.2019.09.031
Nankali A, Kazeminia M, Jamshidi PK, et al. The effect of unilateral and bilateral laparoscopic surgery for endometriosis on Anti-Mullerian Hormone (AMH) level after 3 and 6 months: a systematic review and meta-analysis. Health Qual Life Outcomes. 2020;18(1):314. Published 2020 Sep 24. doi:10.1186/s12955-020-01561-3
Bailleul A, Niro J, Du Cheyron J, Panel P, Fauconnier A. Infertility management according to the Endometriosis Fertility Index in patients operated for endometriosis: What is the optimal time frame?. PLoS One. 2021;16(5):e0251372. Published 2021 May 12. doi:10.1371/journal.pone.0251372
Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609-1615. doi:10.1016/j.fertnstert.2009.09.035
Tummon IS, Asher LJ, Martin JS, Tulandi T. Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. Fertil Steril. 1997;68(1):8-12. doi:10.1016/s0015-0282(97)81467-7
Goyri E, Kohls G, Garcia-Velasco J. IVF stimulation protocols and outcomes in women with endometriosis. Best Pract Res Clin Obstet Gynaecol. 2024;92:102429. doi:10.1016/j.bpobgyn.2023.102429
Dong X, Liao X, Wang R, Zhang H. The impact of endometriosis on IVF/ICSI outcomes. Int J Clin Exp Pathol. 2013;6(9):1911-1918. Published 2013 Aug 15.
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Copyright (c) 2024 Maria Zwierzchowska, Julia Stachowiak, Julia Sosin, Anna Pilarz, Aleksandra Sojka, Dariusz Salamon, Wojciech Domagała
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