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Quality in Sport

Infliximab: Pharmacological Properties, Mechanism of Action, and Clinical Applications in the Treatment of Selected Inflammatory Diseases
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  • Infliximab: Pharmacological Properties, Mechanism of Action, and Clinical Applications in the Treatment of Selected Inflammatory Diseases
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  3. Vol. 36 (2024) /
  4. Medical Sciences

Infliximab: Pharmacological Properties, Mechanism of Action, and Clinical Applications in the Treatment of Selected Inflammatory Diseases

Authors

  • Julia Słowik University Teaching Hospital them F. Chopin in Rzeszów https://orcid.org/0009-0003-3821-5090
  • Daniel Zapasek Medical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, Poland https://orcid.org/0009-0006-1383-1825
  • Mateusz Bajak University Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, Poland https://orcid.org/0009-0006-8237-1295
  • Michał Szczepański Medical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, Poland https://orcid.org/0009-0001-8586-3790
  • Maciej Mamczur Medical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, Poland https://orcid.org/0009-0000-2789-1235
  • Marcin Kuliga College of Medical Sciences, University of Rzeszów, Poland al. Tadeusza Rejtana 16C, 35-310 Rzeszów https://orcid.org/0009-0004-3452-7377
  • Julia Inglot Clinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-301 Rzeszów, Poland https://orcid.org/0000-0002-6604-7229
  • Jadwiga Inglot Clinical Provincial Hospital No. 2 in Rzeszow, Poland Lwowska 60, 35-301 Rzeszów, Poland https://orcid.org/0000-0002-3071-4392
  • Dominik Maciej Feret Independent Public Health Care Complex No. 1 in Rzeszów, ul. Czackiego 3, 35-051 Rzeszów, Poland https://orcid.org/0009-0004-3174-2784
  • Damian Sowa Clinical Provincial Hospital No. 2 in Rzeszow, Poland Lwowska 60, 35-301 Rzeszów, Poland https://orcid.org/0009-0003-0980-9324

DOI:

https://doi.org/10.12775/QS.2024.36.56477

Keywords

Infliximab, TNF-alpha (TNF-α), Inflammatory diseases, Rheumatoid arthritis (RA), Crohn's disease, Psoriasis, Biologic therapy, Monoclonal antibodies

Abstract

Infliximab is a chimeric monoclonal antibody used in the treatment of chronic inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, and psoriasis. It functions by inhibiting tumor necrosis factor-alpha (TNF-α), a cytokine central to the inflammatory processes of these conditions. Since its approval in 1998, infliximab has significantly improved the management of patients who do not respond well to conventional therapies.

The article provides a comprehensive review of infliximab's pharmacological properties, its mechanism of action, FDA-approved uses, and its clinical benefits. It also discusses its safety profile, which includes potential risks like infections, infusion reactions, and long-term concerns such as an increased risk of malignancies. Regular monitoring of adverse effects is crucial for patient safety during treatment.

Infliximab has demonstrated efficacy in reducing symptoms like pain, swelling, and skin lesions, and it helps in maintaining remission in conditions like Crohn's disease and psoriasis. The drug is typically administered via intravenous infusion, and its dosing varies depending on the disease and patient response. Additionally, the article highlights the role of therapeutic drug monitoring (TDM) to optimize treatment outcomes and reduce healthcare costs.

In conclusion, infliximab remains an essential therapeutic option for managing severe chronic inflammatory diseases, though its use requires careful monitoring due to potential risks. Ongoing research is expected to refine its use and expand its indications, further enhancing its clinical application in inflammatory disease management.

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Published

2024-12-19

How to Cite

1.
SŁOWIK, Julia, ZAPASEK, Daniel, BAJAK, Mateusz, SZCZEPAŃSKI, Michał, MAMCZUR, Maciej, KULIGA, Marcin, INGLOT, Julia, INGLOT, Jadwiga, FERET, Dominik Maciej and SOWA, Damian. Infliximab: Pharmacological Properties, Mechanism of Action, and Clinical Applications in the Treatment of Selected Inflammatory Diseases. Quality in Sport. Online. 19 December 2024. Vol. 36, p. 56477. [Accessed 13 June 2025]. DOI 10.12775/QS.2024.36.56477.
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Vol. 36 (2024)

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Medical Sciences

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Copyright (c) 2024 Julia Słowik, Daniel Zapasek, Mateusz Bajak, Michał Szczepański, Maciej Mamczur, Marcin Kuliga, Julia Inglot, Jadwiga Inglot, Dominik Maciej Feret, Damian Sowa

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