The impact of physical activity on depressive and anxiety disorders: A literature review
DOI:
https://doi.org/10.12775/QS.2024.36.56456Keywords
physical activity, running, mental disorders, depression and anxiety, mental healthAbstract
Purpose of Research:
Depression and anxiety affect over 500 million people globally and are leading causes of disability. While pharmacotherapy and psychotherapy are effective for many, a significant proportion of patients remain resistant. This study examines the role of physical activity as a complementary or alternative treatment for these conditions, focusing on its effects on neuroplasticity, inflammation, and metabolic health.
Research Materials and Methods:
A systematic review of clinical and experimental studies was conducted using PubMed with keywords like “physical activity,” “running,” “mental disorder,” and “depression.” Included studies were assessed for methodology, participant demographics, and therapeutic outcomes.
Basic Results:
Physical activity improves depressive symptoms, neuroplasticity, and metabolic health. Running therapy significantly reduces depressive symptoms and inflammation compared to antidepressants. Preclinical studies show exercise reverses depressive-like behaviors and restores hippocampal function in rodents. Meta-analyses confirm the effectiveness of aerobic and strength exercises as standalone or adjunctive treatments, with variations based on age and gender.
Conclusions:
Physical activity is a cost-effective intervention with significant benefits for mental health, particularly for treatment-resistant patients or those with metabolic comorbidities. Its integration into treatment guidelines could enhance outcomes, emphasizing the need for tailored exercise protocols in future research.
References
Brüchle, W., Schwarzer, C., Berns, C., Scho, S., Schneefeld, J., Koester, D., Schack, T., Schneider, U., & Rosenkranz, K. (2021). Physical Activity Reduces Clinical Symptoms and Restores Neuroplasticity in Major Depression. Frontiers in Psychiatry, 12, 660642. https://doi.org/10.3389/FPSYT.2021.660642/BIBTEX
Cuijpers, P., Noma, H., Karyotaki, E., Vinkers, C. H., Cipriani, Andrea, & Furukawa, T. A. (2020). A network meta‐analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. World Psychiatry, 19(1), 92. https://doi.org/10.1002/WPS.20701
Gautam, S., Jain, A., Gautam, M., Vahia, V., & Grover, S. (2017). Clinical Practice Guidelines for the management of Depression. Indian Journal of Psychiatry, 59(5), S34–S50. https://doi.org/10.4103/0019-5545.196973
Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. (2022). The Lancet. Psychiatry, 9(2), 137–150. https://doi.org/10.1016/S2215-0366(21)00395-3
Juan M. Tecco, Noemy Gerard, Rene Llano Lopez, & Dominique A. Badr. (2022). Running to Prevent Depression; Maximal Aerobic Speed for Adolescents in the South of Belgium. Comparison With Their Parents’ Generation and the Impact on Their Physical and Mental Health - PubMed. Psychiatria Danubina. https://pubmed.ncbi.nlm.nih.gov/36170696/
Li, Y., Luo, Y., Zhu, P., Liang, X., Li, J., Dou, X., Liu, L., Qin, L., Zhou, M., Deng, Y., Jiang, L., Wang, S., Yang, W., Tang, J., & Tang, Y. (2024). Running exercise improves astrocyte loss, morphological complexity and astrocyte-contacted synapses in the hippocampus of CUS-induced depression model mice. Pharmacology, Biochemistry, and Behavior, 239. https://doi.org/10.1016/J.PBB.2024.173750
Liu, L., Tang, J., Liang, X., Li, Y., Zhu, P., Zhou, M., Qin, L., Deng, Y., Li, J., Wang, Y., Jiang, L., Huang, D., Zhou, Y., Wang, S., Xiao, Q., Luo, Y., & Tang, Y. (2024). Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress. Molecular Psychiatry, 29(7). https://doi.org/10.1038/S41380-024-02464-1
Luo, L., Song, N., Yang, H., Huang, J. H., Zhou, L., & Zhang, L. (2021). Intervention Effect of Long-Term Aerobic Training on Anxiety, Depression, and Sleep Quality of Middle School Students With Depression After COVID-19. Frontiers in Psychiatry, 12. https://doi.org/10.3389/FPSYT.2021.720833
Milaneschi, Y., Lamers, F., Berk, M., & Penninx, B. W. J. H. (2020). Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression. Biological Psychiatry, 88(5), 369–380. https://doi.org/10.1016/J.BIOPSYCH.2020.01.014
Mul, J. D. (2018). Voluntary exercise and depression-like behavior in rodents: are we running in the right direction? Journal of Molecular Endocrinology, 60(3), R77–R95. https://doi.org/10.1530/JME-17-0165
Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., Del Pozo Cruz, B., Van Den Hoek, D., Smith, J. J., Mahoney, J., Spathis, J., Moresi, M., Pagano, R., Pagano, L., Vasconcellos, R., Arnott, H., Varley, B., Parker, P., Biddle, S., & Lonsdale, C. (2024). Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. The BMJ, 384, e075847. https://doi.org/10.1136/BMJ-2023-075847
Nokia, M. S., Lensu, S., Ahtiainen, J. P., Johansson, P. P., Koch, L. G., Britton, S. L., & Kainulainen, H. (2016). Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. The Journal of Physiology, 594(7), 1855–1873. https://doi.org/10.1113/JP271552
Peluso, M. A. M., & Guerra de Andrade, L. H. S. (2005). PHYSICAL ACTIVITY AND MENTAL HEALTH: THE ASSOCIATION BETWEEN EXERCISE AND MOOD. Clinics, 60(1), 61–70. https://doi.org/10.1590/S1807-59322005000100012
Qi, M., Wu, Y., Shi, H., Liu, J., Zhu, R., Wang, J., Rafique, A., Yang, B., Niu, R., Zhang, D., & Sun, Z. (2024). Effect of Voluntary Wheel Running on Anxiety- and Depression-Like Behaviors in Fluoride-Exposed Mice. Biological Trace Element Research. https://doi.org/10.1007/S12011-024-04433-9
Rice, S. M., Purcell, R., De Silva, S., Mawren, D., McGorry, P. D., & Parker, A. G. (2016). The Mental Health of Elite Athletes: A Narrative Systematic Review. Sports Medicine (Auckland, N.Z.), 46(9), 1333–1353. https://doi.org/10.1007/S40279-016-0492-2
Roeh, A., Lembeck, M., Papazova, I., Pross, B., Hansbauer, M., Schoenfeld, J., Haller, B., Halle, M., Falkai, P., Scherr, J., & Hasan, A. (2020). Marathon running improves mood and negative affect. Journal of Psychiatric Research, 130, 254–259. https://doi.org/10.1016/J.JPSYCHIRES.2020.08.005
Strawbridge, R., Carter, B., Marwood, L., Bandelow, B., Tsapekos, D., Nikolova, V. L., Taylor, R., Mantingh, T., De Angel, V., Patrick, F., Cleare, A. J., & Young, A. H. (2019). Augmentation therapies for treatment-resistant depression: systematic review and meta-analysis. The British Journal of Psychiatry : The Journal of Mental Science, 214(1), 42–51. https://doi.org/10.1192/BJP.2018.233
Verhoeven, J. E., Han, L. K. M., Lever-van Milligen, B. A., Hu, M. X., Révész, D., Hoogendoorn, A. W., Batelaan, N. M., van Schaik, D. J. F., van Balkom, A. J. L. M., van Oppen, P., & Penninx, B. W. J. H. (2023). Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders. Journal of Affective Disorders, 329, 19–29. https://doi.org/10.1016/J.JAD.2023.02.064
Vreijling, S. R., Penninx, B. W. J. H., Verhoeven, J. E., Teunissen, C. E., Blujdea, E. R., Beekman, A. T. F., Lamers, F., & Jansen, R. (2024). Running therapy or antidepressants as treatments for immunometabolic depression in patients with depressive and anxiety disorders: A secondary analysis of the MOTAR study. Brain, Behavior, and Immunity, 123, 876–883. https://doi.org/10.1016/J.BBI.2024.10.033
WHO guidelines on physical activity and sedentary behaviour. (n.d.). Retrieved November 27, 2024, from https://www.who.int/publications/i/item/9789240015128
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