Understanding Buerger's Disease: Symptoms, Diagnosis and Management Strategies
DOI:
https://doi.org/10.12775/QS.2024.36.56426Keywords
Buerger's disease, thromboangiitis obliterans, vasculitisAbstract
Buerger's disease, also known as thromboangiitis obliterans (TAO), is a rare but serious condition that primarily affects the blood vessels in the limbs. This inflammatory vascular disease is characterised by the formation of blood clots in the small and medium-sized arteries and veins, which results in a reduction in blood flow. Patients typically present with symptoms such as pain in the extremities, ulcers, and in severe cases, gangrene. The disease is most commonly observed in young male smokers, which highlights the strong correlation between tobacco use and the onset of this condition.
A comprehensive understanding of Buerger's disease is essential for prompt diagnosis and effective management. This review will examine the historical context, symptoms, diagnostic criteria, therapeutic approaches, and future directions in research and treatment.
References
Arkkila PE. Thromboangiitis obliterans (Buerger's disease). Orphanet J Rare Dis. 2006;1:14. Published 2006 Apr 27. doi:10.1186/1750-1172-1-14
Awara MA, Downing LM, Elnenaei MO. Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature. J Med Case Rep. 2023;17(1):40. Published 2023 Jan 30. doi:10.1186/s13256-022-03694-z
Bae M, Chung SW, Lee J, Kim E, Kang G, Jin M. Early Diagnosis and Intervention Are Needed for a Reasonable Prognosis of Thromboangiitis Obliterans. J Chest Surg. 2023;56(5):328-335. doi:10.5090/jcs.22.148
Barć P, Lubieniecki P, Antkiewicz M, et al. Gene Therapy of Thromboangiitis Obliterans with Growth Factor Plasmid (VEGF165) and Autologous Bone Marrow Cells. Biomedicines. 2024;12(7):1506. Published 2024 Jul 6. doi:10.3390/biomedicines12071506
Del Conde I, Peña C. Buerger disease (thromboangiitis obliterans). Tech Vasc Interv Radiol. 2014;17(4):234-240. doi:10.1053/j.tvir.2014.11.003
Fazeli B, Poredos P, Kozak M, et al. Diagnostic criteria for Buerger's disease: International Consensus of VAS - European Independent Foundation in Angiology/Vascular Medicine. Int Angiol. 2023;42(5):396-401. doi:10.23736/S0392-9590.23.05098-8
Galyfos G, Liakopoulos D, Chamzin A, Sigala F, Filis K. A systematic review and meta-analysis of early and late outcomes after endovascular angioplasty among patients with thromboangiitis obliterans and chronic limb ischemia. J Vasc Surg. 2023;77(5):1534-1541.e2. doi:10.1016/j.jvs.2022.09.017
Guo F, Bi Y, Yin J, Guo Y. Toll-like receptor signaling pathway involved in pathogenesis of thromboangiitis obliterans through activating of NF-κB. Clinics (Sao Paulo). 2024;79:100357. Published 2024 Apr 18. doi:10.1016/j.clinsp.2024.100357
Hamid MS, Harrell J, Mervak JE. True leukonychia as the presenting sign of early thromboangiitis obliterans. JAAD Case Rep. 2024;45:47-49. Published 2024 Jan 13. doi:10.1016/j.jdcr.2024.01.001
Harwood EA, Blazek AJ, Radio SJ, Deibert CM. Buerger's Disease in the Testicle: A Case of Testicular Thromboangiitis Obliterans. Cureus. 2023;15(4):e37693. Published 2023 Apr 17. doi:10.7759/cureus.37693
Hatta H, Setiawan E, Triani ZD, Rifardi D. Successful lumbal sympathetic block as an alternative therapy for improving Buerger's disease: A rare case report and literature review. Int J Surg Case Rep. 2023;110:108778. doi:10.1016/j.ijscr.2023.108778
Homma K, Kagayama T, Iwai T, Kume H, Koizumi S, Sakurazawa K. Ultrasonographic Study of the Corkscrew Arterial Image in Buerger Disease Patients. Ann Vasc Dis. 2024;17(3):228-233. doi:10.3400/avd.oa.24-00086
Hill GL. A rational basis for management of patients with the Buerger syndrome. Br J Surg. 1974;61(6):476-481. doi:10.1002/bjs.1800610615
Komiya D, Iwai K, Ohno T. Efficacy of Supervised Exercise Therapy for Intermittent Claudication in a Case With Buerger's Disease. Cureus. 2023;15(8):e43537. Published 2023 Aug 15. doi:10.7759/cureus.43537
Klein-Weigel PF, Richter JG. Thromboangiitis obliterans (Buerger's disease). Vasa. 2014;43(5):337-346. doi:10.1024/0301-1526/a000371
Liew NC, Lee L, Nor Hanipah Z, Gee T, Jabar MF. Pathogenesis and Management of Buerger's Disease. Int J Low Extrem Wounds. 2015;14(3):231-235. doi:10.1177/1534734615599654
Liu Z, Zhou C, Guo H, Wang M, Liang J, Zhang Y. Knowledge Mapping of Global Status and Trends for Thromboangiitis Obliterans: A Bibliometrics and Visual Analysis. J Pain Res. 2023;16:4071-4087. Published 2023 Nov 30. doi:10.2147/JPR.S437521
Liu Z, Ning W, Liang J, et al. Top 100 cited articles in the thromboangiitis obliterans: a bibliometric analysis and visualized study. Eur J Med Res. 2023;28(1):551. Published 2023 Dec 2. doi:10.1186/s40001-023-01540-6
Mashhadi N, Kasraian L, Ghoddusi Johari H, Hosseinzadeh A, Kheshtchin N, Doroudchi M. Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans. Iran J Immunol. 2023;20(3):262-275. doi:10.22034/iji.2023.99188.2622
Mohamad Yusoff F, Kajikawa M, Yamaji T, et al. Low-intensity pulsed ultrasound improves symptoms in patients with Buerger disease: a double-blinded, randomized, and placebo-controlled study. Sci Rep. 2024;14(1):13704. Published 2024 Jun 14. doi:10.1038/s41598-024-64118-0
Olin JW, Shih A. Thromboangiitis obliterans (Buerger's disease). Curr Opin Rheumatol. 2006;18(1):18-24. doi:10.1097/01.bor.0000198000.58073.aa
Öztan G, Bozbuğa N, İşsever H, et al. Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans. Genes (Basel). 2023;15(1):19. Published 2023 Dec 21. doi:10.3390/genes15010019
Qaja E, Muco E, Hashmi MF. Buerger Disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing; February 19, 2023.
Saeed Modaghegh M H, Saberianpour S. Buerger’s disease: A Bench-to-Bedside Review. Journal title 2021; 1 (1) :11-17
Sharma AM, Norton PT, Zhu D. Conditions presenting with symptoms of peripheral arterial disease. Semin Intervent Radiol. 2014;31(4):281-291. doi:10.1055/s-0034-1393963
Sheng C, Huang W, Liao M, Yang P. The Role of Gut Microbiota in Thromboangiitis Obliterans: Cohort and Mendelian Randomization Study. Biomedicines. 2024;12(7):1459. Published 2024 Jul 1. doi:10.3390/biomedicines12071459
Singh R, Sonkar L. The Safety and Effectiveness of Interval Stellate Ganglion Neurolysis in a Patient with Bilateral Digital Ischemia of Hands Due to Buerger's Disease: A Case Report. J Orthop Case Rep. 2024;14(6):40-44. doi:10.13107/jocr.2024.v14.i06.4496
Thrombo-angiitis obliterans: a study of the vascular lesions leading to presenile spontaneous gangrene by Leo Buerger, M.D.: published, 1908 in the American Journal of the Medical Sciences. Am J Med Sci. 1973;266(4):278-291. doi:10.1097/00000441-197310000-00006
von Winiwarter F. Ueber eine eigenthümliche Form von Endarteriitis und Endophlebitis mit Gangrän des Fusses. Arch Klin Chir 1879;23.
Zhang B, He R, Yao Z, et al. Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study. Thromb Haemost. 2024;124(11):1075-1083. doi:10.1055/s-0044-1786809
Ziaeemehr A, Sharebiani H, Taheri H, Fazeli B. Secondary Infertility: A Neglected Aspect of Buerger's Disease. Rep Biochem Mol Biol. 2022;11(2):246-251. doi:10.52547/rbmb.11.2.246
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Copyright (c) 2024 Adrianna Muciek, Martyna Mocarska, Anna Orłowska, Katarzyna Strakowska, Laura Opalska, Anna Maryńczak, Jan Mencel, Nicole Nitschke
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