The role of the Mediterranean Diet in preventing the development and complications of lifestyle diseases – a Review
DOI:
https://doi.org/10.12775/QS.2024.33.55939Keywords
Mediterranean diet, lifestyle diseases, obesity, cardiovascular diseases, diabetesAbstract
Introduction
The Mediterranean diet, inspired by traditional dietary habits of the Mediterranean region, exhibits anti-inflammatory and protective effects, reducing the risk of civilization diseases such as obesity, type 2 diabetes, and cardiovascular disorders. This diet is characterized by a high intake of plant-based foods, olive oil, and moderate consumption of fish and dairy products. These components provide unsaturated fatty acids, polyphenols, and antioxidants, which positively impact metabolic health and lower the risk of chronic diseases.
In the face of the global obesity epidemic and an increasing number of individuals affected by lifestyle-related diseases, the Mediterranean diet offers a promising tool to support a healthy lifestyle.
Aim of study
This article aims to review current scientific studies evaluating the potential of the Mediterranean diet in preventing and managing civilization diseases. Particular attention is given to its effects on weight loss, improvements in glycemic markers, reductions in low density lipoproteins (LDL) cholesterol levels, and blood pressure control. The article also explores its benefits for athletes' health, as well as its potential to reduce oxidative stress and inflammatory states.
Material and methods
A literature review of the PubMed database was conducted, assessing relevant studies on the Mediterranean diet and its impact on lifestyle diseases.
References
Serra-Majem L, Roman-Vinas B, Sanchez-Villegas A, Guasch-Ferre M, Corella D, La Vecchia C.
Benefits of the Mediterranean diet: Epidemiological and molecular aspects. Mol Aspects Med. 2019;67:1-
Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, et al. Mediterranean
diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995;61(6 Suppl):1402S-6S.
Bach-Faig A, Berry EM, Lairon D, Reguant J, Trichopoulou A, Dernini S, et al. Mediterranean diet
pyramid today. Science and cultural updates. Public Health Nutr. 2011;14(12A):2274-84.
Turrini A, Saba A, Perrone D, Cialfa E, D'Amicis A. Food consumption patterns in Italy: the INN-
CA Study 1994-1996. Eur J Clin Nutr. 2001;55(7):571-88.
Tosti V, Bertozzi B, Fontana L. Health Benefits of the Mediterranean Diet: Metabolic and
Molecular Mechanisms. J Gerontol A Biol Sci Med Sci. 2018;73(3):318-26.
Guasch-Ferre M, Willett WC. The Mediterranean diet and health: a comprehensive overview. J
Intern Med. 2021;290(3):549-66.
Mazza E, Ferro Y, Pujia R, Mare R, Maurotti S, Montalcini T, et al. Mediterranean Diet In Healthy
Aging. J Nutr Health Aging. 2021;25(9):1076-83.
Tektonidis TG, Akesson A, Gigante B, Wolk A, Larsson SC. A Mediterranean diet and risk of
myocardial infarction, heart failure and stroke: A population-based cohort study. Atherosclerosis.
;243(1):93-8.
Schroder H, Marrugat J, Vila J, Covas MI, Elosua R. Adherence to the traditional mediterranean
diet is inversely associated with body mass index and obesity in a spanish population. J Nutr.
;134(12):3355-61.
La Vecchia C. Association between Mediterranean dietary patterns and cancer risk. Nutr Rev.
;67 Suppl 1:S126-9.
Panagiotakos DB, Polystipioti A, Papairakleous N, Polychronopoulos E. Long-term adoption of a
Mediterranean diet is associated with a better health status in elderly people; a cross-sectional survey in
Cyprus. Asia Pac J Clin Nutr. 2007;16(2):331-7.
Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and
survival in a Greek population. N Engl J Med. 2003;348(26):2599-608.
Knoops KT, de Groot LC, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A, et al.
Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE
project. JAMA. 2004;292(12):1433-9.
Piroddi M, Albini A, Fabiani R, Giovannelli L, Luceri C, Natella F, et al. Nutrigenomics of extra-
virgin olive oil: A review. Biofactors. 2017;43(1):17-41.
Fernandez-Prior A, Bermudez-Oria A, Millan-Linares MDC, Fernandez-Bolanos J, Espejo-Calvo
JA, Rodriguez-Gutierrez G. Anti-Inflammatory and Antioxidant Activity of Hydroxytyrosol and 3,4-
Dihydroxyphenyglycol Purified from Table Olive Effluents. Foods. 2021;10(2).
Bucciantini M, Leri M, Nardiello P, Casamenti F, Stefani M. Olive Polyphenols: Antioxidant and
Anti-Inflammatory Properties. Antioxidants (Basel). 2021;10(7).
Karkovic Markovic A, Toric J, Barbaric M, Jakobusic Brala C. Hydroxytyrosol, Tyrosol and
Derivatives and Their Potential Effects on Human Health. Molecules. 2019;24(10).
Williamson G. The role of polyphenols in modern nutrition. Nutr Bull. 2017;42(3):226-35.
Grosso G, Marventano S, Yang J, Micek A, Pajak A, Scalfi L, et al. A comprehensive meta-
analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?
Crit Rev Food Sci Nutr. 2017;57(15):3218-32.
Schwingshackl L, Hoffmann G. Adherence to Mediterranean diet and risk of cancer: a systematic
review and meta-analysis of observational studies. Int J Cancer. 2014;135(8):1884-97.
Ros E. Health benefits of nut consumption. Nutrients. 2010;2(7):652-82.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, et al. Cardioprotection
and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428-38.
Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, et al. Dietary factors
and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011;106 Suppl 3:S5-78.
Longo VD, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular
mechanisms. Trends Pharmacol Sci. 2010;31(2):89-98.
Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, et al. Gut Microbial Metabolite TMAO
Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. 2016;165(1):111-24.
Collaborators GBDRF. Global burden of 87 risk factors in 204 countries and territories, 1990-
: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1223-
Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6-10.
Okunogbe A, Nugent R, Spencer G, Powis J, Ralston J, Wilding J. Economic impacts of
overweight and obesity: current and future estimates for 161 countries. BMJ Glob Health. 2022;7(9).
Li Y, Pan A, Wang DD, Liu X, Dhana K, Franco OH, et al. Impact of Healthy Lifestyle Factors on
Life Expectancies in the US Population. Circulation. 2018;138(4):345-55.
Muscogiuri G, Verde L, Sulu C, Katsiki N, Hassapidou M, Frias-Toral E, et al. Mediterranean Diet
and Obesity-related Disorders: What is the Evidence? Curr Obes Rep. 2022;11(4):287-304.
Esposito K, Kastorini CM, Panagiotakos DB, Giugliano D. Mediterranean diet and weight loss:
meta-analysis of randomized controlled trials. Metab Syndr Relat Disord. 2011;9(1):1-12.
Huo R, Du T, Xu Y, Xu W, Chen X, Sun K, et al. Effects of Mediterranean-style diet on glycemic
control, weight loss and cardiovascular risk factors among type 2 diabetes individuals: a meta-analysis. Eur
J Clin Nutr. 2015;69(11):1200-8.
Jemai H, El Feki A, Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and
oleuropein from olive leaves in alloxan-diabetic rats. J Agric Food Chem. 2009;57(19):8798-804.
Murotomi K, Umeno A, Yasunaga M, Shichiri M, Ishida N, Koike T, et al. Oleuropein-Rich Diet
Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse. J Agric
Food Chem. 2015;63(30):6715-22.
Liu YN, Jung JH, Park H, Kim H. Olive leaf extract suppresses messenger RNA expression of
proinflammatory cytokines and enhances insulin receptor substrate 1 expression in the rats with
streptozotocin and high-fat diet-induced diabetes. Nutr Res. 2014;34(5):450-7.
Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, et al. Olive leaf extract as a
hypoglycemic agent in both human diabetic subjects and in rats. J Med Food. 2012;15(7):605-10.
de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, et al. Olive (Olea
europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized,
placebo-controlled, crossover trial. PLoS One. 2013;8(3):e57622.
Carnevale R, Silvestri R, Loffredo L, Novo M, Cammisotto V, Castellani V, et al. Oleuropein, a
component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects. Br J Clin
Pharmacol. 2018;84(7):1566-74.
Esposito K, Maiorino MI, Bellastella G, Chiodini P, Panagiotakos D, Giugliano D. A journey into a
Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open.
;5(8):e008222.
Rudkowska I, Jones PJ. Functional foods for the prevention and treatment of cardiovascular
diseases: cholesterol and beyond. Expert Rev Cardiovasc Ther. 2007;5(3):477-90.
Chan DC, Lambert G, Barrett PH, Rye KA, Ooi EM, Watts GF. Plasma proprotein convertase
subtilisin/kexin type 9: a marker of LDL apolipoprotein B-100 catabolism? Clin Chem. 2009;55(11):2049-
Martinez-Gonzalez MA, Salas-Salvado J, Estruch R, Corella D, Fito M, Ros E, et al. Benefits of
the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis. 2015;58(1):50-60.
Salas-Salvado J, Farres X, Luque X, Narejos S, Borrell M, Basora J, et al. Effect of two doses of a
mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a
randomised trial. Br J Nutr. 2008;99(6):1380-7.
Theuwissen E, Mensink RP. Water-soluble dietary fibers and cardiovascular disease. Physiol
Behav. 2008;94(2):285-92.
Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart
disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr.
;63 Suppl 2:S22-33.
Estruch R. Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED
study. Proc Nutr Soc. 2010;69(3):333-40.
Nissensohn M, Roman-Vinas B, Sanchez-Villegas A, Piscopo S, Serra-Majem L. The Effect of the
Mediterranean Diet on Hypertension: A Systematic Review and Meta-Analysis. J Nutr Educ Behav.
;48(1):42-53 e1.
Schwingshackl L, Schwedhelm C, Galbete C, Hoffmann G. Adherence to Mediterranean Diet and
Risk of Cancer: An Updated Systematic Review and Meta-Analysis. Nutrients. 2017;9(10).
Phan MAT, Paterson J, Bucknall M, Arcot J. Interactions between phytochemicals from fruits and
vegetables: Effects on bioactivities and bioavailability. Crit Rev Food Sci Nutr. 2018;58(8):1310-29.
Chen H, Liu RH. Potential Mechanisms of Action of Dietary Phytochemicals for Cancer
Prevention by Targeting Cellular Signaling Transduction Pathways. J Agric Food Chem. 2018;66(13):3260-
Fung KY, Cosgrove L, Lockett T, Head R, Topping DL. A review of the potential mechanisms for
the lowering of colorectal oncogenesis by butyrate. Br J Nutr. 2012;108(5):820-31.
Sun L, Brentnall A, Patel S, Buist DSM, Bowles EJA, Evans DGR, et al. A Cost-effectiveness
Analysis of Multigene Testing for All Patients With Breast Cancer. JAMA Oncol. 2019;5(12):1718-30.
Zubair H, Bhardwaj A, Ahmad A, Srivastava SK, Khan MA, Patel GK, et al. Hydroxytyrosol
Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in
Prostate Cancer Cells. Nutr Cancer. 2017;69(6):932-42.
Zhao B, Ma Y, Xu Z, Wang J, Wang F, Wang D, et al. Hydroxytyrosol, a natural molecule from
olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear
factor-kappa B pathways. Cancer Lett. 2014;347(1):79-87.
Chiavarini M, Bertarelli G, Minelli L, Fabiani R. Dietary Intake of Meat Cooking-Related
Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis.
Nutrients. 2017;9(5).
Schwingshackl L, Schwedhelm C, Hoffmann G, Knuppel S, Laure Preterre A, Iqbal K, et al. Food
groups and risk of colorectal cancer. Int J Cancer. 2018;142(9):1748-58.
Xu Y, Yang J, Du L, Li K, Zhou Y. Association of whole grain, refined grain, and cereal
consumption with gastric cancer risk: A meta-analysis of observational studies. Food Sci Nutr.
;7(1):256-65.
Barnard ND, Goldman DM, Loomis JF, Kahleova H, Levin SM, Neabore S, et al. Plant-Based
Diets for Cardiovascular Safety and Performance in Endurance Sports. Nutrients. 2019;11(1).
Chang CC, Chen CW, Owaga E, Lee WT, Liu TN, Hsieh RH. Mangosteen Concentrate Drink
Supplementation Promotes Antioxidant Status and Lactate Clearance in Rats after Exercise. Nutrients.
;12(5).
Ficarra S, Di Raimondo D, Navarra GA, Izadi M, Amato A, Macaluso FP, et al. Effects of
Mediterranean Diet Combined with CrossFit Training on Trained Adults' Performance and Body
Composition. J Pers Med. 2022;12(8).
Dorrell HF, Smith MF, Gee TI. Comparison of Velocity-Based and Traditional Percentage-Based
Loading Methods on Maximal Strength and Power Adaptations. J Strength Cond Res. 2020;34(1):46-53.
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Copyright (c) 2024 Alicja Kapciak, Julia Górny, Rafał Kaczorowski, Aleksandra Pelczarska, Michał Janiszewski, Marcin Komorowski, Tomasz Forenc, Jaromir Hunia, Jonasz Jurek
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