The effect of ischemic preconditioning on the cardiac autonomic nervous system after exercise: A systematic review and meta-analysis
Ischemic preconditioning affects the cardiac autonomic nervous system
DOI:
https://doi.org/10.12775/QS.2024.33.55917Keywords
parasympathetic nerves, intermittent occlusion, cardiac function, cardiac autonomic control, exercise recoveryAbstract
Aims: The objective of this study is to comprehensively evaluate the influence of ischemic preconditioning intervention on the autonomic control nerves of athletes during the post-exercise period.
Methods: Randomized controlled trials (RCTs) were sourced from PubMed, Web of Science, Embase, Wipo, CNKI, and Cochrane databases, covering the period from inception to December 2023. The quality of the included RCTs was evaluated using the Cochrane Risk Assessment Tool, and a systematic assessment was conducted using RevMan 5.3.
Results: Seven randomized controlled trials (RCTs) involving 88 subjects were included in the analysis. The meta-analysis indicated that ischemic preconditioning significantly improved heart rate during both short-term recoveries (mean difference [MD] = -3.99, 95% confidence interval [CI]: -5.93 to -2.05, p < 0.00001) and long-term recovery post-exercise (MD = -9.73, 95% CI: -12.74 to -6.73, p < 0.00001). However, there was no significant effect observed on resting state heart rate variability (HRV) or peak heart rate (HR peak) at the end of exercise (MD = -0.16, 95% CI: -2.46 to 2.14, p = 0.89).
Conclusion: Ischemic preconditioning facilitates the prompt reactivation of cardiac parasympathetic nerves following exercise and enhances both short-term and long-term heart rate recovery. The extent of this recovery effect may be influenced by factors such as the dosage of the intervention, the individual’s training level, and the intensity of the exercise performed.
Limitation: Given the limited number of included studies, the small sample size, and the unclear definition of some experimental procedures, it is essential to design more rigorous and comprehensive high-quality randomized controlled trials (RCTs) in the future to investigate the effects of ischemic preconditioning on cardiac autonomic control nerves following exercise.
Registration: INPLASY202440069
References
Bellenger CR, Fuller JT, Thomson RL, et al. Monitoring Athletic Training Status Through Autonomic Heart Rate Regulation: A Systematic Review and Meta-Analysis. Sports Med 2016;46:1461–86.
Borresen J, Lambert MI. Autonomic control of heart rate during and after exercise : measurements and implications for monitoring training status. Sports Med 2008;38:633–46.
Buchheit M. Monitoring training status with HR measures: do all roads lead to Rome? Front Physiol 2014;5, DOI: 10.3389/fphys.2014.00073.
Stanley J, Peake JM, Buchheit M. Cardiac Parasympathetic Reactivation Following Exercise: Implications for Training Prescription. Sports Med 2013;43:1259–77.
Buchheit M, Papelier Y, Laursen PB et al. Noninvasive assessment of cardiac parasympathetic function: postexercise heart rate recovery or heart rate variability? Am J Physiol Heart Circ Physiol 2007;293:H8-10.
Vesterinen V, Nummela A, Heikura I et al. Individual Endurance Training Prescription with Heart Rate Variability. Med Sci Sports Exerc 2016;48:1347–54.
Gourine A, Gourine AV. Neural Mechanisms of Cardioprotection. Physiology 2014;29:133–40.
Kannankeril PJ, Le FK, Kadish AH et al. Parasympathetic Effects on Heart Rate Recovery after Exercise. J Investig Med 2004;52:394–401.
Cole CR, Blackstone EH, Pashkow FJ et al. Heart-Rate Recovery Immediately after Exercise as a Predictor of Mortality. N Engl J Med 1999;341:1351–7.
Cole CR, Foody JM, Blackstone EH, et al. Heart Rate Recovery after Submaximal Exercise Testing as a Predictor of Mortality in a Cardiovascularly Healthy Cohort. Ann Intern Med 2000;132:552.
Peçanha T, Silva‐Júnior ND, Forjaz CLDM. Heart rate recovery: autonomic determinants, methods of assessment and association with mortality and cardiovascular diseases. Clin Physio Funct Imaging 2014;34:327–39.
Eisen A. Ischemic preconditioning: nearly two decades of research. A comprehensive review. Atherosclerosis 2004;172:201–10.
Caru M, Levesque A, Lalonde F et al. An overview of ischemic preconditioning in exercise performance: A systematic review. Journal of Sport and Health Science 2019;8:355–69.
de Groot PCE, Thijssen DHJ, Sanchez M et al. Ischemic preconditioning improves maximal performance in humans. Eur J Appl Physiol 2010;108:141–6.
Basalay M, Barsukevich V, Mastitskaya S, et al. Remote ischaemic pre‐ and delayed postconditioning – similar degree of cardioprotection but distinct mechanisms. Experimental Physiology 2012;97:908–17.
Mastitskaya S, Marina N, Gourine A et al. Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurons. Cardiovascular Research 2012;95:487–94.
Chen L, Zhou Q, Jin H et al. Effects of Remote Ischaemic Conditioning on Heart Rate Variability and Cardiac Function in Patients With Mild Ischaemic Heart Failure. Heart, Lung, and Circulation 2018;27:477–83.
Enko K, Nakamura K, Yunoki K et al. Intermittent arm ischemia induces vasodilatation of the contralateral upper limb. J Physiol Sci 2011;61:507–13.
Morley WN, Coates AM, Burr JF. Cardiac autonomic recovery following traditional and augmented remote ischemic preconditioning. Eur J Appl Physiol 2021;121:265–77.
Zagidullin N, Scherbakova E, Safina Y et al. The Impact of Remote Ischemic Preconditioning on Arterial Stiffness and Heart Rate Variability in Patients with Angina Pectoris. JCM 2016;5:60.
Lopes TR, Sabino-Carvalho JL, Ferreira THN et al. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. Front Physiol 2018;9:1465.
Sabino-Carvalho JL, Obeid-Freitas T, Paula-Ribeiro M et al. Ischemic preconditioning boosts post-exercise but not resting cardiac vagal control in endurance runners. Eur J Appl Physiol 2019;119:621–32.
Garcia CA, da Mota GR, Leicht AS et al. Ischemic Preconditioning and Acute Recovery of Performance in Rugby Union Players. Sports Med Int Open 2017;1:E107–12.
Arriel RA, Meireles A, Hohl R et al. Ischemic preconditioning improves performance and accelerates the heart rate recovery. J Sports Med Phys Fitness 2020;60:1209–15.
Ceylan B, Taşkın HB, Šimenko J. Effect of Ischemic Preconditioning on Acute Recovery in Elite Judo Athletes: A Randomized, Single-Blind, Crossover Trial. International Journal of Sports Physiology and Performance 2023;18:180–6.
Ceylan B, Franchini E. Ischemic preconditioning does not improve judo-specific performance but leads to better recovery in elite judo athletes. Science & Sports 2022;37:322.e1-322.e7.
Sabino-Carvalho JL, Lopes TR, Obeid-Freitas T et al. Effect of Ischemic Preconditioning on Endurance Performance Does Not Surpass Placebo. Medicine & Science in Sports & Exercise 2017;49:124–32.
Paradis-Deschênes P, Joanisse DR, Billaut F. Sex-Specific Impact of Ischemic Preconditioning on Tissue Oxygenation and Maximal Concentric Force. Front Physiol 2017;7, DOI: 10.3389/fphys.2016.00674.
Paradis-Deschênes P, Lapointe J, Joanisse DR et al. Similar Recovery of Maximal Cycling Performance after Ischemic Preconditioning, Neuromuscular Electrical Stimulation or Active Recovery in Endurance Athletes. 2020.
Del Rosso S, Nakamura FY, Boullosa DA. Heart rate recovery after aerobic and anaerobic tests: is there an influence of anaerobic speed reserve? Journal of Sports Sciences 2017;35:820–7.
Nakamura FY, Soares-Caldeira LF, Laursen PB et al. Cardiac Autonomic Responses to Repeated Shuttle Sprints. Int J Sports Med 2009;30:808–13.
Bailey TG, Jones H, Gregson W et al. Effect of Ischemic Preconditioning on Lactate Accumulation and Running Performance. Med Sci Sports Exerc 2012;44:2084–9.
Seeley AD, Jacobs KA. IPC recovery length of 45 minutes improves muscle oxygen saturation during active sprint recovery. Eur J Sport Sci 2022;22:1383–90.
Buchheit M, Laursen PB, Ahmadi S. Parasympathetic reactivation after repeated sprint exercise. American Journal of Physiology-Heart and Circulatory Physiology 2007;293:H133–41.
Peçanha T, Forjaz CLDM, Low DA. Passive Heating Attenuates Post-exercise Cardiac Autonomic Recovery in Healthy Young Males. Front Neurosci 2017;11:727.
Kido K, Suga T, Tanaka D et al. Ischemic preconditioning accelerates muscle deoxygenation dynamics and enhances exercise endurance during the work-to-work test. Physiol Rep 2015;3:e12395.
Bailey TG, Birk GK, Cable NT, et al. Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise. Am J Physiol Heart Circ Physiol 2012;303:H533-538.
Kimura M, Ueda K, Goto C et al. Repetition of Ischemic Preconditioning Augments Endothelium-Dependent Vasodilation in Humans Role of Endothelium-Derived Nitric Oxide and Endothelial Progenitor Cells. Arterioscler Thromb Vasc Biol 2007;27:1403–10.
Ng MW, Angerosa J, Konstantinov IE et al. Remote ischemic preconditioning modifies serum apolipoprotein D, met-enkephalin, adenosine, and nitric oxide in healthy young adults. Clin Exp Pharmacol Physiol 2019;46:995–1000.
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