The role of vitamin D in ocular diseases - a literature review
DOI:
https://doi.org/10.12775/QS.2024.29.55621Keywords
vitamin D, vitamin D deficiency, dry eye syndrome, vitamin D supplementationAbstract
Introduction: Vitamin D is a steroid hormone that can modulate immune and inflammatory responses. Recent investigations have shed light on its potential role in the pathogenesis of many diseases affecting the eyes.
Aim of the study: This paper aims to provide a comprehensive review of the existing findings on the relationship between vitamin D and ocular diseases. The intention is to present new perspectives that will contribute to a better understanding of the complicated nature of this aspect.
Material and methods: This review included relevant papers from PubMed database using specified keywords.
Analysis of the literature: The role of vitamin D in ocular and visual health has been observed in many studies. A deficiency of vitamin D may play a significant role in the development of many ocular diseases such as dry eye disease, myopia, diabetic retinopathy, keratoconus, and thyroid eye disease.
Conclusions: Adequate vitamin D levels are significant for maintaining ocular health. Recognition of the pivotal role of vitamin D in ocular diseases opens new possibilities for potential therapeutic interventions. Ongoing research is needed to further investigate that aspect. Supplementation of vitamin D may prevent or modulate many diseases affecting the eyes.
References
Rolando M, Barabino S. Dry Eye Disease: What Is the Role of Vitamin D? Int J Mol Sci. 2023;24(2).
Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319-29.
Reins RY, McDermott AM. Vitamin D: Implications for ocular disease and therapeutic potential. Exp Eye Res. 2015;134:101-10.
Johnson JA, Grande JP, Roche PC, Campbell RJ, Kumar R. Immuno-localization of the calcitriol receptor, calbindin-D28k and the plasma membrane calcium pump in the human eye. Curr Eye Res. 1995;14(2):101-8.
Yin Z, Pintea V, Lin Y, Hammock BD, Watsky MA. Vitamin D enhances corneal epithelial barrier function. Invest Ophthalmol Vis Sci. 2011;52(10):7359-64.
Alsalem JA, Patel D, Susarla R, Coca-Prados M, Bland R, Walker EA, et al. Characterization of vitamin D production by human ocular barrier cells. Invest Ophthalmol Vis Sci. 2014;55(4):2140-7.
Gorimanipalli B, Shetty R, Sethu S, Khamar P. Vitamin D and eye: Current evidence and practice guidelines. Indian J Ophthalmol. 2023;71(4):1127-34.
Elizondo RA, Yin Z, Lu X, Watsky MA. Effect of vitamin D receptor knockout on cornea epithelium wound healing and tight junctions. Invest Ophthalmol Vis Sci. 2014;55(8):5245-51.
Cankaya C, Cumurcu T, Gunduz A. Corneal endothelial changes in patients with vitamin D deficiency. Indian J Ophthalmol. 2018;66(9):1256-61.
Arikan S, Kamis F. Effect of vitamin D deficiency on spatial contrast sensitivity function. Clin Exp Optom. 2022;105(7):733-9.
Ozturk E, Cankaya C. Effect of Vitamin D Deficiency on Contrast Sensitivity Function. Curr Eye Res. 2020;45(12):1619-24.
Jin KW, Ro JW, Shin YJ, Hyon JY, Wee WR, Park SG. Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome. Acta Ophthalmol. 2017;95(3):e230-e5.
Komarova TM, Vitovska OP, Komisarenko YI, Scholtz SK. VITAMIN D LEVEL AND ITS LINK WITH VISUAL ACUITY AND CONTRAST SENSITIVITY IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION. Wiad Lek. 2023;76(5 pt 2):1173-8.
Savini G, Prabhawasat P, Kojima T, Grueterich M, Espana E, Goto E. The challenge of dry eye diagnosis. Clin Ophthalmol. 2008;2(1):31-55.
Malik D, Garg R, Sethi S, Mahendru R, Singh S. Serum Vitamin D Levels and Dry Eye Disease in Postmenopausal Women: A Case-Control Study at a Tertiary Care Center in Rural Haryana. Int J Appl Basic Med Res. 2023;13(2):83-8.
Jain N, Sharma P, Chouhan JK. A study of the association between Vitamin D deficiency and Dry Eye Syndrome (DES) in the Indian population. Indian J Ophthalmol. 2022;70(2):500-4.
Lin Y, Su H, Wu J, Yuan M, Zhang Y. Oral vitamin D(3) supplementation for femtosecond LASIK-associated dry eye vitamin D for LASIK dry eye syndrome. Int Ophthalmol. 2022;42(10):3145-52.
Yildirim P, Garip Y, Karci AA, Guler T. Dry eye in vitamin D deficiency: more than an incidental association. Int J Rheum Dis. 2016;19(1):49-54.
Hassanpour K, Langari F, Akbarzadeh AR, Kanavi MR, Barani M, Kheiri B, et al. Safety and Efficacy of Topical Vitamin D in the Management of Dry Eye Disease Associated With Meibomian Gland Dysfunction: A Placebo-Controlled Double-Blind Randomized Controlled Trial. Cornea. 2023.
Najjaran M, Zarei-Ghanavati S, Arjmand Askari E, Eslampoor A, Ziaei M. Effect of oral vitamin D supplementation on dry eye disease patients with vitamin D deficiency. Clin Exp Optom. 2023;106(3):257-62.
Hwang JS, Lee YP, Shin YJ. Vitamin D Enhances the Efficacy of Topical Artificial Tears in Patients With Dry Eye Disease. Cornea. 2019;38(3):304-10.
Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, et al. Age-related macular degeneration. Nat Rev Dis Primers. 2021;7(1):31.
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, et al. Vitamin D and Ocular Diseases: A Systematic Review. Int J Mol Sci. 2022;23(8).
Kaarniranta K, Pawlowska E, Szczepanska J, Jablkowska A, Błasiak J. Can vitamin D protect against age-related macular degeneration or slow its progression? Acta Biochim Pol. 2019;66(2):147-58.
Pérez Serena A, Martínez Betancourt DP, González Del Valle F, Ruiz-Moreno JM. Serum 25-hydroxy vitamin D levels in age-related macular degeneration. Int J Retina Vitreous. 2022;8(1):17.
Kan E, Kan EK, Yücel Ö E. The Possible Link Between Vitamin D Levels and Exudative Age-related Macular Degeneration. Oman Med J. 2020;35(1):e83.
Jamali N, Sorenson CM, Sheibani N. Vitamin D and regulation of vascular cell function. Am J Physiol Heart Circ Physiol. 2018;314(4):H753-h65.
Annweiler C, Drouet M, Duval GT, Paré PY, Leruez S, Dinomais M, et al. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas. 2016;88:101-12.
Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58(11):4569-78.
Fung TH, Patel B, Wilmot EG, Amoaku WM. Diabetic retinopathy for the non-ophthalmologist. Clin Med (Lond). 2022;22(2):112-6.
Gverović Antunica A, Znaor L, Ivanković M, Puzović V, Marković I, Kaštelan S. Vitamin D and Diabetic Retinopathy. Int J Mol Sci. 2023;24(15).
Totolici G, Tiutiuca C, Jurja S, Tutunaru D, Pătrașcu AM. The role of vitamin D in the onset and progression of diabetic retinopathy. Rom J Ophthalmol. 2022;66(3):214-8.
Trott M, Driscoll R, Pardhan S. Associations between diabetic retinopathy and modifiable risk factors: An umbrella review of meta-analyses. Diabet Med. 2022;39(6):e14796.
Aksoy Aydemir G, Aydemir E, Asik A. Changes in Tear Meniscus Analysis of Children Who Have Type 1 Diabetes Mellitus, With and Without Vitamin D Deficiency. Cornea. 2022;41(11):1412-7.
Gungor A, Ates O, Bilen H, Kocer I. Retinal Nerve Fiber Layer Thickness in Early-Stage Diabetic Retinopathy With Vitamin D Deficiency. Invest Ophthalmol Vis Sci. 2015;56(11):6433-7.
Trott M, Driscoll R, Iraldo E, Pardhan S. Associations between vitamin D status and sight threatening and non-sight threatening diabetic retinopathy: a systematic review and meta-analysis. J Diabetes Metab Disord. 2022;21(1):1177-84.
Ruamviboonsuk V, Grzybowski A. The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review. J Clin Med. 2022;11(21).
Santodomingo-Rubido J, Carracedo G, Suzaki A, Villa-Collar C, Vincent SJ, Wolffsohn JS. Keratoconus: An updated review. Cont Lens Anterior Eye. 2022;45(3):101559.
Shetty R, D'Souza S, Khamar P, Ghosh A, Nuijts R, Sethu S. Biochemical Markers and Alterations in Keratoconus. Asia Pac J Ophthalmol (Phila). 2020;9(6):533-40.
Akkaya S, Ulusoy DM. Serum Vitamin D Levels in Patients with Keratoconus. Ocul Immunol Inflamm. 2020;28(3):348-53.
Aslan MG, Fındık H, Okutucu M, Aydın E, Oruç Y, Arpa M, et al. Serum 25-Hydroxy Vitamin D, Vitamin B12, and Folic Acid Levels in Progressive and Nonprogressive Keratoconus. Cornea. 2021;40(3):334-41.
Zarei-Ghanavati S, Yahaghi B, Hassanzadeh S, Mobarhan MG, Hakimi HR, Eghbali P. Serum 25-Hydroxyvitamin D, Selenium, Zinc and Copper in Patients with Keratoconus. J Curr Ophthalmol. 2020;32(1):26-31.
Kizilgul M, Kan S, Ozcelik O, Beysel S, Apaydin M, Ucan B, et al. Vitamin D Replacement Improves Tear Osmolarity in Patients with Vitamin D Deficiency. Semin Ophthalmol. 2018;33(5):589-94.
Shivakumar S, Rohit S, Ghosh A, Jeyabalan N. Vitamin D enhances the autophagic lysosomal clearance in oxidatively stressed human corneal epithelial cells: A therapeutic intervention for keratoconus. Investigative Ophthalmology & Visual Science. 2019;60(9):2819-.
Awad EA, Torky MA, Bassiouny RM, Khattab AM, Elzehery RR, Elhelaly RM. Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus. Eye (Lond). 2023;37(8):1602-7.
Lasagni Vitar RM, Fonteyne P, Knutsson KA, Bertuzzi F, Galli L, Rama P, et al. Vitamin D Supplementation Impacts Systemic Biomarkers of Collagen Degradation and Copper Metabolism in Patients With Keratoconus. Transl Vis Sci Technol. 2022;11(12):16.
Bremond-Gignac D. [Myopia in children]. Med Sci (Paris). 2020;36(8-9):763-8.
Rose KA, Morgan IG, Ip J, Kifley A, Huynh S, Smith W, et al. Outdoor activity reduces the prevalence of myopia in children. Ophthalmology. 2008;115(8):1279-85.
Dirani M, Tong L, Gazzard G, Zhang X, Chia A, Young TL, et al. Outdoor activity and myopia in Singapore teenage children. Br J Ophthalmol. 2009;93(8):997-1000.
Li X, Lin H, Jiang L, Chen X, Chen J, Lu F. Low Serum Vitamin D Is Not Correlated With Myopia in Chinese Children and Adolescents. Front Med (Lausanne). 2022;9:809787.
Zhang RH, Yang Q, Dong L, Li YF, Zhou WD, Wu HT, et al. Association between vitamin D and myopia in adolescents and young adults: Evidence of national cross-sectional study. Eur J Ophthalmol. 2023;33(5):1883-91.
Aaraj S, Kausar A, Khan SA. Vitamin D deficiency: A risk factor for myopia in children - a cross sectional study in a tertiary care centre. J Pak Med Assoc. 2022;72(6):1075-9.
Specht IO, Jacobsen N, Frederiksen P, Heitmann BL. Neonatal vitamin D status and myopia in young adult men. Acta Ophthalmol. 2020;98(5):500-5.
Pan CW, Qian DJ, Saw SM. Time outdoors, blood vitamin D status and myopia: a review. Photochem Photobiol Sci. 2017;16(3):426-32.
Sadaka A, Nguyen K, Malik A, Brito R, Berry S, Lee AG. Vitamin D and Selenium in a Thyroid Eye Disease Population in Texas. Neuroophthalmology. 2019;43(5):291-4.
Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease?: a systematic review. Semin Arthritis Rheum. 2011;40(6):512-31.e8.
Heisel CJ, Riddering AL, Andrews CA, Kahana A. Serum Vitamin D Deficiency Is an Independent Risk Factor for Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2020;36(1):17-20.
Susarla G, Chan W, Li A, Davoudi S, Ahmadi T, Sathe S, et al. Mendelian Randomization Shows a Causal Effect of Low Vitamin D on Non-infectious Uveitis and Scleritis Risk. Am J Ophthalmol. 2022;244:11-8.
Llop SM, Davoudi S, Stanwyck LK, Sathe S, Tom L, Ahmadi T, et al. Association of Low Vitamin D Levels with Noninfectious Uveitis and Scleritis. Ocul Immunol Inflamm. 2019;27(4):602-9.
Chiu ZK, Lim LL, Rogers SL, Hall AJ. Patterns of Vitamin D Levels and Exposures in Active and Inactive Noninfectious Uveitis Patients. Ophthalmology. 2020;127(2):230-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Aleksandra Partyka, Martyna Dyrek, Cezary Kopczyński, Urszula Kopczyńska, Kinga Gurdak, Martyna Dydyk, Piotr Malinowski, Piotr Sikorski, Ewa Błaszczak, Jakub Wójcik

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 160
Number of citations: 0