Does drinking coffee reduce the risk of kidney stone formation?
DOI:
https://doi.org/10.12775/QS.2024.29.55585Keywords
Kidney stones, nephrolithiasis, coffee, caffeineAbstract
Introduction: Kidney stones, a prevalent urological issue affecting 2% to 15% of the global population, result from complex physicochemical processes in urine. Untreated stones can lead to severe complications like ureter blockage and kidney damage. Diet plays a crucial role in stone formation, with historical negative views on coffee consumption. However, new research shows potential benefits of coffee. The purpose of this review was to analyze the association between coffee consumption and the risk of developing kidney stones.
State of knowledge: Kidney stones develop as solid masses in the kidney's collecting system and can consist of various substances like calcium oxalate, calcium phosphate, uric acid, and cystine. Understanding the formation of kidney stones involves analyzing the role of crystal retention. Coffee consumption has shown potential benefits in reducing the risk of kidney stones by influencing urine composition. Additionally, oxalate and calcium are key dietary components to consider in kidney stone prevention strategies. Coffee has demonstrated diverse health benefits, including protection against cardiovascular disease, type 2 diabetes and neurodegenerative conditions. Its impact on blood pressure, glucose metabolism, and neuroprotection highlights its potential role in promoting overall well-being.
Conclusions: Coffee consumption, particularly due to its caffeine content and other compounds like chlorogenic acid, may reduce the risk of kidney stone formation. Caffeine has shown anti-lithogenic properties, decreasing oxalate excretion and increasing magnesium and potassium excretion, potentially preventing stone formation. A study by P. Peerapen and V. Thongboonkerd highlighted caffeine's role in reducing crystal adhesion to renal cells as a key mechanism in preventing kidney stones. In summary, coffee's diverse components could provide protection against kidney stone development.
References
Tamborino, F., Cicchetti, R., Mascitti, M., Litterio, G., Orsini, A., Ferretti, S., Basconi, M., De Palma, A., Ferro, M., Marchioni, M., & Schips, L. (2024). Pathophysiology and Main Molecular Mechanisms of Urinary Stone Formation and Recurrence. International journal of molecular sciences, 25(5), 3075. https://doi.org/10.3390/ijms25053075
Wang, Z., Zhang, Y., Zhang, J., Deng, Q., & Liang, H. (2021). Recent advances on the mechanisms of kidney stone formation (Review). International journal of molecular medicine, 48(2), 149. https://doi.org/10.3892/ijmm.2021.4982
Alelign, T., & Petros, B. (2018). Kidney Stone Disease: An Update on Current Concepts. Advances in urology, 2018, 3068365. https://doi.org/10.1155/2018/3068365
Legay, C., Haeusermann, T., Pasquier, J., Chatelan, A., Fuster, D. G., Dhayat, N., Seeger, H., Ritter, A., Mohebbi, N., Ernandez, T., Chopard, C. S., Buchkremer, F., Segerer, S., Wuerzner, G., Ammor, N., Roth, B., Wagner, C. A., Bonny, O., & Bochud, M. (2023). Differences in the Food Consumption Between Kidney Stone Formers and Nonformers in the Swiss Kidney Stone Cohort. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 33(4), 555–565. https://doi.org/10.1053/j.jrn.2023.04.007
Safe, S., Kothari, J., Hailemariam, A., Upadhyay, S., Davidson, L. A., & Chapkin, R. S. (2023). Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action. International journal of molecular sciences, 24(3), 2706. https://doi.org/10.3390/ijms24032706
Chung H. J. (2014). The role of Randall plaques on kidney stone formation. Translational andrology and urology, 3(3), 251–254. https://doi.org/10.3978/j.issn.2223-4683.2014.07.03
Xu, Z., Yao, X., Duan, C., Liu, H., & Xu, H. (2023). Metabolic changes in kidney stone disease. Frontiers in immunology, 14, 1142207. https://doi.org/10.3389/fimmu.2023.1142207
Cicerello, E., Ciaccia, M., Cova, G. D., & Mangano, M. S. (2021). The new patterns of nephrolithiasis: What has been changing in the last millennium?. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 93(2), 195–199. https://doi.org/10.4081/aiua.2021.2.195
Wong, Y. V., Cook, P., & Somani, B. K. (2015). The association of metabolic syndrome and urolithiasis. International journal of endocrinology, 2015, 570674. https://doi.org/10.1155/2015/570674
Carbone, A., Al Salhi, Y., Tasca, A., Palleschi, G., Fuschi, A., De Nunzio, C., Bozzini, G., Mazzaferro, S., & Pastore, A. L. (2018). Obesity and kidney stone disease: a systematic review. Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 70(4), 393–400. https://doi.org/10.23736/S0393-2249.18.03113-2
Strohmaier, W. L., Hörmann, M., & Schubert, G. (2013). Papillary calcifications: a new prognostic factor in idiopathic calcium oxalate urolithiasis. Urolithiasis, 41(6), 475–479. https://doi.org/10.1007/s00240-013-0606-3
Fuster, D. G., Morard, G. A., Schneider, L., Mattmann, C., Lüthi, D., Vogt, B., & Dhayat, N. A. (2022). Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 37(2), 335–348. https://doi.org/10.1093/ndt/gfaa360
Gupta, K., Gill, G. S., & Mahajan, R. (2016). Possible role of elevated serum testosterone in pathogenesis of renal stone formation. International journal of applied & basic medical research, 6(4), 241–244. https://doi.org/10.4103/2229-516X.192593
Yitgin, Y., Asrak, H., & Tefik, T. (2023). Role, importance and assessment of dietary habits in urolithiasis patient. World journal of urology, 41(5), 1229–1233. https://doi.org/10.1007/s00345-023-04277-3
Ferraro, P. M., Bargagli, M., Trinchieri, A., & Gambaro, G. (2020). Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian-Vegan Diets. Nutrients, 12(3), 779. https://doi.org/10.3390/nu12030779
Littlejohns, T. J., Neal, N. L., Bradbury, K. E., Heers, H., Allen, N. E., & Turney, B. W. (2020). Fluid Intake and Dietary Factors and the Risk of Incident Kidney Stones in UK Biobank: A Population-based Prospective Cohort Study. European urology focus, 6(4), 752–761. https://doi.org/10.1016/j.euf.2019.05.002
Ferraro, P. M., & Bargagli, M. (2021). Dietetic and lifestyle recommendations for stone formers. Consejos dietéticos y de estilo de vida en pacientes con litiasis urinarias. Archivos espanoles de urologia, 74(1), 112–122.
Massey, L.K. and Wise, K.J. (1992) Impact of Gender and Age on Urinary Water and Mineral Excretion Responses to Acute Caffeine Doses. Nutrition Research, 12, 605-612.
https://doi.org/10.1016/S0271-5317(05)80030-2
Ferraro, P. M., Taylor, E. N., Gambaro, G., & Curhan, G. C. (2014). Caffeine intake and the risk of kidney stones. The American journal of clinical nutrition, 100(6), 1596–1603. https://doi.org/10.3945/ajcn.114.089987
Curhan, G. C., Willett, W. C., Rimm, E. B., Spiegelman, D., & Stampfer, M. J. (1996). Prospective study of beverage use and the risk of kidney stones. American journal of epidemiology, 143(3), 240–247. https://doi.org/10.1093/oxfordjournals.aje.a008734
Curhan, G. C., Willett, W. C., Speizer, F. E., & Stampfer, M. J. (1998). Beverage use and risk for kidney stones in women. Annals of internal medicine, 128(7), 534–540. https://doi.org/10.7326/0003-4819-128-7-199804010-00003
Bargagli, M., Tio, M. C., Waikar, S. S., & Ferraro, P. M. (2020). Dietary Oxalate Intake and Kidney Outcomes. Nutrients, 12(9), 2673. https://doi.org/10.3390/nu12092673
Siener R. (2021). Nutrition and Kidney Stone Disease. Nutrients, 13(6), 1917. https://doi.org/10.3390/nu13061917
Han, H., Segal, A. M., Seifter, J. L., & Dwyer, J. T. (2015). Nutritional Management of Kidney Stones (Nephrolithiasis). Clinical nutrition research, 4(3), 137–152. https://doi.org/10.7762/cnr.2015.4.3.137
Wang, X., & Wang, Q. (2024). Current Dietary and Medical Prevention of Renal Calcium Oxalate Stones. International journal of general medicine, 17, 1635–1649. https://doi.org/10.2147/IJGM.S459155
Borghi, L., Schianchi, T., Meschi, T., Guerra, A., Allegri, F., Maggiore, U., & Novarini, A. (2002). Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. The New England journal of medicine, 346(2), 77–84. https://doi.org/10.1056/NEJMoa010369
Socała, K., Szopa, A., Serefko, A., Poleszak, E., & Wlaź, P. (2020). Neuroprotective Effects of Coffee Bioactive Compounds: A Review. International journal of molecular sciences, 22(1), 107. https://doi.org/10.3390/ijms22010107
Surma, S., & Oparil, S. (2021). Coffee and Arterial Hypertension. Current hypertension reports, 23(7), 38. https://doi.org/10.1007/s11906-021-01156-3
Nieber K. (2017). The Impact of Coffee on Health. Planta medica, 83(16), 1256–1263. https://doi.org/10.1055/s-0043-115007
Mendoza, M. F., Sulague, R. M., Posas-Mendoza, T., & Lavie, C. J. (2023). Impact of Coffee Consumption on Cardiovascular Health. Ochsner journal, 23(2), 152–158. https://doi.org/10.31486/toj.22.0073
Antonio, J., Newmire, D. E., Stout, J. R., Antonio, B., Gibbons, M., Lowery, L. M., Harper, J., Willoughby, D., Evans, C., Anderson, D., Goldstein, E., Rojas, J., Monsalves-Álvarez, M., Forbes, S. C., Gomez Lopez, J., Ziegenfuss, T., Moulding, B. D., Candow, D., Sagner, M., & Arent, S. M. (2024). Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?. Journal of the International Society of Sports Nutrition, 21(1), 2323919. https://doi.org/10.1080/15502783.2024.2323919
Kolb, H., Martin, S., & Kempf, K. (2021). Coffee and Lower Risk of Type 2 Diabetes: Arguments for a Causal Relationship. Nutrients, 13(4), 1144. https://doi.org/10.3390/nu13041144
Sirotkin, A. V., & Kolesárová, A. (2021). The anti-obesity and health-promoting effects of tea and coffee. Physiological research, 70(2), 161–168. https://doi.org/10.33549/physiolres.934674
Wasim, S., Kukkar, V., Awad, V. M., Sakhamuru, S., & Malik, B. H. (2020). Neuroprotective and Neurodegenerative Aspects of Coffee and Its Active Ingredients in View of Scientific Literature. Cureus, 12(8), e9578. https://doi.org/10.7759/cureus.9578
Ladewig, T., Kloppenburg, P., Lalley, P. M., Zipfel, W. R., Webb, W. W., & Keller, B. U. (2003). Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouse. The Journal of physiology, 547(Pt 3), 775–787. https://doi.org/10.1113/jphysiol.2002.033605
He, W. J., Chen, J., Razavi, A. C., Hu, E. A., Grams, M. E., Yu, B., Parikh, C. R., Boerwinkle, E., Bazzano, L., Qi, L., Kelly, T. N., Coresh, J., & Rebholz, C. M. (2021). Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease. Clinical journal of the American Society of Nephrology : CJASN, 16(11), 1620–1629. https://doi.org/10.2215/CJN.05520421
Geng, J., Qiu, Y., Kang, Z., Li, Y., Li, J., Liao, R., Qin, Z., Yang, Q., & Su, B. (2022). The association between caffeine intake and risk of kidney stones: A population-based study. Frontiers in nutrition, 9, 935820. https://doi.org/10.3389/fnut.2022.935820
Peerapen, P., & Thongboonkerd, V. (2016). Caffeine prevents kidney stone formation by translocation of apical surface annexin A1 crystal-binding protein into cytoplasm: In vitro evidence. Scientific reports, 6, 38536. https://doi.org/10.1038/srep38536
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Elwira Servaas, Olga Grelewicz, Adam Juśkiewicz, Mateusz Haber, Adrianna Czachor, Alicja Kotula, Paula Kula, Natalia Kucy, Robert Siemiątkowski
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 529
Number of citations: 0
