Lignocaine in Migraine Treatment: A Comprehensive Review
DOI:
https://doi.org/10.12775/QS.2024.23.55066Keywords
Migraine, Anesthesia, Lignocaine, Chronic pain, Pain Management, Refractory MigraineAbstract
Introduction: Migraine is a prevalent and debilitating neurological disorder characterized by recurrent headaches and associated symptoms such as nausea, photophobia, and phonophobia. While conventional treatments exist, a significant subset of patients suffers from refractory migraines, prompting the exploration of alternative therapies like lignocaine.
Purpose of the work: This review examines the mechanisms by which lignocaine modulatespain and underscores the potential of lignocaine as a therapeutic option for refractory migraines, while also highlighting the need for continued research to refine its clinical application.
Materials and methods: A comprehensive analysis of research papers available on PubMed, Google Scholar, Web of Science, Embase and Scopus was undertaken using the searchterms encompassing the following keywords: chronic migraine / lignocaine migraine / migraine treatment/ migraine pain mechanism / migraine chronic pain mechanism / lignocaine and ketamine migraine / lignocaine adverse effects / lignocaine safety / refractory migraine.
Results: Lignocainehas shown promise in alleviating both acute and chronic migraine pain. However, its use requires careful patient selection and monitoring due to potential side effects, such as cardiac and central nervous system toxicity. Despite these risks, the favorable safety profile and efficacy of lignocaine make it a valuable option in migraine management. Future research should focus on optimizing dosing protocols, evaluating long-term outcomes, and identifying biomarkers to guide patient selection.
References
Ashina, M., Katsarava, Z., Do, T. P., Buse, D. C., Pozo-Rosich, P., Özge, A., Krymchantowski, A. V., Lebedeva, E. R., Ravishankar, K., Yu, S., Sacco, S., Ashina, S., Younis, S., Steiner, T. J., & Lipton, R. B. (2021). Migraine: epidemiology and systems of care. In The Lancet (Vol. 397, Issue 10283, pp. 1485–1495). Elsevier B.V. https://doi.org/10.1016/S0140-6736(20)32160-7
Bahar, E., & Yoon, H. (2021). Lidocaine: A local anesthetic, its adverse effects and management. In Medicina (Lithuania) (Vol. 57, Issue 8). https://doi.org/10.3390/medicina57080782
Chan, T. Y. K. (2016). Fatal anaphylactic reactions to lignocaine. In Forensic Science International (Vol. 266). https://doi.org/10.1016/j.forsciint.2016.07.006
Chi, P. W., Hsieh, K. Y., Chen, K. Y., Hsu, C. W., Bai, C. H., Chen, C., & Hsu, Y. P. (2019). Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials. PLoS ONE, 14(10). https://doi.org/10.1371/journal.pone.0224285
Cummins, T. R. (2007). Setting up for the block: The mechanism underlying lidocaine’s use-dependent inhibition of sodium channels. Journal of Physiology, 582(1), 11. https://doi.org/10.1113/jphysiol.2007.136671
Digala, L. P., & Lucchese, S. (2020). IV Lidocaine Infusion Leading to the Toxic Levels in Serum Causing Asystole – A Case Report. Headache, 60(1). https://doi.org/10.1111/head.13699
Edvinsson, L., Haanes, K. A., &Warfvinge, K. (2019). Does inflammation have a role in migraine? In Nature Reviews Neurology (Vol. 15, Issue 8). https://doi.org/10.1038/s41582-019-0216-y
Gronwald, C., Vegh, V., Hollmann, M. W., Hahnenkamp, A., Garaj, V., &Hahnenkamp, K. (2011). The inhibitory potency of local anesthetics on NMDA receptor signallingdepends on their structural features. European Journal of Pharmacology, 674(1). https://doi.org/10.1016/j.ejphar.2011.10.035
Hasan, B., Asif, T., & Hasan, M. (2017). Lidocaine-Induced Systemic Toxicity: A Case Report and Review of Literature. Cureus. https://doi.org/10.7759/cureus.1275
Kalatharan, V., & Al-Karagholi, M. A. M. (2023). Targeting Peripheral N-Methyl-D-Aspartate Receptor (NMDAR): A Novel Strategy for the Treatment of Migraine. In Journal of Clinical Medicine (Vol. 12, Issue 6). https://doi.org/10.3390/jcm12062156
Marmura, M., Rosen, N., Abbas, M., & Silberstein, S. (2009). Intravenous lidocaine in the treatment of refractory headache: A retrospective case series. Headache, 49(2). https://doi.org/10.1111/j.1526-4610.2008.01281.x
Miglis, M. G. (2018). Migraine and Autonomic Dysfunction: Which Is the Horse and Which Is the Jockey? In Current Pain and Headache Reports (Vol. 22, Issue 3). https://doi.org/10.1007/s11916-018-0671-y
Mojica, J. J., Schwenk, E. S., Lauritsen, C., & Nahas, S. J. (2021). Beyond the Raskin Protocol: Ketamine, Lidocaine, and Other Therapies for Refractory Chronic Migraine. In Current Pain and Headache Reports (Vol. 25, Issue 12). https://doi.org/10.1007/s11916-021-00992-x
Ray, J. C., Cheng, S., Tsan, K., Hussain, H., Stark, R. J., Matharu, M. S., & Hutton, E. (2022). Intravenous Lidocaine and Ketamine Infusions for Headache Disorders: A Retrospective Cohort Study. Frontiers in Neurology, 13. https://doi.org/10.3389/fneur.2022.842082
Sacco, S., Lampl, C., Maassen van den Brink, A., Caponnetto, V., Braschinsky, M., Ducros, A., Little, P., Pozo-Rosich, P., Reuter, U., Ruiz de la Torre, E., Sanchez Del Rio, M., Sinclair, A. J., Martelletti, P., Katsarava, Z., Cakciri, G., Djamandi, P., Grabova, S., Halili, G., Kruja, J., … Thura, M. (2021). Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance. Journal of Headache and Pain, 22(1). https://doi.org/10.1186/s10194-021-01252-4
Schwenk, E. S., Walter, A., Torjman, M. C., Mukhtar, S., Patel, H. T., Nardone, B., Sun, G., Thota, B., Lauritsen, C. G., & Silberstein, S. D. (2022). Lidocaine infusions for refractory chronic migraine: a retrospective analysis. In Regional Anesthesia and Pain Medicine (Vol. 47, Issue 7). https://doi.org/10.1136/rapm-2021-103180
Szperka, C., Prado, B., Hsu, J., Gelfand, A., Haagen, D., Kellier, D., Dlugos, D., Raj, N., Hershey, A., & Farrar, J. (2024). Randomized Controlled Trial of Lidocaine Occipital Nerve Blocks to Treat Status Migrainosus in Children/Adolescents (S22.009). Neurology, 102. https://doi.org/10.1212/WNL.0000000000205849
Tierney, K. J., Murano, T., & Natal, B. (2016). Lidocaine-Induced Cardiac Arrest in the Emergency Department: Effectiveness of Lipid Therapy. Journal of Emergency Medicine, 50(1). https://doi.org/10.1016/j.jemermed.2015.07.035
Vazirani, J., & Knott, J. C. (2012). Mandatory pain scoring at triage reduces time to analgesia. Annals of Emergency Medicine, 59(2). https://doi.org/10.1016/j.annemergmed.2011.08.007
Wang, Q., Wang, S., Zhu, Y., & Lin, F. (2023). Clinical efficacy and safety of rimegepant in the treatment of migraine: a meta-analysis of randomized controlled trials. In Frontiers in Neurology (Vol. 14). https://doi.org/10.3389/fneur.2023.1205778
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Copyright (c) 2024 Jakub Kalisiak, Max Tschuschke, Martyna Choinka, Mikołaj Lorenz, Jędrzej Lewandowski, Agata Konopka, Zuzanna Szczepaniak, Natalia Wdowiak, Małgorzata Komarów, Dominika Karasińska
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