Diet and selected stimulants as factors promoting carcinogenesis in oral cancer
DOI:
https://doi.org/10.12775/QS.2024.21.54332Keywords
Oral cancer, Risk factors, Diet, Pro-inflammatory Diet, Polyphenols, Tobacco, Alcohol, BetelAbstract
Introduction and purpose
Oral cancer belongs to a heterogeneous group of head and neck cancers. In many cases, it is detected at an advanced stage, which translates into a relatively high mortality rate among patients. For this reason, the identification of risk factors promoting carcinogenesis is of great importance in terms of prevention. The purpose of our study is to demonstrate the relationship between the type of diet consumed and the intake of stimulants and the risk of developing oral cancer.
State of knowledge
This article is an overview of selected dietary ingredients and stimulants - tobacco, alcohol and betel, presenting their possible effects on the oral area. We have presented both dietary products known for their harmfulness and those with health-promoting effects.
Material and method
In our work, we focused on analyzing medical literature available on PubMed and Google Scholar. The sources we have chosen are based on studies conducted in epidemiology, biochemistry and oncology.
Summary
Dietary habits and ingested stimulants have a direct impact on the development of oral cancer. Depending on the content of various components, the diet may exhibit protective properties or promote carcinogenesis. On the other hand, chronic habitual use of certain substances has been found to be a strong factor in increasing the risk of oral malignancies. Therefore, efforts should be made to raise public awareness of the potential consequences of pro-inflammatory diets and stimulants intake.
References
AJCC Cancer Staging Handbook. From the AJCC Cancer Staging Manual, 6th ed., Greene F.L., Page D.L., Fleming I.D., Fritz A.G., Balch Ch.M., Haller D.G., Morrow M. (eds.), Springer Verlag New York Inc., USA, 2002
Tranby, Eric & Heaton, Lisa & Tomar, Scott & Kelly, Abigail & Fager, Gulielma & Backley, Mary & Frantsve-Hawley, Julie. (2022). Oral Cancer Prevalence, Mortality, and Costs in Medicaid and Commercial Insurance Claims Data. Cancer Epidemiology Biomarkers & Prevention. 31. 10.1158/1055-9965.EPI-22-0114.
Shruti T, Khanna D, Khan A, Dandpat A, Tiwari M, Singh AG, Mishra A, Shetty A, Birur P, Chaturvedi P. Status and Determinants of Early Detection of Oral Premalignant and Malignant Lesions in India. Cancer Control. 2023 Jan-Dec;30:10732748231159556. doi: 10.1177/10732748231159556. PMID: 36809192; PMCID: PMC9947682.
Odell, Edward & Gale, Nina & Thavaraj, Selvam & Nadal, Alfons & Zidar, Nina & Gnepp, Douglas. (2021). Precursor Lesions for Squamous Carcinoma in the Upper Aerodigestive Tract. 10.1016/B978-0-323-53114-6.00001-8.
Irani, Soussan1,2,. New Insights into Oral Cancer—Risk Factors and Prevention: A Review of Literature. International Journal of Preventive Medicine 11(1):p 202, | DOI: 10.4103/ijpvm.IJPVM_403_18
Warnakulasuriya, S. Causes of oral cancer – an appraisal of controversies. Br Dent J 207, 471–475 (2009). DOI: 10.1038/sj.bdj.2009.1009
Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015 Jul;24(3):491-508. doi: 10.1016/j.soc.2015.03.006. Epub 2015 Apr 15. PMID: 25979396; PMCID: PMC5018209.
Zini, A., Czerninski, R. and Sgan-Cohen, H.D. (2010), Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites. Journal of Oral Pathology & Medicine, 39: 299-305. https://doi.org/10.1111/j.1600-0714.2009.00845.x
Tranby EP, Heaton LJ, Tomar SL, Kelly AL, Fager GL, Backley M, Frantsve-Hawley J. Oral Cancer Prevalence, Mortality, and Costs in Medicaid and Commercial Insurance Claims Data. Cancer Epidemiol Biomarkers Prev. 2022 Sep 2;31(9):1849-1857. doi: 10.1158/1055-9965.EPI-22-0114. PMID: 35732291; PMCID: PMC9437560.
Warnakulasuriya S, Kerr AR. Oral Cancer Screening: Past, Present, and Future. Journal of Dental Research. 2021;100(12):1313-1320. doi:10.1177/00220345211014795
Kalavathy Jayapal Elango, Nitin Anandkrishnan, Amritha Suresh, Subramania K. Iyer, Sundaram Karimassery RamaIyer, Moni Abraham Kuriakose, Mouth self-examination to improve oral cancer awareness and early detection in a high-risk population,Oral Oncology,Volume 47, Issue 7,2011,Pages 620-624,ISSN 1368-8375, DOI:10.1016/j.oraloncology.2011.05.001.
Singh K, Sharma D, Kaur M, Gauba K, Thakur JS, Kumar R. Effect of health education on awareness about oral cancer and oral self-examination. J Educ Health Promot. 2017 May 5;6:27. doi: 10.4103/jehp.jehp_82_15. PMID: 28584827; PMCID: PMC5441190.
Rodríguez-Molinero J, Migueláñez-Medrán BDC, Puente-Gutiérrez C, Delgado-Somolinos E, Martín Carreras-Presas C, Fernández-Farhall J, López-Sánchez AF. Association between Oral Cancer and Diet: An Update. Nutrients. 2021 Apr 15;13(4):1299. doi: 10.3390/nu13041299. PMID: 33920788; PMCID: PMC8071138.
Patel, Jayendrakumar B.; Shah, Franky D.; Joshi, Geeta M.1; Patel, Prabhudas S.. Clinical significance of inflammatory mediators in the pathogenesis of oral cancer. Journal of Cancer Research and Therapeutics 12(2):p 447-457, Apr–Jun 2016. | DOI: 10.4103/0973-1482.147765
Mazul AL, Shivappa N, Hébert JR, Steck SE, Rodriguez-Ormaza N, Weissler M, Olshan AF, Zevallos JP. Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer. Int J Cancer. 2018 Oct 1;143(7):1604-1610. doi: 10.1002/ijc.31555. Epub 2018 Jul 26. PMID: 29696631; PMCID: PMC6203678.
Bulanda S, Lau K, Nowak A, Łyko-Morawska D, Kotylak A, Janoszka B. The Risk of Oral Cancer and the High Consumption of Thermally Processed Meat Containing Mutagenic and Carcinogenic Compounds. Nutrients. 2024 Apr 7;16(7):1084. doi: 10.3390/nu16071084. PMID: 38613117; PMCID: PMC11013896.
S.Y. Chung, Ramesh R. Yettella, J.S. Kim, K. Kwon, M.C. Kim, David B. Min, Effects of grilling and roasting on the levels of polycyclic aromatic hydrocarbons in beef and pork, Food Chemistry, Volume 129, Issue 4, 2011, Pages 1420-1426, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2011.05.092.
Ding Y, Yao H, Yao Y, Fai LY, Zhang Z. Protection of dietary polyphenols against oral cancer. Nutrients. 2013 Jun 14;5(6):2173-91. doi: 10.3390/nu5062173. PMID: 23771133; PMCID: PMC3725499.
Stefano Petti, Crispian Scully, Polyphenols, oral health and disease: A review, Journal of Dentistry, Volume 37, Issue 6, 2009, Pages 413-423, ISSN 0300-5712, https://doi.org/10.1016/j.jdent.2009.02.003.
Wang Q, Yang B, Wang N, Gu J. Tumor immunomodulatory effects of polyphenols. Front Immunol. 2022 Nov 24;13:1041138. doi: 10.3389/fimmu.2022.1041138. PMID: 36505462; PMCID: PMC9729837.
Silva P, Latruffe N, Gaetano G. Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus. Molecules. 2020 May 31;25(11):2569. doi: 10.3390/molecules25112569. PMID: 32486484; PMCID: PMC7321235.
Varoni EM, Lodi G, Iriti M. Ethanol versus Phytochemicals in Wine: Oral Cancer Risk in a Light Drinking Perspective. Int J Mol Sci. 2015 Jul 27;16(8):17029-47. doi: 10.3390/ijms160817029. PMID: 26225960; PMCID: PMC4581183.
Saman Warnakulasuriya, Gay Sutherland, Crispian Scully, Tobacco, oral cancer, and treatment of dependence, Oral Oncology, Volume 41, Issue 3, 2005, Pages 244-260, ISSN 1368-8375, https://doi.org/10.1016/j.oraloncology.2004.08.010.
C.J. Smith, S.D. Livingston, D.J. Doolittle, An international literature survey of “IARC group I carcinogens” reported in mainstream cigarette smoke, Food and Chemical Toxicology, Volume 35, Issues 10–11, 1997, Pages 1107-1130, ISSN 0278-6915, https://doi.org/10.1016/S0278-6915(97)00063-X.
Ashek Elahi Noor, Boyapati Ramanarayana, Relationship of smokeless tobacco uses in the perspective of oral cancer: A global burden, Oral Oncology Reports, Volume 10, 2024, 100516, ISSN 2772-9060, https://doi.org/10.1016/j.oor.2024.100516.
Bukowska B, Mokra K, Michałowicz J. Benzo[a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity. Int J Mol Sci. 2022 Jun 6;23(11):6348. doi: 10.3390/ijms23116348. PMID: 35683027; PMCID: PMC9181839.
Dominique Ziech, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis, Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 711, Issues 1–2, 2011, Pages 167-173, ISSN 0027-5107, https://doi.org/10.1016/j.mrfmmm.2011.02.015.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 89. Smokeless Tobacco and some Tobacco-Specific N-nitrosamines. IARC. 2007.
Polesel J, Talamini R, La Vecchia C, Levi F, Barzan L, Serraino D, Franceschi S, Dal Maso L. Tobacco smoking and the risk of upper aero-digestive tract cancers: A reanalysis of case-control studies using spline models. Int J Cancer. 2008 May 15;122(10):2398-402. doi: 10.1002/ijc.23385. PMID: 18224689.
IARC Handbooks of Cancer Prevention, Volume 19. Oral Cancer Prevention. IARC. 2023.
Asthana S, Labani S, Kailash U, Sinha DN, Mehrotra R. Association of Smokeless Tobacco Use and Oral Cancer: A Systematic Global Review and Meta-Analysis. Nicotine Tob Res. 2019 Aug 19;21(9):1162-1171. doi: 10.1093/ntr/nty074. PMID: 29790998.
Sinha, DN; Gupta, PC1; Ray, Cecily1; Singh, PK. Prevalence of smokeless tobacco use among adults in WHO South-East Asia. Indian Journal of Cancer 49(4):p 342-346, Oct–Dec 2012. | DOI: 10.4103/0019-509X.107726
Zhang SZ, Xie L, Shang ZJ. Burden of Oral Cancer on the 10 Most Populous Countries from 1990 to 2019: Estimates from the Global Burden of Disease Study 2019. Int J Environ Res Public Health. 2022 Jan 13;19(2):875. doi: 10.3390/ijerph19020875. PMID: 35055693; PMCID: PMC8775770.
Alice Cameron, Hao Meng Yip, Montey Garg, e-Cigarettes and Oral Cancer: what do we know so far?, British Journal of Oral and Maxillofacial Surgery, Volume 61, Issue 5, 2023, Pages 380-382, ISSN 0266-4356, https://doi.org/10.1016/j.bjoms.2023.03.013.
Chhina, M.S. Are e-cigarettes a safer alternative to reduce incidences of oral cancer?. Evid Based Dent 25, 13–14 (2024). https://doi.org/10.1038/s41432-023-00956-7
Guo J., Hecht S. DNA damage in human oral cells induced by use of e-cigarettes. 2023 Oct;15(10):1189-1197. doi: 10.1002/dta.3375. Epub 2022 Oct 4.
Ilhan MN, Yapar D. Alcohol consumption and alcohol policy. Turk J Med Sci. 2020 Aug 26;50(5):1197-1202. doi: 10.3906/sag-2002-237. PMID: 32421277; PMCID: PMC7491269.
Rumgay H, Murphy N, Ferrari P, Soerjomataram I. Alcohol and Cancer: Epidemiology and Biological Mechanisms. Nutrients. 2021 Sep 11;13(9):3173. doi: 10.3390/nu13093173. PMID: 34579050; PMCID: PMC8470184.
Metro D, Corallo F, Fedele F, Buda M, Manasseri L, Buono VL, Quartarone A, Bonanno L. Effects of Alcohol Consumption on Oxidative Stress in a Sample of Patients Recruited in a Dietary Center in a Southern University Hospital: A Retrospective Study. Medicina (Kaunas). 2022 Nov 18;58(11):1670. doi: 10.3390/medicina58111670. PMID: 36422209; PMCID: PMC9698473.
Wu D, Cederbaum AI. Alcohol, oxidative stress, and free radical damage. Alcohol Res Health. 2003;27(4):277-84. PMID: 15540798; PMCID: PMC6668865.
Molina JC., Guerrero-Morán D., González-Espinosa C. Alcohol: immunomodulatory effects and cancer. 2023;75(3):129-42 DOI: 10.24875/RIC.23000116
Lewin, F., Norell, S.E., Johansson, H., Gustavsson, P., Wennerberg, J., Biörklund, A. and Rutqvist, L.E. (1998), Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck†. Cancer, 82: 1367-1375. https://doi.org/10.1002/(SICI)1097-0142(19980401)82:7<1367::AID-CNCR21>3.0.CO;2-3
Kumar, Malay; Nanavati, Ronak1; Modi, Tapan G.2; Dobariya, Chintan3. Oral cancer: Etiology and risk factors. Journal of Cancer Research and Therapeutics 12(2):p 458-463, Apr–Jun 2016. | DOI: 10.4103/0973-1482.186696
Edward S. Peters, Michael D. McClean, Carmen J. Marsit, Brian Luckett, Karl T. Kelsey; Glutathione S-Transferase Polymorphisms and the Synergy of Alcohol and Tobacco in Oral, Pharyngeal, and Laryngeal Carcinoma. Cancer Epidemiol Biomarkers Prev 1 November 2006; 15 (11): 2196–2202. https://doi.org/10.1158/1055-9965.EPI-06-0503
Thavarajah, Rooban; Ranganathan, Kannan; Joshua, Elizabeth; Rao, Umadevi Krishnamohan. Areca Nut Use Disorder: A Dynamic Model Map. Indian Journal of Dental Research 30(4):p 612-621, Jul–Aug 2019. | DOI: 10.4103/ijdr.IJDR_947_18
Li YC, Cheng AJ, Lee LY, Huang YC, Chang JT. Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation. J Cancer. 2019 Jul 8;10(17):4054-4062. doi: 10.7150/jca.29765. PMID: 31417650; PMCID: PMC6692602.
Alpana K. Gupta, Sonam Tulsyan, Nisha Thakur, Vishwas Sharma, Dhirendra N. Sinha, Ravi Mehrotra, Chemistry, metabolism and pharmacology of carcinogenic alkaloids present in areca nut and factors affecting their concentration, Regulatory Toxicology and Pharmacology, Volume 110, 2020, 104548, ISSN 0273-2300, https://doi.org/10.1016/j.yrtph.2019.104548.
Pant I, Rao SG, Kondaiah P. Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis. Sci Rep. 2016 Oct 6;6:34314. doi: 10.1038/srep34314. PMID: 27708346; PMCID: PMC5052620.
Ray JG., Ranganathan K., Chattopadhyay A., Malignant transformation of oral submucous fibrosis: overview of histopathological aspects, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 122, Issue 2, 2016, Pages 200-209, ISSN 2212-4403, https://doi.org/10.1016/j.oooo.2015.11.024.
Illeperuma RP, Kim DK, Park YJ, Son HK, Kim JY, Kim J, Lee DY, Kim KY, Jung DW, Tilakaratne WM, Kim J. Areca nut exposure increases secretion of tumor-promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes. Int J Cancer. 2015 Dec 1;137(11):2545-57. doi: 10.1002/ijc.29636. Epub 2015 Jun 24. PMID: 26076896; PMCID: PMC4744697.
Chuang HC, Tsai MH, Lin YT, Chou MH, Yang KL, Chien CY. Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer. Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221146870. doi: 10.1177/15330338221146870. PMID: 36575633; PMCID: PMC9806389.
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