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Quality in Sport

Scar Formation, Healing Stages, and Advanced Treatment Strategies – Review
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  • Scar Formation, Healing Stages, and Advanced Treatment Strategies – Review
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  3. Vol. 22 (2024) /
  4. Medical Sciences

Scar Formation, Healing Stages, and Advanced Treatment Strategies – Review

Authors

  • Monika Kienanh Do Warsaw Medical University, Warsaw, Poland https://orcid.org/0009-0000-3155-0513
  • Marcin Mikusek-Pham Van University Clinical Center Medical University of Warsaw, 02-097 Warsaw, Poland https://orcid.org/0009-0004-3920-3099
  • Dominika Zaliwska University Clinical Hospital in Poznań, Przybyszewskiego 49, 60-355 Poznań, Poland https://orcid.org/0009-0009-1423-7918
  • Adrianna Kraszkiewicz University Clinical Hospital in Poznań, Przybyszewskiego 49, 60-355 Poznań, Poland https://orcid.org/0009-0008-4746-903X
  • Natalia Paduszyńska Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland https://orcid.org/0000-0001-9953-662X
  • Marta Justyna Gonciarz Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland https://orcid.org/0009-0006-7746-1237
  • Dominika Karolina Adamiec Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland https://orcid.org/0009-0008-5975-3927
  • Anna Dąbrowska Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland https://orcid.org/0009-0003-2289-5909
  • Monika Anna Kamińska Independent Public Clinical Hospital Witolda Orłowskiego, Czerniakowska 231, 00-416 Warsaw, Poland https://orcid.org/0009-0004-3955-4710
  • Magdalena Czach LUX MED, Postępu 21C, 02-676 Warsaw, Poland https://orcid.org/0009-0009-3786-5706

DOI:

https://doi.org/10.12775/QS.2024.22.54294

Keywords

scar, surgery, postoperative care, laser therapy, dermatology

Abstract

Introduction and Aim of the Study: Scarring is a major concern in clinical dermatology, affecting individuals' quality of life due to both physical and psychological impacts. This review aims to explore the pathophysiology of various scar types—hypertrophic, keloid, and atrophic—and evaluate the effectiveness of current and emerging treatments to inform better clinical practices and therapeutic strategies. Description of the State of Knowledge: Scar formation involves complex biological processes: inflammation, proliferation, and remodeling. The nature of the scar varies with the underlying cause and biological response, influenced by genetic factors, skin tension, and environmental elements such as UV exposure. Recent advances in treatments range from surgical techniques to laser therapy and biological agents like cytokines. Conclusion: The studies reviewed underscore the complexity of scar management, influenced by diverse genetic, biological, and environmental factors. No single treatment is universally effective, but a combination of preventative and therapeutic strategies shows the best promise.

References

Son D, Harijan A. Overview of Surgical Scar Prevention and Management. J Korean Med Sci. 2014;29(6):751. doi:10.3346/jkms.2014.29.6.751

Fife D. Practical evaluation and management of atrophic acne scars: tips for the general dermatologist. J Clin Aesthet Dermatol. 2011;4(8):50-57.

Wang Y, Beekman J, Hew J, et al. Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring. Advanced Drug Delivery Reviews. 2018;123:3-17. doi:10.1016/j.addr.2017.09.018

Shah MG, Maibach HI. Estrogen and Skin: An Overview. American Journal of Clinical Dermatology. 2001;2(3):143-150. doi:10.2165/00128071-200102030-00003

Liu S, Yang H, Song J, Zhang Y, Abualhssain ATH, Yang B. Keloid: Genetic susceptibility and contributions of genetics and epigenetics to its pathogenesis. Experimental Dermatology. 2022;31(11):1665-1675. doi:10.1111/exd.14671

Roberts WE. Skin Type Classification Systems Old and New. Dermatologic Clinics. 2009;27(4):529-533. doi:10.1016/j.det.2009.08.006

Teymour S, Kania B, Lal K, Goldberg D. Energy‐based devices in the treatment of acne scars in skin of color. J of Cosmetic Dermatology. 2023;22(4):1177-1184. doi:10.1111/jocd.15572

Khansa I, Harrison B, Janis JE. Evidence-Based Scar Management: How to Improve Results with Technique and Technology. Plastic & Reconstructive Surgery. 2016;138(3S):165S-178S. doi:10.1097/PRS.0000000000002647

Petersen H, Tavakoli F, Kruber S, et al. Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities. Lasers Surg Med. 2016;48(4):385-391. doi:10.1002/lsm.22498

Amici J, Cogrel O, Jourdan M, et al. Expert recommendations on supportive skin care for non‐surgical and surgical procedures. Acad Dermatol Venereol. 2023;37(S3):16-33. doi:10.1111/jdv.18855

Kim SM, Choi JS, Lee JH, Kim YJ, Jun YJ. Prevention of Postsurgical Scars: Comparsion of Efficacy and Convenience between Silicone Gel Sheet and Topical Silicone Gel. J Korean Med Sci. 2014;29(Suppl 3):S249. doi:10.3346/jkms.2014.29.S3.S249

Gold MH, Andriessen A, Dayan SH, Fabi SG, Lorenc ZP, Henderson Berg M. Hypochlorous acid gel technology—Its impact on postprocedure treatment and scar prevention. J of Cosmetic Dermatology. 2017;16(2):162-167. doi:10.1111/jocd.12330

Meseci E, Kayatas S, Api M, Boza A, Cikman MS. Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the pfannenstiel scar prevention — a randomized controlled trial. Ginekol Pol. 2017;88(11):591-598. doi:10.5603/GP.a2017.0107

Fang Z, Yang X, Wu G, et al. The use of autologous platelet-rich plasma gel increases wound healing and reduces scar development in split-thickness skin graft donor sites. Journal of Plastic Surgery and Hand Surgery. 2019;53(6):356-360. doi:10.1080/2000656X.2019.1635489

Kim JY, Willard JJ, Supp DM, et al. Burn Scar Biomechanics after Pressure Garment Therapy: Plastic and Reconstructive Surgery. 2015;136(3):572-581. doi:10.1097/PRS.0000000000001507

Kim JC, Kang SY, Kim HO, Park CW, Kwon O, Chung BY. Efficacy of combined treatment with intense pulsed light and fractional erbium: YAG Laser in scar prevention: A randomized split wound trial. Dermatologic Therapy. 2021;34(5). doi:10.1111/dth.15061

Kolli H, Moy R. Prevention of Scarring With Intraoperative Erbium: YAG Laser Treatment. JDD. 2020;19(11):1040-1043. doi:10.36849/JDD.2020.5244

Lee SJ, Lee JW, Kim SH, Suh IS, Jeong HS. Comparison of the Scar Prevention Effect Between a Carbon Dioxide Fractional Laser and a Continuous Ablative Carbon Dioxide Laser with a 595-nm Nd:YAG Laser. Aesth Plast Surg. 2019;43(1):213-220. doi:10.1007/s00266-018-1210-2

Clayton NA, Haertsch PA, Maitz PK, Issler-Fisher AC. Ablative Fractional Resurfacing in Acute Care Management of Facial Burns: A New Approach to Minimize the Need for Acute Surgical Reconstruction. Journal of Burn Care & Research. 2019;40(3):368-372. doi:10.1093/jbcr/irz030

Casanova D, Alliez A, Baptista C, Gonelli D, Lemdjadi Z, Bohbot S. A 1-Year Follow-Up of Post-operative Scars After the Use of a 1210-nm Laser-Assisted Skin Healing (LASH) Technology: A Randomized Controlled Trial. Aesth Plast Surg. 2017;41(4):938-948. doi:10.1007/s00266-017-0820-4

Karmisholt KE, Wenande E, Thaysen‐Petersen D, Philipsen PA, Paasch U, Haedersdal M. Early intervention with non‐ablative fractional laser to improve cutaneous scarring—A randomized controlled trial on the impact of intervention time and fluence levels. Lasers Surg Med. 2018;50(1):28-36. doi:10.1002/lsm.22707

Bailey JK, Blackstone BN, DeBruler DM, et al. Effects of early combinatorial treatment of autologous split‐thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO 2 laser. Lasers Surg Med. 2018;50(1):78-87. doi:10.1002/lsm.22702

Pongcharoen P, Pongcharoen B, Disphanurat W. The effectiveness of a 595 nm pulsed-dye-laser in the treatment of surgical scars following a knee arthroplasty. Journal of Cosmetic and Laser Therapy. 2019;21(6):352-356. doi:10.1080/14764172.2019.1661488

Liu X, Ouyang H, Lei Y, Yu Y, Gold MH, Tan J. Moist exposed burn therapy in recovery of patients with immature, red hypertrophic scars successfully treated with a pulsed dye laser in combination with a fractional CO 2 laser. J of Cosmetic Dermatology. 2020;19(6):1353-1358. doi:10.1111/jocd.13426

Karmisholt KE, Banzhaf CA, Glud M, et al. Laser treatments in early wound healing improve scar appearance: a randomized split-wound trial with nonablative fractional laser exposures vs. untreated controls. Br J Dermatol. 2018;179(6):1307-1314. doi:10.1111/bjd.17076

Yenyuwadee S, Achavanuntakul P, Phisalprapa P, et al. Effect of Laser and Energy-based Device Therapies to Minimize Surgical Scar Formation: A Systematic Review and Network Meta-analysis. Acta Derm Venereol. 2024;104:adv18477. doi:10.2340/actadv.v104.18477

Grabowski G, Pacana MJ, Chen E. Keloid and Hypertrophic Scar Formation, Prevention, and Management: Standard Review of Abnormal Scarring in Orthopaedic Surgery. J Am Acad Orthop Surg. 2020;28(10):e408-e414. doi:10.5435/JAAOS-D-19-00690

Nguyen KT, Shikowitz L, Kasabian AK, Bastidas N. A Novel Approach to Keloid Reconstruction with Bilaminar Dermal Substitute and Epidermal Skin Grafting. Plastic & Reconstructive Surgery. 2016;138(1):235-239. doi:10.1097/PRS.0000000000002242

Kim BR, Kwon SH, Kim JW, et al. Early Postoperative Injections of Polydeoxyribonucleotide Prevent Hypertrophic Scarring After Thyroidectomy: A Randomized Controlled Trial. Advances in Wound Care. 2023;12(7):361-370. doi:10.1089/wound.2022.0025

Kim JH, Jeong JJ, Lee YI, et al. Preventive effect of polynucleotide on post‐thyroidectomy scars: A randomized, double‐blinded, controlled trial. Lasers Surg Med. 2018;50(7):755-762. doi:10.1002/lsm.22812

James I, Bourne D, Silva M, et al. Adipose stem cells enhance excisional wound healing in a porcine model. Journal of Surgical Research. 2018;229:243-253. doi:10.1016/j.jss.2018.03.068

Potter K, Konda S, Ren VZ, Wang AL, Srinivasan A, Chilukuri S. Techniques for Optimizing Surgical Scars, Part 3: Erythema, Hyperpigmentation, and Hypopigmentation. Skinmed. 2018;16(2):113-117.

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Published

2024-09-18

How to Cite

1.
DO, Monika Kienanh, MIKUSEK-PHAM VAN, Marcin, ZALIWSKA , Dominika, KRASZKIEWICZ, Adrianna, PADUSZYŃSKA, Natalia, GONCIARZ, Marta Justyna, ADAMIEC, Dominika Karolina, DĄBROWSKA, Anna, KAMIŃSKA, Monika Anna and CZACH, Magdalena. Scar Formation, Healing Stages, and Advanced Treatment Strategies – Review. Quality in Sport. Online. 18 September 2024. Vol. 22, p. 54294. [Accessed 6 July 2025]. DOI 10.12775/QS.2024.22.54294.
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Issue

Vol. 22 (2024)

Section

Medical Sciences

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Copyright (c) 2024 Monika Kienanh Do, Marcin Mikusek-Pham Van, Dominika Zaliwska , Adrianna Kraszkiewicz, Natalia Paduszyńska, Marta Justyna Gonciarz, Dominika Karolina Adamiec, Anna Dąbrowska, Monika Anna Kamińska, Magdalena Czach

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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