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Quality in Sport

The Effects of Oral Collagen Supplementation on Skin Aging
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  • The Effects of Oral Collagen Supplementation on Skin Aging
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  3. Vol. 20 (2024) /
  4. Medical Sciences

The Effects of Oral Collagen Supplementation on Skin Aging

Authors

  • Weronika Zofia Marzec Medical University of Łódź https://orcid.org/0009-0006-2990-4101
  • Marcelina Teresa Marzec University Clinical Hospital No. 2 of the Medical University of Lodz https://orcid.org/0009-0002-6978-4969
  • Aleksandra Łakoma Hospital of St John of God in Lodz https://orcid.org/0009-0004-1019-0773
  • Aleksandra Wydra-Rojek Masovian Specialist Hospital in Radom https://orcid.org/0009-0005-6046-6958
  • Anna Marszałek University Clinical Hospital No. 1 of the Medical University of Lodz https://orcid.org/0009-0000-7348-8498
  • Katarzyna Kutyła Maria Skłodowska-Curie Specialist Hospital in Zgierz https://orcid.org/0009-0007-3424-5291
  • Wojciech Jan Mokot Maria Skłodowska-Curie Specialist Hospital in Zgierz https://orcid.org/0009-0004-3765-4902
  • Paulina Wasiewicz-Ciach University Clinical Hospital No. 2 of the Medical University of Lodz https://orcid.org/0009-0003-8631-7788
  • Piotr Kuczyński Karol Jonscher Municipal Medical Center in Łódź https://orcid.org/0009-0004-9923-8154
  • Maciej Choiński Maria Skłodowska-Curie Specialist Hospital in Zgierz https://orcid.org/0009-0005-3348-1589

DOI:

https://doi.org/10.12775/QS.2024.20.53977

Keywords

collagen, skin aging, supplements, marine collagen

Abstract

This systematic review evaluates the effects of oral collagen supplementation on skin hydration, elasticity, and wrinkle reduction. Collagen, a key protein in the skin, decreases with age, causing visible signs of aging. The review synthesizes findings from 31 articles, including randomized controlled trials, systematic reviews, and meta-analyses, focusing on the efficacy of hydrolyzed collagen (HC), collagen tripeptides (CP), and low molecular weight collagen peptides (LMWCP). The review also highlights collagen peptides' role in stimulating collagen synthesis, improving skin barrier function, and promoting hydration. Despite some limitations, the evidence supports collagen supplements, as a non-invasive option for improving skin health. 

 

Aim of the Study

The study aims to evaluate the impact of oral collagen supplementation, particularly hydrolyzed collagen (HC), collagen tripeptides (CP), and low molecular weight collagen peptides (LMWCP), on improving skin hydration, elasticity, and wrinkle reduction.

 

Materials and methods

A  review  of  the  literature  collected  in  the PubMed  database  was  performed  to  gather information found under the key words “collagen supplementation," "skin aging," "hydrolyzed collagen," "collagen peptides," "skin hydration," "skin elasticity," and "wrinkle reduction."



References

Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021;53(10):1493-1506. doi:10.1007/s00726-021-03072-x

Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides [published correction appears in Appl Physiol Nutr Metab. 2017 Nov;42(11):1237. doi: 10.1139/apnm-2017-0693]. Appl Physiol Nutr Metab. 2017;42(6):588-595. doi:10.1139/apnm-2016-0390

Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301. doi:10.1111/jocd.12174

Jung K, Kim SH, Joo KM, et al. Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum. Nutrients. 2021;13(12):4372. Published 2021 Dec 6. doi:10.3390/nu13124372

Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients. 2019;11(10):2494. Published 2019 Oct 17. doi:10.3390/nu11102494

Na GH, Kim S, Jung HM, Han SH, Han J, Koo YK. Skin Anti-Aging Efficacy of Enzyme-Treated Supercritical Caviar Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;16(1):137. Published 2023 Dec 30. doi:10.3390/nu16010137

Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10(7):826. Published 2018 Jun 26. doi:10.3390/nu10070826

Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-119. doi:10.1159/000355523

Genovese L, Corbo A, Sibilla S. An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants. Skin Pharmacol Physiol. 2017;30(3):146-158. doi:10.1159/000464470

​​Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. doi:10.1111/jocd.13676.

Seong SH, Lee YI, Lee J, et al. Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study. J Cosmet Dermatol. 2024;23(2):554-562. doi:10.1111/jocd.16026

Nomoto T, Iizaka S. Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study. Adv Skin Wound Care. 2020;33(4):186-191. doi:10.1097/01.ASW.0000655492.40898.55

Ito N, Seki S, Ueda F. Effects of composite supplement containing collagen peptide and ornithine on skin conditions and plasma IGF-1 levels - A randomized, double-blind, placebo-controlled trial. *Mar Drugs.* 2018;16(12):482. doi:10.3390/md16120482.

Žmitek K, Žmitek J, Rogl Butina M, Pogačnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: results of a randomized, placebo-controlled, double-blind study. *Nutrients.* 2020;12(3):618. doi:10.3390/nu12030618.

Czajka A, Kania EM, Genovese L, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. *Nutr Res.* 2018;57:97-108. doi:10.1016/j.nutres.2018.06.001

Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomized double-blind placebo-controlled clinical study. *J Sci Food Agric.* 2016;96(12):4077-4081. doi:10.1002/jsfa.7606.

Maia Campos PMBG, Franco RSB, Kakuda L, Cadioli GF, Costa GMD, Bouvret E. Oral supplementation with hydrolyzed fish cartilage improves the morphological and structural characteristics of the skin: a double-blind, placebo-controlled clinical study. Molecules.*2021;26(16):4880. doi:10.3390/molecules26164880.

Pu SY, Huang YL, Pu CM, et al. Effects of oral collagen for skin anti-aging: a systematic review and meta-analysis. *Nutrients.* 2023;15(9):2080. doi:10.3390/nu15092080.

Liu C, Tseng YP, Chan LP, Liang CH. The potential of Streptococcus thermophiles (TCI633) in the anti-aging. *J Cosmet Dermatol.* 2022;21(6):2635-2647. doi:10.1111/jocd.14445.

Žmitek K, Žmitek J, Rogl Butina M, Pogačnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: results of a randomized, placebo-controlled, double-blind study. *Nutrients.* 2020;12(3):618. doi:10.3390/nu12030618.

Geahchan S, Baharlouei P, Rahman A. Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration. Mar Drugs. 2022;20(1):61. Published 2022 Jan 10. doi:10.3390/md20010061

Miyanaga M, Uchiyama T, Motoyama A, Ochiai N, Ueda O, Ogo M. Oral Supplementation of Collagen Peptides Improves Skin Hydration by Increasing the Natural Moisturizing Factor Content in the Stratum Corneum: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Skin Pharmacol Physiol. 2021;34(3):115-127. doi:10.1159/000513988

Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. J Dermatolog Treat. 2021;32(8):991-996. doi:10.1080/09546634.2020.1725412

de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021;60(12):1449-1461. doi:10.1111/ijd.15518

Žmitek K, Žmitek J, Hristov H, Rogl Butina M, Keršmanc P, Pogačnik T. The effects of dietary supplementation with collagen and vitamin C and their combination with hyaluronic acid on skin density, texture, and other parameters: a randomized, double-blind, placebo-controlled trial. *Nutrients.* 2024;16(12):1908. doi:10.3390/nu16121908.

Jhawar N, Wang JV, Saedi N. Oral collagen supplementation for skin aging: a fad or the future? *J Cosmet Dermatol.* 2020;19(4):910-912. doi:10.1111/jocd.13096.

Wong QYA, Chew FT. Defining skin aging and its risk factors: a systematic review and meta-analysis. Sci Rep. 2021;11(1):22075. Published 2021 Nov 11. doi:10.1038/s41598-021-01573-z

Peres G, Ianhez M, Polo TCF, Abbade LPF, Miot HA. Concerning the heterogeneity of the studies included in meta-analyses. Comment on: "Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis". *Int J Dermatol.* 2022;61(3):e99-e101. doi:10.1111/ijd.15748.

Aguirre-Cruz G, León-López A, Cruz-Gómez V, Jiménez-Alvarado R, Aguirre-Álvarez G. Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation. Antioxidants (Basel). 2020;9(2):181. Published 2020 Feb 22. doi:10.3390/antiox9020181

Inacio PAQ, Chaluppe FA, Aguiar GF, Coelho CF, Vieira RP. Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review. Nutrients. 2024;16(11):1543. Published 2024 May 21. doi:10.3390/nu16111543

Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021;53(10):1493-1506. doi:10.1007/s00726-021-03072-x

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Published

2024-08-21

How to Cite

1.
MARZEC, Weronika Zofia, MARZEC, Marcelina Teresa, ŁAKOMA, Aleksandra, WYDRA-ROJEK, Aleksandra, MARSZAŁEK, Anna, KUTYŁA, Katarzyna, MOKOT, Wojciech Jan, WASIEWICZ-CIACH , Paulina, KUCZYŃSKI, Piotr and CHOIŃSKI, Maciej. The Effects of Oral Collagen Supplementation on Skin Aging. Quality in Sport. Online. 21 August 2024. Vol. 20, p. 53977. [Accessed 14 June 2025]. DOI 10.12775/QS.2024.20.53977.
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Issue

Vol. 20 (2024)

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Medical Sciences

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Copyright (c) 2024 Weronika Zofia Marzec, Marcelina Teresa Marzec, Aleksandra Łakoma, Aleksandra Wydra-Rojek, Anna Marszałek, Katarzyna Kutyła, Wojciech Jan Mokot, Paulina Wasiewicz-Ciach , Piotr Kuczyński, Maciej Choiński

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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