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Quality in Sport

Spironolactone as an alternative way of treating acne in women - review
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  • Spironolactone as an alternative way of treating acne in women - review
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Spironolactone as an alternative way of treating acne in women - review

Authors

  • Magdalena Gajkiewicz Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland https://orcid.org/0009-0000-0295-3591
  • Radosław Zaucha Edward Szczeklik Specialist Hospital in Tarnów, Poland https://orcid.org/0009-0001-6328-6443
  • Zuzanna Felińska Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland https://orcid.org/0009-0001-6717-5644
  • Tomasz Fura Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland https://orcid.org/0009-0008-0947-8058
  • Julia Silldorff Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland https://orcid.org/0009-0002-9223-2089
  • Marcin Dudek Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland https://orcid.org/0009-0003-6762-0124
  • Małgorzata Zając St Maximilian District Hospital in Oświęcim https://orcid.org/0009-0003-3870-2382
  • Oliwia Iszczuk District Complex of Health Care Facilities in Będzin https://orcid.org/0009-0002-0478-9582
  • Stanisław Anczyk Students’ Research Group of the Department of Dermatology, Medical University of Silesia https://orcid.org/0009-0006-8424-2147

DOI:

https://doi.org/10.12775/QS.2024.21.53881

Keywords

spironolactone, acne vulgaris, women

Abstract

Introduction and objective:

This paper provides an in-depth exploration of the pharmacology of spironolactone, elucidating its mechanisms of action and clinical implications beyond its conventional indications. Additionally, it examines the pathogenesis, clinical presentation, and current treatment strategies for acne vulgaris, contextualizing spironolactone's role in acne management.

Review methods:

Electronic searches were conducted between 15 and 26 April 2024 and included databases: Pubmed and Google Scholar. The following trials registers were searched using the search terms “spironolactone” AND “acne”. This review focuses on 3 trials that are limited to years 2020-2024.

Brief description of state of knowledge:

Acne vulgaris is a prevalent chronic inflammatory skin condition characterized by sebaceous gland hyperactivity, follicular hyperkeratinization, microbial colonization, and inflammation. Despite the availability of numerous treatment modalities, therapeutic success can be challenging, particularly in cases of hormonal or treatment-resistant acne. Spironolactone, initially developed as an aldosterone antagonist, has emerged as an off-label option for acne management, especially in individuals with hormonal influences on their condition.

Summary:

In light of conflicting recommendations regarding spironolactone's use in acne management, this review aims to provide a comprehensive synthesis of current evidence, guiding its judicious use in clinical practice. By bridging pharmacological insights with clinical data, this paper contributes to a deeper understanding of spironolactone's influence in the treatment landscape of acne vulgaris.

 

Author Biographies

Radosław Zaucha, Edward Szczeklik Specialist Hospital in Tarnów, Poland

Internal Medicine

Zuzanna Felińska, Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland

Internal Medicine

Tomasz Fura, Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland

Internal Medicine

Julia Silldorff, Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland

Internal Medicine

Marcin Dudek, Provincial Specialist Hospital No. 5, St. Barbara in Sosnowiec, Poland

Internal Medicine

Małgorzata Zając, St Maximilian District Hospital in Oświęcim

Internal Medicine

Oliwia Iszczuk, District Complex of Health Care Facilities in Będzin

Internal Medicine

Stanisław Anczyk, Students’ Research Group of the Department of Dermatology, Medical University of Silesia

Dermatology Department

References

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Kelidari HR, Saeedi M, Hajheydari Z, i wsp. Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. Colloids Surf B Biointerfaces. 2016;146:47-53. doi:10.1016/j.colsurfb.2016.05.042

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Published

2024-08-23

How to Cite

1.
GAJKIEWICZ, Magdalena, ZAUCHA, Radosław, FELIŃSKA, Zuzanna, FURA, Tomasz, SILLDORFF, Julia, DUDEK, Marcin, ZAJĄC, Małgorzata, ISZCZUK, Oliwia and ANCZYK, Stanisław. Spironolactone as an alternative way of treating acne in women - review. Quality in Sport. Online. 23 August 2024. Vol. 21, p. 53881. [Accessed 17 July 2025]. DOI 10.12775/QS.2024.21.53881.
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Issue

Vol. 21 (2024)

Section

Medical Sciences

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Copyright (c) 2024 Magdalena Gajkiewicz, Radosław Zaucha, Zuzanna Felińska, Tomasz Fura, Julia Silldorff, Marcin Dudek, Małgorzata Zając, Oliwia Iszczuk, Stanisław Anczyk

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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