Stem Cell Therapy for Hashimoto's Disease - a Promising Treatment Method?

Oliwia Kozyra; Oliwia Bochenek; Aleksandra Nowak; Jessica Kałuża; Adrian Konaszczuk; Klaudia Ratyna; Mateusz Koper; Zofia Szypuła; Katarzyna Paluch; Małgorzata Skarbek

doi:10.12775/QS.2024.21.53856

Authors

Oliwia Kozyra Prague hospital dedicated to the Transfiguration of the Lord Sp. z o. o., Aleja Solidarności 67, 03-401, Warsaw, Poland https://orcid.org/0009-0004-4882-3126
Oliwia Bochenek Grochowski Hospital, Grenadierów 51/59, 04-073 Warsaw, Poland https://orcid.org/0009-0005-1482-2544
Aleksandra Nowak Infant Jesus Clinical Hospital UCC MUW, Lindleya 4, 02-005 Warsaw, Poland https://orcid.org/0009-0009-6602-4017
Jessica Kałuża University Clinical Centre of the Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland https://orcid.org/0009-0002-5050-2538
Adrian Konaszczuk Standalone Public Health Care Facility in Świdnik ul. Leśmiana 4, 21-040 Świdnik Poland https://orcid.org/0009-0006-5775-5035
Klaudia Ratyna Infant Jesus Clinical Hospital UCC MUW, Lindleya 4, 02-005 Warsaw, Poland https://orcid.org/0009-0005-2235-1105
Mateusz Koper National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, Poland National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, Poland https://orcid.org/0000-0002-1048-2774
Zofia Szypuła Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0007-1671-5587
Katarzyna Paluch Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0004-2190-855X
Małgorzata Skarbek Provincial Hospital Center of the Jelenia Gora Valley, Oginskiego 6, 58-506 Jelenia Gora https://orcid.org/0000-0001-6227-4283

DOI:

https://doi.org/10.12775/QS.2024.21.53856

Keywords

stem cells, immune response, mesenchymal stem cells (MSC), MSC transplantation, hematopoietic stem cells (HSCs), immunomodulatory therapies, regenerative medicine, Hashimoto's disease

Abstract

Hashimoto's disease, an autoimmune disorder characterized by chronic inflammation and progressive destruction of the thyroid gland, leads to hypothyroidism and a range of metabolic disturbances. Conventional treatments primarily focus on hormone replacement therapy, which does not address the underlying autoimmune mechanisms. Stem cell therapy has emerged as a potential revolutionary treatment for Hashimoto's disease, aiming to regenerate thyroid tissue and modulate the immune response. This abstract explores the potential of stem cell therapy in restoring thyroid function and reducing autoimmune activity. Preclinical studies using animal models and in vitro human cell studies have demonstrated promising results, showing that stem cells can reduce thyroid inflammation, promote tissue regeneration, and restore hormone production. Early-phase clinical trials are underway to assess the safety and efficacy of mesenchymal stem cells (MSCs) and other stem cell types in patients with Hashimoto's disease. Despite the promise, challenges such as immune rejection, ethical considerations, regulatory hurdles, and cost must be addressed. Ongoing research and technological advancements hold the potential to transform the treatment landscape for Hashimoto's disease, offering hope for improved outcomes and quality of life for patients.

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Stem Cell Therapy for Hashimoto's Disease - a Promising Treatment Method?

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