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Quality in Sport

The Use of GLP-1 Receptor Agonists in the Treatment of Obesity in Women with PCOS
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The Use of GLP-1 Receptor Agonists in the Treatment of Obesity in Women with PCOS

Authors

  • Aleksandra Jaroń Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw, Poland https://orcid.org/0009-0003-7877-5308
  • Agata Wiklińska Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw, Poland https://orcid.org/0009-0008-8758-5860
  • Katarzyna Jastrzębska Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw, Poland https://orcid.org/0009-0006-0398-828X
  • Maria Witkowska Jerzy Popiełuszko Memorial Bielański Hospital, ul. Cegłowska 80, 01-809 Warsaw, Poland https://orcid.org/0009-0001-4019-938X
  • Joanna Skotnicka Jerzy Popiełuszko Memorial Bielański Hospital, ul. Cegłowska 80, 01-809 Warsaw, Poland https://orcid.org/0009-0008-7792-5817
  • Karolina Błaszczak Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Marcina Kasprzaka 17, 01-211 Warsaw, Poland https://orcid.org/0009-0000-1534-6977
  • Monika Turek Southern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw, Poland https://orcid.org/0009-0008-4034-3346
  • Klara Wojciechowska Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw https://orcid.org/0009-0006-3370-7864
  • Adrian Borkowski Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw, Poland https://orcid.org/0000-0002-8582-1873
  • Mateusz Sawicki Southern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw, Poland https://orcid.org/0009-0000-6272-5670

DOI:

https://doi.org/10.12775/QS.2024.20.53831

Keywords

Polycystic Ovary Syndrome, Obesity, Glucagon-Like Peptide-1 Receptor Agonists

Abstract

Introduction and aim of study: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting young women. It is diagnosed in individuals who meet 2 of the following 3 criteria: hyperandrogenism, ovarian dysfunction or polycystic ovarian morphology on ultrasound. A common component of this disease is obesity that leads to many serious health complications. This review paper aims to discuss the use of glucagon-like peptide-1 (GLP-1) receptor agonists as a therapeutic option to treat obesity in female patients with PCOS.

Materials and Methods: The authors conducted a comprehensive review of the literature available in databases: PubMed and Medline focusing on the terms “PCOS”, “GLP-1”, “obesity”.

Results: The first-line treatment of metabolic disorders in the course of PCOS is lifestyle modification. In patients who do not achieve sufficient results pharmacotherapy is recommended. Therapy with GLP-1 receptor agonists shows beneficial effects not only on weight loss, but also on metabolic and endocrine disorders. Studies have proven the superiority of these medications over metformin in the treatment of obesity associated with PCOS. However, the simultaneous use of GLP-1 receptor agonists and metformin may be beneficial for the patients.

Conclusions: GLP-1 receptor agonists appear to be a promising therapeutic option in obese women with PCOS according to safety profile and effectiveness proven in studies.

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2024-08-18

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JAROŃ, Aleksandra, WIKLIŃSKA, Agata, JASTRZĘBSKA, Katarzyna, WITKOWSKA, Maria, SKOTNICKA, Joanna, BŁASZCZAK, Karolina, TUREK, Monika, WOJCIECHOWSKA, Klara, BORKOWSKI, Adrian and SAWICKI, Mateusz. The Use of GLP-1 Receptor Agonists in the Treatment of Obesity in Women with PCOS. Quality in Sport. Online. 18 August 2024. Vol. 20, p. 53831. [Accessed 14 June 2025]. DOI 10.12775/QS.2024.20.53831.
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Copyright (c) 2024 Aleksandra Jaroń, Agata Wiklińska, Katarzyna Jastrzębska, Maria Witkowska, Joanna Skotnicka, Karolina Błaszczak, Monika Turek, Klara Wojciechowska, Adrian Borkowski, Mateusz Sawicki

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