Efficacy of novel drugs hypoxia inducible factor prolyl hydroxylase inhibitor in therapy of posttransplant anemia. A review
DOI:
https://doi.org/10.12775/QS.2024.21.53825Keywords
Prolyl hydroxylase inhibitor, Hypoxia inducible factor, Anemia, Kidney transplant, Chronic kidney diseaseAbstract
Introduction
The aim of our study was to evaluate the efficacy of novel drugs from the group of hypoxia-inducible factor prolyl hydroxylase inhibitors, using roxadustat as an example, in the treatment of anemia occurring in kidney recipients. In the study, we included data from recent original papers that examined the efficacy of these drugs in the treatment of post-transplant anemia. We assumed an absolute increase in hemoglobin concentration as a factor expressing the effectiveness of the therapy.
Aim of the study
The aim of our study was to evaluate the efficacy of novel drugs from the group of hypoxia-inducible factor prolyl hydroxylase inhibitors, using roxadustat as an example, in the treatment of anemia occurring in kidney recipients. In the study, we included data from recent original papers that examined the efficacy of these drugs in the treatment of post-transplant anemia. We assumed an absolute increase in hemoglobin concentration as a factor expressing the effectiveness of the therapy.
Materials and Methods
This review was conducted using publications available in databases such as PubMed, Google Scholar, Scopus and ScienceDirect. These databases were searched using keywords such as hypoxia-inducible factor prolyl hydroxylase inhibitor, roxadustat, anemia, kidney transplant, posttransplant anemia, chronic kidney disease. The time range of published articles was set to 2017-2024, and some older publications were included if they were considered to bring valuable background information necessary for understanding the issue. Articles written in English and Polish were sought; however, all publications used in this review were in English. The main reason of bias of this study may be the limited group of participants that may not be sufficiently representative, the lack of randomization in some studies, and the limited number of publications in the problem area.
References
World Health Organization Na. Report of a WHO scientific group. (WHO Technical Report Series, No 405: 1–40), Geneva, Switzerland. 1968.
Shah, N., Al-Khoury, S., Afzali, B., Covic, A., Roche, A., Marsh, J., Macdougall, I. C., & Goldsmith, D. J. (2006). Posttransplantation anemia in adult renal allograft recipients: prevalence and predictors. Transplantation, 81(8), 1112–1118. https://doi.org/10.1097/01.tp.0000205174.97275.b5
Gafter-Gvili, A., Ayalon-Dangur, I., Cooper, L., Shochat, T., Rahamimov, R., Gafter, U., ... & Grossman, A. (2017). Posttransplantation anemia in kidney transplant recipients: a retrospective cohort study. Medicine, 96(32), e7735.
Gafter-Gvili, A., & Gafter, U. (2019). Posttransplantation Anemia in Kidney Transplant Recipients. Acta haematologica, 142(1), 37–43. https://doi.org/10.1159/000496140
Zheng, S., Coyne, D. W., Joist, H., Schuessler, R., Godboldo-Brooks, A., Ercole, P., & Brennan, D. C. (2009). Iron deficiency anemia and iron losses after renal transplantation. Transplant international : official journal of the European Society for Organ Transplantation, 22(4), 434–440. https://doi.org/10.1111/j.1432-2277.2008.00814.x
Jimeno, L., Rodado, R., Campos, M., & Lanuza, M. (2005). Iron deficiency--an underrecognized problem in nonanemic and erythrocytic kidney transplant recipients: risks and effects of ACEI and of iron treatment. Transplantation proceedings, 37(2), 1007–1008. https://doi.org/10.1016/j.transproceed.2004.11.081
Lorenz, M., Kletzmayr, J., Perschl, A., Furrer, A., Hörl, W. H., & Sunder-Plassmann, G. (2002). Anemia and iron deficiencies among long-term renal transplant recipients. Journal of the American Society of Nephrology : JASN, 13(3), 794–797. https://doi.org/10.1681/ASN.V133794
Yorgin, P. D., Scandling, J. D., Belson, A., Sanchez, J., Alexander, S. R., & Andreoni, K. A. (2002). Late post-transplant anemia in adult renal transplant recipients. An under-recognized problem?. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2(5), 429–435. https://doi.org/10.1034/j.1600-6143.2002.20506.x
Turkowski-Duhem, A., Kamar, N., Cointault, O., Lavayssiere, L., Ribes, D., Esposito, L., Fillola, G., Durand, D., & Rostaing, L. (2005). Predictive factors of anemia within the first year post renal transplant. Transplantation, 80(7), 903–909. https://doi.org/10.1097/01.tp.0000173791.42893.08
Kouri, A., Balani, S., & Kizilbash, S. (2022). Anemia in Pediatric Kidney Transplant Recipients-Etiologies and Management. Frontiers in pediatrics, 10, 929504. https://doi.org/10.3389/fped.2022.929504
Santos, E. J. F., Dias, R. S. C., Lima, J. F. B., Salgado Filho, N., & Miranda Dos Santos, A. (2020). Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives. International journal of nephrology and renovascular disease, 13, 231–237. https://doi.org/10.2147/IJNRD.S239151
Santos, E. J. F., Dias, R. S. C., Lima, J. F. B., Salgado Filho, N., & Miranda Dos Santos, A. (2020). Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives. International journal of nephrology and renovascular disease, 13, 231–237. https://doi.org/10.2147/IJNRD.S239151
Santos, E. J. F., Dias, R. S. C., Lima, J. F. B., Salgado Filho, N., & Miranda Dos Santos, A. (2020). Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives. International journal of nephrology and renovascular disease, 13, 231–237. https://doi.org/10.2147/IJNRD.S239151
Disease KDIGOKcpgfAiCK. Notice. Kidney Int. 2012;2(4):279–335. https://doi.org/10.1038/kisup.2012.370085-2538
Li, Q. Y., Xiong, Q. W., Yao, X., Liu, F., Tang, X., Fu, H., Tong, T., Mao, J., & Peng, W. X. (2023). Roxadustat: Do we know all the answers?. Biomolecules & biomedicine, 23(3), 354–363. https://doi.org/10.17305/bb.2022.8437
Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991). Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America, 88(13), 5680–5684. https://doi.org/10.1073/pnas.88.13.5680
Fishbane, S., & Spinowitz, B. (2018). Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018. American journal of kidney diseases : the official journal of the National Kidney Foundation, 71(3), 423–435. https://doi.org/10.1053/j.ajkd.2017.09.026
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proceedings of the National Academy of Sciences of the United States of America, 92(12), 5510–5514. https://doi.org/10.1073/pnas.92.12.5510
Semenza G. L. (2001). HIF-1 and mechanisms of hypoxia sensing. Current opinion in cell biology, 13(2), 167–171. https://doi.org/10.1016/s0955-0674(00)00194-0
Haase V. H. (2013). Regulation of erythropoiesis by hypoxia-inducible factors. Blood reviews, 27(1), 41–53. https://doi.org/10.1016/j.blre.2012.12.003
Weiwei Kong, Xiaoying Wu, Zhuowei Shen, Meifang Wang, Xinyu Liu, Xiaoli Lin, Yingyin Qiu, Hong Jiang, Jianghua Chen, Yan Lou, Hongfeng Huang, The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study, Kidney International Reports, Volume 9, Issue 6, 2024, Pages 1705-1717, ISSN 2468-0249, https://doi.org/10.1016/j.ekir.2024.04.021.
Katsuyuki Miki, Yuki Nakamura, Takayoshi Yokoyama, Manabu Kamiyama, Yasuo Ishii, Therapeutic Effect of Roxadustat on Patients With Posttransplant Anemia, Transplantation Proceedings, Volume 54, Issue 3, 2022, Pages 671-677, ISSN 0041-1345, https://doi.org/10.1016/j.transproceed.2022.02.004.
Toshihide Naganuma, Tomoaki Iwai, Yoshiaki Takemoto, Junji Uchida, Experience With the Use of a Novel Agent, Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, for Posttransplant Anemia in Renal Transplant Recipients: A Case Report, Transplantation Proceedings, Volume 54, Issue 2, 2022, Pages 544-548, ISSN 0041-1345, https://doi.org/10.1016/j.transproceed.2021.10.022.
Yudai Ishiyama, Takafumi Yagisawa, Makiko Ichioka, Ayumu Hagiwara, Tomokazu Shimizu, Kazuya Omoto, Taiji Nozaki, Masashi Inui, Jun Ino, Kazuhiro Takeda, Hiroshi Toma, Shoichi Iida, Comparative Analysis of Real-World Efficacy and Safety of Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitors in Kidney Transplant Recipients Versus Nontransplant Individuals: A Single-Center Study, Transplantation Proceedings, 2024, ISSN 0041-1345, https://doi.org/10.1016/j.transproceed.2024.05.029.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Piotr Pawlowski, Julia Rybak, Paula Bieganek, Bartosz Sadłowski, Stanisław Łukaszewicz, Jakub Kordialik, Sandra Sarnacka, Julia Koćwin, Michał Tokarski, Angelika Tokarska
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 103
Number of citations: 0
