Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Quality in Sport

Chronic Fatigue Syndrome: Insights and Treatment Perspectives – a literature review
  • Home
  • /
  • Chronic Fatigue Syndrome: Insights and Treatment Perspectives – a literature review
  1. Home /
  2. Archives /
  3. Vol. 18 (2024) /
  4. Medical Sciences

Chronic Fatigue Syndrome: Insights and Treatment Perspectives – a literature review

Authors

  • Iga Ślesicka Medical University of Warsaw https://orcid.org/0000-0001-7282-4875
  • Magda Przestrzelska Faculty of Medicine Collegium Medicum Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie Wóycickiego 1/3, 01-938 Warszawa Poland https://orcid.org/0009-0009-8688-7047
  • Natalia Zozula District Medical Center in Grójec Piotra Skargi 10 street, 05-600 Grójec Poland https://orcid.org/0009-0009-9741-5061
  • Zuzanna Tomczewska Provincial Specialist Hospital named after Blessed Father Jerzy Popiełuszko in Włocławek, Wieniecka 49, 87-800 Włocławek Poland https://orcid.org/0000-0002-4327-3311
  • Aleksandra Rykucka Rear Admiral Professor Wiesław Łasiński 7th Military Navy Hospital with Outpatient Clinic named after in Gdańsk Polanki 117 street, 80-305 Gdańsk Poland https://orcid.org/0009-0003-0171-8647
  • Marcin Wąs District Medical Center in Grójec Piotra Skargi 10 street, 05-600 Grójec Poland https://orcid.org/0009-0004-8645-0121
  • Aleksandra Latała District Medical Center in Grójec Piotra Skargi 10 street, 05-600 Grójec Poland https://orcid.org/0009-0007-1701-2728
  • Justyna Kiełbasa Independent Public Healthcare Complex in Pruszków 2/4 Armii Krajowej Avenue, 05-800 Pruszków Poland https://orcid.org/0009-0002-0616-7402
  • Agata Kowalczyk Mazovian Specialized Hospital in Ostrołęka of Józef Psarski, Jana Pawła II 120A, 07-410 Ostrołęka Poland https://orcid.org/0009-0007-9497-0970
  • Katarzyna Bil Independent Public Specialist Western Hospital named after St John Paul II, Daleka 11, 05-825 Grodzisk Mazowiecki Poland https://orcid.org/0009-0003-6518-1711

DOI:

https://doi.org/10.12775/QS.2024.18.53589

Keywords

CFS, Neuroimmune Disorders, Chronić Fatigue Syndrome, Myalgic Encephalomyelitis, Malaise

Abstract

Introduction: Chronic Fatigue Syndrome (CFS) is an exhausting continuous medical condition. In most cases it affects patients after a flu-like infection. CFS correlates with alterations in the nervous and immune systems, metabolism, and hormone secretion. Diagnostic process is very challenging due to the absence of a definitive diagnostic test and wide symptomatology. It negatively impacts people's both mental and physical health.


Aim of the study: The aim of this literature review is to comprehensively examine current research findings and literature on Chronic Fatigue Syndrome (CFS), understand its etiology, how it affects the body, why it's challenging to diagnose, the various treatments available, new ideas and viewpoints in the field.

Describing the State of Knowledge: Despite extensive investigation, the exact etiology of CFS remains unknown. In literature CFS is also often described as Myalgic Encephalomyelitis. In the WHO's most recent classification, the ICD-11, both Chronic Fatigue Syndrome and Myalgic Encephalomyelitis are classified as “other disorders of the nervous system” which indicates the significance of the issue.


Conclusions: This literature review underlines the importance of a comprehensive and collaborative approach in addressing the complexities of CFS and improving outcomes for individuals living with this debilitating condition.

References

Bierl C, Nisenbaum R, Hoaglin DC, Randall B, Jones AB, Unger ER, Reeves WC. Regional distribution of fatiguing illnesses in the United States: a pilot study. Popul Health Metr. 2004 Feb 4;2(1):1. doi: 10.1186/1478-7954-2-1. PMID: 14761250; PMCID: PMC356930.

Reeves WC, Jones JF, Maloney E, Heim C, Hoaglin DC, Boneva RS, Morrissey M, Devlin R. Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia. Popul Health Metr. 2007 Jun 8;5:5. doi: 10.1186/1478-7954-5-5. PMID: 17559660; PMCID: PMC1904178.

Clauw DJ, Phadke S, Hoffman D. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from? Pharmacol Res. 2021 Mar;165:105465. doi: 10.1016/j.phrs.2021.105465. Epub 2021 Jan 30. PMID: 33529750.

Sukocheva OA, Maksoud R, Beeraka NM, Madhunapantula SV, Sinelnikov M, Nikolenko VN, Neganova ME, Klochkov SG, Amjad Kamal M, Staines DR, Marshall-Gradisnik S. Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome. J Adv Res. 2022 Sep;40:179-196. doi: 10.1016/j.jare.2021.11.013. Epub 2021 Nov 26. PMID: 36100326; PMCID: PMC8619886.

Lee JS, Sato W, Son CG. Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis. Autoimmun Rev. 2024 Feb;23(2):103484. doi: 10.1016/j.autrev.2023.103484. Epub 2023 Nov 26. PMID: 38016575.

Scheibenbogen C, Freitag H, Blanco J, Capelli E, Lacerda E, Authier J, Meeus M, Castro Marrero J, Nora-Krukle Z, Oltra E, Strand EB, Shikova E, Sekulic S, Murovska M. The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE. J Transl Med. 2017 Jul 26;15(1):162. doi: 10.1186/s12967-017-1263-z. PMID: 28747192; PMCID: PMC5530475.

Nijs J, Nees A, Paul L, De Kooning M, Ickmans K, Meeus M, et al. (2014). "Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review". Exercise Immunology Review. 20: 94–116. PMID 24974723.

Lee JS, Sato W, Son CG. Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis. Autoimmun Rev. 2024 Feb;23(2):103484. doi: 10.1016/j.autrev.2023.103484. Epub 2023 Nov 26. PMID: 38016575.

R.K. Naviaux, J.C. Naviaux, K. Li, A.T.Bright, W.A. Alaynick, L. Wang, A. Baxter, N. Nathan, W. Anderson, E. Gordon, Metabolic features of chronic fatigue syndrome, Proc Natl Acad Sci U S A, 113 (2016), pp. E5472-5480, PMCID:5027464

Turner-Stokes L, Wade DT. Updated NICE guidance on chronic fatigue syndrome. BMJ. 2020 Dec 16;371:m4774. doi: 10.1136/bmj.m4774. PMID: 33328173.

Brkić S, Tomić S, Ruzić M, Marić D. Chronic fatigue syndrome. Srp Arh Celok Lek. 2011 Mar-Apr;139(3-4):256-61. doi: 10.2298/sarh1104256b. PMID: 21618868.

Krupp LB, Mendelson WB, Friedman R. An overview of chronic fatigue syndrome. J Clin Psychiatry. 1991 Oct;52(10):403-10. PMID: 1938975.

Youssefi M, Linkowski P. Le syndrome de fatigue chronique: aspects psychiatriques [Chronic fatigue syndrome: psychiatric perspectives]. Rev Med Brux. 2002 Sep;23(4):A299-304. French. PMID: 12422451.

Bateman L, Bested AC, Bonilla HF, Chheda BV, Chu L, Curtin JM, et al. (November 2021). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management". Mayo Clinic Proceedings. 96 (11): 2861–2878. doi:10.1016/j.mayocp.2021.07.004. PMID 34454716

Kennedy G, Abbot NC, Spence V, Underwood C, Belch JJ. The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria. Ann Epidemiol. 2004 Feb;14(2):95-100. doi: 10.1016/j.annepidem.2003.10.004. PMID: 15018881.

Hlavaty LE, Brown MM, Jason LA. The effect of homework compliance on treatment outcomes for participants with myalgic encephalomyelitis/chronic fatigue syndrome. Rehabil Psychol. 2011 Aug;56(3):212-8. doi: 10.1037/a0024118. PMID: 21767035; PMCID: PMC3166212.

Smith ME, Haney E, McDonagh M, Pappas M, Daeges M, Wasson N, Fu R, Nelson HD. Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med. 2015 Jun 16;162(12):841-50. doi: 10.7326/M15-0114. PMID: 26075755.

Larun L, Brurberg KG, Odgaard-Jensen J, Price JR. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2017 Apr 25;4(4):CD003200. doi: 10.1002/14651858.CD003200.pub7. Update in: Cochrane Database Syst Rev. 2019 Oct 02;10:CD003200. PMID: 28444695; PMCID: PMC6419524.

Bjørklund G, Dadar M, Pen JJ, Chirumbolo S, Aaseth J. Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach. Biomed Pharmacother. 2019 Jan;109:1000-1007. doi: 10.1016/j.biopha.2018.10.076. Epub 2018 Nov 5. PMID: 30551349.

Vink M, Vink-Niese A. Cognitive behavioural therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective. Re-analysis of a Cochrane review. Health Psychol Open. 2019 May 2;6(1):2055102919840614. doi: 10.1177/2055102919840614. PMID: 31080632; PMCID: PMC6498783.

Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004 Mar-Apr;66(2):276-82. doi: 10.1097/01.psy.0000116249.60477.e9. PMID: 15039515.

Pheby DFH, Araja D, Berkis U, Brenna E, Cullinan J, de Korwin J-D, Gitto L, Hughes DA, Hunter RM, Trepel D, et al. The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE). Medicina. 2021; 57(4):388. https://doi.org/10.3390/medicina57040388

Crawley E, Collin SM, White PD, Rimes K, Sterne JA, May MT; CFS/ME National Outcomes Database. Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database. QJM. 2013 Jun;106(6):555-65. doi: 10.1093/qjmed/hct061. Epub 2013 Mar 28. Erratum in: QJM. 2013 Jun;106(6):567. Erratum in: QJM. 2023 Sep 12;116(8):731. PMID: 23538643; PMCID: PMC3665909.

Ross SD, Estok RP, Frame D, Stone LR, Ludensky V, Levine CB. Disability and chronic fatigue syndrome: a focus on function. Arch Intern Med. 2004 May 24;164(10):1098-107. doi: 10.1001/archinte.164.10.1098. PMID: 15159267.

Nacul LC, Lacerda EM, Pheby D, Campion P, Molokhia M, Fayyaz S, Leite JC, Poland F, Howe A, Drachler ML. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care. BMC Med. 2011 Jul 28;9:91. doi: 10.1186/1741-7015-9-91. PMID: 21794183; PMCID: PMC3170215.

Jason LA, Sunnquist M, Brown A, Evans M, Vernon SD, Furst J, Simonis V. Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis. Fatigue. 2014 Jan 1;2(1):40-56. doi: 10.1080/21641846.2013.862993. PMID: 24511456; PMCID: PMC3912876.

Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review. Diagnostics (Basel). 2019 Aug 7;9(3):91. doi: 10.3390/diagnostics9030091. PMID: 31394725; PMCID: PMC6787585.

Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jul 30;13(8):2658. doi: 10.3390/nu13082658. PMID: 34444817; PMCID: PMC8399248.

Twisk FN, Maes M. A review on cognitive behavorial therapy (CBT) and graded exercise therapy (GET) in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS): CBT/GET is not only ineffective and not evidence-based, but also potentially harmful for many patients with ME/CFS. Neuro Endocrinol Lett. 2009;30(3):284-99. PMID: 19855350.

Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004 Mar-Apr;66(2):276-82. doi: 10.1097/01.psy.0000116249.60477.e9. PMID: 15039515.

Prins JB, van der Meer JW, Bleijenberg G. Chronic fatigue syndrome. Lancet. 2006 Jan 28;367(9507):346-55. doi: 10.1016/S0140-6736(06)68073-2. PMID: 16443043.

Downloads

  • PDF

Published

2024-08-15

How to Cite

1.
ŚLESICKA, Iga, PRZESTRZELSKA, Magda, ZOZULA, Natalia, TOMCZEWSKA, Zuzanna, RYKUCKA, Aleksandra, WĄS, Marcin, LATAŁA, Aleksandra, KIEŁBASA, Justyna, KOWALCZYK, Agata and BIL, Katarzyna. Chronic Fatigue Syndrome: Insights and Treatment Perspectives – a literature review. Quality in Sport. Online. 15 August 2024. Vol. 18, p. 53589. [Accessed 16 May 2025]. DOI 10.12775/QS.2024.18.53589.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 18 (2024)

Section

Medical Sciences

License

Copyright (c) 2024 Iga Ślesicka, Magda Przestrzelska, Natalia Zozula, Zuzanna Tomczewska, Aleksandra Rykucka, Marcin Wąs, Aleksandra Latała, Justyna Kiełbasa, Agata Kowalczyk, Katarzyna Bil

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Stats

Number of views and downloads: 166
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

CFS, Neuroimmune Disorders, Chronić Fatigue Syndrome, Myalgic Encephalomyelitis, Malaise
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop