Irritable bowel syndrome: systematic review of origin, pathology, diagnosis and treatment
DOI:
https://doi.org/10.12775/QS.2024.20.53413Keywords
IBS, IRRITABLE BOWEL SYNDROME, IBS DIET, ROME CRITERIA, GUT-BRAIN AXIS, CAUSES OF IBS, low FODMAPAbstract
Irritable bowel syndrome is the most common problem of gastrointestinal practice worldwide. It contains group of symptoms that affect the gastrointestinal tract. People with IBS may experience abdominal pain, diarrhea, constipation, cramps.
It’s still being under discussion whether the irritable bowel is a pathological or a psychological syndrome. People report various symptoms, so they also consult doctors of different medical specializations. For the same reason doctors may have problems with accurate diagnosis of IBS.
As evidenced by recent studies, IBS is associated with psychological distress and impaired quality of life. It’s also important from economical and medical care system point of view - they utilize the health care system to a greater degree than patients without this diagnosis.
The aim of this review is to provide a comprehensive evidence-based review of the diagnosis, pathogenesis and treatment to guide clinicians diagnosing and treating their patients.
References
Maxwell PR, Mendall MA, Kumar D. Irritable bowel syndrome. Lancet. 1997;350(9092):1691-1695. doi:10.1016/s0140-6736(97)05276-8
http://www.jupiterpharma.in/journalpdf/IBS%20WORLD%20GASTRO.pdf. Accessed July 2, 2024. http://www.jupiterpharma.in/journalpdf/IBS%20WORLD%20GASTRO.pdf
Drossman DA. The functional gastrointestinal disorders and the Rome II process. Gut. 1999;45 Suppl 2:II1-5. doi:10.1136/gut.45.2008.ii1
Holten KB, Wetherington A, Bankston L. Diagnosing the patient with abdominal pain and altered bowel habits: is it irritable bowel syndrome? Am Fam Physician. 2003;67(10):2157-2162.
Talley NJ, Spiller R. Irritable bowel syndrome: a little understood organic bowel disease? Lancet. 2002;360(9332):555-564. doi:10.1016/S0140-6736(02)09712-X
Saito YA, Petersen GM, Locke GR, Talley NJ. The genetics of irritable bowel syndrome. Clin Gastroenterol Hepatol. 2005;3(11):1057-1065. doi:10.1016/s1542-3565(05)00184-9
Matricon J, Meleine M, Gelot A, et al. Review article: Associations between immune activation, intestinal permeability and the irritable bowel syndrome. Aliment Pharmacol Ther. 2012;36(11-12):1009-1031. doi:10.1111/apt.12080
Belmonte L, Beutheu Youmba S, Bertiaux-Vandaële N, et al. Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype. PLoS ONE. 2012;7(8):e42777. doi:10.1371/journal.pone.0042777
Spiller RC. Effects of serotonin on intestinal secretion and motility. Curr Opin Gastroenterol. 2001;17(2):99-103. doi:10.1097/00001574-200103000-00001
De Ponti F. Pharmacology of serotonin: what a clinician should know. Gut. 2004;53(10):1520-1535. doi:10.1136/gut.2003.035568
Derbyshire SWG. A systematic review of neuroimaging data during visceral stimulation. Am J Gastroenterol. 2003;98(1):12-20. doi:10.1111/j.1572-0241.2003.07168.x
Tack J, Broekaert D, Fischler B, Van Oudenhove L, Gevers AM, Janssens J. A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome. Gut. 2006;55(8):1095-1103. doi:10.1136/gut.2005.077503
Mayer EA, Bradesi S. Alosetron and irritable bowel syndrome. Expert Opin Pharmacother. 2003;4(11):2089-2098. doi:10.1517/14656566.4.11.2089
Spiegel BMR. Questioning the bacterial overgrowth hypothesis of irritable bowel syndrome: an epidemiologic and evolutionary perspective. Clin Gastroenterol Hepatol. 2011;9(6):461-469; quiz e59. doi:10.1016/j.cgh.2011.02.030
Koloski NA, Talley NJ, Boyce PM. A history of abuse in community subjects with irritable bowel syndrome and functional dyspepsia: the role of other psychosocial variables. Digestion. 2005;72(2-3):86-96. doi:10.1159/000087722
Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology. 2002;123(6):2108-2131. doi:10.1053/gast.2002.37095
Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47(6):861-869. doi:10.1136/gut.47.6.861
Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology. 1994;107(1):271-293. doi:10.1016/0016-5085(94)90086-8
Mayer EA, Naliboff BD, Craig ADB. Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders. Gastroenterology. 2006;131(6):1925-1942. doi:10.1053/j.gastro.2006.10.026
Mayer EA, Berman S, Suyenobu B, et al. Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis. Pain. 2005;115(3):398-409. doi:10.1016/j.pain.2005.03.023
Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut. 2005;54(5):601-607. doi:10.1136/gut.2004.047423
Adriani A, Ribaldone DG, Astegiano M, Durazzo M, Saracco GM, Pellicano R. Irritable bowel syndrome: the clinical approach. Panminerva Med. 2018;60(4):213-222. doi:10.23736/S0031-0808.18.03541-3
Defrees DN, Bailey J. Irritable bowel syndrome: epidemiology, pathophysiology, diagnosis, and treatment. Prim Care. 2017;44(4):655-671. doi:10.1016/j.pop.2017.07.009
Garrigues V, Mearin F, Badía X, et al. Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study). Aliment Pharmacol Ther. 2007;25(3):323-332. doi:10.1111/j.1365-2036.2006.03197.x
Sayuk GS, North CS, Pollio DE, Gott BM, Alpers DH. Episodic memories among irritable bowel syndrome (IBS) patients: an important aspect of the IBS symptom experience. Front Pain Res (Lausanne). 2022;3:892313. doi:10.3389/fpain.2022.892313
Ford AC, Talley NJ, Veldhuyzen van Zanten SJO, Vakil NB, Simel DL, Moayyedi P. Will the history and physical examination help establish that irritable bowel syndrome is causing this patient’s lower gastrointestinal tract symptoms? JAMA. 2008;300(15):1793-1805. doi:10.1001/jama.300.15.1793
Ford AC, Sperber AD, Corsetti M, Camilleri M. Irritable bowel syndrome. Lancet. 2020;396(10263):1675-1688. doi:10.1016/S0140-6736(20)31548-8
Bonetto S, Fagoonee S, Battaglia E, Grassini M, Saracco GM, Pellicano R. Recent advances in the treatment of irritable bowel syndrome. Pol Arch Intern Med. 2021;131(7-8):709-715. doi:10.20452/pamw.16067
Menees SB, Powell C, Kurlander J, Goel A, Chey WD. A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS. Am J Gastroenterol. 2015;110(3):444-454. doi:10.1038/ajg.2015.6
Schmulson MJ, Drossman DA. What is new in rome IV. J Neurogastroenterol Motil. 2017;23(2):151-163. doi:10.5056/jnm16214
Irvine AJ, Chey WD, Ford AC. Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis. Am J Gastroenterol. 2017;112(1):65-76. doi:10.1038/ajg.2016.466
Ford AC, Lacy BE, Talley NJ. Irritable Bowel Syndrome. N Engl J Med. 2017;376(26):2566-2578. doi:10.1056/NEJMra1607547
van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. BMJ. 2010;341:c3369. doi:10.1136/bmj.c3369
Camilleri M. Management options for irritable bowel syndrome. Mayo Clin Proc. 2018;93(12):1858-1872. doi:10.1016/j.mayocp.2018.04.032
Galica AN, Galica R, Dumitrașcu DL. Diet, fibers, and probiotics for irritable bowel syndrome. J Med Life. 2022;15(2):174-179. doi:10.25122/jml-2022-0028
Pessarelli T, Sorge A, Elli L, Costantino A. The low-FODMAP diet and the gluten-free diet in the management of functional abdominal bloating and distension. Front Nutr. 2022;9:1007716. doi:10.3389/fnut.2022.1007716
Simon E, Călinoiu LF, Mitrea L, Vodnar DC. Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome. Nutrients. 2021;13(6). doi:10.3390/nu13062112
Dale HF, Rasmussen SH, Asiller ÖÖ, Lied GA. Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Nutrients. 2019;11(9). doi:10.3390/nu11092048
Ford AC, Lacy BE, Harris LA, Quigley EMM, Moayyedi P. Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis. Am J Gastroenterol. 2019;114(1):21-39. doi:10.1038/s41395-018-0222-5
Black CJ, Thakur ER, Houghton LA, Quigley EMM, Moayyedi P, Ford AC. Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis. Gut. 2020;69(8):1441-1451. doi:10.1136/gutjnl-2020-321191
Vasant DH, Paine PA, Black CJ, et al. British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut. 2021;70(7):1214-1240. doi:10.1136/gutjnl-2021-324598
Savarino E, Zingone F, Barberio B, et al. Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. United European Gastroenterol J. 2022;10(6):556-584. doi:10.1002/ueg2.12259
Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther. 2022;56(6):932-941. doi:10.1111/apt.17179
Chen L, Ilham SJ, Feng B. Pharmacological approach for managing pain in irritable bowel syndrome: A review article. Anesth Pain Med. 2017;7(2):e42747. doi:10.5812/aapm.42747
Kułak-Bejda A, Bejda G, Waszkiewicz N. Antidepressants for irritable bowel syndrome-A systematic review. Pharmacol Rep. 2017;69(6):1366-1379. doi:10.1016/j.pharep.2017.05.014
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Kacper Kwiliński, Roksana Zdunek, Karolina Strus, Magdalena Madera, Adrian Kruszewski, Anna Dąbrowska, Natalia Paduszyńska, Barbara Wawrzyńska
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 239
Number of citations: 0
