Apple Cider Vinegar in the Combat Against Type 2 Diabetes and Obesity – An Overview of Recent Research
DOI:
https://doi.org/10.12775/QS.2024.20.53303Keywords
diabetes, glucose, obesity, apple cider vinegarAbstract
ABSTRACT
Introduction
Apple Cider Vinegar, primarily composed of acetic acid, is gaining more recognition for its possible health advantages, especially its anti-diabetic effects and its beneficial impact on weight loss.
Aim of this study
The aim of this review is to discuss the current state of knowledge regarding the influence of ACV on glycemic indices and weight management in diabetic and obese patients, explore the possibilities of preventing comorbidities, and assess the safety of ACV consumption.
Materials and Methods
Research was performed based on Pubmed and Google Scholar databases. The literature was reviewed using the keywords : Apple Cider Vinegar, Diabetes, Glucose, Obesity.
Results
Studies have confirmed that apple cider vinegar exhibits significant anti-obesity and anti-diabetic properties. It demonstrates dose- and time-dependent effects on reducing fasting glucose, postprandial glucose, glycated hemoglobin, and lipid parameters. It positively impacts weight loss, reducing waist and hip circumference, and enhances tissue sensitivity to insulin. Additionally, apple cider vinegar has been shown to potentiate the effects of metformin, with liquid consumption yielding better results than pill form.
Conclusions
Although initial findings are encouraging, additional research with a larger participant pool and an extended duration of vinegar consumption is necessary. The brevity of the study period restricts the observation of long-term effects, and a larger sample size would improve the applicability of the findings.
Key words: apple cider vinegar; diabetes; glucose; obesity
References
Lin, X., Xu, Y., Pan, X. et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):14790. https://doi.org/10.1038/s41598-020-71908-9
Sofia Kausar, Muhammad Arshad Abbas, Hajra Ahmad, Nazia Yousef, Zaheer Ahmed, Naheed Humayun, Hira Ashfaq, Ayesha Humayun. Effect of Apple Cider Vinegar in Type 2 Diabetic Patients with Poor Glycemic Control: A Randomized Placebo Controlled Design®. International Journal of Medical Research & Health Sciences, 2019, 8(2): 149-159.
Sima Jafarirad, Mohammad-Reza Elahi, Anahita Mansoori, Abdollah Khanzadeh, Mohammad-Hossein Haghighizadeh. The improvement effect of apple cider vinegar as a functional food on anthropometric indices, blood glucose and lipid profile in diabetic patients: a randomized controlled clinical trial. Front Clin Diabetes Healthc.2023;4: 1288786. https://doi.org/10.3389/fcdhc.2023.1288786
Sofia Kausar, Ayesha Humayun, Zaheer Ahmed, Muhammad Arshad Abbas, Aroosha Tahir. Effect of Apple Cider Vinegar on Glycemic Control, Hyperlipidemia and Control on Body Weight in Type 2 Diabetes Patients. International Journal of Medical Research & Health Sciences. 2019,8(5): 59-74.
Chandrasekaran P., Weiskirchen R. The Role of Obesity in Type 2 Diabetes Mellitus—An Overview. Int. J. Mol. Sci. 2024;25(3):1882. doi:10.3390/ijms25031882
Harreiter J, Roden M. Diabetes mellitus – definition, classification, diagnosis, screening and prevention (update 2023). Wien, Klin Wochenschr. 2023;135(1):7-17. https://doi.org/10.1007/s00508-022-02122-y. German.
Saad Masood Butt. Management and Treatment of Type 2 Diabetes. International Journal of Computations, Information and Manufacturing (IJCIM).2022;2(1). https://doi.org/10.54489/ijcim.v2i1.71
8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes–2024. 2024. Diabetes Care 47 (January). American Diabetes Association Inc.: S145–57. https://doi.org/10.2337/dc24-S008
Eleni I Petsiou, Panayota I Mitrou, Sotirios A Raptis, George D Dimitriadis. Effect and mechanisms of action of vinegar on glucose metabolism, lipid profile, and body weight. Nutrition Reviews. 2014;72(10):651–661. https://doi.org/10.1111/nure.12125
Budak N, Aykin E, Seydim A, Greene A, Guzel-Seydim Z. Functional properties of vinegar. Journal of Food Science. 2014;79(5):757-764. https://doi.org/10.1111/1750-3841.12434
Tripathi S. Health Benefits and Modern Applications of Apple Cider Vinegar: A Four-Decade Review of the Scientific Literature (Review Article on Bibliometric Investigation of Apple Cider Vinegar). BJMHS. 2023;5(8):1-10.
Ousaaid D, Mechchate H, Laaroussi H, Hano C, Bakour M, El Ghouizi A, et al. Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality. Molecules. 2022;27(1);222. https://doi.org/10.3390/molecules27010222
Sirotkin A. Could apple cider vinegar be used for health improvement and weight loss?. New Insights in Obesity: Genetics and Beyond. 2021;5(1):14-16. https://doi.org/10.29328/journal.niogb.1001016
Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized controlled clinical trial. Clin Nutr ESPEN. 2019;33:132-138. https://doi.org/10.1016/j.clnesp.2019.06.006
Kumar, S., Sharma, S. K., Mudgal, S. K., Gaur, R., Agarwal, R., et al. Comparative effectiveness of six herbs in the management of glycemic status of type 2 diabetes mellitus patients: A systematic review and network meta-analysis of randomized controlled trials. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. Elsevier Ltd. 2023. https://doi.org/10.1016/j.dsx.2023.102826
Momina Abid, Farah Ahmed, Shehla Shaheen, Zahida Memon, M. Zaman Shaikh, Faiza Agha. Evaluating the Synergistic Activity of Metformin and Apple Cider Vinegar in Type 2 Diabetics. Journal of Pharmaceutical Research International. 2019;31:1-7. https://doi.org/10.9734/jpri/2019/v31i630376
Abid M., Memon Z., Shaheen S., Ahmed F., Shaikh M.Z., Agha F. Comparison of Apple Cider Vinegar and Metformin Combination with Metformin Alone in Newly Diagnosed Type 2 Diabetic Patients: A Randomized Controlled Trial. Int J Med Res Health Sci. 2020;9(2):1-7.
Khezri S., Saidpour A., Hosseinzadeh N., Amiri Z. Beneficial effects of Apple Cider Vinegar on weight management, Visceral Adiposity Index and lipid profile in overweight or obese subjects receiving restricted calorie diet: A randomized clinical trial. Journal of Functional Foods. 2018;43:95-102. https://doi.org/10.1016/j.jff.2018.02.003
Abou-Khalil R., Andary J., Hayek E. Apple cider vinegar for weight management in Lebanese adolescents and young adults with overweight and obesity: a randomised, double-blind, placebo-controlled study. BJM Nutrition, Prevention & Health. 2024. https://doi.org/10.1136/bmjnph-2023-000823
Khalid A., Khalid A.S., Ashiq E., Ahtisham. Effect of the Apple Cider Vinegar on Weight Management, Blood Glucose Levels and Lipid Profile among Obese/Overweight Adults: A Randomised Control Trial. PJMHS. 2022;16(7). DOI: https://doi.org/10.53350/pjmhs22167286
Blessy Pusparatha S, Gayatri Devi R, Jyothipriya A. Effects of apple cider vinegar on diabetic and obese patients. Drug Invention Today. 2019;12(5):968–970.
Ousaaid D., Laaroussi H., Bakour M., Elghouizi A., Aboulghazi A., Badiaa L., et al. Beneficial Effects of Apple Vinegar on Hyperglycemia and Hyperlipidemia in Hypercaloric-Fed Rats. Journal of Diabetes Research. 2020;(3):7. https://doi.org/10.1155/2020/9284987
Hmad Halima B, Sarra K, Jemaa Houda B, Sonia G, Abdallah A. Antidiabetic and Antioxidant Effects of Apple Cider Vinegar on Normal and Streptozotocin-Induced Diabetic Rats. Int J Vitam Nutr Res. 2018;88(5-6):223-233. https://doi.org/10.1024/0300-9831/a000246
Bukhari H, Zahran S, Bakr E, Sahibzadah F, Header E. Comparison study between drugs (Orlistat and chitocal) and food supplements (green tea and apple cider vinegar) for weight loss and hepatoprotection in rats. Egyptian Journal of Hospital Medicine. 2021;83(1): 1218–1223. https://doi.org/10.21608/EJHM.2021.165165
Halima B, Sonia G, Sarra K, Houda B, Fethi B, Abdallah A. Apple Cider Vinegar Attenuates Oxidative Stress and Reduces the Risk of Obesity in High-Fat-Fed Male Wistar Rats. Journal of Medicinal Food. 2018;21(1),70–80. https://doi.org/10.1089/jmf.2017.0039
Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther. 2021;21(1):179. https://doi.org/10.1186/s12906-021-03351-w
Martini N. Apple cider vinegar. Potion or Poison?. J Prim Health Care. 2021;13(2):191-192. https://doi.org/10.1071/HC19561
Heitor O. Santos, Wilson Max Moraes, Guilherme A.R. da Silva, Jonato Prestes, Brad J Schoenfeld. Vinegar (acetic acid) intake on glucose metabolism: A narrative review. Clinical Nutrition ESPEN 32. 2019;32:1-7. https://doi.org/10.1016/j.clnesp.2019.05.008
Johnston C, Feise N. A comparison of liquid vinegar and commercial vinegar pills for managing insulin resistance and postprandial glucose concentrations. The FASEB Journal.2018;32(S1):925.10-925.10.https://doi.org/10.1096/fasebj.2018.32.1_supplement.925.10
Feise N, Johnston C. Commercial Vinegar Tablets Do Not Display the Same Physiological Benefits for Managing Postprandial Glucose Concentrations as Liquid Vinegar. Journal of Nutrition and Metabolism. 2020;2020(4):1-5. https://doi.org/10.1155/2020/9098739
Hmad Halima B, Sarra K, Abdallah, A, Mohamed S, Louay T, Fethi B, et al. Apple cider vinegar ameliorates hyperglycemia and hyperlipidemia in Tunisian type 2 diabetic patients. International Journal of Multidisciplinary and Current Research. 2017;5.
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