Asthma - a healthcare, environment and green transformation - associated disease
DOI:
https://doi.org/10.12775/QS.2024.18.53276Keywords
air pollution, asthmaAbstract
Air pollution both anthropogenic and from natural sources impacts human health and is a rising problem for healthcare around the world. Key pollutants, such as particulate matter, carbon monoxide, ozone, nitrogen dioxide, and sulphur dioxide, contribute especially to respiratory illnesses. This review examines recent studies in the field of asthma and air pollution correlation, particularly mechanisms of air pollution-related damage, asthma symptoms exacerbations and the risk of developing the disease due to poor air quality. Studies show that pollutants affect the immune system by triggering pro-inflammatory responses and oxidative stress, particularly in individuals with asthma. The review present findings of exacerbation of asthma symptoms and increased frequency of asthma attacks along with higher rates of hospital admissions and emergency room visits due to exposure to common air pollutants. Additionally, prenatal and early-life exposure to traffic-related air pollution proved to significantly increase the risk of developing asthma in children. The review also critically identifies data gaps and methodological inconsistencies in some investigations. The complex relationship between air pollution and asthma is for sure an interesting field to explore furtherly. Analysed materials emphasize the critical need for global measures to reduce air pollution, including stricter air quality regulations and public awareness initiatives.
References
A. I. Tiotiu et al., “Impact of Air Pollution on Asthma Outcomes,” IJERPH, vol. 17, no. 17, Art. no. 17, Aug. 2020, doi: 10.3390/ijerph17176212.
I. Annesi-Maesano and F. Forastiere, “Doubts about the adverse effects of air pollution on asthma?,” Eur Respir J, vol. 54, no. 4, Art. no. 4, Oct. 2019, doi: 10.1183/13993003.01900-2019.
H. Boogaard et al., “Long-term exposure to traffic-related air pollution and selected health outcomes: A systematic review and meta-analysis,” Environment International, vol. 164, p. 107262, Jun. 2022, doi: 10.1016/j.envint.2022.107262.
“Household air pollution.” Accessed: Jun. 19, 2024. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/household-air-pollution-and-health
I. Eguiluz‐Gracia et al., “The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma,” Allergy, vol. 75, no. 9, Art. no. 9, Sep. 2020, doi: 10.1111/all.14177.
“Ambient (outdoor) air pollution.” Accessed: Jun. 19, 2024. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health
J. Bi et al., “Acute Effects of Ambient Air Pollution on Asthma Emergency Department Visits in Ten U.S. States,” Environ Health Perspect, vol. 131, no. 4, Art. no. 4, Apr. 2023, doi: 10.1289/EHP11661.
WHO global air quality guidelines: particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. Bonn, Germany: WHO European Centre for Environment and Health, 2021.
P. I. Beamer, “Air Pollution Contributes to Asthma Deaths,” Am J Respir Crit Care Med, vol. 200, no. 1, Art. no. 1, Jul. 2019, doi: 10.1164/rccm.201903-0579ED.
H. Khreis et al., “Outdoor air pollution and the burden of childhood asthma across Europe,” Eur Respir J, vol. 54, no. 4, Art. no. 4, Oct. 2019, doi: 10.1183/13993003.02194-2018.
I. Annesi-Maesano, C. N. Maesano, B. Biagioni, G. D’Amato, and L. Cecchi, “Call to action: Air pollution, asthma, and allergy in the exposome era,” Journal of Allergy and Clinical Immunology, vol. 148, no. 1, Art. no. 1, Jul. 2021, doi: 10.1016/j.jaci.2021.05.026.
D. A. Glencross, T.-R. Ho, N. Camiña, C. M. Hawrylowicz, and P. E. Pfeffer, “Air pollution and its effects on the immune system,” Free Radical Biology and Medicine, vol. 151, pp. 56–68, May 2020, doi: 10.1016/j.freeradbiomed.2020.01.179.
Serafini MM, Maddalon A, Iulini M, Galbiati V., “Air Pollution: Possible Interaction between the Immune and Nervous System?,” Int J Environ Res Public Health, vol. 2022 Nov 30, p. 16037, doi: 10.3390/ijerph192316037.
M. Aghapour et al., “Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD,” Eur Respir Rev, vol. 31, no. 163, p. 210112, Mar. 2022, doi: 10.1183/16000617.0112-2021.
M. Guarnieri and J. R. Balmes, “Outdoor air pollution and asthma,” Lancet, vol. 383, no. 9928, pp. 1581–1592, May 2014, doi: 10.1016/S0140-6736(14)60617-6.
M. Schatz and L. Rosenwasser, “The Allergic Asthma Phenotype,” The Journal of Allergy and Clinical Immunology: In Practice, vol. 2, no. 6, pp. 645–648, Nov. 2014, doi: 10.1016/j.jaip.2014.09.004.
E. Melen et al., “Air pollution and IgE sensitization in 4 European birth cohorts-the MeDALL project,” Journal of Allergy and Clinical Immunology, vol. 147, no. 2, pp. 713–722, Feb. 2021, doi: 10.1016/j.jaci.2020.08.030.
L. Li, C. Chang, and K. Guan, “Birch Pollen Allergens,” Current Protein & Peptide Science, vol. 23, no. 11, pp. 731–743, doi: 10.2174/1389203723666220815095725.
“Effect of air pollution on the human immune system - PMC.” Accessed: Jun. 19, 2024. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714391/
P. Orellano, N. Quaranta, J. Reynoso, B. Balbi, and J. Vasquez, “Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis,” PLoS ONE, vol. 12, no. 3, Art. no. 3, Mar. 2017, doi: 10.1371/journal.pone.0174050.
N. J. Nassikas, K. Spangler, and G. A. Wellenius, “Asthma Exacerbations Attributable to Ozone Air Pollution in New England,” R I Med J (2013), vol. 104, no. 9, Art. no. 9, Nov. 2021.
Z. Hehua, C. Qing, G. Shanyan, W. Qijun, and Z. Yuhong, “The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review,” Environmental Research, vol. 159, pp. 519–530, Nov. 2017, doi: 10.1016/j.envres.2017.08.038.
K. Han et al., “Traffic-related organic and inorganic air pollution and risk of development of childhood asthma: A meta-analysis,” Environmental Research, vol. 194, p. 110493, Mar. 2021, doi: 10.1016/j.envres.2020.110493.
H. Khreis, C. Kelly, J. Tate, R. Parslow, K. Lucas, and M. Nieuwenhuijsen, “Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis,” Environment International, vol. 100, pp. 1–31, Mar. 2017, doi: 10.1016/j.envint.2016.11.012.
U. Gehring, A. H. Wijga, G. H. Koppelman, J. M. Vonk, H. A. Smit, and B. Brunekreef, “Air pollution and the development of asthma from birth until young adulthood,” Eur Respir J, vol. 56, no. 1, Art. no. 1, Jul. 2020, doi: 10.1183/13993003.00147-2020.
C. Lu et al., “Interaction effect of prenatal and postnatal exposure to ambient air pollution and temperature on childhood asthma,” Environment International, vol. 167, p. 107456, Sep. 2022, doi: 10.1016/j.envint.2022.107456.
M. Pedersen et al., “Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark,” Environ Health Perspect, vol. 131, no. 5, Art. no. 5, May 2023, doi: 10.1289/EHP11539.
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Copyright (c) 2024 Sylwia Mazur, Natalia Dąbrowska, Magdalena Madera, Roksana Zdunek, Krzysztof Marcinkowski, Karolina Strus, Aleksandra Kublińska, Emilia Nagórska
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