The Impact of Diet on Male Fertility
DOI:
https://doi.org/10.12775/QS.2024.17.53057Keywords
male fertility, diet and semen parameters, diet and male fertility, impact of diet on semen quality, types of diets and fertilityAbstract
Introduction:
Infertility is a reproductive health issue where the inability to conceive after 12 months of regular unprotected intercourse affects about 8 to 12% of couples of reproductive age. Factors such as diet, lifestyle, and exposure to toxins can negatively impact men's reproductive capacity, including semen parameters and gonadal function. The impact of diet on male fertility, including hormone levels and the process of spermatogenesis, is the subject of intense research.
Aim of the Study:
This study aims to review current scientific research on the impact of diet on male fertility to provide updated knowledge on this topic, essential for preventive and therapeutic actions in this field.
Materials and Methods:
A comprehensive review of scientific and medical literature was conducted using PubMed and Google Scholar databases. The search terms included: impact of diet on male fertility, impact of diet on semen parameters, impact of diet on semen quality, male fertility, diet and male fertility, types of diets and fertility.
Conclusion:
Diet plays a crucial role in male fertility, affecting semen quality. It is recommended to consume meat in moderation, especially organic, and to increase the intake of fish rich in omega-3 while avoiding contaminants. Regular consumption of fruits, vegetables, and grains improves semen parameters, while limiting sweets, sugary drinks, and alcohol, as well as quitting smoking, is beneficial for reproductive health. Men planning fatherhood should also consider reducing cannabis use. Future research should focus on the impact of individual dietary factors on male fertility.
References
Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018 Dec;62:2-10. doi: 10.1016/j.clinbiochem.2018.03.012. Epub 2018 Mar 16. PMID: 29555319
Giulia Pecora, Francesca Sciarra, Elena Gangitano, and Mary Anna Venneri How Food Choices Impact on Male Fertility Curr Nutr Rep. 2023; 12(4): 864–876. Published online 2023 Oct 20. doi: 10.1007/s13668-023-00503-x PMCID: PMC10766669PMID: 37861951
Albert Salas-Huetos, Mònica Bulló, Jordi Salas-Salvadó, Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies, Human Reproduction Update, Volume 23, Issue 4, July-August 2017, Pages 371–389
Davit Pipoyan, Stella Stepanyan, Seda Stepanyan, Meline Beglaryan, Lara Costantini, Romina Molinari, and Nicolò Merendino, The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns, Foods. 2021 Oct; 10(10): 2452. Published online 2021 Oct 14. doi: 10.3390/foods10102452 PMCID: PMC8535577PMID: 34681504
Jill A. Attaman, Thomas L. Toth, Jeremy Furtado, Hannia Campos, Russ Hauser and Jorge. E. Chavarro, Dietary fat and semen quality among men attending a fertility clinic Hum Reprod. 2012 May; 27(5): 1466–1474. Published online 2012 Mar 13. doi: 10.1093/humrep/des065 PMCID: PMC3329193PMID: 22416013
Myriam C. Afeiche, Audrey J. Gaskins, Paige L. Williams, Thomas L. Toth, Diane L. Wright, Cigdem Tanrikut, Russ Hauser, and Jorge E. Chavarro, Processed Meat Intake Is Unfavorably and Fish Intake Favorably Associated with Semen Quality Indicators among Men Attending a Fertility Clinic J Nutr. 2014 Jul; 144(7): 1091–1098. Published online 2014 May 21. doi: 10.3945/jn.113.190173 PMCID: PMC4056648PMID: 24850626
Carolina Veaute , María Florencia Andreoli, Andrea Racca, Alejandra Bailat, María Victoria Scalerandi, Claudio Bernal, Ileana Malan Borel Effects of isomeric fatty acids on reproductive parameters in mice, 2007 Dec;58(6):487-96. doi: 10.1111/j.1600-0897.2007.00530.x., PMID: 17997747
V Esmaeili, A H Shahverdi, A R Alizadeh, H Alipour, M Chehrazi, Saturated, omega-6 and omega-3 dietary fatty acid effects on the characteristics of fresh, frozen-thawed semen and blood parameters in rams, 2014 Feb;46(1):42-49. doi: 10.1111/and.12040. Epub 2012 Nov 16, PMID: 23157190 DOI: 10.1111/and.12040
Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi MR, Baghestani AR, Hekmatdoost A. Dietary fatty acid intakes and asthenozoospermia: A casecontrol study. Fertil Steril 2015;103:190–198.
Lijun Ye, Wensi Huang, Su Liu, Songchen Cai, Ling Hong, Weiqiang Xiao, Kristin Thiele, Yong Zeng, Mingzhe Song, Lianghui Diao, Saturated, omega-6 and omega-3 dietary fatty acid effects on the characteristics of fresh, frozen-thawed semen and blood parameters in rams, 2014 Feb;46(1):42-49. doi: 10.1111/and.12040. Epub 2012 Nov 16, PMID: 23157190 DOI: 10.1111/and.12040
Swan SH, Liu F, Overstreet JW, Brazil C, Skakkebaek NE. Semen quality of fertile US males in relation to their mothers’ beef consumption during pregnancy. Hum Reprod 2007;22:1497–1502
Rozati R, Reddy PP, Reddanna P, Mujtaba R. Role of environmental estrogens in the deterioration of male factor fertility. Fertil Steril 2002;78:1187–1194.
A Lenzi, L Gandini, V Maresca, R Rago, P Sgrò, F Dondero, M Picardo, Fatty acid composition of spermatozoa and immature germ cells, Mol Hum Reprod, 2000 Mar;6(3):226-31. doi: 10.1093/molehr/6.3.226. PMID: 10694269
A Lenzi 1, L Gandini, F Lombardo, M Picardo, V Maresca, E Panfili, F Tramer, C Boitani, F Dondero, Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx: from basic to clinic, PMID: 12020783, DOI: 10.1016/s0010-7824(02)00276-7
M R Safarinejad, Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study, 2011 Feb;43(1):38-47. doi: 10.1111/j.1439-0272.2009.01013.x. Epub 2010 Dec 19, PMID: 21219381
Gulaya NM, Margitich VM, Govseeva NM, Klimashevsky VM, Gorpynchenko II, Boyko MI. Phospholipid composition of human sperm and seminal plasma in relation to sperm fertility. Arch Androl 2001;46:169–175.
Reza Ghiasvand, Laleh Dehghan Marvast, Seyyed Payam Shariatpanahi, Makan Pourmasoumi,corresponding author Cain C. T. Clark and Farahnaz Haericorresponding, The association between animal flesh foods consumption and semen parameters among infertile Iranian men: a cross-sectional study, Nutr J. 2020; 19: 113. Published online 2020 Oct 6. doi: 10.1186/s12937-020-00633-w PMCID: PMC7541170 PMID: 33023581
R. J. Aitken, Oxidative stress and the etiology of male infertility, J Assist Reprod Genet. 2016 Dec; 33(12): 1691–1692. Published online 2016 Aug 20. doi: 10.1007/s10815-016-0791-4 PMCID: PMC5171887 PMID: 27544275
Kelton Tremellen, Oxidative stress and male infertility--a clinical perspective, Hum Reprod Update 2008 May-Jun;14(3):243-58. Epub 2008 Feb 14, PMID: 18281241, DOI: 10.1093/humupd/dmn004
Yu Yamamoto, Koichi Aizawa, Makiko Mieno, Mika Karamatsu, Yasuko Hirano, Kuniko Furui , Tatsuya Miyashita, Kazumitsu Yamazaki, Takahiro Inakuma, Ikuo Sato, Hiroyuki Suganuma, Teruaki Iwamoto, The effects of tomato juice on male infertility, Clin Nutr 2017 Jan;26(1):65-71. PMID: 28049263, DOI: 10.6133/apjcn.102015.17
Nooshin Amini, Abdolhossein Shiravi, Naser Mirazi, Vida Hojati, and Roghayeh Abbasalipourkabir, Protective effects of the fruit extract of raspberry (Rubus fruticosus L.) on pituitary-gonadal axis and testicular histopathology in streptozotocin induced diabetic male rats, Avicenna J Phytomed. 2021 Mar-Apr; 11(2): 199–209. PMCID: PMC8051313 PMID: 33907678
Young SS, Eskenazi B, Marchetti FM, Block G, Wyrobek AJ. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum Reprod 2008;23:1014–1022.
Wong W, Merkus H, Thomas C, Menkveld R, Zielhuis G, Steegers-Theunissen R. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril 2002;77:491–498.
Goldin B, Adlercreutz H, Gorbach S, Warram J, Dwyer J, Swenson L, Woods M. Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. N Engl J Med 1982;307:1542–1547.
Amarnath R, Jesse NM, Jacob R. The role of estrogen modulators in male hypogonadism and infertility. Rev Urol 2016;18:66–72.
Guo-Lian Ding, Ye Liu, Miao-E Liu, Jie-Xue Pan, Meng-Xi Guo, Jian-Zhong Sheng,and He-Feng Huang, The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis, Asian J Androl. 2015 Nov-Dec; 17(6): 948–953. Published online 2015 Mar 24. doi: 10.4103/1008-682X.150844 PMCID: PMC4814953 PMID: 25814158
Schoeller EL, Albanna G, Frolova AI, Moley KH. Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary- gonadal axis in Akita diabetic mice and restores male fertility. Diabetes 2012a;61:1869–1878.
La Vignera, S., Condorelli, R.A., Giancarlo Balercia, G., Vicari, E., & Calogero, A.E. (2013) Does alcohol have any effect on male reproductive function? A review of literature. Asian J Androl. 15, 221–225.
Guthauser B, Boitrelle F, Plat A, et al.Chronic excessive alcoho consumption and male fertility: a case report on reversible azoospermia and a literature review. Alcohol Alcohol. 2014;49:42-4.
Jensen TK,Gottschau M,MadsenJ O,et al. Habitual alcohol consumption associated with reduced semen qualityand changes inreproductive hormones;a cross-sectional study among 1221 young Danish men. BMJ Open.2014;4:e005462, PMID: 25277121 PMCID: PMC4185337 DOI: 10.1136/bmjopen-2014-005462
Nicolau P, Miralpeix E, SolàI,et al. Alcohol consumption and in vitro fertilization: a review of the literature. GynecolEndocrinol.2014;30:759-63
Komiya, A., Kato, T., Kawauchi, Y., Watanabe, A., & Fuse, H. (2014) Clinical factors associated with sperm DNA fragmentation in male patients with infertility. Scientific World Journal. 2014, PMID: 25165747 PMCID: PMC4137616 DOI: 10.1155/2014/868303
Antoniassi MP, IntasquiP, CamargoM ,et al. Analysis of the functionala spects and seminal plasma proteomic profile of sperm from smokers.BJUInt.2016;118:814-822
Sepaniak S, Forges T, GerardH ,et al. The influence of cigarette smoking on human sperm quality and DNAfragmentation.Toxicology.2006;223:54-60.
du Plessis SS, Agarwal A, Syriac A. Marijuana, phytocannabi-noids, the endocannabinoid system, and male fertility. J Assist Reprod Genet. 2015;32:1575-88
Gundersen TD, Jørgensen N, Andersson AM, et al.Association between use of marijuana and male reproductive hormones and semen quality:a study among 1,215 healthy young men. AmJEpidemiol.2015;182:473-81.
West M.C.L., Anderson L., Mcclure N., Lewis S.E.M. Dietary oestrogens and male fertility potential. Hum. Fertil. 2005;8:197–207. doi: 10.1080/14647270500030266, PMID: 16234205
Orzylowska E.M., Jacobson J.D., Bareh G.M., Ko E.Y., Corselli J.U., Chan P.J. Food intake di-et and sperm characteristics in a blue zone: A Loma Linda Study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2016;203:112–115. doi: 10.1016/j.ejogrb.2016.05.043, PMID: 27280539
Kljajic M., Hammadeh M., Wagenpfeil G., Baus S., Sklavounos P., Solomayer E.-F., Kasoha M. Impact of the vegan diet on sperm quality and sperm oxidative stress values: A prelim-inary study. J. Hum. Reprod. Sci. 2021;14:365. doi: 10.4103/jhrs.jhrs_90_21, PMID: 35197681 PMCID: PMC8812397
Gasior M., Rogawski M.A., Hartman A.L. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav. Pharmacol. 2006;17:431–439. doi: 10.1097/00008877-200609000-00009, PMCID: PMC2367001, PMID: 16940764
Liu CY, et al. Is a ketogenic diet superior to a high-fat, high-cholesterol diet regarding testicular function and spermatogenesis? Front Nutr. 2022;9:805794. doi: 10.3389/fnut.2022.805794
Tsao CW, et al. Curcumin remedies testicular function and spermatogenesis in male mice with low-carbohydrate-diet-induced metabolic dysfunction. Int J Mol Sci. 2022;23(17)
Psilopanagioti A., Papadaki H., Kranioti E.F., Alexandrides T.K., Varakis J.N. Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology. 2008;89:38–47. doi: 10.1159/000151396.
Zhang Y., Chua S., Jr. Leptin Function and Regulation. Compr. Physiol. 2017;8:351–369. doi: 10.1002/cphy.c160041, PMID: 36077406 PMCID: PMC9456534 DOI: 10.3390/ijms231710009, PMID: 31087711
Monteiro L., Pereira J.A.d.S., Palhinha L., Moraes-Vieira P.M.M. Leptin in the regulation of the immunometabolism of adipose tissue-macrophages. J. Leukoc. Biol. 2019;106:703–716. doi: 10.1002/JLB.MR1218-478R, PMID: 31087711
Ferramosca A., Provenzano S.P., Montagna D.D., Coppola L., Zara V. Oxidative stress negatively affects human sperm mitochondrial respiration. Urology. 2013;82:78–83. doi: 10.1016/j.urology.2013.03.058, PMID: 23806394
Wu X., Tao Y., Ren Y., Zhang Z., Zhao Y., Tian Y., Li Y., Hou M., Guo Y., Gong Y., et al. Adiponectin inhibits GnRH secretion via activating AMPK and PI3K signaling pathways in chicken hypothalamic neuron cells. Poult. Sci. 2023;102:103028. doi: 10.1016/j.psj.2023.103028
Keys A., Mienotti A., Karvonen M.J., Aravanis C., Blackburn H., Buzina R., Djordjevic B.S., Dontas A.S., Fidanza F., Keys M.H., et al. The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol. 1986;124:903–915. doi: 10.1093/oxfordjournals.aje.a114480, PMID: 3776973
Petre G.C., Francini-Pesenti F., Di Nisio A., De Toni L., Grande G., Mingardi A., Cusmano A., Spinella P., Ferlin A., Garolla A. Observational Cross-Sectional Study on Mediterranean Diet and Sperm Parameters. Nutrients. 2023;15:4989. doi: 10.3390/nu15234989, PMID: 38068847 PMCID: PMC10707842
Montano L., Ceretti E., Donato F., Bergamo P., Zani C., Viola G.C.V., Notari T., Pappalardo S., Zani D., Ubaldi S., et al. Effects of a Lifestyle Change Intervention on Semen Quality in Healthy Young Men Living in Highly Polluted Areas in Italy: The FASt Randomized Controlled Trial. Eur. Urol. Focus. 2021;8:351–359. doi: 10.1016/j.euf.2021.01.017, PMID: 33579652
Muffone A, de Oliveira Lübke PDP, Rabito EI. Mediterranean diet and infertility: a systematic review with meta-analysis of cohort studies. Nutr Rev. 2023;81(7):775–789. doi: 10.1093/nutrit/nuac087, PMID: 36346903
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Copyright (c) 2024 Barbara Serkis, Zuzanna Bentkowska, Małgorzata Miazga, Magdalena Celichowska, Aleksandra Bogoń, Jagna Golemo, Izabela Kałuża, Justyna Szpyra, Julia Dębińska, Gabriela Dziuba
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