Is blue light solely detrimental for human eyes?
A concise overview of the current knowledge on how blue light affects eye health.
DOI:
https://doi.org/10.12775/QS.2024.21.52981Keywords
blue-blocking lenses, blue light, light-emitting diodes, ocular growth, oxidative stress, phototoxicityAbstract
It has long been assumed that blue light is solely detrimental to the eyes and that it is a serious risk factor for a number of ocular diseases. In order to gain a more nuanced comprehension of the impact of blue light on the eye and to ascertain whether there are any beneficial aspects to this influence, this article presents a synthesis of the relevant research and offers updates on the current understanding of the subject matter. The review encompasses the environmental and societal changes that result in increased light exposure, the working principle and reasons for the prevalence of light-emitting diodes, and the safety classification of artificial light sources. Subsequently, we present the impact of blue light on ocular growth and the known mechanisms by which blue light affects different areas of the eye, including the cornea, conjunctiva, lens and retina. Finally, we discuss the validity of blue-blocking lenses and review other recommended strategies aimed at minimising the negative effects of blue light exposure.
References
Hölker F, Bolliger J, Davies TW, et al. 11 Pressing Research Questions on How Light Pollution Affects Biodiversity. Front Ecol Evol. 2021;9:767177. doi:10.3389/fevo.2021.767177
Hölker F, Jechow A, Schroer S, Tockner K, Gessner MO. Light pollution of freshwater ecosystems: principles, ecological impacts and remedies. Philos Trans R Soc B Biol Sci. 2023;378(1892):20220360. doi:10.1098/rstb.2022.0360
Wang L, Yu X, Zhang D, et al. Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro. J Photochem Photobiol B. 2023;240:112654. doi:10.1016/j.jphotobiol.2023.112654
Wong NA, Bahmani H. A review of the current state of research on artificial blue light safety as it applies to digital devices. Heliyon. 2022;8(8):e10282. doi:10.1016/j.heliyon.2022.e10282
Light-Emitting Diodes (LEDS): Implications for Safety. Health Phys. 2020;118(5):549-561. doi:10.1097/HP.0000000000001259
Trott M, Driscoll R, Iraldo E, Pardhan S. Changes and correlates of screen time in adults and children during the COVID-19 pandemic: A systematic review and meta-analysis. eClinicalMedicine. 2022;48:101452. doi:10.1016/j.eclinm.2022.101452
Hedderson MM, Bekelman TA, Li M, et al. Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021. JAMA Netw Open. 2023;6(2):e2256157. doi:10.1001/jamanetworkopen.2022.56157
Cougnard-Gregoire A, Merle BMJ, Aslam T, et al. Blue Light Exposure: Ocular Hazards and Prevention-A Narrative Review. Ophthalmol Ther. 2023;12(2):755-788. doi:10.1007/s40123-023-00675-3
Lawrenson JG, Hull CC, Downie LE. The effect of blue‐light blocking spectacle lenses on visual performance, macular health and the sleep‐wake cycle: a systematic review of the literature. Ophthalmic Physiol Opt. 2017;37(6):644-654. doi:10.1111/opo.12406
Dain SJ. The blue light dose from white light emitting diodes (LEDs) and other white light sources. Ophthalmic Physiol Opt. 2020;40(5):692-699. doi:10.1111/opo.12713
Jin M, Li X, Yan F, Chen W, Jiang L, Zhang X. The effects of low-color-temperature dual-primary-color light-emitting diodes on three kinds of retinal cells. J Photochem Photobiol B. 2021;214:112099. doi:10.1016/j.jphotobiol.2020.112099
Menéndez-Velázquez A, García-Delgado AB, Morales D. Human-Centric Lighting: Rare-Earth-Free Photoluminescent Materials for Correlated Color Temperature Tunable White LEDs. Int J Mol Sci. 2023;24(4):3602. doi:10.3390/ijms24043602
IEC 62471. Photobiological safety of lamps and lamp systems. Published online 2006.
Norton TT, Siegwart JT. Light levels, refractive development, and myopia--a speculative review. Exp Eye Res. 2013;114:48-57. doi:10.1016/j.exer.2013.05.004
Ouyang X, Yang J, Hong Z, Wu Y, Xie Y, Wang G. Mechanisms of blue light-induced eye hazard and protective measures: a review. Biomed Pharmacother Biomedecine Pharmacother. 2020;130:110577. doi:10.1016/j.biopha.2020.110577
O’Hagan JB, Khazova M, Price LLA. Low-energy light bulbs, computers, tablets and the blue light hazard. Eye Lond Engl. 2016;30(2):230-233. doi:10.1038/eye.2015.261
Russo A, Boldini A, Romano D, et al. Myopia: Mechanisms and Strategies to Slow Down Its Progression. J Ophthalmol. 2022;2022:1004977. doi:10.1155/2022/1004977
Gajjar S, Ostrin LA. A systematic review of near work and myopia: measurement, relationships, mechanisms and clinical corollaries. Acta Ophthalmol (Copenh). 2022;100(4):376-387. doi:10.1111/aos.15043
Gupta S, Joshi A, Saxena H, Chatterjee A. Outdoor activity and myopia progression in children: A follow-up study using mixed-effects model. Indian J Ophthalmol. 2021;69(12):3446-3450. doi:10.4103/ijo.IJO_3602_20
Biswas S, El Kareh A, Qureshi M, et al. The influence of the environment and lifestyle on myopia. J Physiol Anthropol. 2024;43(1):7. doi:10.1186/s40101-024-00354-7
Lin G, Taylor C, Rucker F. Effect of duration, and temporal modulation, of monochromatic light on emmetropization in chicks. Vision Res. 2020;166:12-19. doi:10.1016/j.visres.2019.11.002
Rucker FJ, Wallman J. Cone signals for spectacle-lens compensation: differential responses to short and long wavelengths. Vision Res. 2008;48(19):1980-1991. doi:10.1016/j.visres.2008.06.003
Jiang X, Pardue MT, Mori K, et al. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Proc Natl Acad Sci U S A. 2021;118(22):e2018840118. doi:10.1073/pnas.2018840118
Strickland R, Landis EG, Pardue MT. Short-Wavelength (Violet) Light Protects Mice From Myopia Through Cone Signaling. Invest Ophthalmol Vis Sci. 2020;61(2):13. doi:10.1167/iovs.61.2.13
Jiang L, Zhang S, Schaeffel F, et al. Interactions of chromatic and lens-induced defocus during visual control of eye growth in guinea pigs (Cavia porcellus). Vision Res. 2014;94:24-32. doi:10.1016/j.visres.2013.10.020
Torii H, Kurihara T, Seko Y, et al. Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression. EBioMedicine. 2017;15:210-219. doi:10.1016/j.ebiom.2016.12.007
Ward AH, Norton TT, Huisingh CE, Gawne TJ. The hyperopic effect of narrow-band long-wavelength light in tree shrews increases non-linearly with duration. Vision Res. 2018;146-147:9-17. doi:10.1016/j.visres.2018.03.006
Gawne TJ, Ward AH, Norton TT. Juvenile Tree Shrews Do Not Maintain Emmetropia in Narrow-band Blue Light. Optom Vis Sci Off Publ Am Acad Optom. 2018;95(10):911-920. doi:10.1097/OPX.0000000000001283
Smith EL, Hung LF, Arumugam B, Holden BA, Neitz M, Neitz J. Effects of Long-Wavelength Lighting on Refractive Development in Infant Rhesus Monkeys. Invest Ophthalmol Vis Sci. 2015;56(11):6490-6500. doi:10.1167/iovs.15-17025
Thakur S, Dhakal R, Verkicharla PK. Short-Term Exposure to Blue Light Shows an Inhibitory Effect on Axial Elongation in Human Eyes Independent of Defocus. Invest Ophthalmol Vis Sci. 2021;62(15):22. doi:10.1167/iovs.62.15.22
Yang J, Ouyang X, Fu H, et al. Advances in biomedical study of the myopia-related signaling pathways and mechanisms. Biomed Pharmacother Biomedecine Pharmacother. 2022;145:112472. doi:10.1016/j.biopha.2021.112472
Li L, Yu Y, Zhuang Z, Wu Q, Lin S, Hu J. Circadian rhythm, ipRGCs, and dopamine signalling in myopia. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol. 2024;262(3):983-990. doi:10.1007/s00417-023-06276-x
Chakraborty R, Landis EG, Mazade R, et al. Melanopsin modulates refractive development and myopia. Exp Eye Res. 2022;214:108866. doi:10.1016/j.exer.2021.108866
Rucker FJ, Eskew RT, Taylor C. Signals for defocus arise from longitudinal chromatic aberration in chick. Exp Eye Res. 2020;198:108126. doi:10.1016/j.exer.2020.108126
Marek V, Mélik-Parsadaniantz S, Villette T, et al. Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions. Free Radic Biol Med. 2018;126:27-40. doi:10.1016/j.freeradbiomed.2018.07.012
Craig JP, Nelson JD, Azar DT, et al. TFOS DEWS II Report Executive Summary. Ocul Surf. 2017;15(4):802-812. doi:10.1016/j.jtos.2017.08.003
Sheppard AL, Wolffsohn JS. Digital eye strain: prevalence, measurement and amelioration. BMJ Open Ophthalmol. 2018;3(1):e000146. doi:10.1136/bmjophth-2018-000146
Lee B, Afshari NA, Shaw PX. Oxidative stress and antioxidants in cataract development. Curr Opin Ophthalmol. 2024;35(1):57-63. doi:10.1097/ICU.0000000000001009
Zhao ZC, Zhou Y, Tan G, Li J. Research progress about the effect and prevention of blue light on eyes. Int J Ophthalmol. 2018;11(12):1999-2003. doi:10.18240/ijo.2018.12.20
Hsueh YJ, Chen YN, Tsao YT, Cheng CM, Wu WC, Chen HC. The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases. Int J Mol Sci. 2022;23(3):1255. doi:10.3390/ijms23031255
Antemie RG, Samoilă OC, Clichici SV. Blue Light-Ocular and Systemic Damaging Effects: A Narrative Review. Int J Mol Sci. 2023;24(6):5998. doi:10.3390/ijms24065998
Wirz-Justice A, Skene DJ, Münch M. The relevance of daylight for humans. Biochem Pharmacol. 2021;191:114304. doi:10.1016/j.bcp.2020.114304
Moyano DB, Sola Y, González-Lezcano RA. Blue-Light Levels Emitted from Portable Electronic Devices Compared to Sunlight. Energies. 2020;13(16):4276. doi:10.3390/en13164276
Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016;22:61-72.
Mainster MA, Turner PL. Blue-blocking IOLs decrease photoreception without providing significant photoprotection. Surv Ophthalmol. 2010;55(3):272-289. doi:10.1016/j.survophthal.2009.07.006
Position Statement on the Blue Light Hazard (April 23, 2019) | CIE. Accessed June 10, 2024. https://cie.co.at/publications/position-statement-blue-light-hazard-april-23-2019
Tso MO, La Piana FG. The human fovea after sungazing. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1975;79(6):OP788-795.
Mainster MA, Findl O, Dick HB, et al. The Blue Light Hazard Versus Blue Light Hype. Am J Ophthalmol. 2022;240:51-57. doi:10.1016/j.ajo.2022.02.016
Fleckenstein M, Keenan TDL, Guymer RH, et al. Age-related macular degeneration. Nat Rev Dis Primer. 2021;7(1):31. doi:10.1038/s41572-021-00265-2
Zhou H, Zhang H, Yu A, Xie J. Association between sunlight exposure and risk of age-related macular degeneration: a meta-analysis. BMC Ophthalmol. 2018;18(1):331. doi:10.1186/s12886-018-1004-y
Leung TW, Li RWH, Kee CS. Blue-Light Filtering Spectacle Lenses: Optical and Clinical Performances. PloS One. 2017;12(1):e0169114. doi:10.1371/journal.pone.0169114
Baldasso M, Roy M, Boon MY, Dain SJ. Effect of blue-blocking lenses on colour discrimination. Clin Exp Optom. 2021;104(1):56-61. doi:10.1111/cxo.13139
Alzahran HS, Roy M, Honson V, Khuu SK. Effect of blue-blocking lenses on colour contrast sensitivity. Clin Exp Optom. 2021;104(2):207-214. doi:10.1111/cxo.13135
Vagge A, Ferro Desideri L, Del Noce C, Di Mola I, Sindaco D, Traverso CE. Blue light filtering ophthalmic lenses: A systematic review. Semin Ophthalmol. 2021;36(7):541-548. doi:10.1080/08820538.2021.1900283
Singh S, Keller PR, Busija L, et al. Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults. Cochrane Database Syst Rev. 2023;8(8):CD013244. doi:10.1002/14651858.CD013244.pub2
Desmettre T, Baillif S, Mathis T, Gatinel D, Mainster M. [Blue light and intraocular lenses (IOLs): Beliefs and realities]. J Fr Ophtalmol. 2024;47(2):104043. doi:10.1016/j.jfo.2023.104043
Lian Y, Lu W, Huang H, Wu G, Xu A, Jin W. The Long-Term Effect of Blue-Light Blocking Spectacle Lenses on Adults’ Contrast Perception. Front Neurosci. 2022;16:898489. doi:10.3389/fnins.2022.898489
Henderson BA, Grimes KJ. Blue-blocking IOLs: a complete review of the literature. Surv Ophthalmol. 2010;55(3):284-289. doi:10.1016/j.survophthal.2009.07.007
Tosini G. Blue-light-blocking Lenses in Eyeglasses: A Question of Timing. Optom Vis Sci Off Publ Am Acad Optom. 2022;99(3):228-229. doi:10.1097/OPX.0000000000001866
Digital Devices and Your Eyes. American Academy of Ophthalmology. Published November 27, 2023. Accessed April 29, 2024. https://www.aao.org/eye-health/tips-prevention/digital-devices-your-eyes
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Copyright (c) 2024 Emilia Żurowska, Urszula Guderska, Karolina Krawiel, Marek Król, Jacek Kurzeja, Iga Markowska, Hubert Piotrowicz, Katarzyna Piotrowicz
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