The effect of vitamin D on the development of Hashimoto's disease and the reduction of the inflammatory process in its course - review
DOI:
https://doi.org/10.12775/QS.2024.16.52799Keywords
diet Hashimoto, vitamin D, vitamin D Hashimoto’s thyroditis, Hashimoto’s thyroditis, diet, diet in autoimmune diseaseAbstract
Introduction
Hashimoto's disease is an autoimmune chronic lymphocytic thyroiditis. It is a common condition, more frequent in women. Its diagnosis is based on the presence of specific antithyroid antibodies in the patient's blood which lead to the destruction of the thyroid gland. This can result in the development of hypothyroidism, requiring levothyroxine replacement therapy.
Aim of the review
A summary of the information gathered so far on the involvement of vitamin D in the development and course of Hashimoto's disease.
Results
The articles analyzed have mixed results. Most of them show a positive correlation between vitamin D and Hashimoto's disease, paying particular attention to the contribution of vitamin D in moderating the inflammatory process in HT. Other studies show significant differences in vitamin D levels between groups with different HT severity. Others show a negative correlation between vitamin D levels and the development of Hashimoto's disease.
Conclusions
Large well-controlled randomized double blind trials are needed in order to determine the exact role of vitamin D in Hashimoto’s disease.
References
Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. DOI: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13. PMID: 24434360.
Mincer DL, Jialal I. Hashimoto Thyroiditis. 2023 Jul 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29083758.
Hu X, Chen Y, Shen Y, Tian R, Sheng Y, Que H. Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis. Front Public Health. 2022 Oct 13;10:1020709. DOI: 10.3389/fpubh.2022.1020709. PMID: 36311599; PMCID: PMC9608544.
Weetman AP. An update on the pathogenesis of Hashimoto's thyroiditis. J Endocrinol Invest. 2021 May;44(5):883-890. doi: 10.1007/s40618-020-01477-1. Epub 2020 Dec 17. PMID: 33332019; PMCID: PMC8049926.
Ralli M, Angeletti D, Fiore M, et al. Hashimoto’s thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun Rev 2020; 19: 102649. DOI: 10.1016/j.autrev.2020.102649.
Zhang J, Chen Y, Li H, Li H. Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis. J Int Med Res. 2021 Dec;49(12):3000605211060675. doi: 10.1177/03000605211060675. PMID: 34871506; PMCID: PMC8711703.
Simsek Y, Cakir I, Yetmis M, et al. Effects of Vitamin D treatment on thyroid autoimmunity. J Res Med Sci 2016; 21: 85. DOI: 10.4103/1735-1995.192501.
Zhao L, Wang L and Fu B. Clinical application of calcitriol in Hashimoto’s thyroiditis with hypothyroidism. Medical Review 2016; 22: 2410–2412.
Jia R. Observation on the efficacy of calcitriol combined with levothyroxine sodium tablets in Hashimoto’s thyroiditis with hypothyroidism. Journal of Medical Forum 2020; 41: 133–135.
Yin H, Gu J, Guo X, et al. Application of calcitriol in hypothyroidism patients with Hashimoto’s thyroiditis. Journal of Medical Forum 2019; 40: 140–142.
Han Y, Chen YJ, Li YM, et al. Effect of calcitriol treatment on Hashimoto’s thyroiditis with hypothyroidism. Chinese Clinical Research 2015; 28: 17–19. DOI:10.13429/j.cnki.cjcr.2015.01.006.
Chahardoli R, Saboor-Yaraghi AA, Amouzegar A, et al. Can Supplementation 10 Journal of International Medical Research with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto’s Thyroiditis? A Double Blind, Randomized Clinical Trial. Horm Metab Res 2019; 51: 296–301. DOI: 10.1055/a-0856-1044.
Vahabi Anaraki P, Aminorroaya A, Amini M, et al. Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double-blind randomized placebocontrolled clinical trial. J Res Med Sci 2017; 22: 103. DOI: 10.4103/jrms.JRMS_1048_16.
Knutsen KV, Madar AA, Brekke M, et al. Effect of Vitamin D on Thyroid Autoimmunity: A Randomized, DoubleBlind, Controlled Trial Among Ethnic Minorities. J Endocr Soc 2017; 1: 470–479. DOI: 10.1210/js.2017-00037.
Lopez DV, Al-Jaberi FAH, Woetmann A, Ødum N, Bonefeld CM, Kongsbak-Wismann M, Geisler C. Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses. Front Immunol. 2021 Sep 21;12:722806. doi: 10.3389/fimmu.2021.722806. PMID: 34621269; PMCID: PMC8490813.
Pearce EN, Farwell AP and Braverman LE. Thyroiditis. N Engl J Med 2003; 348: 2646–2655. DOI: 10.1056/NEJMra021194.
Safdari V, Alijani E, Nemati M, et al. Imbalances in T Cell-Related Transcription Factors Among Patients with Hashimoto’s Thyroiditis. Sultan Qaboos Univ Med J 2017; 17: e174–e180. DOI: 10.18295/squmj.2016.17.02.007.
Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007; 179: 1634–1647. DOI: 10.4049/jimmunol.179.3.1634.
Cvek, M.; Kaliˇcanin, D.; Bari´c, A.; Vuleti´c, M.; Gunjaˇca, I.; Torlak Lovri´c, V.; Škrabi´c, V.; Punda, A.; Boraska Perica, V. Vitamin D and Hashimoto’s Thyroiditis: Observations from CROHT Biobank. Nutrients 2021, 13, 2793.
Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR, Kolkata, RGKar, NorthBengal, Siliguri. A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis. J Assoc Physicians India. 2023 Jan;71(1):1. PMID: 37116030.
Kolypetri, P.; King, J.; Larijani, M.; Carayanniotis, G. Genes and Environment as Predisposing Factors in Autoimmunity: Acceleration of Spontaneous Thyroiditis by Dietary Iodide in NOD.H2(h4) Mice. Int. Rev. Immunol. 2015, 34, 542–556. [CrossRef] Nutrients 2021, 13, 2793 11 of 12.
Wu, L.; Yu, J.-C.; Kang, W.-M.; Ma, Z.-Q. Iodine nutrition and thyroid diseases. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2013, 35, 1–8.
Desailloud, R.; Hober, D. Viruses and thyroiditis: An update. Virol. J. 2009, 6, 5.
Burek, C.L.; Talor, M.V. Environmental triggers of autoimmune thyroiditis. J. Autoimmun. 2009, 33, 183–189.
Liontiris, M.; Mazokopakis, E. A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients: Points that need more investigation. Hell. J. Nucl. Med. 2017, 20, 51–56.
Tamer, G.; Arik, S.; Tamer, I.; Coksert, D. Relative vitamin D insufficiency in Hashimoto’s thyroiditis. Thyroid 2011, 21, 891–896.
Ventura, M.; Melo, M.; Carrilho, F. Selenium and Thyroid Disease: From Pathophysiology to Treatment. Int. J. Endocrinol. 2017, 2017, 1297658.
Holick, M.; Binkley, N.C.; Bischoff-Ferrari, H.; Gordon, C.M.; Hanley, D.A.; Heaney, R.P.; Murad, M.H.; Weaver, C.M. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2011, 96, 1911–1930.
Kowalówka, M.; Główka, A.K.; Kara´zniewicz-Łada, M.; K
osewski, G. Clinical Significance of Analysis of Vitamin D Status in Various Diseases. Nutrients 2020, 12, 2788.
Pilz, S.; Zittermann, A.; Trummer, C.; Theiler-Schwetz, V.; Lerchbaum, E.; Keppel, M.H.; Grübler, M.R.; März, W.; Pandis, M. Vitamin D testing and treatment: A narrative review of current evidence. Endocr. Connect. 2019, 8, R27–R43.
Štefanić M, Tokić S. Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto's thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies. Eur J Nutr. 2020 Apr;59(3):859-872. doi: 10.1007/s00394-019-01991-w. Epub 2019 May 14. PMID: 31089869.
Wang S, Wu Y, Zuo Z, Zhao Y, Wang K. The effect of vitamin D supplementation on thyroid autoantibody levels in the treatment of autoimmune thyroiditis: a systematic review and a meta-analysis. Endocrine. 2018 Mar;59(3):499-505. doi: 10.1007/s12020-018-1532-5. Epub 2018 Jan 31. PMID: 29388046.
Ovesen, L.; Andersen, R.; Jakobsen, J. Geographical differences in vitamin D status, with particular reference to European countries. Proc. Nutr. Soc. 2003, 62, 813–821.
Zhu, X.-W.; Liu, K.-Q.; Wang, P.-Y.; Liu, J.-Q.; Chen, J.-Y.; Xu, X.-J.; Xu, J.-J.; Qiu, M.-C.; Sun, Y.; Liu, C.; et al. Cohort profile: The Westlake BioBank for Chinese (WBBC) pilot project. BMJ Open 2021, 11, e045564.
Tirabassi, G.; Cutini, M.; Salvio, G.; Cerqueni, G.; Lenzi, A.; Balercia, G. Influence of vitamin D levels on the cardiovascular profile of hypogonadal men. J. Endocrinol. Investig. 2017, 40, 1007–1014.
Ferrari, D.; Lombardi, G.; Strollo, M.; Pontillo, M.; Motta, A.; Locatelli, M. Association between solar ultraviolet doses and vitamin D clinical routine data in European mid-latitude population between 2006 and 2018. Photochem. Photobiol. Sci. 2019, 18, 2696–2706.
Cai, Z.; Zhang, Q.; Xia, Z.; Zheng, S.; Zeng, L.; Han, L.; Yan, J.; Ke, P.; Zhuang, J.; Wu, X.; et al. Determination of serum 25-hydroxyvitamin D status among population in southern China by a high accuracy LC-MS/MS method traced to reference measurement procedure. Nutr. Metab. 2020, 17, 8–13.
Won, J.W.; Jung, S.K.; Jung, I.A.; Lee, Y. Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area. Pediatr. Gastroenterol. Hepatol. Nutr. 2021, 24, 207–217.
Botelho, I.M.B.; Neto, A.M.; Silva, C.A.; Tambascia, M.A.; Alegre, S.M.; Zantut-Wittmann, D.E. Vitamin D in Hashimoto’s thyroiditis and its relationship with thyroid function and inflammatory status. Endocr. J. 2018, 65, 1029–1037. [CrossRef]
Effraimidis, G.; Badenhoop, K.; Tijssen, J.G.P.; Wiersinga, W.M. Vitamin D deficiency is not associated with early stages of thyroid autoimmunity. Eur. J. Endocrinol. 2012, 167, 43–48.
Musa, I.R.; Gasim, G.I.; Khan, S.; Ibrahim, I.A.; Abo-Alazm, H.; Adam, I. No Association between 25 (OH) Vitamin D Level and Hypothyroidism among Females. Open Access Maced. J. Med. Sci. 2017, 5, 126–130.
Yasmeh, J.; Farpour, F.; Rizzo, V.; Kheradnam, S.; Sachmechi, I. Hashimoto Thyroiditis not Associated with Vitamin D Deficiency. Endocr. Pract. 2016, 22, 809–813.
Chao G, Zhu Y, Fang L. Correlation Between Hashimoto's Thyroiditis-Related Thyroid Hormone Levels and 25-Hydroxyvitamin D. Front Endocrinol (Lausanne). 2020 Feb 14;11:4. doi: 10.3389/fendo.2020.00004. PMID: 32117049; PMCID: PMC7034299.
Lei Y, Yang J, Li H, Zhong H, Wan Q. Changes in glucose-lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease. Clin Lab Anal. (2019) 33:e22929. doi: 10.1002/jcla.22929.
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