Creatine supplementation in sport and medicine - a review of recent reports
DOI:
https://doi.org/10.12775/QS.2024.16.52680Keywords
Creatine, sport, activity and healthAbstract
Introduction and objective
The role of creatine as a dietary supplement to enhance ergogenic performance in strength sports is well established and researched, both among professionals and amateurs. In this article, we will focus not only on analysing creatine supplementation as an agent used in sport, but also as a supplement that may find a medical application.
Review methods
A literature search of Google Scholar and PubMed medical databases from the last eight years (2016-2024) was performed.
Articles were searched in English using the following keywords: Creatine, Supplementation, Sport, Athletes
Abbreviated description of the state of knowledge
The role of creatine in strength sports is firmly established. Recent reports present creatine as an agent with many other uses. Endurance sports, rehabilitation or injury prevention are just a few of the areas mentioned where creatine finds its use. In the medical sciences, it is of interest to fields such as neurology, psychiatry, cardiology, geriatrics or rheumatology. Although many misconceptions have grown up around creatine, one of the best confirming its safety may be the fact that there are reports of benefits for pregnant women and the foetus.
Summary
Research shows the extensive use of creatine in various sports and medical fields. The high safety profile and efficacy in resistance training has been confirmed and is now known to an increasing number of people, not only in competitive sport. New promising reports in many areas of medicine and sport are described in an increasing number of reports, with the need for further research, often using more widely available modern technologies.
References
Del Franco A, Ambrosio G, Baroncelli L, Pizzorusso T, Barison A, Olivotto I, Recchia FA, Lombardi CM, Metra M, Ferrari Chen YF, Passino C, Emdin M, Vergaro G. Creatine deficiency and heart failure. Heart Fail Rev. 2022; 27(5):1605-1616. doi: 10.1007/s10741-021-10173-y. Epub 2021 Oct 7. PMID: 34618287; PMCID: PMC9388465.
Candow DG, Vogt E, Johannsmeyer S, Forbes SC, Farthing JP. Strategic creatine supplementation and resistance training in healthy older adults. Appl Physiol Nutr Metab. 2015;40(7): 689-94. doi: 10.1139/apnm-2014-0498. Epub 2015 Feb 26. PMID: 25993883.
Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, Rawson ES, Smith-Ryan AE, VanDusseldorp TA, Willoughby DS, Ziegenfuss TN. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? Journal of the International Society of Sports Nutrition. 2021;18(1): 13. https://doi.org/10.1186/s12970-021-00412-w
Forbes SC, Candow DG, Neto JHF, Kennedy MD, Forbes JL, Machado M, Bustillo E, Gomez-Lopez J, Zapata A, Antonio J. Creatine supplementation and endurance performance: surges and sprints to win the race. Journal of the International Society of Sports Nutrition. 2023; 20(1): 2204071. https://doi.org/10.1080/15502783.2023.2204071
Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults- a meta-analysis. Medicine and science in sports and exercise. 2014; 46(6): 1194–1203. https://doi.org/10.1249/MSS.0000000000000220
Negro M, Cerullo G, Perna S, Beretta-Piccoli M, Rondanelli M, Liguori G, Cena H, Phillips SM, Cescon C, D'Antona G. Effects of a Single Dose of a Creatine-Based Multi-Ingredient Pre-workout Supplement Compared to Creatine Alone on Performance Fatigability After Resistance Exercise: A Double-Blind Crossover Design Study. Frontiers in nutrition. 2023; 9: 887523. https://doi.org/10.3389/fnut.2022.887523
Candow DG, Forbes SC, Roberts MD, Roy BD, Antonio J, Smith-Ryan AE, Rawson ES, Gualano B, Roschel H. Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance? Frontiers in sports and active living. 2022; 4: 893714. https://doi.org/10.3389/fspor.2022.893714
Kaviani M, Shaw K, Chilibeck PD. Benefits of Creatine Supplementation for Vegetarians Compared to Omnivorous Athletes: A Systematic Review. International journal of environmental research and public health. 2020; 17(9): 3041. https://doi.org/10.3390/ijerph17093041
Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition. 2017; 14: 18. https://doi.org/10.1186/s12970-017-0173-z
Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutrition reviews. 2023; 81(4): 416–427. https://doi.org/10.1093/nutrit/nuac064
Wang CC, Fang CC, Lee YH, Yang MT, Chan KH. Effects of 4-Week Creatine Supplementation Combined with Complex Training on Muscle Damage and Sport Performance. Nutrients. 2018; 10(11): 1640. https://doi.org/10.3390/nu10111640
Kreider RB, Stout JR. Creatine in Health and Disease. Nutrients. 2021; 13(2): 447. https://doi.org/10.3390/nu13020447
Solis MY, Artioli GG, Gualano B. Potential of Creatine in Glucose Management and Diabetes. Nutrients. 2021; 13(2): 570. doi: 10.3390/nu13020570. PMID: 33572228; PMCID: PMC7915263.
Roschel H, Gualano B, Ostojic SM, Rawson ES. Creatine Supplementation and Brain Health. Nutrients. 2021; 13(2): 586. https://doi.org/10.3390/nu13020586
Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients. 2021; 13(6): 1915. https://doi.org/10.3390/nu13061915
Ribeiro F, Longobardi I, Perim P, Duarte B, Ferreira P, Gualano B, Roschel H, & Saunders B. Timing of Creatine Supplementation around Exercise: A Real Concern? Nutrients. 2021; 13(8): 2844. https://doi.org/10.3390/nu13082844
Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, Rawson ES, Roy BD, Prokopidis K, Giannos P, Candow DG. Effects of Creatine Supplementation on Brain Function and Health. Nutrients. 2022; 14(5): 921. https://doi.org/10.3390/nu14050921
Longobardi I, Gualano B, Seguro AC, & Roschel H. Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review. Nutrients. 2023; 15(6): 1466. https://doi.org/10.3390/nu15061466
Burke R, Piñero A, Coleman M, Mohan A, Sapuppo M, Augustin F, Aragon AA, Candow DG, Forbes SC, Swinton P, Schoenfeld BJ. The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta- Analysis. Nutrients. 2023; 15(9): 2116. https://doi.org/10.3390/nu15092116
Harty PS, Zabriskie HA, Erickson JL, Molling PE, Kerksick CM, Jagim AR. Multi-ingredient pre-workout supplements, safety implications, and performance outcomes: a brief review. Journal of the International Society of Sports Nutrition. 2018; 15(1):41. https://doi.org/10.1186/s12970-018-0247-6
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