Sports Performance and Intermittent Fasting: Impact on Training and Results, Mechanisms and Health Benefits in Weight Management, Metabolic Health, and Chronic Diseases – A Review of Risks, Current Evidence, and Future Research Directions
DOI:
https://doi.org/10.12775/QS.2024.16.52500Keywords
Intermittent Fasting, sport, Cardiovascular Diseases, Obesity, Diabetes Mellitus, resistance exerciseAbstract
Introduction:
Intermittent Fasting (IF) has become a popular method in the contemporary medical world as an up-to date technique of the health and wellbeing in the last several years.
Purpose:
This research aims to investigate the both impact of IF on sports performance and therapeutic potential of IF on cardiovascular, metabolic and neurological diseases with focus on obesity, diabetes and impact on cardiometabolic risk.
State of Knowledge:
Intermittent fasting has been found to extend both life and health span by positively impacting weight management, reducing the risk of cardiovascular incidents, promoting cellular repair, and exhibiting anti-inflammatory actions. It improves blood sugar levels, provides protection against hepatosteatosis, enhances lipid metabolism and has beneficial effects on the brain-gut-microbiome system. IF leads to improved mental performance and offers benefits for neurological disorders such as epilepsy, Alzheimer's, and multiple sclerosis IF has shown beneficial effects on body composition and lean muscle mass without compromising physical performance nor impair strength. However, concerns about nutritional deficiencies, sustainability, and social implications are evident. Common drawbacks of IF include feelings of hunger, irritability, fatigue and hypoglycemia risk. IF is not recommended for pregnant woman and individuals suffering from eating disorders.
Conclusions:
IF is as a promising tool alongside traditional therapeutic strategies, particularly for addressing obesity, diabetes, and managing cardiovascular risk. For athletes it is a valuable tool in managing fat-mass particularly combined with high-intensity interval training (HIIT). However it is not recommended for certain groups. The diverse landscape of IF patterns, coupled with drawbacks, underscores the necessity for long-term research before routinely recommending IF for athletes and patients.
References
Chen S, Han R, Liu H. A Bibliometric and Visualization Analysis of Intermittent Fasting. Frontiers in Public Health. 2022;10. doi:https://doi.org/10.3389/fpubh.2022.946795
Anton SD, Moehl K, Donahoo WT, et al. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring, Md). 2018;26(2):254-268. doi:https://doi.org/10.1002/oby.22065
Wilhelmi de Toledo F, Grundler F, Sirtori CR, Ruscica M. Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition. Annals of Medicine. 2020;52(5):147-161. doi:https://doi.org/10.1080/07853890.2020.1770849
Song DK, Kim YW. Beneficial effects of intermittent fasting: a narrative review. Journal of Yeungnam Medical Science. Published online April 4, 2022. doi:https://doi.org/10.12701/jyms.2022.00010
Regmi P, Heilbronn LK. Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation. iScience. 2020;23(6):101161. doi:https://doi.org/10.1016/j.isci.2020.101161
Gudden J, Arias Vasquez A, Bloemendaal M. The Effects of Intermittent Fasting on Brain and Cognitive Function. Nutrients. 2021;13(9):3166. doi:https://doi.org/10.3390/nu13093166
Persynaki A, Karras S, Pichard C. Unraveling the metabolic health benefits of fasting related to religious beliefs: A narrative review. Nutrition. 2017;35:14-20. doi:https://doi.org/10.1016/j.nut.2016.10.005
Hu D, Xie Z, Ye Y, Bahijri S, Chen M. The beneficial effects of intermittent fasting: an update on mechanism, and the role of circadian rhythm and gut microbiota. Hepatobiliary Surgery and Nutrition. 2020;9(5):597-602. doi:https://doi.org/10.21037/hbsn-20-317
Aoun A, Ghanem C, Hamod N, Sawaya S. The Safety and Efficacy of Intermittent Fasting for Weight Loss. Nutrition Today. 2020;55(6):270-277. doi:https://doi.org/10.1097/nt.0000000000000443
Skaznik-Wikiel ME, Polotsky AJ. The health pros and cons of continuous versus intermittent calorie restriction: more questions than answers. Maturitas. 2014;79(3):275-278. doi:https://doi.org/10.1016/j.maturitas.2014.08.007
Fallows E, McKenzie HS. Intermittent fasting. Elsevier eBooks. Published online January 1, 2021:287-296. doi:https://doi.org/10.1016/b978-0-12-821573-9.00026-6
Santos HO. Intermittent Fasting and Fat Mass: What Is the Clinical Magnitude? Obesities. 2022;2(1):1-7. doi:https://doi.org/10.3390/obesities2010001
Chair SY, Cai H, Cao X, Qin Y, Cheng HY, Ng MT. Intermittent Fasting in Weight Loss and Cardiometabolic Risk Reduction: A Randomized Controlled Trial. Journal of Nursing Research. 2022;30(1):e185. doi:https://doi.org/10.1097/jnr.0000000000000469
Domaszewski P, Konieczny M, Pakosz P, Bączkowicz D, Sadowska-Krępa E. Effect of a Six-Week Intermittent Fasting Intervention Program on the Composition of the Human Body in Women over 60 Years of Age. International Journal of Environmental Research and Public Health. 2020;17(11):4138. doi:https://doi.org/10.3390/ijerph17114138
Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutrition Reviews. 2015;73(10):661-674. doi:https://doi.org/10.1093/nutrit/nuv041
Vasim I, Majeed CN, DeBoer MD. Intermittent fasting and metabolic health. Nutrients. 2022;14(3):631. doi:https://doi.org/10.3390/nu14030631
Tagde P, Tagde S, Bhattacharya T, Tagde P, Akter R, Rahman MdH. Multifaceted Effects of Intermittent Fasting in the Treatment and Prevention of Diabetes, Cancer and Obesity or Other Chronic Diseases. Current Diabetes Reviews. 2021;18. doi:https://doi.org/10.2174/1573399818666211213103315
Varady KA. Impact of intermittent fasting on glucose homeostasis. Current Opinion in Clinical Nutrition and Metabolic Care. 2016;19(4):300-302. doi:https://doi.org/10.1097/mco.0000000000000291
Belkacemi L, Selselet-Attou G, Hupkens E, et al. Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats. International Journal of Endocrinology. 2012;2012:1-12. doi:https://doi.org/10.1155/2012/962012
Schless GL, Duncan GG. The beneficial effect of intermittent total fasts on the glucose tolerance in obese diabetic patients. Metabolism. 1966;15(2):98-102. doi:https://doi.org/10.1016/0026-0495(66)90029-1
Yuan X, Wang J, Yang S, et al. Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis. Zhou HD, ed. International Journal of Endocrinology. 2022;2022:1-9. doi:https://doi.org/10.1155/2022/6999907
Sarkar A, Jin Y, DeFelice BC, et al. Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver. Mistry P, Zaidi M, Mistry P, Bird T, eds. eLife. 2023;12:e82311. doi:https://doi.org/10.7554/eLife.82311
Mihaylova MM, Cheng CW, Cao AQ, et al. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell. 2018;22(5):769-778.e4. doi:https://doi.org/10.1016/j.stem.2018.04.001
Frank J, Gupta A, Osadchiy V, Mayer EA. Brain–Gut–Microbiome Interactions and Intermittent Fasting in Obesity. Nutrients. 2021;13(2):584. doi:https://doi.org/10.3390/nu13020584
Tiwari S, Sapkota N, Han Z. Effect of fasting on cancer: A narrative review of scientific evidence. Cancer Science. 2022;113(10):3291-3302. doi:https://doi.org/10.1111/cas.15492
Zhao X, Yang J, Huang R, Guo M, Zhou Y, Xu L. The role and its mechanism of intermittent fasting in tumors: friend or foe? Cancer Biology and Medicine. 2021;18(1):63-73. doi:https://doi.org/10.20892/j.issn.2095-3941.2020.0250
Clifton KK, Ma CX, Fontana L, Peterson LL. Intermittent fasting in the prevention and treatment of cancer. CA: A Cancer Journal for Clinicians. 2021;71(6):527-546. doi:https://doi.org/10.3322/caac.21694
Fann DYW, Ng GYQ, Poh L, Arumugam TV. Positive effects of intermittent fasting in ischemic stroke. Experimental Gerontology. 2017;89:93-102. doi:https://doi.org/10.1016/j.exger.2017.01.014
Fann DYW, Santro T, Manzanero S, et al. Intermittent fasting attenuates inflammasome activity in ischemic stroke. Experimental Neurology. 2014;257:114-119. doi:https://doi.org/10.1016/j.expneurol.2014.04.017
Vemuganti R, Arumugam TV. Molecular Mechanisms of Intermittent Fasting-induced Ischemic Tolerance. Conditioning Medicine. 2020;3(1):9-17. Accessed March 21, 2024. https://pubmed.ncbi.nlm.nih.gov/34278242/
Refaat M, El Jamal N, El-Rayess H, Gebran A, Salam A. The Impact of Diurnal Fasting During Ramadan on Patients with Established Cardiac Disease: A Systematic Review. International Cardiovascular Forum Journal. 2019;15. doi:https://doi.org/10.17987/icfj.v15i0.549
Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nature Reviews Neuroscience. 2018;19(2):80-80. doi:https://doi.org/10.1038/nrn.2017.156
de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. Longo DL, ed. New England Journal of Medicine. 2019;381(26):2541-2551. doi:https://doi.org/10.1056/nejmra1905136
Mishra S, Singh B. Intermittent Fasting and Metabolic Switching: A Brief Overview. Biomedical and Pharmacology Journal. 2020;13(3):1555-1562. https://biomedpharmajournal.org/vol13no3/intermittent-fasting-and-metabolic-switching-a-brief-overview/
Orngreen MC, Zacho M, Hebert A, Laub M, Vissing J. Patients with severe muscle wasting are prone to develop hypoglycemia during fasting. Neurology. 2003;61(7):997-1000. doi:https://doi.org/10.1212/01.wnl.0000086813.59722.72
Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD. Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabetic Medicine. 2018;35(5):588-594. doi:https://doi.org/10.1111/dme.13595
Harris MD, Davidson MB. Idiopathic fasting hypoglycemia in an adult. The American Journal of Medicine. 1987;82(2):303-306. doi:https://doi.org/10.1016/0002-9343(87)90074-x
Stratton MT, Albracht-Schulte K, Harty PS, Siedler MR, Rodriguez C, Tinsley GM. Physiological responses to acute fasting: implications for intermittent fasting programs. Nutrition Reviews. 2021;80(3):439-452. doi:https://doi.org/10.1093/nutrit/nuab094
Kim BH, Joo Y, Kim MS, Choe HK, Tong Q, Kwon O. Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones. Endocrinology and Metabolism. 2021;36(4):745-756. doi:https://doi.org/10.3803/enm.2021.405
Moller L, Dalman L, Norrelund H, et al. Impact of Fasting on Growth Hormone Signaling and Action in Muscle and Fat. The Journal of Clinical Endocrinology & Metabolism. 2009;94(3):965-972. doi:https://doi.org/10.1210/jc.2008-1385
Darzy KH, Murray RD, Gleeson HK, Pezzoli SS, Thorner MO, Shalet SM. The Impact of Short-Term Fasting on the Dynamics of 24-Hour Growth Hormone (GH) Secretion in Patients with Severe Radiation-Induced GH Deficiency. The Journal of Clinical Endocrinology & Metabolism. 2006;91(3):987-994. doi:https://doi.org/10.1210/jc.2005-2145
Nørrelund H, Frystyk J, Jørgensen JOL, et al. The Effect of Growth Hormone on the Insulin-Like Growth Factor System during Fasting. The Journal of Clinical Endocrinology & Metabolism. 2003;88(7):3292-3298. doi:https://doi.org/10.1210/jc.2002-021983
Runchey SS, Pollak MN, Valsta LM, et al. Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study. European Journal of Clinical Nutrition. 2012;66(10):1146-1152. doi:https://doi.org/10.1038/ejcn.2012.107
Cienfuegos S, Corapi S, Gabel K, et al. Effect of Intermittent Fasting on Reproductive Hormone Levels in Females and Males: A Review of Human Trials. Nutrients. 2022;14(11):2343. doi:https://doi.org/10.3390/nu14112343
Cherif A, Roelands B, Meeusen R, Chamari K. Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults. Sports Medicine. 2015;46(1):35-47. doi:https://doi.org/10.1007/s40279-015-0408-6
Laessle RG, Platte P, Schweiger U, Pirke KM. Biological and psychological correlates of intermittent dieting behavior in young women. A model for bulimia nervosa. Physiology & Behavior. 1996;60(1):1-5. doi:https://doi.org/10.1016/0031-9384(95)02215-5
Zhu S, Surampudi P, Rosharavan B, Chondronikola M. Intermittent fasting as a nutrition approach against obesity and metabolic disease. Current Opinion in Clinical Nutrition & Metabolic Care. 2020;23(6). doi:https://doi.org/10.1097/mco.0000000000000694
Lee JH, Verma N, Thakkar N, Yeung C, Sung HK. Intermittent Fasting: Physiological Implications on Outcomes in Mice and Men. Physiology. 2020;35(3):185-195. doi:https://doi.org/10.1152/physiol.00030.2019
Rajpal A, Ismail‐Beigi F. Intermittent fasting and “metabolic switch”: Effects on metabolic syndrome, prediabetes and type 2 diabetes. Diabetes, Obesity and Metabolism. Published online June 3, 2020. doi:https://doi.org/10.1111/dom.14080
Almeneessier AS, BaHammam AS. How does diurnal intermittent fasting impact sleep, daytime sleepiness, and markers of the biological clock? Current insights. Nature and Science of Sleep. 2018;Volume 10:439-452. doi:https://doi.org/10.2147/nss.s165637
Qasrawi SO, Pandi-Perumal SR, BaHammam AS. The effect of intermittent fasting during Ramadan on sleep, sleepiness, cognitive function, and circadian rhythm. Sleep and Breathing. 2017;21(3):577-586. doi:https://doi.org/10.1007/s11325-017-1473-x
Alhamdan BA, Garcia-Alvarez A, Alzahrnai AH, et al. Alternate-day versus daily energy restriction diets: which is more effective for weight loss? A systematic review and meta-analysis. Obesity Science & Practice. 2016;2(3):293-302. doi:https://doi.org/10.1002/osp4.52
Varady KA, Gabel K. Safety and efficacy of alternate day fasting. Nature Reviews Endocrinology. 2019;15(12):686-687. doi:https://doi.org/10.1038/s41574-019-0270-y
Wilhelmi de Toledo F, Grundler F, Bergouignan A, Drinda S, Michalsen A. Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects. Ruscica M, ed. PLOS ONE. 2019;14(1):e0209353. doi:https://doi.org/10.1371/journal.pone.0209353
Varady KA, Cienfuegos S, Ezpeleta M, Gabel K. Cardiometabolic Benefits of Intermittent Fasting. Annual Review of Nutrition. 2021;41(1):333-361. doi:https://doi.org/10.1146/annurev-nutr-052020-041327
Kucuk B, Berg RC. Alternate day fasting on subjective feelings of appetite and body weight for adults with overweight or obesity: a systematic review. Journal of Nutritional Science. 2022;11. doi:https://doi.org/10.1017/jns.2022.90
Ganesan K, Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. 2018;10(7). doi:https://doi.org/10.7759/cureus.2947
Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Translational Research. 2014;164(4):302-311. doi:https://doi.org/10.1016/j.trsl.2014.05.013
Conde-Pipó J, Mora-Fernandez A, Martinez-Bebia M, et al. Intermittent Fasting: Does It Affect Sports Performance? A Systematic Review. Nutrients. 2024;16(1):168-168. doi:https://doi.org/10.3390/nu16010168
Kowalczuk M, Lipińska J, Lipiński Ł, Kopeć I. Intermittent fasting and its influence on health and sports results. Journal of Education, Health and Sport. 2024;57:11-25. doi:https://doi.org/10.12775/jehs.2024.57.001
Drummond M, Soares P, Savoi L, Silva R. Fasting reduces satiety and increases hunger but does not affect the performance in resistance training. Biology of Sport. Published online January 1, 2024. doi:https://doi.org/10.5114/biolsport.2024.131814
Gillen JB, Percival ME, Ludzki A, Tarnopolsky MA, Gibala MartinJ. Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obesity. 2013;21(11):2249-2255. doi:https://doi.org/10.1002/oby.20379
Martínez-Rodríguez A, Rubio-Arias JA, García-De Frutos JM, Vicente-Martínez M, Gunnarsson TP. Effect of High-Intensity Interval Training and Intermittent Fasting on Body Composition and Physical Performance in Active Women. International Journal of Environmental Research and Public Health. 2021;18(12):6431. doi:https://doi.org/10.3390/ijerph18126431
Ashtary-Larky D, Bagheri R, Tinsley GM, Asbaghi O, Paoli A, Moro T. Effects of intermittent fasting combined with resistance training on body composition: a systematic review and meta‐analysis. Physiology & Behavior. 2021;237:113453. doi:https://doi.org/10.1016/j.physbeh.2021.113453
Keenan SJ, Cooke MB, Hassan EB, et al. Intermittent fasting and continuous energy restriction result in similar changes in body composition and muscle strength when combined with a 12 week resistance training program. European Journal of Nutrition. Published online January 27, 2022. doi:https://doi.org/10.1007/s00394-022-02804-3
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