Congenital melanocytic nevi – a literature review
DOI:
https://doi.org/10.12775/QS.2024.15.52340Keywords
pigmented nevi, melanoma, dermoscopy, confocal microscopyAbstract
Introduction: Congenital melanocytic nevi (CMN) are small, congenital pigmented moles on the skin that may appear after or shortly after the birth of a child (up to 12–24 months of age). CMN usually increases proportionately with the baby's physical development and occupies the same area of skin as at birth. The incidence of CMN among newborns is relatively low and ranges from 0.2% to 6%.
Purpose of work: To collect information on the congenital melanocytic nevi.
Summary: The initial step in caring for a patient with CMN involves obtaining a history and conducting a physical examination. We are able to examine the CMN using dermatoscopy, confocal microscopy, and histopathological examination. Melanoma is not common in people with CMN, but it can develop, so it is worth maintaining oncological vigilance and checking them regularly. In our literature review, we reviewed the clinical presentation of CMN and the dermatoscopic image, as well as the light microscopic and confocal microscopic picture of congenital melanocytic nevi.
References
Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS. Fitzpatrick's Dermatology, 9e. New York, NY: McGraw-Hill Education; 2019.
Moustafa D, Blundell AR, Hawryluk EB. Congenital melanocytic nevi. Current Opinion in Pediatrics. 2020;32(4):491-7.
Castilla EE, da Graça Dutra M, Orioli-Parreiras IM. Epidemiology of congenital pigmented naevi: I. Incidence rates and relative frequencies. Br J Dermatol. 1981;104(3):307-15.
Escandón-Pérez S, Landeta-Sa AP, González-Jasso Y, Arenas-Guzmán R. Giant congenital melanocytic nevi. Bol Med Hosp Infant Mex. 2019;76(6):251-8.
Wertheim-Tysarowska K, Szczygielski O, Seliga K, Tysarowski A, Bal J, Michalak E, et al. The retrospective molecular analysis of large or giant congenital melanocytic nevi in a group of Polish children. J Mother Child. 2021;25(1):19-24.
Roh MR, Eliades P, Gupta S, Tsao H. Genetics of melanocytic nevi. Pigment Cell Melanoma Res. 2015;28(6):661-72.
Jahnke MN, O’Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, et al. Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations. Pediatrics. 2021;148(6).
Tan S, Hu H, Xin X, Wu D. A clinical and biologic review of congenital melanocytic nevi. The Journal of Dermatology. 2024;51(1):12-22.
Stark MS. Large-Giant Congenital Melanocytic Nevi: Moving Beyond NRAS Mutations. Journal of Investigative Dermatology. 2019;139(4):756-9.
Maher NG, Scolyer RA, Colebatch AJ. Biology and genetics of acquired and congenital melanocytic naevi. Pathology. 2023;55(2):169-77.
Krengel S, Scope A, Dusza SW, Vonthein R, Marghoob AA. New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol. 2013;68(3):441-51.
Macneal P, Patel BC. Congenital Melanocytic Nevi. [Updated 2023 Apr 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www-1ncbi-1nlm-1nih-1gov-100001agb0269.han3.wum.edu.pl/books/NBK563168/.
Mologousis MA, Tsai SY, Tissera KA, Levin YS, Hawryluk EB. Updates in the Management of Congenital Melanocytic Nevi. Children (Basel). 2024;11(1).
Wu M, Yu Q, Gao B, Sheng L, Li Q, Xie F. A large-scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics. Exp Ther Med. 2020;19(1):313-8.
Quaedvlieg PJ, Frank J, Vermeulen AH, Toonstra J, van Neer FJ. Giant ceribriform intradermal nevus on the back of a newborn. Pediatr Dermatol. 2008;25(1):43-6.
Bartenstein Reusch D, Hawryluk EB. Pigmented Lesions in Children: Update on Clinical, Histopathologic and Ancillary Testing. Dermatol Clin. 2022;40(1):25-36.
Scard C, Aubert H, Wargny M, Martin L, Barbarot S. Risk of melanoma in congenital melanocytic nevi of all sizes: A systematic review. J Eur Acad Dermatol Venereol. 2023;37(1):32-9.
Vourc'h-Jourdain M, Martin L, Barbarot S. Large congenital melanocytic nevi: therapeutic management and melanoma risk: a systematic review. J Am Acad Dermatol. 2013;68(3):493-8.e1-14.
Schaffer JV. Pigmented lesions in children: when to worry. Curr Opin Pediatr. 2007;19(4):430-40.
Solomon L, Eng AM, Bené M, Loeffel ED. Giant congenital neuroid melanocytic nevus. Arch Dermatol. 1980;116(3):318-20.
Stefanaki C, Stefanaki K, Antoniou C, Argyrakos T, Patereli A, Stratigos A, Katsambas A. Cell cycle and apoptosis regulators in Spitz nevi: comparison with melanomas and common nevi. J Am Acad Dermatol. 2007;56(5):815-24.
Streams BN, Lio PA, Mihm MC, Sober AJ. A nonepidermal, primary malignant melanoma arising in a giant congenital melanocytic nevus 40 years after partial surgical removal. J Am Acad Dermatol. 2004;50(5):789-92.
Kinsler VA, Birley J, Atherton DJ. Great Ormond Street Hospital for Children Registry for congenital melanocytic naevi: prospective study 1988-2007. Part 1-epidemiology, phenotype and outcomes. Br J Dermatol. 2009;160(1):143-50.
Criscito MC, Correa LM, Koshenkov VP, Firoz BF. Recurrent Nevi in a Skin Graft Following Excision of Giant Congenital Melanocytic Nevus. Dermatol Surg. 2016;42(9):1113-6.
Coughlin CC, Council ML, Gru AA, Fields RC, Bayliss SJ. Malignant Melanoma Arising at the Site of a Previously Excised Giant Congenital Melanocytic Nevus. JAMA Dermatology. 2014;150(1):100-1.
Rocha C, Grazziotin TC, Bonamigo RR. Dermoscopic characteristics of congenital melanocytic nevi in a cohort study in southern Brazil. An Bras Dermatol. 2022;97(5):660-5.
Barnhill RL, Fleischli M. Histologic features of congenital melanocytic nevi in infants 1 year of age or younger. J Am Acad Dermatol. 1995;33(5 Pt 1):780-5.
Jensen SL, Radfar A, Bhawan J. Mitoses in conventional melanocytic nevi. Journal of Cutaneous Pathology. 2007;34(9):713-5.
Paddock SW, Eliceiri KW. Laser scanning confocal microscopy: history, applications, and related optical sectioning techniques. Methods Mol Biol. 2014;1075:9-47.
Scharf C, Di Brizzi EV, Licata G, Piccolo V, Argenziano G, Moscarella E. Reflectance confocal microscopy in paediatric patients: Applications and limits. Exp Dermatol. 2023;32(2):210-3.
Odorici G, Longhitano S, Kaleci S, Chester J, Ciardo S, Pellacani G, Farnetani F. Morphology of congenital nevi in dermoscopy and reflectance confocal microscopy according to age: a pilot study. J Eur Acad Dermatol Venereol. 2020;34(12):e787-e9.
Farabi B, Akay BN, Goldust M, Wollina U, Atak MF, Rao B. Congenital melanocytic naevi: An up-to-date overview. Australas J Dermatol. 2021;62(2):e178-e91.
Marghoob AA, Charles CA, Busam KJ, Rajadhyaksha M, Lee G, Clark-Loeser L, Halpern AC. In vivo confocal scanning laser microscopy of a series of congenital melanocytic nevi suggestive of having developed malignant melanoma. Arch Dermatol. 2005;141(11):1401-12.
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