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Quality in Sport

Stem Cell Therapies for Spinal Cord Injury - A Review
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Stem Cell Therapies for Spinal Cord Injury - A Review

Authors

  • Filip Borodziuk 1 Military Clinical Hospital in Lublin https://orcid.org/0009-0000-0394-1816
  • Barbara Borodziuk 1 Military Clinical Hospital in Lublin, al. Racławickie 23,20-049 Lublin, Poland https://orcid.org/0009-0009-2716-6653
  • Katarzyna Ciuba Province Specialist Hospital named after Stefan Cardinal Wyszyński in Lublin al. Kraśnicka 100, 20-718 Lublin, Poland https://orcid.org/0009-0007-8347-3282
  • Paulina Dąbrowska Province Specialist Hospital named after Stefan Cardinal Wyszyński in Lublin al. Kraśnicka 100, 20-718 Lublin, Poland https://orcid.org/0009-0004-6439-3357
  • Michał Żuber 4th Clinical University Hospital in Lublin, Poland https://orcid.org/0009-0000-2538-8556
  • Karol Bochyński 4th Clinical University Hospital in Lublin ul. Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland https://orcid.org/0009-0003-8309-2800
  • Katarzyna Molenda 1 Military Clinical Hospital in Lublin, al. Racławickie 23,20-049 Lublin, Poland https://orcid.org/0009-0005-1928-4220
  • Michał Dacka Uniwersytet Medyczny w Lublinie Aleje Racławickie 1, 20-059 Lublin https://orcid.org/0009-0005-8783-6517
  • Kamila Giżewska 1 Military Clinical Hospital in Lublin https://orcid.org/0000-0003-1682-180X
  • Konrad Białogłowski University Clinical Hospital No. 1 in Lublin, ul. Stanisława Staszica 16, 20-081 Lublin, Poland https://orcid.org/0009-0001-1705-254X

DOI:

https://doi.org/10.12775/QS.2024.15.52258

Keywords

Stem Cells, Spinal Cord Injury, SCI, Regenerative Medicine, Neural Stem Cells, NSCs, Embryonic Stem Cells, ESCs, Induced Pluripotent Stem Cells, IPSCs, Mesenchymal Stem Cells, MSCs

Abstract

The escalating incidence of Spinal Cord Injury (SCI), with approximately 0.9 million cases globally, underscores its growing public health concern. Traumatic SCI, often prevalent in developing nations due to factors like motor vehicle accidents and falls, leads to secondary damage involving inflammation, neuronal death, and ionic dysregulation. Despite the absence of an effective treatment for SCI, Stem Cell Therapy (SCT) emerges as a promising avenue, harnessing stem cells' unique capabilities for regeneration and replacement. The review explores various stem cell types, such as Neural Stem/Progenitor Cells (NS/PCs), Embryonic Stem Cells (ESCs), Induced Pluripotent Stem Cells (iPSCs), and Mesenchymal Stem Cells (MSCs), detailing their potential in preclinical and clinical contexts. Specifically, NSCs exhibit therapeutic promise by modulating astrocyte contribution, enhancing differentiation, and promoting growth factors. ESCs, despite their pluripotency, face ethical concerns and potential teratocarcinoma formation. IPSCs, reprogrammed from somatic cells, showcase potential in treating SCI without ethical issues. MSCs, with diverse sources like bone marrow, umbilical cord, and adipose tissue, offer versatility in differentiation and therapeutic benefits. Clinical trials with MSCs, especially BM-MSCs, UC-MSCs, and AD-MSCs, demonstrate improvements in motor and sensory functions, highlighting their regenerative potential. Despite promising results, challenges such as potential tumorigenesis and high costs persist, warranting further exploration and clinical translation of these stem cell therapies for SCI.

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2024-07-07

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BORODZIUK, Filip, BORODZIUK, Barbara, CIUBA, Katarzyna, DĄBROWSKA, Paulina, ŻUBER, Michał, BOCHYŃSKI, Karol, MOLENDA, Katarzyna, DACKA, Michał, GIŻEWSKA, Kamila and BIAŁOGŁOWSKI, Konrad. Stem Cell Therapies for Spinal Cord Injury - A Review. Quality in Sport. Online. 7 July 2024. Vol. 15, p. 52258. [Accessed 15 June 2025]. DOI 10.12775/QS.2024.15.52258.
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Copyright (c) 2024 Filip Borodziuk, Barbara Borodziuk, Katarzyna Ciuba, Paulina Dąbrowska, Michał Żuber, Karol Bochyński, Katarzyna Molenda, Michał Dacka, Kamila Giżewska, Konrad Białogłowski

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