Assessment of mercury exposure and its impacts on human health
DOI:
https://doi.org/10.12775/QS.2024.15.51924Keywords
mercury, mercury exposure, heavy metals, healthAbstract
Introduction: Mercury, found both naturally and as a man-made contaminant, affects diverse populations globally, mainly through dietary consumption of seafood and occupational exposure. Mercury poses a significant threat to human, with well-documented adverse effects observed globally, especially among vulnerable communities. The aim of this study was to review the literature on mercury exposure and its effects on human health.
Material and methods of research: A literature review was performed using databases like PubMed and Google Scholar focused on keywords related to the topic.
Brief description of the state of knowledge: Dietary intake, notably from seafood containing methylmercury, constitutes a significant pathway for human mercury exposure. Additionally, occupational exposure, such as in artisanal and small-scale gold mining operations, poses significant risks, particularly in communities residing near these operations. Mercury exposure poses significant health risks across multiple bodily systems, including the nervous, cardiovascular, endocrine, reproductive, gastrointestinal, pulmonary, urinary, and immune system, potentially leading to a wide range of adverse effects. The intricacies of mercury's impact have been extensively discussed in research, delving into its specific mechanisms of harm within each bodily system.
Summary: Although a plethora of studies demonstrate the toxicity of mercury and its detrimental effects on human health, further research exploring this topic is essential, particularly on a pathophysiological level, to comprehensively understand the complex interactions between mercury exposure and its diverse effects on human health across various populations and exposure scenarios.
References
UN Environment, 2019. Global Mercury Assessment 2018. UN Environment Programme, Chemicals and Health Branch Geneva, Switzerland.
Andreoli V, Sprovieri F. Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview. Int J Environ Res Public Health. 2017; 14(1):93. doi: 10.3390/ijerph14010093.
Jinadasa BKKK, Jayasinghe GDTM, Pohl P, et al. Mitigating the impact of mercury contaminants in fish and other seafood-A review. Mar Pollut Bull. 2021; 171:112710. doi: 10.1016/j.marpolbul.2021.112710.
Næss S, Kjellevold M, Dahl L, et al. Effects of seafood consumption on mercury exposure in Norwegian pregnant women: A randomized controlled trial. Environ Int. 2020; 141:105759. doi: 10.1016/j.envint.2020.105759.
Dix-Cooper L, Kosatsky T. Blood mercury, lead and cadmium levels and determinants of exposure among newcomer South and East Asian women of reproductive age living in Vancouver, Canada. Sci Total Environ. 2018; 619-620:1409-1419. doi: 10.1016/j.scitotenv.2017.11.126.
Kvestad I, Vabø S, Kjellevold M, et al. Fatty fish, hair mercury and cognitive function in Norwegian preschool children: Results from the randomized controlled trial FINS-KIDS. Environ Int. 2018; 121(Pt 2):1098-1105. doi: 10.1016/j.envint.2018.10.022.
Solvik BS, Øyen J, Kvestad I, et al. Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children. J Nutr. 2021; 151(8):2134-2141. doi: 10.1093/jn/nxab112.
Hustad KS, Ottestad I, Olsen T, et al. Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial. Eur J Nutr. 2022; 61(6):3085-3093. doi: 10.1007/s00394-022-02857-4.
Ursinyova M, Masanova V, Uhnakova I, et al. Prenatal and Early Postnatal Exposure to Total Mercury and Methylmercury from Low Maternal Fish Consumption. Biol Trace Elem Res. 2019; 191(1):16-26. doi: 10.1007/s12011-018-1585-6.
Rodrigues PA, de Oliveira AT, Ramos-Filho AM, et al. Human health risks assessment of the fluctuations in mercury levels in seafood from different key regions of Rio de Janeiro, Brazil. Environ Sci Pollut Res Int. 2024; 31(21):30467-30483. doi: 10.1007/s11356-024-33267-0.
Jirau-Colón H, González-Parrilla L, Martinez-Jiménez J, et al. Rethinking the Dental Amalgam Dilemma: An Integrated Toxicological Approach. Int J Environ Res Public Health. 2019; 16(6):1036. doi: 10.3390/ijerph16061036.
Jonidi Jafari A, Esrafili A, Moradi Y, et al. Mercury level in biological samples of dentists in Iran: a systematic review and meta-analysis. J Environ Health Sci Eng. 2020; 18(2):1655-1669. doi: 10.1007/s40201-020-00558-w.
Tuček M, Bušová M, Čejchanová M, et al. Exposure to mercury from dental amalgam: actual contribution for risk assessment. Cent Eur J Public Health. 2020; 28(1):40-43. doi: 10.21101/cejph.a5965.
Aaseth J, Hilt B, Bjørklund G. Mercury exposure and health impacts in dental personnel. Environ Res. 2018; 164:65-69. doi: 10.1016/j.envres.2018.02.019.
Harianja AH, Saragih GS, Fauzi R, et al. Mercury Exposure in Artisanal and Small-Scale Gold Mining Communities in Sukabumi, Indonesia. J Health Pollut. 2020; 10(28):201209. doi: 10.5696/2156-9614-10.28.201209.
Calao-Ramos C, Bravo AG, Paternina-Uribe R, et al. Occupational human exposure to mercury in artisanal small-scale gold mining communities of Colombia. Environ Int. 2021; 146:106216. doi: 10.1016/j.envint.2020.106216.
Taux K, Kraus T, Kaifie A. Mercury Exposure and Its Health Effects in Workers in the Artisanal and Small-Scale Gold Mining (ASGM) Sector-A Systematic Review. Int J Environ Res Public Health. 2022; 19(4):2081. doi: 10.3390/ijerph19042081.
Decharat S. Urinary Mercury Levels Among Workers in E-waste Shops in Nakhon Si Thammarat Province, Thailand. J Prev Med Public Health. 2018; 51(4):196-204. doi: 10.3961/jpmph.18.049.
Hore P, Alex-Oni K, Sedlar S, et al. Health Remedies as a Source of Lead, Mercury, and Arsenic Exposure, New York City, 2010-2019. Am J Public Health. 2022; 112(S7):S730-S740. doi: 10.2105/AJPH.2022.306906.
Wiseman CLS, Parnia A, Chakravartty D, et al. Total, methyl and inorganic mercury concentrations in blood and environmental exposure sources in newcomer women in Toronto, Canada. Environ Res. 2019; 169:261-271. doi: 10.1016/j.envres.2018.11.011.
Yang L, Zhang Y, Wang F, et al. Toxicity of mercury: Molecular evidence. Chemosphere. 2020; 245:125586. doi: 10.1016/j.chemosphere.2019.125586.
Wells EM, Kopylev L, Nachman R, et al. Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers. Biol Trace Elem Res. 2022; 200(8):3867-3875. doi: 10.1007/s12011-021-02968-9.
Department of Environment, Climate Change and Health, World Health Organization 2021. Exposure to mercury: a major public health concern, second edition. Preventing disease through healthy environments.
Puty B, Leão LKR, Crespo-Lopez ME, et al. Association between methylmercury environmental exposure and neurological disorders: A systematic review. J Trace Elem Med Biol. 2019; 52:100-110. doi: 10.1016/j.jtemb.2018.12.001.
Santos-Sacramento L, Arrifano GP, Lopes-Araújo A, et al. Human neurotoxicity of mercury in the Amazon: A scoping review with insights and critical considerations. Ecotoxicol Environ Saf. 2021; 208:111686. doi: 10.1016/j.ecoenv.2020.111686.
Hu XF, Lowe M, Chan HM. Mercury exposure, cardiovascular disease, and mortality: A systematic review and dose-response meta-analysis. Environ Res. 2021; 193:110538. doi: 10.1016/j.envres.2020.110538.
Genchi G, Sinicropi MS, Carocci A, et al. Mercury Exposure and Heart Diseases. Int J Environ Res Public Health. 2017; 14(1):74. doi: 10.3390/ijerph14010074.
Pamphlett R, Doble PA, Bishop DP. Mercury in the human thyroid gland: Potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism. PLoS One. 2021; 16(2):e0246748. doi: 10.1371/journal.pone.0246748.
Liu D, Shi Q, Liu C, et al. Effects of Endocrine-Disrupting Heavy Metals on Human Health. Toxics. 2023; 11(4):322. doi: 10.3390/toxics11040322.
Pamphlett R, Kum Jew S, Doble PA, et al. Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause. Front Endocrinol (Lausanne). 2019; 10:419. doi: 10.3389/fendo.2019.00419.
Henriques MC, Loureiro S, Fardilha M, et al. Exposure to mercury and human reproductive health: A systematic review. Reprod Toxicol. 2019; 85:93-103. doi: 10.1016/j.reprotox.2019.02.012.
Bjørklund G, Chirumbolo S, Dadar M, et al. Mercury exposure and its effects on fertility and pregnancy outcome. Basic Clin Pharmacol Toxicol. 2019; 125(4):317-327. doi: 10.1111/bcpt.13264.
Renu K, Chakraborty R, Myakala H, et al. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review. Chemosphere. 2021; 271:129735. doi: 10.1016/j.chemosphere.2021.129735.
Teschke R. Aluminum, Arsenic, Beryllium, Cadmium, Chromium, Cobalt, Copper, Iron, Lead, Mercury, Molybdenum, Nickel, Platinum, Thallium, Titanium, Vanadium, and Zinc: Molecular Aspects in Experimental Liver Injury. Int J Mol Sci. 2022; 23(20):12213. doi: 10.3390/ijms232012213.
Tian X, Lin X, Zhao J, et al. Gut as the target tissue of mercury and the extraintestinal effects. Toxicology. 2023; 484:153396. doi: 10.1016/j.tox.2022.153396.
Güven D, Özbek İ. Characteristics, Treatment, and Prognosis of Elemental Mercury Intoxication in Children: A Single-Center Retrospective Study. Pediatr Emerg Care. 2022; 38(10):481-488. doi: 10.1097/PEC.0000000000002834.
Wu YS, Osman AI, Hosny M, et al. The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review. ACS Omega. 2024; 9(5):5100-5126. doi: 10.1021/acsomega.3c07047.
Bridges CC, Zalups RK. The aging kidney and the nephrotoxic effects of mercury. J Toxicol Environ Health B Crit Rev. 2017; 20(2):55-80. doi: 10.1080/10937404.2016.1243501.
Barnett LMA, Cummings BS. Nephrotoxicity and Renal Pathophysiology: A Contemporary Perspective. Toxicol Sci. 2018; 164(2):379-390. doi: 10.1093/toxsci/kfy159.
Pollard KM, Cauvi DM, Toomey CB, et al. Mercury-induced inflammation and autoimmunity. Biochim Biophys Acta Gen Subj. 2019; 1863(12):129299. doi: 10.1016/j.bbagen.2019.02.001.
Zheng K, Zeng Z, Tian Q, et al. Epidemiological evidence for the effect of environmental heavy metal exposure on the immune system in children. Sci Total Environ. 2023; 868:161691. doi: 10.1016/j.scitotenv.2023.161691.
Balali-Mood M, Naseri K, Tahergorabi Z, et al. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol. 2021; 12:643972. doi: 10.3389/fphar.2021.643972.
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