Strength Through Science: A Comprehensive Look at Resistance Training and Protein Intake in Muscle Development
DOI:
https://doi.org/10.12775/QS.2024.15.51852Keywords
High-Protein Diet, Resistance Training, Muscles Hypertrophy, StrengthAbstract
Introduction: Resistance training (RT) has become integral to fitness and rehabilitation, offering significant advantages in muscle growth and strength, and has been associated with a reduced risk of mortality. This study underscores the effectiveness of combining RT with increased dietary protein intake to amplify muscle hypertrophy and strength gains, highlighting RT's role in stimulating muscle protein synthesis and the importance of protein in muscle repair and growth.
Material and Methods of Research: A comprehensive literature review using databases like PubMed and Google Scholar focused on keywords related to the topic.
Results: Resistance training induces a multitude of cellular and molecular changes within skeletal muscle, leading to notable outcomes such as muscle hypertrophy and strength gains. This process is facilitated by the production and release of myokines - cytokines produced by muscle fibers during contraction - and an increase in muscle protein synthesis, which are essential for muscle growth and functional improvement. The integration of a high-protein diet with a structured resistance training regimen has been shown to significantly enhance these adaptations, underscoring the vital role of nutrition in augmenting the effects of physical training. By providing the necessary amino acids for muscle repair and growth, a high-protein diet complements the mechanical stimuli from resistance training, leading to greater increases in muscle mass and strength.
Conclusion: This study demonstrates that combining resistance training with a high-protein diet significantly boosts muscle hypertrophy and strength, highlighting the synergy between exercise and nutrition in enhancing muscle development and necessitating further investigation into their combined effects on various populations.
References
Maestroni L, Read P, Bishop C, Papadopoulos K, Suchomel TJ, Comfort P, Turner A. The Benefits of Strength Training on Musculoskeletal System Health: Practical Applications for Interdisciplinary Care. Sports Med. 2020 Aug;50(8):1431-1450. doi: 10.1007/s40279-020-01309-5. PMID: 32564299.
Shailendra P, Baldock KL, Li LSK, Bennie JA, Boyle T. Resistance Training and Mortality Risk: A Systematic Review and Meta-Analysis. Am J Prev Med. 2022 Aug;63(2):277-285. doi: 10.1016/j.amepre.2022.03.020. Epub 2022 May 20. PMID: 35599175.
Schoenfeld BJ, Contreras B, Krieger J, Grgic J, Delcastillo K, Belliard R, Alto A. Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men. Med Sci Sports Exerc. 2019 Jan;51(1):94-103. doi: 10.1249/MSS.0000000000001764. PMID: 30153194; PMCID: PMC6303131.
Škarabot J, Brownstein CG, Casolo A, Del Vecchio A, Ansdell P. The knowns and unknowns of neural adaptations to resistance training. Eur J Appl Physiol. 2021 Mar;121(3):675-685. doi: 10.1007/s00421-020-04567-3. Epub 2020 Dec 23. PMID: 33355714; PMCID: PMC7892509.
Morton RW, Murphy KT, McKellar SR, Schoenfeld BJ, Henselmans M, Helms E, Aragon AA, Devries MC, Banfield L, Krieger JW, Phillips SM. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018 Mar;52(6):376-384. doi: 10.1136/bjsports-2017-097608. Epub 2017 Jul 11. Erratum in: Br J Sports Med. 2020 Oct;54(19):e7. PMID: 28698222; PMCID: PMC5867436.
Delezie J, Handschin C. Endocrine Crosstalk Between Skeletal Muscle and the Brain. Front Neurol. 2018 Aug 24;9:698. doi: 10.3389/fneur.2018.00698. PMID: 30197620; PMCID: PMC6117390.
Zunner BEM, Wachsmuth NB, Eckstein ML, Scherl L, Schierbauer JR, Haupt S, Stumpf C, Reusch L, Moser O. Myokines and Resistance Training: A Narrative Review. Int J Mol Sci. 2022 Mar 23;23(7):3501. doi: 10.3390/ijms23073501. PMID: 35408868; PMCID: PMC8998961.
Hughes DC, Ellefsen S, Baar K. Adaptations to Endurance and Strength Training. Cold Spring Harb Perspect Med. 2018 Jun 1;8(6):a029769. doi: 10.1101/cshperspect.a029769. PMID: 28490537; PMCID: PMC5983157.
Haun CT, Vann CG, Roberts BM, Vigotsky AD, Schoenfeld BJ, Roberts MD. A Critical Evaluation of the Biological Construct Skeletal Muscle Hypertrophy: Size Matters but So Does the Measurement. Front Physiol. 2019 Mar 12;10:247. doi: 10.3389/fphys.2019.00247. PMID: 30930796; PMCID: PMC6423469.
Schiaffino S, Reggiani C, Akimoto T, Blaauw B. Molecular Mechanisms of Skeletal Muscle Hypertrophy. J Neuromuscul Dis. 2021;8(2):169-183. doi: 10.3233/JND-200568. PMID: 33216041; PMCID: PMC8075408.
Fink J, Schoenfeld BJ, Nakazato K. The role of hormones in muscle hypertrophy. Phys Sportsmed. 2018 Feb;46(1):129-134. doi: 10.1080/00913847.2018.1406778. Epub 2017 Nov 25. PMID: 29172848.
Lim C, Nunes EA, Currier BS, McLeod JC, Thomas ACQ, Phillips SM. An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise-Induced Human Skeletal Muscle Hypertrophy. Med Sci Sports Exerc. 2022 Sep 1;54(9):1546-1559. doi: 10.1249/MSS.0000000000002929. Epub 2022 Apr 6. PMID: 35389932; PMCID: PMC9390238.
Wackerhage H, Schoenfeld BJ, Hamilton DL, Lehti M, Hulmi JJ. Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise. J Appl Physiol (1985). 2019 Jan 1;126(1):30-43. doi: 10.1152/japplphysiol.00685.2018. Epub 2018 Oct 18. PMID: 30335577.
Joanisse S, Lim C, McKendry J, Mcleod JC, Stokes T, Phillips SM. Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans. F1000Res. 2020 Feb 24;9:F1000 Faculty Rev-141. doi: 10.12688/f1000research.21588.1. PMID: 32148775; PMCID: PMC7043134.
Lundberg TR, Feuerbacher JF, Sünkeler M, Schumann M. The Effects of Concurrent Aerobic and Strength Training on Muscle Fiber Hypertrophy: A Systematic Review and Meta-Analysis. Sports Med. 2022 Oct;52(10):2391-2403. doi: 10.1007/s40279-022-01688-x. Epub 2022 Apr 27. PMID: 35476184; PMCID: PMC9474354.
Beaudart C, Rolland Y, Cruz-Jentoft AJ, Bauer JM, Sieber C, Cooper C, Al-Daghri N, Araujo de Carvalho I, Bautmans I, Bernabei R, Bruyère O, Cesari M, Cherubini A, Dawson-Hughes B, Kanis JA, Kaufman JM, Landi F, Maggi S, McCloskey E, Petermans J, Rodriguez Mañas L, Reginster JY, Roller-Wirnsberger R, Schaap LA, Uebelhart D, Rizzoli R, Fielding RA. Assessment of Muscle Function and Physical Performance in Daily Clinical Practice : A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Calcif Tissue Int. 2019 Jul;105(1):1-14. doi: 10.1007/s00223-019-00545-w. Epub 2019 Apr 10. PMID: 30972475.
Benfica PDA, Aguiar LT, Brito SAF, Bernardino LHN, Teixeira-Salmela LF, Faria CDCM. Reference values for muscle strength: a systematic review with a descriptive meta-analysis. Braz J Phys Ther. 2018 Sep-Oct;22(5):355-369. doi: 10.1016/j.bjpt.2018.02.006. Epub 2018 May 3. Erratum in: Braz J Phys Ther. 2019 Nov - Dec;23(6):549. PMID: 29764761; PMCID: PMC6157470.
Del Vecchio A, Casolo A, Negro F, Scorcelletti M, Bazzucchi I, Enoka R, Felici F, Farina D. The increase in muscle force after 4 weeks of strength training is mediated by adaptations in motor unit recruitment and rate coding. J Physiol. 2019 Apr;597(7):1873-1887. doi: 10.1113/JP277250. Epub 2019 Feb 6. PMID: 30727028; PMCID: PMC6441907.
Pearcey GEP, Alizedah S, Power KE, Button DC. Chronic resistance training: is it time to rethink the time course of neural contributions to strength gain? Eur J Appl Physiol. 2021 Sep;121(9):2413-2422. doi: 10.1007/s00421-021-04730-4. Epub 2021 May 30. PMID: 34052876.
Lacio M, Vieira JG, Trybulski R, Campos Y, Santana D, Filho JE, Novaes J, Vianna J, Wilk M. Effects of Resistance Training Performed with Different Loads in Untrained and Trained Male Adult Individuals on Maximal Strength and Muscle Hypertrophy: A Systematic Review. Int J Environ Res Public Health. 2021 Oct 26;18(21):11237. doi: 10.3390/ijerph182111237. PMID: 34769755; PMCID: PMC8582674.
Grgic J, Schoenfeld BJ, Orazem J, Sabol F. Effects of resistance training performed to repetition failure or non-failure on muscular strength and hypertrophy: A systematic review and meta-analysis. J Sport Health Sci. 2022 Mar;11(2):202-211. doi: 10.1016/j.jshs.2021.01.007. Epub 2021 Jan 23. PMID: 33497853; PMCID: PMC9068575.
Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW. Strength and Hypertrophy Adaptations Between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-analysis. J Strength Cond Res. 2017 Dec;31(12):3508-3523. doi: 10.1519/JSC.0000000000002200. PMID: 28834797.
Carvalho L, Junior RM, Barreira J, Schoenfeld BJ, Orazem J, Barroso R. Muscle hypertrophy and strength gains after resistance training with different volume-matched loads: a systematic review and meta-analysis. Appl Physiol Nutr Metab. 2022 Apr;47(4):357-368. doi: 10.1139/apnm-2021-0515. Epub 2022 Jan 11. PMID: 35015560.
Otsuka Y, Yamada Y, Maeda A, Izumo T, Rogi T, Shibata H, Fukuda M, Arimitsu T, Miyamoto N, Hashimoto T. Effects of resistance training intensity on muscle quantity/quality in middle-aged and older people: a randomized controlled trial. J Cachexia Sarcopenia Muscle. 2022 Apr;13(2):894-908. doi: 10.1002/jcsm.12941. Epub 2022 Feb 20. PMID: 35187867; PMCID: PMC8977953.
Wilk M, Zajac A, Tufano JJ. The Influence of Movement Tempo During Resistance Training on Muscular Strength and Hypertrophy Responses: A Review. Sports Med. 2021 Aug;51(8):1629-1650. doi: 10.1007/s40279-021-01465-2. Epub 2021 May 27. PMID: 34043184; PMCID: PMC8310485.
Prestes J, A Tibana R, de Araujo Sousa E, da Cunha Nascimento D, de Oliveira Rocha P, F Camarço N, Frade de Sousa NM, Willardson JM. Strength and Muscular Adaptations After 6 Weeks of Rest-Pause vs. Traditional Multiple-Sets Resistance Training in Trained Subjects. J Strength Cond Res. 2019 Jul;33 Suppl 1:S113-S121. doi: 10.1519/JSC.0000000000001923. PMID: 28617715.
Schoenfeld BJ, Wackerhage H, De Souza E. Inter-set stretch: A potential time-efficient strategy for enhancing skeletal muscle adaptations. Front Sports Act Living. 2022 Nov 15;4:1035190. doi: 10.3389/fspor.2022.1035190. PMID: 36457663; PMCID: PMC9706104.
Aragon AA, Schoenfeld BJ, Wildman R, Kleiner S, VanDusseldorp T, Taylor L, Earnest CP, Arciero PJ, Wilborn C, Kalman DS, Stout JR, Willoughby DS, Campbell B, Arent SM, Bannock L, Smith-Ryan AE, Antonio J. International society of sports nutrition position stand: diets and body composition. J Int Soc Sports Nutr. 2017 Jun 14;14:16. doi: 10.1186/s12970-017-0174-y. PMID: 28630601; PMCID: PMC5470183.
Cava E, Yeat NC, Mittendorfer B. Preserving Healthy Muscle during Weight Loss. Adv Nutr. 2017 May 15;8(3):511-519. doi: 10.3945/an.116.014506. PMID: 28507015; PMCID: PMC5421125.
Eglseer D, Traxler M, Embacher S, Reiter L, Schoufour JD, Weijs PJM, Voortman T, Boirie Y, Cruz-Jentoft A, Bauer S; SO-NUTS consortium. Nutrition and Exercise Interventions to Improve Body Composition for Persons with Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2023 May;14(3):516-538. doi: 10.1016/j.advnut.2023.04.001. Epub 2023 Apr 6. PMID: 37028708; PMCID: PMC10201832.
Antonio J, Candow DG, Forbes SC, Ormsbee MJ, Saracino PG, Roberts J. Effects of Dietary Protein on Body Composition in Exercising Individuals. Nutrients. 2020 Jun 25;12(6):1890. doi: 10.3390/nu12061890. PMID: 32630466; PMCID: PMC7353221.
Bagheri R, Kargarfard M, Sadeghi R, Scott D, Camera DM. Effects of 16 weeks of two different high-protein diets with either resistance or concurrent training on body composition, muscular strength and performance, and markers of liver and kidney function in resistance-trained males. J Int Soc Sports Nutr. 2023 Dec;20(1):2236053. doi: 10.1080/15502783.2023.2236053. PMID: 37516903; PMCID: PMC10388821.
Monteyne AJ, Coelho MOC, Murton AJ, Abdelrahman DR, Blackwell JR, Koscien CP, Knapp KM, Fulford J, Finnigan TJA, Dirks ML, Stephens FB, Wall BT. Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults. J Nutr. 2023 Jun;153(6):1680-1695. doi: 10.1016/j.tjnut.2023.02.023. Epub 2023 Feb 22. PMID: 36822394; PMCID: PMC10308267.
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