Preserving fertility in young adolescents with cancer - an oncofertility perspective
DOI:
https://doi.org/10.12775/QS.2023.12.01.008Keywords
Oncofertility, fertility preservation, cancer, spermatogenesis, oogenesis, adolescentAbstract
Oncofertility is an emerging field at the intersection of oncology and reproductive medicine that aims to address the fertility-related consequences of cancer treatment. Advances in cancer diagnosis and treatment have led to significant improvements in survival rates, but many cancer treatments can cause infertility or premature ovarian failure, which can have a profound impact on the quality of life and overall well-being of cancer survivors. Oncofertility seeks to provide patients with the opportunity to preserve their reproductive potential before undergoing cancer treatment, thus ensuring that they have options for starting a family after treatment. This field encompasses a range of approaches, including fertility preservation techniques. While oncofertility is still a relatively new field, it has already made significant strides in improving the quality of life for cancer survivors. However, there are still many challenges that must be addressed, including access to oncofertility services and the development of new and more effective techniques. This paper will explore the current state of oncofertility research and highlight some of the key challenges and opportunities in this important field.
References
Steliarova-Foucher, E.; Colombet, M.; Ries, L.A.G.; Moreno, F.; Dolya, A.; Bray, F.; Hesseling, P.; Shin, H.Y.; Stiller, C.A.; Bouzbid, S.; et al. International incidence of childhood cancer, 2001–2010: A population-based registry study. Lancet Oncol. 2017, 18, 719–731.
Balcerska A. Epidemiologia chorób nowotworowych u dzieci. Forum Medycyny Rodzinnej 2009; 3: 61–63.
Phillips, S.M.; Padgett, L.S.; Leisenring,W.M.; Stratton, K.K.; Bishop, K.; Krull, K.R.; Alfano, C.M.; Gibson, T.M.; deMoor, J.S.; Hartigan, D.B.; et al. Survivors of childhood cancer in the United States: Prevalence and burden of morbidity. Cancer Epidemiol. Biomark. Prev. 2015, 24, 653–663.
Armenian, S.H.; Landier, W.; Hudson, M.M.; Robison, L.L.; Bhatia, S.; on behalf of the COG Survivorship and Outcomes Committee. Children’s Oncology Group’s 2013 blueprint for research: Survivorship and outcomes. Pediatr. Blood Cancer 2013, 60, 1063–1068.
Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today. Lyon 2020, France
Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 2014; 64: 83-103.
Anderson RA, Mitchell RT, Kelsey TW, et al. Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinol 2015; 3: 556–567.
Parker C, Milosevic M, Panzarella T i in. Prognostyczne znaczenie liczby limfocytów naciekających guz w nasieniaku jądra w I stopniu zaawansowania leczonym przez obserwację. Eur J Rak 2002; 38 :2014-9. 10.1016/S0959-8049(02)00235-6
Bîcă O, Sârbu I, Ciongradi CI. Pediatric and adolescent oncofertility in male patients–from alpha to omega. Genes (Basel) 2021; 12: 701.
Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012;166:765-78. 10.1530/EJE-11-0984
Inui A. Cancer anorexia-cachexia syndrome: are neuropeptides the key? Cancer Res 1999;59:4493-501.
Campos CA, Bowen AJ, Han S, et al. Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. Nat Neurosci 2017;20:934-42. 10.1038/nn.4574
Carlsen E, Andersson AM, Petersen JH, et al. History of febrile illness and variation in semen quality. Hum Reprod 2003;18:2089-92. 10.1093/humrep/deg412
Marmor D, Elefant E, Dauchez C, et al. Semen analysis in Hodgkin's disease before the onset of treatment. Cancer 1986;57:1986-7. 10.1002/1097-0142(19860515)57:10<1986::AID-CNCR2820571017>3.0.CO;2-W
Viviani S, Ragni G, Santoro A, et al. Testicular dysfunction in Hodgkin's disease before and after treatment. Eur J Cancer 1991;27:1389-92. 10.1016/0277-5379(91)90017-8
Bhongade MB, Prasad S, Jiloha RC, et al. Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples. Andrologia 2015;47:336-42. 10.1111/and.12268
Rowley M.J., Leach D.R., Warner G.A., Heller C.G. Effect of graded doses of ionizing radiation on the human testis. Radiat. Res. 1974;59:665–678. doi: 10.2307/3574084.
Jeruss J.S., Woodruff T.K. Preservation of Fertility in Patients with Cancer. N. Engl. J. Med. 2009;360:902–911. doi: 10.1056/NEJMra0801454.
Little J.B. Radiation carcinogenesis. Carcinogenesis. 2000;21:397–404. doi: 10.1093/carcin/21.3.397.
Dickinson B.C., Chang C.J. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat. Chem. Biol. 2011;7:504–511. doi: 10.1038/nchembio.607.
Agarwal A., Said T.M. Oxidative stress, DNA damage and apoptosis in male infertility: A clinical approach. BJU Int. 2005;95:503–507. doi: 10.1111/j.1464-410X.2005.05328.x.
Antal Z., Sklar C.A. Gonadal function and fertility among survivors of childhood cancer. Endocrinol. Metab. Clin. N. Am. 2015;44:739e49. doi: 10.1016/j.ecl.2015.08.002.
Howell S., Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol. Metab. Clin. N. Am. 1998;27:927e43. doi: 10.1016/S0889-8529(05)70048-7.
Bahadur G., Ozturk O., Muneer A., Wafa R., Ashraf A., Jaman N., Patel S., Oyede A.W., Ralph D.J. Semen quality before and after gonadotoxic treatment. Hum. Reprod. 2005;20:774–781. doi: 10.1093/humrep/deh671.
van Alphen M.M., van de Kant H.J., de Rooij D.G. Depletion of the spermatogonia from the seminiferous epithelium of the rhesus monkey after X irradiation. Radiat. Res. 1988;3:473–486. doi: 10.2307/3577244.
Meistrich M.L. Effects of chemotherapy and radiotherapy on spermatogenesis in humans. Fertil. Steril. 2013;100:1180–1186. doi: 10.1016/j.fertnstert.2013.08.010.
Crawshaw M. Psychosocial oncofertility issues faced by adolescents and young adults over their lifetime: A review of the research. Hum. Fertil. 2013;16:59–63. doi: 10.3109/14647273.2012.733480.
Reinmuth S., Liebeskind A.K., Wickmann L., Bockelbrink A., Keil T., Henze G., Borgmann A. Having children after surviving cancer in childhood or adolescence—Results of a Berlin survey. Klin. Padiatr. 2008;220:159–165. doi: 10.1055/s-2008-1073143.
Sánchez F, Smitz J. Molecular control of oogenesis. Biochim Biophys Acta. 2012 Dec;1822(12):1896-912. doi: 10.1016/j.bbadis.2012.05.013. Epub 2012 May 24. PMID: 22634430
Anderson R.A., Brewster D.H., Wood R., Nowell S., Fischbacher C., Kelsey T.W., Wallace W.H.B. The impact of cancer on subsequent chance of pregnancy: A population-based analysis. Hum. Reprod. 2018;33:1281–1290. doi: 10.1093/humrep/dey216.
Di Tucci C, Galati G, Mattei G, Chinè A, Fracassi A, Muzii L. Fertility after Cancer: Risks and Successes. Cancers (Basel). 2022 May 19;14(10):2500. doi: 10.3390/cancers14102500. PMID: 35626104; PMCID: PMC9139810
Tarasiewicz M, Martynowicz I, Knapp P, Sieczyński P. "Oncofertility" procedures in children and adolescents. Pediatr Endocrinol Diabetes Metab. 2019;25(3):144-149. English. doi: 10.5114/pedm.2019.87710. PMID: 31769272
Overbeek A., van den Berg M.H., van Leeuwen F.E., Kaspers G.J., Lambalk C.B., van Dulmen-den Broeder E. Chemotherapy-related late adverse effects on ovarian function in female survivors of childhood and young adult cancer: A systematic review. Cancer Treat. Rev. 2017;53:10–24. doi: 10.1016/j.ctrv.2016.11.006.
Buchanan JD, Fairley KF, Barrie JU. Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet 1975;2:156-7. 10.1016/S0140-6736(75)90059-8
Aslam I, Fishel S, Moore H, et al. Fertility preservation of boys undergoing anti-cancer therapy: a review of the existing situation and prospects for the future. Hum Reprod 2000;15:2154-9. 10.1093/humrep/15.10.2154
Brydøy M, Fossa SD, Klepp O, et al. Paternity and testicular function among testicular cancer survivors treated with two to four cycles of cisplatin-based chemotherapy. Eur Urol 2010;58:134-40. 10.1016/j.eururo.2010.03.041
Halpern JA, Das A, Faw CA, Brannigan RE. Oncofertility in adult and pediatric populations: options and barriers. Transl Androl Urol 2020; 9: S227-S238.
Rinaldi VD, Hsieh K, Munroe R, Bolcun-Filas E, Schimenti JC. Pharmacological inhibition of the DNA damage checkpoint prevents radiation induced oocyte death. Genetics 2017; 206: 1823-1828.
Waimey KE, Smith BM, Confino R, Jeruss JS, Pavone ME. Understanding fertility in young female cancer patients. J Womens Health (Larchmt) 2015; 24: 812-818.
Fukunaga H, Yokoya A, Prise KM. A brief overview of radiation-induced effects on spermatogenesis and oncofertility. Cancers (Basel) 2022; 14: 805.
Rousset-Jablonski C, Chevillon F, Dhedin N, Poirot C. [Fertility preservation in adolescents and young adults with cancer]. Bull Cancer 2016; 103: 1019-1034.
Foster RS, Bennett R, Bihrle R, et al. A preliminary report: postoperative fertility assessment in nerve-sparing RPLND patients. Eur Urol 1993;23:165-7; discussion 168. 10.1159/000474587
Beck SD, Bey AL, Bihrle R, et al. Ejaculatory status and fertility rates after primary retroperitoneal lymph node dissection. J Urol 2010;184:2078-80. 10.1016/j.juro.2010.06.146
Lange MM, van de Velde CJ. Urinary and sexual dysfunction after rectal cancer treatment. Nat Rev Urol 2011;8:51-7. 10.1038/nrurol.2010.206
Eveno C, Lamblin A, Mariette C, et al. Sexual and urinary dysfunction after proctectomy for rectal cancer. J Visc Surg 2010;147:e21-30. 10.1016/j.jviscsurg.2010.02.001
Jacobsen KD, Ous S, Waehre H, et al. Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection. Br J Cancer 1999;80:249-55. 10.1038/sj.bjc.6690347
Terrone C, Cracco C, Scarpa RM, et al. Supra-ampullar cystectomy with preservation of sexual function and ileal orthotopic reservoir for bladder tumor: twenty years of experience. Eur Urol 2004;46:264-9; discussion 269-70. 10.1016/j.eururo.2004.03.006
Heyn R, Raney RB, Jr, Hays DM, et al. Late effects of therapy in patients with paratesticular rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. J Clin Oncol 1992;10:614-23. 10.1200/JCO.1992.10.4.614
T Rague J , Varda BK, Wagner AA, et al. Delayed Return of Ejaculatory Function in Adolescent Males Treated With Retroperitoneal Lymph Node Dissection and Adjuvant Therapy for Paratesticular Rhabdomyosarcoma. Urology 2019;124:254-6. 10.1016/j.urology.2018.10.030
Maurer CA, Z'Graggen K, Renzulli P, et al. Total mesorectal excision preserves male genital function compared with conventional rectal cancer surgery. Br J Surg 2001;88:1501-5. 10.1046/j.0007-1323.2001.01904.x
Lim RS, Yang TX, Chua TC. Postoperative bladder and sexual function in patients undergoing surgery for rectal cancer: a systematic review and meta-analysis of laparoscopic versus open resection of rectal cancer. Tech Coloproctol 2014;18:993-1002. 10.1007/s10151-014-1189-x
Jacobsen KD, Theodorsen L, Fossa SD. Spermatogenesis after unilateral orchiectomy for testicular cancer in patients following surveillance policy. J Urol 2001;165:93-6. 10.1097/00005392-200101000-00023
Rodriguez-Wallberg KA, Oktay K. Fertility preservation during cancer treatment: clinical guidelines. Cancer Manag Res 2014; 6: 105-117
Wang X, Yang J, Li J, Zhao J, Ren T, Feng F, Wan X, Xiang Y. Fertility-sparing uterine lesion resection for young women with gestational trophoblastic neoplasias: single institution experience. Oncotarget. 2017 Jun 27;8(26):43368-43375. doi: 10.18632/oncotarget.14727. PMID: 28108735; PMCID: PMC5522152.
Oktay K, Harvey BE, Partridge AH, et al. Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol 2018;36:1994-2001. 10.1200/JCO.2018.78.1914
Schover LR, Brey K, Lichtin A, et al. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol 2002;20:1880-9. 10.1200/JCO.2002.07.175
Donnez J., Dolmans M.-M. Fertility preservation in women. N. Engl. J. Med. 2017;377:1657–1665. doi: 10.1056/NEJMra1614676.
Coyne K., Purdy M., O′Leary K., Yaklic J.L., Lindheim S.R., Appiah L.A. Challenges and considerations in optimizing ovarian stimulation protocols in oncofertility patients. Front. Public Health. 2014;2:246. doi: 10.3389/fpubh.2014.00246.
Salama M., Anazodo A., Woodruff T. Preserving fertility in female patients with hematological malignancies: A multidisciplinary oncofertility approach. Ann. Oncol. 2019;30:1760–1775. doi: 10.1093/annonc/mdz284.
Porcu E, Cipriani L, Dirodi M, et al.. Successful pregnancies, births, and children development following oocyte cryostorage in female cancer patients during 25 years of fertility preservation. Cancers (Basel) 2022; 14: 1429.
Teresa A, Santos A, Sousa G. Recomendações clínicas para a preservação da fertilidade no doente oncológico. Available from: https://www.spmr.pt/attachments/recom-spmr.pdf.
Diaz-Garcia C, Domingo J, Garcia-Velasco JA, et al.. Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study. Fertil Steril 2018; 109: 478-485.e2.
Appiah LC, Fei YF, Olsen M, Lindheim SR, Puccetti DM. Disparities in female pediatric, adolescent and young adult oncofertility: a needs assessment. Cancers (Basel) 2021; 13: 1-14.
Dolmans MM, Marotta ML, Pirard C, Donnez J, Donnez O. Ovarian tissue cryopreservation followed by controlled ovarian stimulation and pick-up of mature oocytes does not impair the number or quality of retrieved oocytes. J Ovarian Res 2014; 7: 80.
Takae S, Furuta S, Iwahataa H, et al.. Cryopreservation of paediatric ovarian tissue with an updated version of the Edinburgh criteria for appropriate patient selection. Reprod Biomed Online 2022; 44: 667-676.
Madeleine van der Perk ME, van der Kooi ALLF, van de Wetering MD, et al.. Oncofertility care for newly diagnosed girls with cancer in a national pediatric oncology setting, the first full year experience from the Princess Máxima Center, the PEARL study. PLoS One 2021; 16: 1-18.
. Committee P, Society A. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril 2019; 112: 1022-1033.
Burns KC, Hoefgen H, Strine A, Dasgupta R. Fertility preservation options in pediatric and adolescent patients with cancer. Cancer 2018; 124: 1867-1876.
Bisharah M., Tulandi T. Laparoscopic preservation of ovarian function: An underused procedure. Am. J. Obstet. Gynecol. 2003;188:367–370. doi: 10.1067/mob.2003.38.
Lau GA, Schaeffer AJ. Current standing and future directions in pediatric oncofertility: a narrative review. Transl Androl Urol 2018; 7: S276-S282.
Salsman JM, Yanez B, Snyder MA, et al.. Attitudes and practices about fertility preservation discussions among young adults with cancer treated at a comprehensive cancer center: patient and oncologist perspectives. Support Care Cancer 2021; 29: 5945-5955.
Mitchell RT, Williams SA. A fertile future: fertility preservation special series. Reprod Fertil 2022; 3: C1-C3.
Tran KTD, Valli-Pulaski H, Colvin A, Orwig KE. Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies. Biol Reprod 2022; 107: 382-405.
Vadaparampil S, Quinn G, King L, Wilson C, Nieder M. Barriers to fertility preservation among pediatric oncologists. Patient Educ Couns 2008; 72: 402-410.
Glazer TS, Schulte F. Barriers to oncofertility care among female adolescent cancer patients in Canada. Curr Oncol 2022; 29: 1583-1593.
Boone AN, Arbuckle JL, Ye Y, Wolfson JA. How accurate is oncologist knowledge of fertility preservation options, cost, and time in female adolescents and young adults? J Adolesc Young Adult Oncol 2022.
Ramstein JJ, Halpern J, Gadzinski AJ, et al. Ethical, moral, and theological insights into advances in male pediatric and adolescent fertility preservation. Andrology 2017;5:631-39. 10.1111/andr.12371
Frederick NN, Klosky JL, Meacham LR, et al.. Infrastructure of fertility preservation services for pediatric cancer patients: a report from the Children’s Oncology Group. JCO Oncol Pract 2021; 18: e325-e333.
Cerić T, Sokolović E, Hasanbegović B, et al.. The Oncology Association of Bosnia and Herzegovina’s Recommendations for fertility preservation in oncologic patients. Bosn J Basic Med Sci 2022.
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Copyright (c) 2023 Jakub Kwieciński, Marek Leśniak, Agnieszka Błaszczyk, Urszula Fussek-Styga, Sara Trojan, Sławomir Miszuda, Bartosz Basiaga, Krzysztof Bednarz, Agata Szwedkowicz, Jakub Heluszka
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