Sexual dimophism in plasma nitrogenous metabolites levels and some psycho-neuro-endocrine parameters
Keywordsnitrogenous metabolites, adaptation hormones, anxiety, HRV, EEG, women, men
Background. We previously showed that the factor structure of the relationships between the plasma levels of nitrogenous metabolites (uric acid, bilirubin, urea, and creatinine), on the one hand, and the parameters of anxiety and neuro-endocrine status, on the other hand, is significantly different in men and women of reproductive age and postmenopausal. The purpose of this study is to identify the metabolic and psycho-neuro-endocrine features of these three cohorts of people. Materials and methods. The object of observation were 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (45÷76 y) and 12 of reproductive age (30÷42 y), with dysfunction of neuro-endocrine-immune complex. In basal conditions we determined plasma levels of nitrogenous metabolites and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. To achieve the goal, the registered parameters were subjected to discriminant analysis. Along with the quite expected nitrogenous metabolites, age, testosterone and calcitonin (both raw and sex- and age-standardized values), trait anxiety, Kerdö's Vegetative Index, one of the vagal markers (SDNN), as well as 10 EEG parameters emerged as characteristic features of the cohorts. In the information space of two discriminant roots, three cohorts are clearly demarcated. Conclusion. We interpret this as another proof of the existence of connections between nitrogenous metabolites and psycho-neuro-endocrine parameters in line with the concept of the functional-metabolic continuum.
Abhishekh HA, Nisarga P, Kisan R, Meghana A, Chandran S, Raju T, et al. Influence of age and gender on autonomic regulation of heart. J Clin Monit Comput. 2013; 27: 259-264.
Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.
Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.
Bombushkar IS, Gozhenko AI, Badiuk NS, Smagliy VS, Korda MM, Popovych IL, Blavatska OM. Relationships between parameters of uric acid metabolism and neuro-endocrine factors of adaptation [in Ukrainian]. Herald of marine medicine. 2022; 2(95): 59-74.
Bombushkar IS, Gozhenko AI, Korda MM, Żukow X, Popovych IL. Relationships between plasma levels of nitrogenous metabolites and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2022; 12(6): 365-383.
Bombushkar IS, Korda MM, Gozhenko AI, Żukow X, Popovych IL. Psycho-neuro-endocrine accompaniments of individual variants of nitrogenous metabolites exchange. Journal of Education, Health and Sport. 2022; 12(7): 994-1008.
Bombushkar IS, Anchev AS, Żukow X, Popovych IL. Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters Journal of Education, Health and Sport. 2022; 12(8): 1198-1205.
Bombushkar IS, Anchev AS, Żukow X, Popovych IL. Sexual dimorphism in relationships between of plasma creatinine and some neuro-endocrine parameters. Journal of Education, Health and Sport. 2022; 12(9): 985-997.
Bombushkar IS, Gozhenko AI, Korda MM, Żukow X, Popovych IL. Peculiarities of relationships between plasma levels of nitrogenous metabolites and EEG&HRV parameters in patients with postradiation encephalopaty. Journal of Education, Health and Sport. 2022; 12(10): 335-355.
Bombushkar IS, Anchev AS, Żukow X, Popovych IL. Sexual dimorphism in relationships between of plasma bilirubin and some neuro-endocrine parameters. Journal of Education, Health and Sport. 2022; 12(11): 381-389.
Cave AE, Barry RJ. Sex differences in resting EEG in healthy young adults. Int J Psychophysiol. 2021; 161: 35-43.
Clarke AR, Barry RJ, McCarthy R, Selikowitz M. Age and sex effects in the EEG: development of the normal child. Clin Neurophysiol. 2001; 112(5): 806-814.
Fajda OI, Hrinchenko BV, Snihur OV, Barylyak LG, Zukow W. What Kerdoe’s Vegetative Index really reflects? Journal of Education, Health and Sport. 2015; 5(12): 279-288.
Goryachkovskiy AM. Clinical biochemi [in Russian]. Odesa: Astroprint; 1998: 608.
Gozhenko AI. Essays on disease theory [in Russian]. Odesa; 2010: 24.
Gozhenko AI. Functional-metabolic continuum [in Russian]. J of NAMS of Ukraine. 2016; 22 (1): 3-8.
Gozhenko АІ, Korda MM, Popadynets’ OO, Popovych IL. Entropy, Harmony, Synchronization and Their Neuro-Endocrine-Immune Correlates [in Ukrainian]. Odesa. Feniks; 2021: 232.
Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200.
Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.
Kerdö I. Ein aus Daten der Blutzirkulation kalkulierter Index zur Beurteilung der vegetativen Tonuslage. Acta Neurovegetativa (Wien). 1966; 29(2): 250-268.
Khmelevskyi YV, Usatenko OK. Basic Biochemical Constants of Humans at Norm and at Pathology [in Russian]. Kyiv. Zdorovya; 1987: 160.
Klecka WR. Discriminant Analysis [trans. from English in Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskva. Finansy i Statistika; 1989: 78-138.
Koenig J, Thayer JF. Sex differences in healthy human heart rate variability: A meta-analysis. Neurosci Biobehav Rev. 2016; 64: 288-310.
Korkushko OV, Pysaruk AV, Shatylo VB. The value of heart rate variability analysis in cardiology: age aspects [in Russian]. Circulation and Hemostase. 2009; 1-2: 127-139.
Kuo TB, Lin T, Yang CC, Li CL, Chen CF, Chou P. Effect of aging on gender differences in neural control of heart rate. Am J Physiol. 1999; 277(6): H2233-H2239.
Popovych IL, Gozhenko AI, Bombushkar IS, Korda MM, Zukow W. Sexual dimorphism in relationships between of uricemia and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2015; 5(5): 556-581.
Popovych IL, Gozhenko AI, Korda MM, Klishch IM, Popovych DV, Zukow W (editors). Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex. Odesa. Feniks; 2022: 252.
Practical psychodiagnostics. Techniques and tests [in Russian]. Samara. Bakhrakh; 1998: 59-64.
Proverbio AM. Sexual dimorphism in hemispheric processing of faces in humans: A meta-analysis of 817 cases. Soc Cogn Affect Neurosci. 2021; 16(10):1023-1035.
Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017; 5: 258.
Shannon CE. A mathematical theory of information. Bell Syst Tech J. 1948; 27: 379-423.
Spielberger CD. Manual for the State-Trait Anxiety Inventory (Form Y) Consulting Psychologists Press; Palo Alto (CA): 1983.
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