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Quality in Sport

The potential usage of thyroid hormones as sport doping - a mini-review
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The potential usage of thyroid hormones as sport doping - a mini-review

Authors

  • Jakub Krzysztof Gałązka Students’ Scientific Association at the Department and Clinic of Endocrinology, Diabetology and Metabolic Diseases, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland https://orcid.org/0000-0003-3128-773X

DOI:

https://doi.org/10.12775/QS.2022.08.03.007

Keywords

thyroid hormones, triiodothyronine, thyroxine, skeletal muscles, sport doping

Abstract

A thyroid gland is one of the most important organs of a human body. Thyroid hormones, at least in physiological concentration, have anabolic features. The aid of this review is to summarize knowledge on potential usage of thyroid hormones in sport doping.

            Thyroid hormones play a crucial role in skeletal muscles physiology. The exposition to T3 and T4 may improve myogenesis, muscles regeneration and muscles blood blow. In a long-time perspective, those hormones may help in reducing body weight.

            According to those mechanisms, thyroid hormones may be considered as a plausible agent in sport doping. However WADA guidelines does not include T3 or T4 in a list o sport doping substances, the debate on their inclusion is on-going, and the physicians should be aware of thyroid hormones effects on human metabolism from sports medicine perspective.

References

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Bloise, F. F., Cordeiro, A., & Ortiga-Carvalho, T. M. (2018). Role of thyroid hormone in skeletal muscle physiology. The Journal of Endocrinology, 236(1), R57–R68. https://doi.org/10.1530/JOE-16-0611

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di Iorio, A., Paganelli, R., Abate, M., Barassi, G., Ireland, A., Macchi, C., Molino-Lova, R., & Cecchi, F. (2021). Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. GeroScience, 43(2), 1053–1064. https://doi.org/10.1007/S11357-020-00302-0

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Li, J., Abe, K., Milanesi, A., Liu, Y. Y., & Brent, G. A. (2019). Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis. Endocrinology, 160(10), 2243–2256. https://doi.org/10.1210/EN.2019-00125

Lourbopoulos, A. I., Mourouzis, I. S., Trikas, A. G., Tseti, I. K., & Pantos, C. I. (2021). Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy. Journal of Clinical Medicine 2021, Vol. 10, Page 5855, 10(24), 5855. https://doi.org/10.3390/JCM10245855

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Published

2022-12-19

How to Cite

1.
GAŁĄZKA, Jakub. The potential usage of thyroid hormones as sport doping - a mini-review. Quality in Sport [online]. 19 December 2022, T. 8, nr 3, s. 61–65. [accessed 1.4.2023]. DOI 10.12775/QS.2022.08.03.007.
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Vol. 8 No. 3 (2022)

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Copyright (c) 2022 Jakub Krzysztof Gałązka

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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