The potential usage of thyroid hormones as sport doping - a mini-review
DOI:
https://doi.org/10.12775/QS.2022.08.03.007Keywords
thyroid hormones, triiodothyronine, thyroxine, skeletal muscles, sport dopingAbstract
A thyroid gland is one of the most important organs of a human body. Thyroid hormones, at least in physiological concentration, have anabolic features. The aid of this review is to summarize knowledge on potential usage of thyroid hormones in sport doping.
Thyroid hormones play a crucial role in skeletal muscles physiology. The exposition to T3 and T4 may improve myogenesis, muscles regeneration and muscles blood blow. In a long-time perspective, those hormones may help in reducing body weight.
According to those mechanisms, thyroid hormones may be considered as a plausible agent in sport doping. However WADA guidelines does not include T3 or T4 in a list o sport doping substances, the debate on their inclusion is on-going, and the physicians should be aware of thyroid hormones effects on human metabolism from sports medicine perspective.
References
Barroso, O., Mazzoni, I., & Rabin, O. (2008). Hormone abuse in sports: the antidoping perspective. Asian Journal of Andrology, 10(3), 391–402. https://doi.org/10.1111/J.1745-7262.2008.00402.X
Bloise, F. F., Cordeiro, A., & Ortiga-Carvalho, T. M. (2018). Role of thyroid hormone in skeletal muscle physiology. The Journal of Endocrinology, 236(1), R57–R68. https://doi.org/10.1530/JOE-16-0611
Bogdan-Alexandru Hagiu, B., & Ghiciuc, C.-M. (2020). Sports Genomics and Sport Doping. Athens Journal of Sports, 7(3), 163–172. https://doi.org/10.30958/ajspo.7-3-2
di Iorio, A., Paganelli, R., Abate, M., Barassi, G., Ireland, A., Macchi, C., Molino-Lova, R., & Cecchi, F. (2021). Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. GeroScience, 43(2), 1053–1064. https://doi.org/10.1007/S11357-020-00302-0
Gao, Y., Zhao, L., Son, J. S., Liu, X., Chen, Y., Deavila, J. M., Zhu, M. J., Murdoch, G. K., & Du, M. (2022). Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling. Thyroid : Official Journal of the American Thyroid Association, 32(5), 581–593. https://doi.org/10.1089/THY.2021.0639
Gild, M. L., Stuart, M., Clifton-Bligh, R. J., Kinahan, A., & Handelsman, D. J. (2022). Thyroid Hormone Abuse in Elite Sports: The Regulatory Challenge. The Journal of Clinical Endocrinology and Metabolism, 107(9), E3562–E3573. https://doi.org/10.1210/CLINEM/DGAC223
Goyal, M., Yadav, K., & Solanki, R. (2021). A study of thyroid profile in patients suffering from the first episode of mania: A cross-sectional study. Indian Journal of Psychiatry, 63(4), 395. https://doi.org/10.4103/PSYCHIATRY.INDIANJPSYCHIATRY_33_20
Li, J., Abe, K., Milanesi, A., Liu, Y. Y., & Brent, G. A. (2019). Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis. Endocrinology, 160(10), 2243–2256. https://doi.org/10.1210/EN.2019-00125
Lourbopoulos, A. I., Mourouzis, I. S., Trikas, A. G., Tseti, I. K., & Pantos, C. I. (2021). Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy. Journal of Clinical Medicine 2021, Vol. 10, Page 5855, 10(24), 5855. https://doi.org/10.3390/JCM10245855
Martínez Brito, D., Botrè, F., Romanelli, F., & de la Torre, X. (2022). Thyroid metabolism and supplementation: A review framed in sports environment. Drug Testing and Analysis, 14(7), 1176–1186. https://doi.org/10.1002/DTA.3257
Ribeiro, M. O. (2008). Effects of thyroid hormone analogs on lipid metabolism and thermogenesis. Thyroid : Official Journal of the American Thyroid Association, 18(2), 197–203. https://doi.org/10.1089/THY.2007.0288
Salvatore, D., Simonides, W. S., Dentice, M., Zavacki, A. M., & Larsen, P. R. (2013). Thyroid hormones and skeletal muscle—new insights and potential implications. Nature Reviews Endocrinology 2013 10:4, 10(4), 206–214. https://doi.org/10.1038/nrendo.2013.238
Selivanova, E. K., & Tarasova, O. S. (2020). Nongenomic Effects of Thyroid Hormones: Their Role in Regulation of the Vascular System. Moscow University Biological Sciences Bulletin, 75(4), 189–198. https://doi.org/10.3103/S0096392520040094/FIGURES/2
Wiacek, M., Markuszewski, L., Tomasiuk, R., & Zubrzycki, I. Z. (2021). Relations Between Performance Enhancement Drugs and Health-defining Parameters During the Competition Preparation Period of World-class Bodybuilders. https://doi.org/10.21203/RS.3.RS-779161/V1
Zeng, B., Liu, L., Liao, X., & Zhang, C. (2021). Cardiomyocyte protective effects of thyroid hormone during hypoxia/reoxygenation injury through activating of IGF-1-mediated PI3K/Akt signalling. Journal of Cellular and Molecular Medicine, 25(7), 3205–3215. https://doi.org/10.1111/JCMM.16389
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