Sprzężone z białkami G receptory wolnych kwasów tłuszczowych

Justyna Kalinowska; Katarzyna Winiarska

doi:10.12775/KOSMOS.2025.002

Authors

Justyna Kalinowska Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, University of Warsaw https://orcid.org/0009-0008-1163-0151
Katarzyna Winiarska Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology; University of Warsaw https://orcid.org/0000-0001-8693-6069

DOI:

https://doi.org/10.12775/KOSMOS.2025.002

Keywords

free fatty acids, G protein-coupled receptors (GPCR), free fatty acid receptors (FFAR), signal transduction, metabolic diseases, therapy

Abstract

Free fatty acid receptors (FFAR) belong to the family of G protein-coupled receptors (GPCR), i.e. the most abundant group of membrane proteins involved in signal transduction from the outer environment to the cell. In the present paper we characterize four human receptors activated by free fatty acids: FFAR1/GPR40, FFAR2 /GPR43, FFAR3/GPR41 and FFAR4/GPR120. We describe signaling pathways trigged by these receptors and we discuss their importance under both physiological and pathological conditions. We also indicate future perspectives of FFAR ligands application in therapy, including the treatment of cancers, diabetes and obesity.

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G protein-coupled receptors activated by free fatty acids

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