Sprzężone z białkami G receptory wolnych kwasów tłuszczowych

Justyna Kalinowska; Katarzyna Winiarska

doi:10.12775/KOSMOS.2025.002

Autor

Justyna Kalinowska Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii, Uniwersytet Warszawski, https://orcid.org/0009-0008-1163-0151
Katarzyna Winiarska Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii, Uniwersytet Warszawski https://orcid.org/0000-0001-8693-6069

DOI:

https://doi.org/10.12775/KOSMOS.2025.002

Słowa kluczowe

wolne kwasy tłuszczowe, receptory sprzężone z białkami G (GPCR), receptory wolnych kwasów tłuszczowych (FFAR), przekazywanie sygnału, choroby metaboliczne, terapia, terapia

Abstrakt

Receptory wolnych kwasów tłuszczowych (FFAR) należą do rodziny receptorów sprzężonych z białkami G (GPCR) – najliczniejszej grupy białek błonowych odpowiedzialnych za przekazywanie sygnałów z otoczenia komórki do jej wnętrza. W pracy scharakteryzowano cztery ludzkie receptory aktywowane przez wolne kwasy tłuszczowe: FFAR1/GPR40, FFAR2 /GPR43, FFAR3/GPR41 i FFAR4/GPR120. Przedstawiono szlaki sygnałowe uruchamiane przez te receptory oraz omówiono znaczenie FFAR w warunkach normy i patologii. Wskazano również perspektywy wykorzystania ligandów FFAR w celach terapeutycznych, między innymi w leczeniu chorób nowotworowych, cukrzycy i otyłości.

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Sprzężone z białkami G receptory wolnych kwasów tłuszczowych

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